Typing tool
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Typing tool
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Complete norovirus genomes
| MW305518 | GII.14 | |
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| GII.P7 |
ORF1: 1..5063
ORF2: 5044..6654
ORF3: 6654..7448
LOCUS MW305518 7493 bp RNA linear VRL 18-JUL-2024
DEFINITION Norovirus GII isolate PNV014022 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305518
VERSION MW305518.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7493)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7493)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7493
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="PNV014022"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Peru"
/collection_date="03-Feb-2009"
/note="genotype: GII.14[GII.P7]"
gene <1..5063
/gene="ORF1"
CDS <1..5063
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ58890.1"
/translation="FGSQNSVNDSINATPSNKEEVGTFSNIKVGFKKMLGAVPKGTKT
PSSGQHCPTVKIGPKTLTIPPEPPNGEDTVQFDAKSETIIGLPDLTTVQNEHENTPYT
VPPLSEREHRPATEPLPGTILEMWDGEFYHYSVYVSDGKALGVHKPPAAISLATIELT
PISLYWRPVYTPNYLVSPDTLKGLAGEKFPYTAFSNNCYNFCCWVLELNDTWLNRRCI
SRTTGFFKPYQPWNRKPLPTVDDGKIKKVANAILCALGSLFSKPIKDLLGKLKPLNLL
HLLASCDWTFAGVVETVILMAELFNIFWTPPDVSNFIASLIGDFELQGPEDLAVELVP
VVMGGIGMVLGFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMKWFFPKKEEKAE
METLRAIEDAVLDMEAIGNNHLTTLLKDKDSLTAFMKTLDLEEEKARKLSTKSSSPDI
VGTINAILARIAAARSLLHKAKEEMFSRIRPVVVMISGRPGIGKTHMARHLAKSIANT
MSGDQRVGLVPRNGVDHWDAYRGERVVLWDDYGMGSPVKDALTLQELADTCPVTLNCD
RIENKGKMFDSDVIIITTNLVNPAPLDYVNFEACSRRVDFLVYAESPEIEKVKRDFPG
QPDMWKDHFKPDFSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSLTARVAGLVHER
RDEFQLQGSDLQTYNFDTNRVSAFRKLAADNKYGIMETMRVGAALKNVKTLEDLKFAL
RDVKFNECEIIYKNSKYRVSSNGKGSVSVDKIEDNASQTANEVQSALLRLRQARARYY
ISCFQDLVYTLIQVAGASFVVNRISKRFCWERWVKPTETQEVNESEKEVAQGRWEIEP
KDTEPEGKKGKNKKGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDRDR
YYEEVAVARATEEDFCEEEEAKIRQRIFRPTKKQRKEERGVLGLVTGTDIRKRRPDDF
QPKGNLWADDTRSVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNLLITTTHVLPKG
VKELFGVEIKQIQVHKSGEFCRFRFPRPIRPDVTGLVLEEGAPEGTVCSILIRRPTGE
MIPLAVRMGTHASMKIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCGCPYIYKRGNDI
VVAGVHTAAARGGNTVICATQGQDGEAVLEGNEDLGTYCGAPILGPGKAPKLSTKTKF
WRSSPDALPPGTYEPAYLGGRDPRVERGPSLQQVMRDQLRPFTEPRGKPPRPAVLEEA
KKTVMNVLEQTIDPAKPWSYSQACASLDKTTSSGSPHHVKKNDHWNGESFTGPLADQA
SKANLMYEQAKHVQPVYTAALKDELVKTDKIYKKIKKRLLWGSDLGTMIRCARAFGGL
MDSMKASCIALPCRVGMNMNEDGPIIFDKHSKYRYHYDADYSRWDSTQQRNVLTAAME
VMVRFSAEPELAQVVAEDLLAPSQLDVGDFIISVQEGLPSGVPCTSQWNSIAHWILTL
SAMAEVSGLSPDVIQAHSCFSFYGDDEIVSTDINLDPMKLTQKLREYGLVPTRPDKTE
GPLVITEDLTGLTFLRRSIARDPAGWFGKLDQDSILRQLYWTRGPNHENPYESMVPHS
QRATQLMALLGEASLHGPQFYKKVSKMVINEIKSGGLEFYVPRQEAMFRWMRFSDLST
WEGDRNLAPEGVNEDGVE"
mat_peptide <1..971
/gene="ORF1"
/product="p48"
mat_peptide 972..2069
/gene="ORF1"
/product="NTPase"
mat_peptide 2070..2588
/gene="ORF1"
/product="p22"
mat_peptide 2589..2987
/gene="ORF1"
/product="VPg"
mat_peptide 2988..3530
/gene="ORF1"
/product="Pro"
mat_peptide 3531..5060
/gene="ORF1"
/product="RdRp"
gene 5044..6654
/gene="ORF2"
CDS 5044..6654
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58891.1"
/translation="MKMASNDATPSDDGAAGLVPEINNEVMALEPVAGASLAAPVVGQ
QNIIDPWIRNNFVQAPAGEFTVSPRNSPGELLLDLELGPELNPYLAHLARMYNGHAGG
MEVQIVLAGNAFTAGKILFAAIPPSFPYENLSPAQLTMCPHVIVDVRQLEPVLLPMPD
IRNVFYHYNQNNSPKLRLVAMLYTPLRANNSGDDVFTVSCRVLTRPSPDFQFTFLVPP
TVESKTKNFTLPVLRVSEMTNSRFPVVLDQMYTSRNENIIVQPQNGRCTTDGELLGTT
ILQSVSICNFKGTMQAKMNEEPRYQLQLTNLDGSPIDPTDDMPAPLGTPDFQAMLYGV
ASQRSSRDNATRAHDAQIDTAGDTFAPKIGQVRFKSSSNDFDLHDPTKFTPIGVNVDD
QHPFRQWTLPNYGGHLALNNHLAPAVTPLFPGEQILFFRSYIPSAGGHTDGAMDCLLP
QEWIEHFYQEAAPSQSDIALVRFINPDTGRVLFEAKLHKQGFLTIAASGDHPIVMPTN
GYFRFEAWVNPFYTLAPVGTGSGRRRIQ"
gene 6654..7448
/gene="ORF3"
CDS 6654..7448
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58892.1"
/translation="MAGAFLAGLAGDVVTSSLGSLVGAGANAINQKVEYDFNRQLQEA
SFRHDKDMLKAQVAATAGLQQAMIDIKREALTAGGFSPADAARGAVRAPMTQILDWNG
SRYWAPSSMKTTGYSGTFASQGIKSSPHLSNQIPSAVKITKTSPSISSSSSVYSSPST
APSQSTQSITLSAGTGSSRSNTVSTKTSTLSRTSDWVRGQNEMLGPFMSGALQTAYVT
PPSSRASSQGTVSTVPKAVLDSWTPMFNTHRQPLFAHLRRRGESQI"
ORIGIN
1 cttttggcag tcaaaactct gtcaatgaca gtattaatgc caccccttcc aataaggaag
61 aggttggtac attctccaat atcaaagttg gatttaagaa aatgctgggt gctgtaccca
121 agggcaccaa aacacccagc agtggtcaac attgtcccac agttaagatc gggcctaaaa
181 cattaacaat tccccctgag cccccaaatg gtgaagacac tgtgcagttt gatgcaaagt
241 cggaaactat aatcgggctg ccggacttga caacggtaca aaacgaacat gaaaacaccc
301 catacaccgt tcccccatta agtgagaggg agcacagacc ggccactgaa ccacttcctg
361 gcacaatatt ggagatgtgg gatggtgaat tttaccatta ctccgtgtat gtcagcgatg
421 gcaaagccct gggggtccac aaaccaccgg ctgctataag cctcgcgacg atagagctca
481 cccccatatc tctctactgg agacccgttt acacccccaa ctatttggtc tccccagaca
541 cattgaaagg ccttgctggt gagaagttcc cctacacggc ctttagtaac aactgctata
601 acttttgttg ttgggtgctt gagctcaacg acacgtggct caacagaaga tgcatttcca
661 gaaccaccgg cttcttcaaa ccttatcagc cttggaacag gaaacccctc ccaaccgttg
721 atgatgggaa gatcaaaaag gtggccaacg cgatcctctg tgcactcggc tcactgttct
781 caaaaccaat caaagatctg ttaggtaaac ttaagccatt gaacctgcta cacttgcttg
841 cgtcatgcga ctggacattt gcgggtgtag tggagacagt cattttaatg gcggagcttt
901 tcaacatctt ctggaccccg ccagatgttt ctaattttat agcctccctg ataggtgatt
961 ttgagttaca agggcctgag gatctggctg tggagctcgt tcctgtggtt atgggtggca
1021 taggaatggt tctcggtttc accgctgaga agataggtcg tatgctatcg tccgccgcat
1081 caacattgcg ggcatgcaaa gacctaggaa actatgccct tgacattctc aaattggtca
1141 tgaagtggtt cttcccaaag aaggaagaga aagctgagat ggaaaccttg agggcgatcg
1201 aggatgccgt cctggacatg gaagctatag ggaataacca tctcacgacc ctccttaagg
1261 acaaagacag ccttacggct tttatgaaga ccctggactt agaagaggaa aaagcaagga
1321 aactgtccac taagtcatct tcaccggaca ttgttggcac cattaatgcc atactagcta
1381 ggattgctgc tgccagatcc cttctacata aggccaaaga agagatgttt agtaggatta
1441 gaccagtggt cgttatgata tcaggcagac ctggcattgg caagacccac atggcaagac
1501 atttggctaa gagcatcgcc aacaccatga gtggcgacca gagagttggg ctcgtcccac
1561 gtaacggtgt cgaccactgg gatgcctaca gaggagagag ggtggtctta tgggatgact
1621 atggtatggg gagccctgtt aaagatgcct taacactaca ggagctggcc gacacctgtc
1681 cagtcacttt aaattgtgat aggattgaga acaaggggaa gatgttcgac agtgatgtca
1741 tcataatcac aaccaacctg gtcaaccccg cgcccctcga ctatgtgaac ttcgaagcgt
1801 gttccaggag agttgacttc ttggtatatg cagagtcacc agagattgaa aaggtcaaga
1861 gggacttccc tggccaacct gacatgtgga aagaccattt taagccagac ttttctcaca
1921 tcaagctaac tttggccccc cagggcgggt ttgacaagaa tggtaacact ccgcacggta
1981 agggtaccat gcggtccctg acccaggggt ccctgactgc aagagttgcg ggccttgtcc
2041 atgagaggag agatgagttc caactccaag gaagtgacct ccaaacatat aattttgaca
2101 ccaacagagt ctccgcattc cgaaaactgg ctgcagataa caagtatggt atcatggaga
2161 cgatgagagt aggtgcggca ctcaaaaatg taaagacctt ggaagatcta aaatttgcat
2221 tgagggatgt aaaattcaat gagtgtgaaa taatttacaa gaactctaag tatcgagtct
2281 cttccaacgg taaaggctca gtttctgttg acaaaattga ggacaatgca tcccagaccg
2341 caaatgaggt acaatcagca cttctcaggc ttaggcaagc gagggccaga tattacatca
2401 gctgcttcca agacctcgtc tacactctca tacaggttgc cggagcatca ttcgttgtca
2461 acagaatttc caaaaggttc tgctgggaaa ggtgggtcaa accaaccgag acccaggagg
2521 taaatgagtc cgaaaaggaa gtggctcaag gtagatggga aattgagccc aaggacacag
2581 aaccagaagg caagaagggc aagaacaaga aaggaagggg caagaaacac acagctttct
2641 ctagcaaagg cctgagtgat gaagagtatg atgagtacaa gagaatcagg gaagaaagga
2701 atggaaagta ctccattgag gaatacctgc aagaccggga ccgctactat gaagaagtgg
2761 cagttgcccg ggcaacggag gaggacttct gtgaagagga agaggccaaa ataagacaaa
2821 gaatcttccg cccgacaaag aagcaaagga aggaggaaag gggtgtactt ggattagtca
2881 ccggcacaga catcagaaag aggagaccag acgattttca accaaaaggc aatctatggg
2941 cagatgacac caggagtgtg gactacaatg agagacttga ttttgaagcg cccccaagtg
3001 tctggtcaag aatagtccca ctaggcactg gttggggttt ctgggtctca tccaaccttt
3061 tgatcacaac aacacatgtc ctgcctaaag gggttaagga actctttgga gttgaaatta
3121 aacagatcca agttcacaag tctggagagt tttgcaggtt tagattccca agaccaatca
3181 ggccagatgt cacagggctc gtgttggagg aaggcgcccc agaaggcact gtctgttcta
3241 tactcataag aagacctacg ggtgagatga ttcccttggc agtgaggatg ggcacacacg
3301 catccatgaa aatacaaggc aggaccgtcg gcggccagat gggaatgctt ctaacaggag
3361 caaatgcaaa gaatatggat ctcggcaccg gccctggtga ctgcggttgc ccctacatct
3421 acaaacgcgg caacgacata gttgtcgcgg gtgtccatac cgcagcagcc cggggaggta
3481 acactgtcat atgcgccact caagggcaag atggggaagc agtccttgag ggaaatgagg
3541 acctcggtac ctactgtggc gccccaattc tgggccctgg caaggcacct aaactaagca
3601 cgaagaccaa gttttggcgc tcatcaccag atgccttgcc acctggcaca tatgaacctg
3661 cttacctggg aggcagagac cccagagtgg aaagaggacc ttccctgcag caagtcatga
3721 gagaccagtt aagacccttc acagaaccta ggggaaaacc acctagacct gcagtcttag
3781 aagaagccaa gaagacagtg atgaatgttt tagaacaaac cattgaccct gcaaaaccat
3841 ggtcctactc gcaagcatgt gcctcactgg acaaaaccac ttccagtggt agcccccatc
3901 atgtaaagaa aaatgaccac tggaatgggg aatccttcac tggtcccctt gcagatcagg
3961 catctaaagc caacctcatg tatgaacagg ctaaacatgt gcagcccgtg tacacggccg
4021 cgcttaaaga tgagcttgtc aagactgaca agatctacaa aaagataaag aagaggctcc
4081 tatgggggtc ggaccttggc acaatgatca ggtgcgctag ggcttttggt ggtctcatgg
4141 acagcatgaa ggcaagctgc atagctcttc catgtagggt aggaatgaac atgaatgaag
4201 acggccctat catatttgac aaacattcta agtacagata ccactatgat gctgactatt
4261 ctaggtggga ctcaacccag caaaggaacg ttctcactgc cgctatggaa gtgatggtgc
4321 ggttttctgc cgaaccagaa ttggcacaag tggttgcaga ggaccttttg gcgcctagcc
4381 agcttgatgt tggtgatttt atcatctcag tccaggaggg tctgccatcc ggagtcccat
4441 gtacatcaca atggaattca atagcacact ggatcctaac tttgagtgca atggcagaag
4501 tgtcaggtct ctcaccagat gttatccaag ctcactcctg cttttcattt tatggggacg
4561 atgagatcgt cagcactgac atcaaccttg accccatgaa gttgacacag aagcttaggg
4621 agtacggcct ggtccccacc cgacctgata agactgaagg tcccctcgtt ataactgaag
4681 acctcaccgg cctgacgttc cttcgtaggt cgattgcacg ggacccagct ggatggtttg
4741 gaaaattgga ccaagattca atcctcaggc aactatactg gactaggggg cctaaccatg
4801 agaacccgta cgagagcatg gtccctcatt cccagcgggc cacacagctt atggccctcc
4861 ttggtgaggc ttcactgcat ggtccccagt tttacaagaa agttagcaag atggttatta
4921 atgagatcaa gagtggtggt ctggaatttt atgtgcccag acaggaggcc atgttcaggt
4981 ggatgagatt ctctgacctc agcacatggg agggcgatcg caatcttgct cccgaaggtg
5041 tgaatgaaga tggcgtcgaa tgacgctact ccatctgatg atggtgcagc cggcctcgta
5101 ccagagatca acaatgaggt tatggctctt gaacccgtcg ctggggcctc ccttgcagcc
5161 cccgtagtcg gtcagcagaa tataattgat ccctggatta gaaataattt tgtacaagcc
5221 cctgctggtg aatttacagt ttcccctaga aactctcctg gagaacttct acttgatttg
5281 gaattgggtc ctgaacttaa tccctatctt gcacatttgg ccaggatgta caatgggcac
5341 gcaggaggaa tggaagtgca gatagtactg gctgggaatg cgttcacagc tggtaagatc
5401 ctatttgctg ccatcccgcc tagcttcccc tatgaaaatt tgtcacccgc tcaattgact
5461 atgtgccccc atgtgatagt ggatgtgaga caattagaac cagtgctttt gccaatgcca
5521 gacataagaa atgttttcta ccactataat cagaacaata gtcccaaact taggcttgta
5581 gctatgcttt atacccctct gagggctaac aactcaggtg atgacgtgtt cacggtgtct
5641 tgccgcgttt taacacgtcc ttctccagat ttccagttca cttttctggt cccacctaca
5701 gttgagtcta aaactaagaa tttcaccctc cccgttctta gagtctcaga gatgacaaac
5761 tcaaggttcc ccgttgtttt ggaccaaatg tatacaagca ggaatgaaaa catcattgtc
5821 caaccccaaa acggcaggtg cacaactgac ggtgagctgc ttggcactac catcttacag
5881 tctgtgtcta tttgcaactt taaaggaaca atgcaggcaa agatgaatga agaaccacga
5941 taccaattac aactcaccaa cttggatggt tcacctatag atccaacaga tgatatgcct
6001 gcccctcttg gcacgccaga cttccaggcc atgttatatg gcgttgcaag ccaacgctct
6061 tccagagaca atgccaccag ggcacatgat gcacagattg acactgcggg tgacacattc
6121 gccccgaaaa ttggccaggt tcgattcaaa tcaagctcta atgattttga cctacatgac
6181 cctacaaaat tcacacctat tggtgtcaat gtggatgatc agcacccttt tagacagtgg
6241 accctgccaa actacggtgg tcaccttgcc ctgaacaatc atttagcccc agctgtgaca
6301 ccactctttc ctggtgagca gattttgttc tttaggtcat acattccaag cgccggaggc
6361 cacacagacg gtgctatgga ctgcttgctg ccccaagagt ggatagagca cttctaccag
6421 gaagcggccc cttcccaatc tgacatcgca ctggtaaggt ttatcaaccc tgacacagga
6481 agagtgctct ttgaagctaa attgcacaaa caaggtttcc ttacaattgc agcatctgga
6541 gatcacccca ttgtgatgcc tactaatggt tactttaggt ttgaagcttg ggtcaaccct
6601 ttctatactc tcgcccccgt gggaactggg tctgggcgca ggaggattca ataatggctg
6661 gagctttcct tgcaggcttg gcaggtgacg ttgtgacttc cagcttgggc tcacttgtgg
6721 gcgctggagc caacgccatc aaccagaaag tggagtatga cttcaacaga cagctccagg
6781 aggcatcttt tagacatgat aaggatatgc tcaaagccca ggttgcagca acagcaggcc
6841 ttcaacaggc catgatagac atcaagcggg aggcattgac cgcaggcggc ttttcccccg
6901 ctgatgctgc aagaggtgca gtcagagcgc ctatgacaca gattcttgac tggaatggtt
6961 ctaggtattg ggcccctagc tccatgaaga caactggcta ttcaggtaca tttgcttccc
7021 aaggcattaa aagttccccc cacctgtcta atcaaattcc aagtgctgtt aaaattacta
7081 agacttcacc atctatatct agttcttcta gtgtatatag ttctccttct actgccccct
7141 cacaatcaac acaatcaata acgctgtctg caggaacagg gtcatccaga tctaacaccg
7201 tgtccacaaa gacctccaca ctgtcgagga caagtgactg ggtcagaggt caaaatgaga
7261 tgcttggccc gttcatgagt ggtgcactcc aaactgctta tgtcacacca ccatcgagca
7321 gggcctcatc acaagggacg gtctcgaccg tacccaaggc tgttttggac tcctggactc
7381 ccatgttcaa cacccacagg cagcctctct tcgcccactt gcgtaggcga ggggagtcac
7441 agatttagtg aaaaggatga ttagggtttc ttcattctcc cttcttattc ttt
//