Typing tool
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Typing tool
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Complete norovirus genomes
| MW305545 | GII.4 Osaka | |
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| GII.P4 US95 |
ORF1: 1..5067
ORF2: 5048..6670
ORF3: 6670..7476
LOCUS MW305545 7518 bp RNA linear VRL 18-JUL-2024
DEFINITION Norovirus GII isolate PNV007123 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305545
VERSION MW305545.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7518)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7518)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7518
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="PNV007123"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Peru"
/collection_date="01-Jun-2008"
/note="genotype: GII.4[GII.P4]"
gene <1..5067
/gene="ORF1"
CDS <1..5067
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="QPJ58971.1"
/translation="AVANSNNDIAKSSSDGVLSSMAVTFKRALGARPKQPPPREVPQR
PPRPPTPELVKKIPPPPPNGEDEIVVSYSVKDGVSGLPELSTVRQPEENNTAFSVPPL
NQRENRDAKEPLTGTILEMWDGEIYHYGLYVEQGLVLGVHKPPAAISLAKVELSPLSL
FWRPVYTPQYLISPDTLRKLHGESFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQRTT
GFFRPYQDWNRKPLPTMDDSKLKKVANVFLCALSSLFTRPIKDIIGKLRPLNILNILA
SCDWTFAGIVESLILLAELFGVYWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVVMG
GIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKQEENELAMV
RSIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTI
NALLARIAAARSLVHRAKEELSSRPRPVVLMISGRPGIGKTHLAREVAKRIASTLTGD
QRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIEN
KGKVFDSDVIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPDVEKAKRDFPGQPDM
WKNAFSSDFSHIKLTLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERMDEF
ELQGPALTTFNFDRNKVLAFRQLAAENKYGLVDTMRVGRQLKEVKTMPDLKQALRNIS
IKKCQIVYSGCTYVLESDGKGNVKVDKVQSTSVQTNNELSGALHHLRCARIRYYVKCV
QEALYSIIQIAGAAFVTTRIVKRMNIQDLWSKPQVEDTGEAINKDGCPKPKDDEEFVI
SSDDIKTEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDR
DKYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRNPD
DFKPKGKLWADDDRSVDYNEKLSFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIP
QGAKEFFGVPIKQIQIHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVVTLLIKRPT
GELMPLAARMGTHATMRIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKREN
DYVVIGVHTAAARGGNTVICATQGSEGEATLEGSDSKGTYCGAPILGPGSAPKLSTKT
KFWRSSTTPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGRPPKPSVLE
AAKKTIINVLEQTIDPPEKWSFAQACASLDKTTSSGHPHHMRKNDCWNGESFTGKLAD
QASKANLMFEEGKNMTPVYTGALKDELVKTDKIYGRIKKRLLWGSDLATMIRCARAFG
GLMDELKAHCVTLPIRVGMNMNEDGPIIFEKHARYKYHYDADYSRWDSTQQRAVLASA
LEIMVKFSSEPHLAQVVAEDLLSPSVVDVGDFKISINEGLPSGVPCTSQWNSIAHWLL
TLCALSEVTNLSPDIIQANSLFSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTRPDK
TKGPLVISEDLNGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHEDPSETMIP
HSQRPIQLMSLLGEAALHGPAFYSKISKLVIAELKEGGMDFYVPRQEPMFRWMRFSDL
STWEGDRNLAPSFVNEDGVE"
mat_peptide <1..957
/gene="ORF1"
/product="p48"
mat_peptide 958..2055
/gene="ORF1"
/product="NTPase"
mat_peptide 2056..2592
/gene="ORF1"
/product="p22"
mat_peptide 2593..2991
/gene="ORF1"
/product="VPg"
mat_peptide 2992..3534
/gene="ORF1"
/product="Pro"
mat_peptide 3535..5064
/gene="ORF1"
/product="RdRp"
gene 5048..6670
/gene="ORF2"
CDS 5048..6670
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58972.1"
/translation="MKMASNDANPSDGSTANLVPEVNNEVMALEPVVGAAIAAPVAGQ
QNVIDPWIRNNFVQAPGGEFTVSPRNAPGEILWSAPLGPDLNPYLSHLARMYNGYAGG
FEVQVILAGNAFTAGKIIFAAVPPNFPTEGLSPSQVTMFPHIIVDVRQLEPVLIPLPD
VRNNFYHYNQSNDPTIKLIAMLYTPLRANNAGDDVFTVSCRVLTRPSPDFDFIFLVPP
TVESRTKPFTVPILTVEEMTNSRFPIPLERLYTGPSSAFVVQPQNGRCTTDGVLLGTT
QLSAVNICTFRGDVTHIAGSRNYAMNLASQNWSNYDPTEEIPAPLGTPDFVGKIQGML
TQTTRRDGSTRGHKATVLTGSADFAPKLGRVQFATDTDNDFESGENTKFTPVGVIQDG
STTHRNEPQQWVLPNYSGRTGHNVHLAPAVAPTYPGEQLLFFRSTMPGCSGYPNMDLD
CLLPQEWVRHFYQEAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYVTVAHTGQHDLV
IPPNGYFRFDSWVNQFYTLAPMGNGTGRRRAL"
gene 6670..7476
/gene="ORF3"
CDS 6670..7476
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58973.1"
/translation="MAGAFFAGLASDVLGSGLGSLIGAGAGAINQKIDFENNRKLQQA
SFQFSSNLQQASFQHDKEMLQAQIEATKKLQQEMMKVKQAMLLEGGFSETDAARGAIN
APMTKALDWSGTRYWAPDARTTTYNAGRFSTPQPSGALPGRINSRTPTPARGSSSTSS
NASIATSIYSNQTVSTRLGSTAGSGTNVSSLPSTARTRSWVEDQNRNLSPFMRGAHNI
SFVTPPSSRSSSQGTVSTVPKEILDSWTGAFNTRRQPLFAHIRRRGESRV"
ORIGIN
1 gctgttgcca acagcaacaa cgacatcgca aaatcttcaa gtgacggagt gctttctagc
61 atggctgtca cttttaaaag agccctcggg gcgcggccta aacagccccc cccgagggaa
121 gtaccacaaa gacccccacg accacccacc ccagaactgg tcaaaaagat cccccccccc
181 ccgcccaacg gggaggatga aatagtggtt tcctatagtg tcaaagatgg tgtttccggc
241 ttgcccgaac tttccaccgt cagacaaccg gaagaaaaca atacagcctt cagtgttccc
301 ccactcaacc agagggaaaa tagggatgct aaggagccac tgactgggac aattttggaa
361 atgtgggatg gagagatcta tcattacggt ctctatgtgg agcaaggtct tgtacttggt
421 gtgcacaaac caccagctgc cattagcctc gccaaggtcg agctatcacc actctccttg
481 ttctggagac ctgtgtatac cccacaatac ctcatttccc cagacactct caggaaatta
541 cacggggagt cgtttcccta cacagccttt gacaacaatt gctatgcctt ctgttgttgg
601 gtcttggacc taaacgactc gtggctgagt aggaggatga tccagagaac tactggcttt
661 ttcagaccct accaagattg gaataggaaa cccctcccca ctatggatga ttccaaatta
721 aagaaagtag ccaacgtatt cctgtgtgct ctatcttcac tattcaccag gcccataaaa
781 gatataatag ggaaactaag gccccttaac atcctcaaca tcttggcctc atgtgattgg
841 actttcgcag gtatagtgga atccctgata cttctggcgg agctctttgg agtttactgg
901 acacccccag atgtgtctgc aatgattgcc cccttactcg gcgattacga gttgcaaggg
961 cctgaggacc ttgcagtgga acttgttcct gtagtgatgg ggggaattgg tttggtgcta
1021 ggatttacca aagagaagat tggaaaaatg ctgtcatctg ctgcatccac cttaagggct
1081 tgtaaagatc ttggtgcata cgggctggaa atcctaaagt tagttatgaa gtggttcttc
1141 ccaaagaaac aggaagaaaa tgaactggct atggtgaggt ccatcgagga tgcagtgctg
1201 gacctcgagg caattgaaaa caaccacatg accacattgc tcaaggacaa agacagtctg
1261 gcaacctaca tgagaaccct tgaccttgag gaggagaaag ccaggaagct ctcaaccaag
1321 tccgcttcac ctgacatcgt gggcacaatc aacgcccttc tggcgaggat cgctgctgca
1381 cgttccctgg tgcatcgagc aaaggaggag ctttccagca gaccaagacc agttgtcctg
1441 atgatatcag gcagaccagg aatagggaag actcaccttg ctagagaagt ggccaagaga
1501 atcgcatcca ccctcacagg agaccagcgt gtgggcctca tcccacgcaa tggcgtcgac
1561 cactgggatg cgtacaaggg ggaaagggtc gtcctatggg acgactacgg gatgagtaat
1621 cccatccacg acgcactcag gctgcaagaa ctcgctgaca cctgccccct cactctgaac
1681 tgtgacagga ttgagaacaa aggaaaggtc tttgacagtg atgtcataat tattaccact
1741 aatctggcca acccagcacc actggactat gtcaactttg aggcgtgctc gaggcgcatc
1801 gatttcctcg tgtatgcgga agcccctgat gttgagaagg cgaaacgtga cttcccagga
1861 caaccagaca tgtggaagaa cgccttcagt tctgacttct cacacataaa actgacactg
1921 gccccacaag gtggcttcga caagaacgga aacaccccgc acggaaaggg cgtcatgaag
1981 acactcacca ctggctccct cattgcccgg gcatcagggc tacttcatga gaggatggat
2041 gagtttgaat tacagggccc ggctctcacc accttcaact ttgatcgcaa caaagtgctt
2101 gcctttaggc agcttgctgc tgaaaacaaa tacgggttgg tggacacaat gagagtcgga
2161 aggcagctca aggaggttaa aaccatgcca gatcttaaac aggcactcag gaacatctca
2221 attaagaagt gccagattgt gtacagtggt tgtacttatg tacttgagtc tgatggcaag
2281 ggcaacgtga aagttgacaa agttcagagc acctctgtgc agaccaacaa cgagctgtcc
2341 ggcgccctac accatctgag gtgcgccaga attaggtatt acgttaagtg tgttcaggag
2401 gccctgtatt ccatcatcca aattgctgga gctgcatttg tcaccacgcg catcgtcaag
2461 cgcatgaaca tacaagacct ctggtccaag ccacaagtgg aagacacagg ggaggctatc
2521 aataaggacg ggtgcccaaa acccaaagat gatgaggagt tcgtcatttc atctgacgat
2581 atcaaaactg agggcaagaa agggaagaac aagactggcc gcggcaagaa gcacacagcc
2641 ttctcaagca aaggtcttag tgatgaagag tacgatgagt acaagaggat tagagaagaa
2701 agaaatggca agtactctat agaagagtac ctccaggaca gggacaaata ctatgaggag
2761 gtggccattg ctagggcaac tgaggaagac ttctgtgaag aagaggaggc caagattcgg
2821 caaaggattt tcaggccaac aaggaaacaa cgcaaggagg aaagggcctc tctcggtttg
2881 gtcacaggct ctgaaatcag gaaaagaaac ccagatgatt tcaagcccaa ggggaagctg
2941 tgggccgacg atgacagaag tgtggactac aatgaaaaac tcagttttga ggccccaccg
3001 agcatctggt cgaggatagt caactttggc tcgggttggg gcttttgggt ctctcccagt
3061 ctgttcataa catcaaccca cgtcataccc cagggtgcta aagagttctt tggagtccct
3121 atcaagcaga tccagataca taagtcaggc gagttttgtc gcttgagatt cccaaaacca
3181 atcagaactg atgtgacggg catgatctta gaagaaggtg cgcccgaagg caccgtggtc
3241 acactgctca tcaagaggcc tactggagaa cttatgccct tagcagctag aatggggacc
3301 catgcaacca tgagaattca agggcgcact gttgggggtc agatgggcat gcttctgaca
3361 ggatccaacg ccaaaagtat ggatctaggc accacaccag gtgactgcgg ctgcccttac
3421 atctataaga gggaaaatga ctatgtggtc attggagtcc acacggctgc cgctcgtggg
3481 ggaaataccg tcatatgtgc cacccaggga agtgaggggg aggccacact tgaaggtagt
3541 gacagtaagg gaacatactg tggagcacca atcctaggcc cagggagcgc cccaaaactc
3601 agcaccaaga ccaaattctg gagatcgtcc acaacaccac tcccacctgg cacttatgaa
3661 ccagcctacc ttggtggtaa ggaccccaga gtcaagggtg gcccttcatt gcagcaggtt
3721 atgagggatc agttgaaacc atttacagaa cccagaggca gaccaccaaa gccaagtgtg
3781 ttggaagccg ccaagaaaac tattatcaat gtccttgaac aaacaattga cccacctgag
3841 aaatggtcat tcgcgcaagc ttgtgcgtcc ctcgataaga ccacttccag tggccacccg
3901 caccacatgc ggaaaaatga ctgctggaac ggggaatcct tcacaggtaa gctggcagat
3961 caggcttcca aggccaacct gatgtttgaa gaggggaaga acatgacccc agtctacaca
4021 ggtgcgctca aggacgaact agttaaaact gacaaaattt atggcagaat caagaagagg
4081 ctgctctggg gctcggactt agcgaccatg atccggtgcg cccgagcgtt tgggggctta
4141 atggatgaac tcaaagcaca ctgtgtcaca cttcctatca gagttggtat gaacatgaat
4201 gaggatggcc ctatcatctt tgagaagcat gccagataca agtaccatta tgatgctgac
4261 tactctcggt gggattcaac acaacagaga gccgtgttag catcagcttt agaaatcatg
4321 gttaaattct cctcagaacc acatttggcc caggtagtcg cagaagacct tctctctcct
4381 agcgtggttg atgtgggcga cttcaaaata tcaatcaatg agggtctccc ctctggggtg
4441 ccctgcacct ctcaatggaa ctccatcgcc cactggcttc tcactctctg tgcgctctct
4501 gaagtcacaa acttgtcccc tgacatcata caggctaatt ccctcttctc cttctatggc
4561 gatgatgaaa ttgttagtac agatataaaa ctagatccag agaaattgac agcgaagctc
4621 aaagaatatg ggttgaaacc aacccgccct gacaagacta aaggacccct tgtcatttct
4681 gaagacctga atggtctgac cttcctgcgg agaactgtga cccgcgatcc agctggttgg
4741 tttggaaaat tggagcagag ttcaatactc agacaaatgt actggactag gggccccaac
4801 catgaagacc catctgaaac aatgattcca cattcccaaa gacccataca attgatgtcc
4861 ctgctgggag aggccgcact ccacggccca gcattctaca gcaagattag caagttggtt
4921 attgcagagc taaaagaagg tggcatggat ttttacgtgc ccaggcaaga gccaatgttc
4981 agatggatga gattctcaga tctgagcacg tgggagggcg atcgcaatct ggctcccagc
5041 tttgtgaatg aagatggcgt cgaatgacgc caacccatct gatgggtcca cagccaacct
5101 cgtcccagag gtcaacaatg aggttatggc tttggagccc gttgtaggtg ccgctattgc
5161 ggcgcctgta gcgggccaac aaaatgtaat tgacccctgg attagaaata attttgtaca
5221 agcccctggt ggagagttta cagtgtcccc tagaaacgct ccaggtgaga tactatggag
5281 tgcgcccttg ggccctgatt tgaaccctta cctttctcat ttggccagaa tgtacaatgg
5341 ttatgcaggt ggttttgaag tgcaggtaat ccttgcgggg aacgcgttca ccgccggaaa
5401 aatcatattt gcagcagtcc caccaaattt tccaactgaa ggcttgagcc ccagccaggt
5461 taccatgttc ccccacataa tagtggatgt taggcaattg gaacctgtgt taatccccct
5521 acctgatgtt aggaacaatt tctatcacta caaccaatca aatgacccca ccattaaatt
5581 gatagcaatg ctgtatacac cacttagggc caataatgct ggagatgatg tcttcacggt
5641 ctcttgtcga gtgctcacga ggccatcccc tgattttgat ttcatatttc tggtaccgcc
5701 aacagttgaa tcaagaacca aaccattcac tgtcccaatc ttaactgttg aggaaatgac
5761 caattcaaga ttccccattc ctttggagag gttgtacacg ggtcccagca gtgcttttgt
5821 tgttcaacca caaaacggca ggtgcacgac tgatggcgtg ctcttaggca ctacccagct
5881 gtctgctgtc aacatctgca cctttagagg agatgtcacc cacattgcag gctctcgcaa
5941 ttatgcaatg aatttggcct ctcaaaattg gagcaactat gacccaacag aagaaatccc
6001 agcccccctg ggaaccccag attttgtggg aaagatccaa ggcatgctca cccaaaccac
6061 aagaagagat ggctcgaccc gcggccacaa agccacagtg ctcactggga gtgccgactt
6121 tgccccaaaa ttgggcagag tccaattcgc cactgacaca gacaacgatt tcgagtctgg
6181 cgaaaacacg aaattcaccc cagtcggcgt catccaggat ggttccacca cccaccggaa
6241 tgaaccccaa caatgggtgc tcccaaatta ctcaggtaga actggtcata atgtgcacct
6301 agcccctgcc gttgccccca cttacccggg agagcaactc cttttcttca ggtccactat
6361 gcccggatgc agcgggtatc ccaacatgga tttggattgc ctactccccc aggagtgggt
6421 gcggcacttc taccaagagg cagccccggc acaatctgat gtggctctat tgagatttgt
6481 gaatccagac acgggtaggg tcctgtttga gtgcaaactt cataaatcag gctatgtcac
6541 agtggctcac accggccagc atgatttggt catccccccc aatggctatt tcaggtttga
6601 ttcctgggtt aatcaattct acacacttgc ccccatggga aatggaacgg ggcgtagacg
6661 tgctttataa tggctggagc tttctttgct ggattggcat ctgatgtcct tggctctgga
6721 cttggttccc taatcggtgc tggggctggg gctatcaacc aaaagattga ttttgaaaat
6781 aacagaaaat tgcagcaagc ttccttccag tttagcagta atctgcaaca ggcttccttt
6841 caacatgata aagagatgct ccaagcacaa attgaggcca ctaaaaagct gcaacaggaa
6901 atgatgaaag tcaaacaggc aatgctctta gagggtggat tctctgaaac agatgcagcc
6961 cgtggggcaa ttaacgcccc catgacaaag gctttggact ggagcggaac aaggtactgg
7021 gcccctgatg ctaggactac aacatacaat gcaggccgct tttccacccc tcaaccttcg
7081 ggggcactgc caggaagaat taactctagg actcctaccc ccgctcgggg ctcctccagc
7141 acatcttcta atgcttctat tgctacttct atatattcaa atcaaactgt ttcaacgaga
7201 cttggttcta cagctggttc tggcaccaat gtctcgagtc tcccgtctac tgcaaggact
7261 aggagttggg ttgaggatca aaacagaaac ttgtcacctt tcatgagggg ggctcacaac
7321 atatcgtttg tcaccccacc atctagcaga tcctctagcc aaggcacagt ctcaaccgtg
7381 cctaaagaaa ttttggactc ctggactggc gctttcaaca cgcgcaggca gcctctcttc
7441 gctcacattc gtaggcgagg ggagtcacgg gtgtaatgtg aaaagacaaa attgattatc
7501 tttcttttct ttttcttt
//