Typing tool
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Typing tool
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Complete norovirus genomes
| MW305521 | GII.4 Osaka | |
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| GII.P4 US95 |
ORF1: 1..5069
ORF2: 5050..6672
ORF3: 6672..7478
LOCUS MW305521 7520 bp RNA linear VRL 18-JUL-2024
DEFINITION Norovirus GII isolate PNV008673 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305521
VERSION MW305521.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7520)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7520)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7520
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="PNV008673"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Peru"
/collection_date="21-Jul-2008"
/note="genotype: GII.4[GII.P4]"
gene <1..5069
/gene="ORF1"
CDS <1..5069
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ58899.1"
/translation="AVANSNNDIAKSSSDGVLSSMAVTFKRALGARPKQPPPRETPQR
PPRPPTPELVKKIPPPPPNGEDEIVVSYSVKDGVSGLPELSTVRQPEENNTAFSVPPL
NQRENRDAKEPLTGTILEMWDGEIYHYGLYVEQGLVLGVHKPPAAISLAKVELSPLSL
FWRPVYTPQYLISPDTLRKLHGESFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQRTT
GFFRPYQDWNRKPLPTMDDSKLKKVANVFLCALSSLFTRPIKDIIGKLRPLNILNILA
SCDWTFAGIVESLILLAELFGVYWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVVMG
GIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKQEENELAMV
RSIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTI
NALLARIAAARSLVHRAKEELSSRPRPVVLMISGRPGIGKTHLAREVAKRIASTLTGD
QRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIEN
KGKVFDSDVIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPDVEKAKRDFPGQPDM
WKNAFSSDFSHIKLTLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERMDEF
ELQGPALTTFNFDRNKVLAFRQLAAENKYGLMDTMRVGRQLKEVKTMPDLKQALRNIS
IKKCQIVYSGCTYVLESDGKGNVKVDKVQSTSVQTNNELSGALHHLRCARIRYYVKCV
QEALYSIIQIAGAAFVTTRIVKRMNIQDLWSKPQVEDTGEAINKDGCPKPKDDEEFVI
SSDDIKTEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDR
DKYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRNPD
DFKPKGKLWADDDRSVDYNEKLSFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIP
QGVKEFFGVPIKQIQIHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVVTLLIKRPT
GELMPLAARMGTHATMRIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKREN
DYVVIGVHTAAARGGNTVICATQGSEGEATLEGGDSKGTYCGAPILGPGSAPKLSTKT
KFWRSSTTPLPPGTYEPAYLGGKDPRVKGGPSLQQVMREQLKPFTEPRGRPPKPSVLE
AAKKTIINVLEQTIDPPEKWSFAQACASLDKTTSSGHPHHMRKNDCWNGESFTGKLAD
QASKANLMFEEGKNMTPVYTGALKDELVKTDKIYGRIKKRLLWGSDLATMIRCARAFG
GLMDELKAHCVTLPIRVGMNMNEDGPIIFEKHARYKYHYDADYSRWDSTQQRAVLASA
LEIMVKFSSEPHLAQVVAEDLLSPSVVDVGDFRISINEGLPSGVPCTSQWNSIAHWLL
TLCALSEVTNLSPDIIQANSLFSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTRPDK
TEGPLVISEDLNGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHEDPSETMIP
HSQRPIQLMSLLGEAALHGPAFYSKISKLVIAELKEGGMDFYVPRQEPMFRWMRFSDL
STWEGDRNLAPSFVNEDGVE"
mat_peptide <1..959
/gene="ORF1"
/product="p48"
mat_peptide 960..2057
/gene="ORF1"
/product="NTPase"
mat_peptide 2058..2594
/gene="ORF1"
/product="p22"
mat_peptide 2595..2993
/gene="ORF1"
/product="VPg"
mat_peptide 2994..3536
/gene="ORF1"
/product="Pro"
mat_peptide 3537..5066
/gene="ORF1"
/product="RdRp"
gene 5050..6672
/gene="ORF2"
CDS 5050..6672
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58900.1"
/translation="MKMASNDANPSDGSTANLVPEVNNEVMALEPVVGAAIAAPVAGQ
QNVIDPWIRGNFVQAPGGEFTVSPRNAPGEILWSAPLGPDLNPYLSHLARMYNGYAGG
FEVQVILAGNAFTAGKIIFAAVPPNFPTEGLSPSQVTMFPHIIVDVRQLEPVLIPLPD
VRNNFYHYNQSNDPTIKLIAMLYTPLRANNAGDDVFTVSCRVLTRPSPDFDFIFLVPP
TVESRTKPFTVPILTVEEMTNSRFPIPLERLYTGPSSAFVVQPQNGRCTTDGVLLGTT
QLSAVNICTFRGDVTHIAGSRNYTMNLASQNWSNYDPTEEIPAPLGTPDFVGRIQGML
TQTTRRDGSTRGHKATVLTGSADFAPKLGRVQFATDTDNDFESGENTKFTPVGVIQDG
STTHRNEPQQWVLPNYSGRTGHNVHLAPAVAPTYPGEQLLFFRSTMPGCSGYPNMDLD
CLLPQEWVRHFYQEAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYVTVAHTGQHDLV
IPPNGYFRFDSWVNQFYTLAPMGNGTGRRRAL"
gene 6672..7478
/gene="ORF3"
CDS 6672..7478
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58901.1"
/translation="MAGAFFAGLASDVLGSGLGSLIGAGAGAINQKIDFENNRKLQQA
SFQFSSNLQQASFQHDKEMLQAQIEATKKLQQEVMKVKQAMLLEGGFSETDAARGAIN
APMTKALDWSGTRYWAPDARTTTYNVGRFSTPQPSGALPGRINPRTPTPARGSSSTSS
NASIATSIYSNQTVSTRLGSTAGSGTNVSSLPSTARTRSWVEDQNRNLSPFMRGAHNI
SFVTPPSSRSSSQGTVSTVPKEVLDSWTGAFNTRRQPLFAHIRRRGESRV"
ORIGIN
1 ccgctgttgc caacagcaac aacgacatcg caaaatcttc aagtgacgga gtgctttcta
61 gcatggctgt cacttttaaa agagccctcg gggcgcggcc taaacagccc cccccgaggg
121 aaacaccaca aagaccccca cgaccaccca ccccagaact ggtcaaaaag atcccccccc
181 ccccgcccaa cggggaggat gaaattgtgg tttcctatag tgtcaaagat ggtgtttccg
241 gcttgcccga gctttccacc gtcagacaac cggaagaaaa caatacagcc ttcagtgtcc
301 ccccactcaa ccagagggaa aatagggatg ctaaggagcc gctgactggg acaattttgg
361 aaatgtggga tggagagatc tatcattacg gtctctatgt ggagcaaggt ctcgtacttg
421 gtgtgcacaa accaccagct gccattagcc tcgctaaggt cgagctatca ccactctcct
481 tgttctggag acctgtgtat accccacaat acctcatttc cccagacact ctcaggaaat
541 tacacgggga gtcgtttccc tacacagcct ttgacaacaa ttgctatgcc ttctgttgtt
601 gggtcttgga cctaaacgat tcgtggctga gtaggaggat gatccagaga actactggct
661 ttttcagacc ctaccaagat tggaatagga aacccctccc caccatggat gattccaagc
721 taaagaaagt agccaacgta ttcctgtgtg ctctatcttc actattcacc aggcccataa
781 aagatataat agggaaacta aggcccctta acatcctcaa catcttggcc tcatgtgatt
841 ggactttcgc aggtatagtg gaatccctga tacttctggc agagctcttt ggagtttact
901 ggacaccccc agatgtgtct gcaatgattg cccccttgct cggcgattac gagttgcaag
961 ggcctgagga ccttgcagtg gaacttgttc ctgtagtgat ggggggaatt ggtttggtgc
1021 taggatttac caaagagaag attggaaaaa tgctgtcatc tgctgcatcc actttaaggg
1081 cttgtaaaga tctcggtgca tacgggctgg aaatcctaaa gttagttatg aagtggttct
1141 tcccaaagaa acaggaagaa aatgaactgg ctatggtgag gtccatcgag gatgcagtgc
1201 tggacctcga ggcaattgaa aacaaccata tgaccacctt gctcaaggac aaagacagtc
1261 tggcaaccta catgagaacc cttgaccttg aggaggagaa agccaggaag ctctcaacca
1321 agtccgcttc acctgatatc gtgggcacaa tcaacgccct tctggcgagg atcgctgctg
1381 cacgttccct ggtgcatcga gcaaaggagg agctttccag cagaccaaga ccagttgtcc
1441 tgatgatatc aggcagacca ggaataggga agactcacct tgctagagaa gtggccaaga
1501 gaattgcatc caccctcaca ggagaccagc gtgtgggcct catcccacgc aatggcgtcg
1561 accactggga tgcgtacaag ggggagaggg tcgtcctatg ggacgactat gggatgagta
1621 atcccatcca cgacgcactc aggctgcaag aactcgctga cacctgcccc ctcactctga
1681 actgtgacag gattgagaac aaaggaaagg tctttgacag tgatgtcata attattacca
1741 ctaatctggc caacccagca ccactggact atgtcaactt tgaggcgtgc tcgaggcgca
1801 tcgatttcct cgtgtatgcg gaagcccctg atgttgagaa ggcgaaacgt gacttcccag
1861 gacaaccaga catgtggaag aacgccttca gctctgactt ctcacacata aaactgacat
1921 tggccccaca gggtggcttc gacaagaacg gaaacacccc gcacggaaag ggcgtcatga
1981 agacactcac cactggctcc ctcattgccc gggcatcagg gctacttcat gagaggatgg
2041 atgagtttga attacagggc ccggctctca ccaccttcaa ctttgatcgc aacaaagtgc
2101 ttgcctttag gcagcttgct gctgaaaata aatacgggtt gatggacaca atgagagtcg
2161 gaaggcagct caaggaggtt aaaaccatgc cagatcttaa acaggcactc aggaacatct
2221 caattaagaa gtgccagatt gtgtacagtg gttgtactta tgtacttgag tctgatggca
2281 agggcaatgt gaaagttgac aaagttcaga gcacctctgt gcagaccaac aacgagctgt
2341 ccggcgccct acaccacctg aggtgcgcca gaattaggta ttacgttaag tgtgttcagg
2401 aagccctgta ttccatcatc caaattgctg gagctgcatt tgtcaccacg cgcatcgtca
2461 agcgcatgaa catacaagac ctctggtcca agccacaagt ggaagacaca ggggaggcta
2521 tcaataagga cgggtgccca aaacccaaag atgatgagga gttcgtcatt tcatccgacg
2581 atatcaaaac tgagggcaag aaagggaaga acaagactgg ccgcggcaag aagcacacag
2641 ccttctcaag caaaggtctc agtgatgaag agtacgatga gtacaagagg attagagaag
2701 aaagaaatgg caagtactct atagaagagt acctccagga cagggacaaa tactatgagg
2761 aggtggccat tgctagggcg actgaggaag acttctgtga agaagaggag gccaagattc
2821 ggcaaaggat tttcaggcca acaaggaaac aacgcaagga ggagagggcc tctctcggtt
2881 tggtcacagg ctctgaaatc aggaaaagaa atccagacga tttcaagccc aaggggaagc
2941 tgtgggccga cgatgacaga agtgtggact acaatgaaaa actcagtttt gaggccccac
3001 cgagcatctg gtcgaggata gtcaactttg gttcgggttg gggcttttgg gtctctccca
3061 gtctgttcat aacatcaacc catgtcatac cccagggtgt taaagagttc tttggagtcc
3121 ctatcaagca gatccagata cataagtcag gcgagttttg tcgcttgagg ttcccgaaac
3181 caattagaac tgatgtgacg ggcatgatct tagaagaagg tgcgcccgaa ggcaccgtgg
3241 tcacactgct catcaagagg cctactggag aacttatgcc cttagcagct agaatgggga
3301 cccatgcaac catgagaatt caagggcgca ctgttggagg tcagatgggc atgcttctga
3361 caggatccaa cgccaaaagt atggatctag gcaccacacc aggtgactgc ggctgccctt
3421 acatctataa gagggaaaat gactatgtgg tcattggagt ccacacggct gccgctcgtg
3481 ggggaaatac cgtcatatgt gccacccagg gaagtgaggg ggaggccacg cttgaaggtg
3541 gtgacagtaa gggaacatac tgtggagcac caatcctagg cccagggagc gccccaaaac
3601 tcagcaccaa gaccaaattc tggagatcgt ccacaacacc actcccacct ggcacttatg
3661 aaccagccta ccttggtggt aaggacccca gagtcaaggg tggcccttca ttgcagcagg
3721 ttatgaggga acagttgaaa ccatttacag aacccagagg cagaccacca aaaccaagtg
3781 tgttggaagc cgccaagaaa actattatca atgtccttga acaaacaatt gacccacctg
3841 agaaatggtc attcgcgcaa gcttgcgcgt ccctcgataa gaccacttcc agtggccacc
3901 cgcaccacat gcggaaaaat gactgctgga acggggaatc cttcacaggt aagctggcag
3961 atcaggcttc caaggccaac ctgatgtttg aagaggggaa gaacatgacc ccagtttaca
4021 caggtgcgct caaggatgaa ctagttaaaa ctgacaaaat ttatggcaga atcaagaaga
4081 ggctgctctg gggctcggac ttagcgacca tgatccggtg cgcccgagcg tttgggggct
4141 taatggatga actcaaagca cactgtgtca cacttcctat cagagttggt atgaacatga
4201 atgaggatgg ccctatcatc ttcgagaagc atgccagata caagtaccat tatgatgctg
4261 actactctcg gtgggattca acacaacaga gagccgtgtt agcatcagct ttagaaatca
4321 tggttaaatt ctcctcagaa ccacatttgg cccaggtagt cgcagaagac cttctctctc
4381 ctagcgtggt tgatgtgggc gacttcagaa tatcaatcaa tgagggtctc ccctctgggg
4441 tgccctgcac ctctcaatgg aactccatcg cccactggct tctcactctc tgtgcgctct
4501 ctgaagtcac aaacttgtct cctgacatca tacaggctaa ttccctcttc tccttctatg
4561 gcgatgatga aattgttagt acagatataa aactagatcc agagaaattg acagcgaagc
4621 tcaaagaata tgggttgaaa ccaacccgcc ctgacaaaac tgaaggaccc cttgtcattt
4681 ctgaagacct gaatggtctg accttcctgc ggagaactgt gacccgcgat ccagctggtt
4741 ggtttggaaa attggagcag agttcaatac tcagacaaat gtactggact aggggcccca
4801 accatgaaga cccatctgaa acaatgattc cacattccca aagacccata caattgatgt
4861 ccctgctggg agaggccgca ctccacggcc cagcattcta cagcaagatt agcaagttag
4921 ttattgcaga gctaaaagaa ggtggcatgg atttttacgt gcccagacaa gagccaatgt
4981 tcagatggat gagattctca gatctgagca cgtgggaggg cgatcgcaat ctggctccca
5041 gctttgtgaa tgaagatggc gtcgaatgac gccaacccat ctgatgggtc cacagccaac
5101 ctcgtcccag aggtcaacaa tgaggttatg gctttggagc ccgttgtagg tgccgctatt
5161 gcggcgcctg tagcgggcca acaaaatgta attgacccct ggattagagg taattttgta
5221 caagcccctg gtggagagtt tactgtgtcc cctagaaatg ctccaggtga gatactatgg
5281 agtgcgccct tgggccctga tttgaaccct tacctttctc atttggccag aatgtacaat
5341 ggttatgcag gtggttttga agtgcaggta atccttgcgg ggaacgcgtt caccgccgga
5401 aaaatcatat ttgcagcagt cccaccaaac ttcccaactg aaggcttgag ccccagccag
5461 gtcaccatgt tcccccacat aatagtggat gttaggcaat tggaacctgt gttaatcccc
5521 ctacctgatg ttaggaacaa tttctatcac tacaaccaat caaatgaccc taccattaaa
5581 ttgatagcaa tgctgtacac accacttagg gccaataacg ctggagatga tgtcttcaca
5641 gtctcttgtc gagtgctcac gaggccatcc cctgattttg acttcatatt tctggtaccg
5701 ccaacagttg aatcaagaac caaaccattc actgtcccaa tcttaactgt tgaggaaatg
5761 accaattcaa gattccccat tcctttggag agattgtaca cgggtcccag cagtgctttt
5821 gttgtccaac cacaaaacgg caggtgcacg actgatggcg tgctattagg cactacccag
5881 ctgtctgctg tcaacatctg cacctttaga ggagatgtca cccacattgc aggctctcgc
5941 aattatacaa tgaatttggc ctctcaaaat tggagcaact atgacccaac agaagaaatc
6001 ccagcccccc tgggaacccc agattttgtg ggaaggatcc aaggcatgct cacccaaacc
6061 acaagaagag atggctcgac ccgcggccac aaagccacag tgctcactgg gagtgccgac
6121 tttgccccaa aattgggcag agtccaattc gccactgaca cagacaacga tttcgaatct
6181 ggcgaaaaca cgaaattcac cccagtcggc gtcatccagg atggttccac cacccaccgg
6241 aatgaacccc aacaatgggt gctcccaaat tactcaggta gaactggtca taatgtgcac
6301 ctagcccctg ccgttgcccc cacttacccg ggagagcaac tccttttctt caggtccact
6361 atgcccggat gcagcgggta tcccaacatg gatttggatt gcctactccc ccaggagtgg
6421 gtgcggcact tctaccaaga ggcagctccg gcacaatctg atgtggctct attgagattt
6481 gtgaatccag acacgggtag ggtcctgttt gagtgcaaac ttcataaatc aggctatgtc
6541 acagtggctc acaccggcca gcatgatttg gtcattcccc ccaatggcta ttttaggttt
6601 gattcctggg ttaatcaatt ctacacactc gcccccatgg gaaatggaac ggggcgtaga
6661 cgtgctttat aatggctgga gccttctttg ctggattggc atctgatgtc cttggctctg
6721 gacttggttc cctaatcggt gctggggctg gggctatcaa ccaaaagatt gattttgaaa
6781 ataacagaaa attgcagcaa gcttccttcc agtttagcag taatctacaa caggcttcct
6841 ttcaacatga taaagagatg ctccaagcac aaattgaggc cactaaaaag ttgcaacagg
6901 aagtgatgaa agtcaaacag gcaatgctct tagagggtgg attctctgaa acagatgcag
6961 cccgtggggc aattaacgcc cccatgacaa aggctttgga ctggagcgga acaaggtact
7021 gggcccctga tgctaggact acaacataca atgtaggccg cttttccacc cctcaacctt
7081 cgggggcact gccaggaaga attaacccta ggactcctac ccccgctcgg ggctcctcca
7141 gcacatcttc taatgcttct attgctactt ctatatattc aaatcaaact gtttcaacga
7201 gacttggttc tacagctggt tctggcacca atgtctcgag tctcccgtct actgcaagaa
7261 ctaggagttg ggttgaggat caaaacagaa acttgtcacc tttcatgagg ggggctcaca
7321 acatatcgtt tgtcacccca ccatctagca gatcctctag ccaaggcaca gtctcaaccg
7381 tgcctaaaga agttttggac tcctggactg gcgctttcaa cacgcgcagg cagcctctct
7441 tcgctcacat tcgtaggcga ggggagtcac gggtgtaatg tgaaaaggca aaattgatta
7501 tctttctttt ctttttcttt
//