Typing tool
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Typing tool
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Complete norovirus genomes
| MW305549 | GII.6 | |
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| GII.P7 |
ORF1: 1..5063
ORF2: 5044..6687
ORF3: 6687..7463
LOCUS MW305549 7515 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate 92HBO nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305549
VERSION MW305549.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7515)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7515)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7515
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="92HBO"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Paraguay"
/collection_date="04-Jul-2016"
/note="genotype: GII.6[GII.P7]"
gene <1..5063
/gene="ORF1"
CDS <1..5063
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ58983.1"
/translation="FGSQNSVNDSINTAPSNKEEVGAFSNIKVGFKKMLGAVPKGTKA
PSSDQHCPSVKIGTKTLTVPPEPPNGEDTVQFDAKSETVRGLPDLTTVQNEHENTPYT
VPPLSEREHRPATEPLPGTILEMWDGEFYHYSVYVSGGKALGVHKPPAAISLATIELT
PISLYWRPVYTPNYLVCPDTLKGLAGEKFPYTAFSNNCYNFCCWVLELNDTWLSRRSI
SRTTGFFKPYQSWNRKPLPTVDDGKIKKVANAILCALGSLFSKPIKDLLGKLKPLNLL
HLLASCDWTFAGIVETVILMAELFGIFWTPPDVSSFIASLIGDFELQGPEDLAVELVP
VVMGGIGMVLGFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMKWFFPKKEEKAE
METLRAIEDAVLDMEAIGNNHLTTLLKDKDSLTAFMKTLDLEEEKARRLSTKSSSPDI
VGTINAILARIAAARSLLHKAKEEMFSRIRPVVVMISGRPGIGKTHMARHLAKSIANT
MSGDQRVGLVPRNGVDHWDAYRGERVVLWDDYGMGNPVKDALTLQELADTCPVTLNCD
RIENKGKMFDSDVIIITTNLVNPAPLDYVNFEACSRRVDFLVYAESPEIEKVKRDFPG
QPDMWKDHFKPDFSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSLTARVAGLVHER
RDEFQLQGNDLQTYNFDTNRVSAFRKLAADNKYGIMETMRVGTALKSVKTLEDLKVAL
RDVKFNECEIIYKNSKYRVSSNGKGSVSVDKVEDQTSQTANEVGAALLRLRQARARYY
VSCFQDLVYTLIQVAGASFVVNRISKRFCWERWVKPTETQEASESEKEVAQGRWEIEP
KDTEPEGKKGKNKKGRGKKHTAFSSKGLSDEEYDEFKRIREERNGKYSIEEYLQDRDR
YYEEVAVARATEEDFCEEEEAKIRQRIFRPTKKQRKEERGVLGLVTGSDIRRRRPDDF
QPKGNLWADDTRSVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNLLITTTHVLPKG
INELFGVEIKQIQIHKSGEFCRFRFPRPIRPDVTGLVLEEGAPEGTVCSILVKRPTGE
MIPLAVRMGTHASMKIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCGCPYIYKRGNDI
VVAGVHTAAARGGNTVICATQGQDGEAVLEGNENLGTYCGAPILGPGKAPKLSTKTKF
WRSSPDALPPGTYEPAYLGGKDPRVEKGPSLQQVMRDQLKPFTEPRGKPPRPAVLEEA
KKTVMNVLEQTIDPAKPWTYSQACASLDKTTSSGSPHHVRKNDHWNGESFTGPLADQA
SKANLMYEQAKHVQPVYTAALKDELVKTDKIYKKIKKRLLWGSDLGTMIRCARAFGGL
MDSMKASCITLPCRVGMNMNEDGPIIFDKHSKYRYHYDADYSRWDSTQQRSILSAAME
VMVRFSAEPELAQVVAEDLLAPSQLDVGDFVISVQEGLPSGVPCTSQWNSIAHWILTL
SAMAEVSGLSPDVVQAHSCFSFYGDDEIVSTDINLDPMKLTQKLREYGLVPTRPDKTE
GPLVITEDLTGLTFLRRSIARDPAGWFGKLDQDSILRQLYWTRGPNHENPYESMVPHS
QRATQLMALLGEASLHGPQFYKKVSKMVINEIKSGGLEFYVPRQEAMFRWMRFSDLST
WEGDRNLAPEGVNEDGVE"
mat_peptide <1..971
/gene="ORF1"
/product="p48"
mat_peptide 972..2069
/gene="ORF1"
/product="NTPase"
mat_peptide 2070..2588
/gene="ORF1"
/product="p22"
mat_peptide 2589..2987
/gene="ORF1"
/product="VPg"
mat_peptide 2988..3530
/gene="ORF1"
/product="Pro"
mat_peptide 3531..5060
/gene="ORF1"
/product="RdRp"
gene 5044..6687
/gene="ORF2"
CDS 5044..6687
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58984.1"
/translation="MKMASNDAAPSNDGAANLVPEATNEVMALEPVVGASIAAPVVGQ
QNVIDPWIRENFVQAPQGEFTVSPRNSPGEMLLNLELGPELNPYLSHLSRMYNGYAGG
MQVQVVLAGNAFTAGKIIFAAVPPHFPVDNISAAQITMCPHVIVDVRQLEPVLLPLPD
IRNRFFHYNQENTPRMRLVAMLYTPLRANSGEDVFTVSCRVLTRPAPDFEFTFLVPPT
VESKTKPFTLPILTLGELSNSRFPAPIDMLYTDPNEAIVVQPQNGRCTLDGTLQGTTQ
LVPTQICSFRGTLISQTSRSVDSTDSAPRARNHPLHVQLKNLDGTPYDPTDEVPAVLG
AIDFKGTVFGVASQRNTTGNSIGATRAHEVHIDTTNPRYTPKLGSVLMYSESTDFDDG
QPTRFTPIGMGADDWHQWELPEYSGHLTLNMNLAPAVAPAFPGERILFFRSVVPSAGG
YGSGHIDCLIPQEWVQHFYQEAAPSQSAVALIRYVNPDTGRNIFEAKLHREGFITVAN
SGNNPIVVPPNGYFRFEAWVNQFYTLTPMGTGQGRRRIQ"
gene 6687..7463
/gene="ORF3"
CDS 6687..7463
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58985.1"
/translation="MAGAFLAGLAGDAITSGVGSLINAGANAINQKVEYDFNKQLQLA
SFKHDKEMLQSQVLATKQLQQEMMNIRQGVLSAGGFSPTDAARGAVNAPMTKILDWNG
TRYFAPNSMKTTSYSGQFSSNPVHRQPTLPRSEPPKIKVNSDSASVYSSASTVPSQST
HSTALTAGSSSSRTTSSSAAASTLSRTSDWVRGQNERLSPFMDGALQTTFVTPPSSKA
SSYGSVSTVPKAVLDSWTPMFNTHRQPLFAHVRRRGESQI"
ORIGIN
1 cctttggcag ccaaaactct gtcaatgaca gtatcaacac cgccccttct aataaagaag
61 aggttggtgc attctccaac atcaaagttg gttttaagaa aatgctgggt gccgttccca
121 aggggaccaa agcacccagt agtgatcaac actgcccctc agttaagatc gggaccaaga
181 cattaacagt tccccctgag cccccaaatg gtgaagacac cgtgcagttt gatgcgaagt
241 cggaaactgt gcgcgggtta ccagacttga caacggtgca gaacgaacac gaaaacacac
301 catacactgt ccccccattg agtgaaaggg agcacagacc agctactgaa ccgcttcctg
361 gcacgatact ggagatgtgg gatggtgaat tctaccatta ctctgtgtac gtcagcggtg
421 gcaaagccct aggggttcac aagccccctg cagcgataag cctcgcgacg atagagctca
481 cacccatatc tctttattgg aggcccgttt acacccccaa ctatctggtc tgtccagaca
541 cgttgaaggg ccttgctggt gagaagttcc cctacacggc cttcagcaac aactgttaca
601 acttctgttg ctgggtgctc gagctcaatg acacgtggct tagcaggaga agcatttcta
661 ggaccaccgg cttcttcaaa ccataccagt cttggaatag aaaacccctt ccaaccgttg
721 atgatggaaa gatcaaaaag gtggccaacg caattctctg tgcactcgga tcactgtttt
781 caaaaccaat caaggaccta ttgggcaaac ttaaaccatt gaacttgctg cacttgctcg
841 catcatgtga ctggacgttt gcgggtatag tagagacagt catcctaatg gcggaacttt
901 tcggcatctt ttggacaccg ccagatgttt ccagtttcat agcctccctg ataggtgatt
961 ttgaattgca agggccggag gacctggctg tggagcttgt acccgtggtc atgggtggca
1021 taggaatggt cctcggcttt actgctgaga agataggccg catgttatcg tccgctgcat
1081 caacactacg ggcgtgcaaa gacttgggga attatgctct tgacatattg aaactggtta
1141 tgaagtggtt cttcccaaag aaagaagaga aagccgagat ggaaacccta agggcgattg
1201 aggatgccgt cctggacatg gaagctatag gaaataacca tctcacaacc ctcctcaagg
1261 acaaggatag cctcacggct ttcatgaaga ctctagatct agaagaagag aaggcgagga
1321 ggctgtctac caaatcatcc tcaccggaca ttgtcggcac cattaatgcc atactggcta
1381 gaatagctgc tgccaggtcc ctcttgcaca aggctaaaga agaaatgttc agcaggatca
1441 gacccgtggt tgtcatgatc tcaggtaggc ctggcattgg caaaacccac atggcgagac
1501 acttggccaa gagtatcgcc aacaccatga gcggcgacca gagagtgggg ctcgtcccac
1561 gcaacggggt tgatcattgg gacgcctaca ggggagagag ggtggtttta tgggatgatt
1621 atggcatggg aaaccctgtc aaagatgcct taacactaca agagctggcc gacacctgtc
1681 cagtaactct aaactgtgat aggattgaga acaaggggaa aatgtttgac agtgatgtca
1741 ttataatcac gaccaattta gtcaacccag cgcccctcga ttatgtaaac ttcgaggcgt
1801 gctccagaag ggtcgacttt ctggtctatg cagagtcgcc agaaattgag aaggttaaga
1861 gagacttccc cggccaacct gacatgtgga aggaccattt caagccagac ttttcccaca
1921 taaaactgac tctagcccca cagggtggat ttgacaagaa tggcaacacc ccgcatggta
1981 agggcaccat gcgatcccta acccaggggt ccctgactgc aagggttgca ggtcttgttc
2041 atgagaggag agacgagttt cagctccagg ggaacgacct ccaaacatat aactttgata
2101 ccaacagagt ctctgcattt aggaagctgg ccgcagacaa caagtatggg atcatggaga
2161 ctatgagagt gggcacagcg cttaagagcg tcaagacctt ggaagatctg aaagtagcac
2221 tgagggatgt gaaattcaat gagtgtgaga taatttacaa aaactccaaa taccgagtct
2281 cttccaatgg taaaggctct gtctctgttg acaaagttga ggaccaaaca tcccagaccg
2341 caaacgaagt gggcgcagca ctccttagac tcagacaggc aagagccagg tactatgtca
2401 gctgcttcca agacctcgtt tacactctaa tacaggtcgc cggagcatca ttcgttgtca
2461 acaggatctc taaaaggttc tgctgggaga gatgggtcaa accaaccgag acccaggaag
2521 cgagtgaatc cgaaaaggaa gtggcccaag gcagatggga gattgagccc aaggacacag
2581 aaccagaagg taagaagggt aagaacaaga aaggaagagg caagaaacac acagctttct
2641 ccagtaaagg cctgagtgac gaggagtatg atgagttcaa gagaatcaga gaagaaagga
2701 acggaaaata ctccattgag gaatacctgc aagaccggga tcgctactat gaggaagtgg
2761 cagttgcccg ggcgacggag gaggacttct gtgaagagga agaggccaag ataagacaaa
2821 gaatctttcg ccccacaaag aaacagagga aggaagaaag gggggtgctt ggtttggtca
2881 ctggctcaga catcagaagg agaagaccag acgattttca accgaagggc aacctgtggg
2941 cagacgacac caggagtgtg gactacaacg agagacttga tttcgaggcc cccccgagtg
3001 tctggtcaag aatagtccca ttgggcactg gctggggctt ctgggtctca tcaaacctcc
3061 tgatcacaac aacgcacgtc ctacctaagg ggattaatga actctttgga gttgagatca
3121 aacagattca gattcataag tctggagagt tctgcaggtt cagattccca agaccaatta
3181 gaccggatgt cacagggctc gtgttggagg aaggcgctcc agaaggcact gtctgctcca
3241 tactcgtaaa gagacctaca ggtgagatga tccccctggc agtgaggatg ggtacgcatg
3301 catccatgaa gatacagggt aggaccgtcg gtggccagat ggggatgctc ctcacagggg
3361 caaacgcgaa gaacatggat cttggcaccg gtcctggtga ttgcggttgc ccttacatct
3421 acaaacgtgg caatgatata gttgtcgcgg gtgtccacac cgcagcagcc cgagggggca
3481 acactgtcat atgtgccact caagggcagg atggggaagc agtccttgag ggaaatgaga
3541 accttggcac ttactgtggt gctccaatct tgggtccagg caaggcgccc aaacttagca
3601 cgaagaccaa gttctggcgt tcatcaccag acgctttgcc gccaggcact tatgaacctg
3661 cctacttggg aggtaaggac cctagagtgg aaaaaggacc atccctgcag caagtcatga
3721 gggaccagct aaaacctttc acagaaccca ggggcaagcc acctagacct gcagtcttag
3781 aagaagccaa aaagacagtg atgaatgttc tagagcaaac cattgaccct gctaaaccat
3841 ggacctattc ccaagcatgt gcctcactgg acaagaccac ttccagtggt agcccccatc
3901 atgtcaggaa aaatgaccat tggaatgggg aatccttcac tggccccctc gcagaccaag
3961 catccaaagc caacctcatg tacgagcagg ccaagcacgt gcagcccgtg tacacggccg
4021 cacttaaaga tgaactagtc aaaactgata agatctacaa gaagataaag aaaaggctct
4081 tatgggggtc ggatcttggt acaatgatta ggtgtgccag ggcctttggc ggtctcatgg
4141 atagcatgaa ggcaagctgc ataaccctcc catgtagggt aggaatgaac atgaatgaag
4201 atggccccat catatttgac aagcattcta agtataggta ccattatgat gctgactatt
4261 ccaggtggga ctcaacccag cagaggagca ttctctcggc cgctatggaa gtgatggttc
4321 ggttctctgc tgaaccagag ctggcacaag tggttgcaga ggacctcctg gcacccagcc
4381 aactagatgt tggcgatttc gtcatctcag tccaggaggg tctgccatca ggggtcccat
4441 gcacatcaca atggaactca atagcacact ggatcctgac cttgagtgca atggcagaag
4501 tatcgggtct ctcaccagat gttgttcaag cccactcctg tttctcattc tacggtgatg
4561 atgagatcgt cagcactgac atcaaccttg accccatgaa gttgacacag aagctcagag
4621 agtatggcct ggtccccacc cgacctgaca aaactgaggg tcccctcgta ataactgaag
4681 atctcaccgg cctaacgttc ctgcgtaggt caattgcacg ggacccagct gggtggtttg
4741 gaaaattgga ccaagactca atcctcagac agttgtactg gacaaggggc cccaaccatg
4801 agaacccata tgagagcatg gtccctcatt cccagcgggc cacacaactt atggccctcc
4861 tcggtgaggc ttcactgcat ggtcctcagt tttacaagaa agttagcaag atggttatta
4921 atgagatcaa aagtggtggt ctggaattct atgtgcccag acaagaggcc atgttcagat
4981 ggatgagatt ctctgacctc agcacatggg agggcgatcg caatcttgct cccgagggtg
5041 tgaatgaaga tggcgtcgaa tgacgctgct ccatcgaatg atggtgctgc caacctcgta
5101 ccagaggcca ccaatgaggt tatggcactt gagccggtgg tgggagcctc aattgctgct
5161 cctgttgtcg gccaacaaaa tgtaattgac ccctggatta gagaaaattt tgttcaggca
5221 ccacagggtg agtttactgt atcaccaagg aactcacctg gtgagatgct tctaaatctt
5281 gaattaggcc ctgagctcaa cccttatttg agtcatttgt cccgcatgta taacggctat
5341 gctggtggta tgcaggttca ggtggtccta gctgggaatg cgttcacagc tggtaaaatc
5401 atctttgccg ccgtcccacc acatttccct gttgataaca ttagtgcagc ccaaatcaca
5461 atgtgccccc atgtaattgt tgatgtaaga cagcttgagc cagtgctttt gcccctccct
5521 gacataagga atagattctt tcattacaat caggaaaata ccccccggat gagacttgtg
5581 gctatgttgt atacacccct tagagcaaat tctggtgagg atgtgtttac ggtgtcttgc
5641 agagttctga cccgccctgc ccccgacttt gagttcacgt ttttggtgcc accaactgtg
5701 gagtcaaaga ctaagccctt tacactccct attctgactc ttggagagct gtccaactcc
5761 agattccccg ctccgataga catgttgtac actgacccca atgaggcaat tgtggtgcaa
5821 ccacaaaatg gcaggtgcac tctagatgga acacttcaag ggaccaccca actggtaccc
5881 acccagattt gctccttcag gggcacgcta attagtcaga cgtcgaggtc cgtagattca
5941 acagattcag ccccacgggc gaggaaccac cctctccacg ttcagctgaa gaacctcgat
6001 gggacaccat atgacccaac agatgaggtg ccagcagttt tgggtgccat agatttcaaa
6061 ggaactgtgt ttggggtcgc tagccaaaga aacaccacag ggaactctat aggagcaacc
6121 cgcgcccatg aagtgcacat agacaccaca aaccctagat ataccccaaa gcttggctct
6181 gtgttgatgt attctgaatc tactgatttt gatgatggac aacccacccg cttcaccccc
6241 attggtatgg gagccgatga ttggcaccaa tgggaattgc ccgaatattc tggtcacctc
6301 actcttaata tgaatttggc ccctgcagtt gcccccgctt tccctggtga gcgcattctc
6361 ttcttcagat cagtggtgcc gtctgctggt ggctatggat caggtcacat agattgcctc
6421 atcccacagg agtgggttca gcatttctac caggaggccg ctccatcaca gtctgcggtg
6481 gctcttatca gatatgtcaa ccctgacact ggaagaaaca tctttgaggc aaaactgcat
6541 agagaagggt tcatcactgt ggcaaattct ggaaacaacc ccatagttgt gcccccaaat
6601 ggttacttca ggtttgaggc ctgggtcaat caattctaca cactcacccc catgggaact
6661 ggacaggggc gcagaagaat tcagtaatgg caggagcttt cttagctgga ttggcaggtg
6721 acgccataac aagtggtgtc gggtccctaa tcaatgctgg ggccaatgca attaaccaaa
6781 aggtagaata tgactttaat aaacaactcc aattggcatc cttcaaacat gataaagaga
6841 tgttgcaatc acaagtactg gccactaaac agctccagca ggagatgatg aacataaggc
6901 aaggggtctt gtccgctggc ggcttttccc ctacagatgc cgcgagaggt gctgtgaacg
6961 caccgatgac aaaaattttg gattggaatg gaacaaggta ctttgcccca aatagcatga
7021 agacaactag ttattcgggc cagttttcca gcaaccccgt gcataggcag cccactttgc
7081 cccgttctga acccccaaaa attaaggtta atagtgattc tgctagtgtg tatagttctg
7141 catctactgt tccttcacaa tcaactcact caacggcttt gactgcgggg tctagctcat
7201 ctaggacaac atcctcttct gcagcagctt ccaccctatc taggactagt gactgggtga
7261 gaggacaaaa tgaaaggctt agcccgttta tggatggtgc tctccaaaca acttttgtca
7321 caccaccatc gagcaaagct tcatcatatg ggtcggtctc aaccgtcccc aaagctgttt
7381 tggactcctg gacccccatg ttcaataccc ataggcagcc tctcttcgct cacgtgcgca
7441 ggcgagggga gtcacaaatt tagtgaaaag attgattagg ttttctttct ttcttctttt
7501 ccttttcttt ctttt
//