Typing tool
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Typing tool
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Complete norovirus genomes
| MW305512 | GII.17 | |
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| GII.P13 |
ORF1: 1..5078
ORF2: 5059..6684
ORF3: 6684..7463
LOCUS MW305512 7505 bp RNA linear VRL 18-JUL-2024
DEFINITION Norovirus GII isolate PNV010077 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305512
VERSION MW305512.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7505)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REFERENCE 2 (bases 1 to 7505)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7505
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="PNV010077"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Peru"
/collection_date="05-Sep-2008"
/note="genotype: GII.17[GII.P13]"
gene <1..5078
/gene="ORF1"
CDS <1..5078
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ58872.1"
/translation="VAGKNNNNDNAKSSSDGLFSNMSVTLKKALGARPKQPPPGETKQ
ISKPPRPPTPELVKIIPPPPPNGEDEPKVVYKVGEGVSGLPDLTTVTQPDARCTAYSV
PPLSQREAGDAKEPLPGSILEMWDGEIYHYGLYVERGLVLGVHKPPAAISLAKIELTP
LSLYWRVVYTPQYLIAPDTLKNLNGESFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQ
RTTGFFRPYQEWNRKPLPTMDEPKIKKVANAVLCALSSLFTRPIKDIIGKLKPMNILN
ILATCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDFEMQGPEDLAVELVPV
VMGGIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANEL
AMVRAIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIV
GTINSLLARIAAARSLVHKAKEELSSRQRPVVVMISGRPGIGKTHLARELAKKVASTL
AGDQRIGLVPRNGVDHWDAYKGERVVLWDDYGMSNPIQDALRLQELADTCPLTLNCDR
IENKGKVFDSDAIIITTNLSNPAPLDYVNFEACSRRIDFLVYADAPDIEKAKRDFPGQ
PDMWKDHYRPDFSHIKLQLAPQGGFDKNGNTPHGKGVMKSLTVGSLIARASGLLHERM
DEFELQGPGLSTFNFDRNKVAAFRQLAAENKYGMLDTLRVGNQLKGVKTMDELKRAIN
NITIKKCLIVYNGCTYTMESDGRGKVLVDKVQNTTVQTNNELAGALHHLRSARIRYYV
KCFQEAIYSLLQIAGAAFVTSRIVRRMNISNLWSKPPAEDNDESEDKGGCPKPRDEDE
FTVDSKDIKVEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYL
QDRDRYYEELAIAKATEEDFCEEEEAKIRQRIFRPTRKQRKEERVTLGLVTGSEIRKR
NPDDFKPRGKLWADDDRSVDYNEKISFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTH
VIPKGITEAFGVPINQIQIHKSGEFCRLRFPKPIRTDVSGMILEEGAPEGTVATILVK
RPTGELMPLAARMGTHATMKIQGRMVGGQMGMLLTGSNAKGMDLGTTPGDCGCPYIYK
RGNDFVVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPILGPGNAPKLS
TKTKFWRSSNAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPNPS
ILESAKRTIINVLEQTIDPPQKWTYAQACASLDKTTSSGYPHHVRKNDYWSGETFTGK
LADQASKANLMYEEGKHMTPVYTAALKDELVKTDKIYGKIKKRLLWGSDLSTMIRCAR
AFGGLMEELKAHCITLPVRVGMNMNEDGPIIFEKHSRYNYHYDADYSRWDSTQQRAVL
ASALEIMVRFSAEPQLAQKVAEDLLSPSVVDVGDFKITINEGLPSGVPCTSQWNSISH
WLLTLCALSEVTGLGPDIIQANSMFSFYGDDEIVSTDIKLDPEKLTAKLREYGLKPTR
PDKTEGPLVISEDLNGLTFLRRTVTRDPAGWFGKLDQSSILRQLYWTKGPNHEDPSET
MIPHAQRPVQLMALLGESSLHGPSFYSKVSKLVISELKEGGMDFYVPRQESMFRWMRF
SDLSTWEGDRNLAPSFVNEDGVE"
mat_peptide <1..968
/gene="ORF1"
/product="p48"
mat_peptide 969..2066
/gene="ORF1"
/product="NTPase"
mat_peptide 2067..2603
/gene="ORF1"
/product="p22"
mat_peptide 2604..3002
/gene="ORF1"
/product="VPg"
mat_peptide 3003..3545
/gene="ORF1"
/product="Pro"
mat_peptide 3546..5075
/gene="ORF1"
/product="RdRp"
gene 5059..6684
/gene="ORF2"
CDS 5059..6684
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58873.1"
/translation="MKMASNDAAPSNDGAAGLVPEINTETLPLEPVAGAALAAAVTGQ
NNIIDPWIRTNFVQAPNGEFTVSPRNSPGEILLNLELGPDLNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKILFAAVPPNFPVEFLSPAQITMLPHLIVDVRTLEPIMIPLPD
VRNTFFHYNNRPSERMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPTPDFEFTYLVPP
SVESKTKPFSLPILTISELTNSRFPAPIDSLFTAQNNNLNVQCQNGRCTLDGELQGTT
QLLPTGICAFRGKISADVESSHQDRWHMQLTNLNGTPFDPTDDVPAPLGTPDFTGLLF
GVASQRNVGGTGNNTTRAHEVVIATTSTQFVPKLGSINFGSESDDFQVGPPTKFTPVG
IKIETGHPFRQWDLPNYSGALTLNMNLAPPVAPNFPGEQLLFFRSNVPCAGGVSEGII
DCLLPQEWIQHFYQESAPSQSDVALIRYVNPDTGRTLFEAKLHRTGYITVAHSGDYPL
VVPSNGYFRFDSWVNQFYSLAPMGTGNGRRRVQ"
gene 6684..7463
/gene="ORF3"
CDS 6684..7463
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58874.1"
/translation="MAGAFIAGLAGDMLTSAVGSLANAGANAITQKIDFENNKQLQAA
SFQHDKDMLRAQVDATKQLQAEMIAIKQGILTAGGFSPADAARGAVGAPMTKVLDWSG
TRYWAPNSTKTTSYSGQFTPTPVHIPNFNSKPRPPAKTQPSSSSSGSVYSLSTQSTSL
PGPSSSGSSVSSVSTQSTKLSSVSSMSRTADWVNQQRNLSPYMSGALNISHVTPPSSR
ASSSGTVSTVPKEVLDSWTSAFNTRRQPLFAHLRVRGESRV"
ORIGIN
1 ccgttgctgg caaaaacaac aacaacgaca acgcaaaatc ttcaagtgac ggattgtttt
61 ctaacatgtc tgtcactctt aagaaagccc tcggggcgcg gcctaaacag ccgcccccgg
121 gagaaacaaa gcaaatctct aaaccgccaa gaccgccaac accggaattg gtgaagataa
181 tacccccacc cccacccaat ggcgaagacg agccaaaagt ggtgtacaag gtgggagaag
241 gtgtatctgg gctgcctgac ttaacaacag tcacgcagcc tgatgcacga tgtacagcct
301 atagcgtccc cccgctcagt caaagagagg cgggtgacgc gaaggaacca ttacctggct
361 ccatcttgga gatgtgggat ggtgagatct atcattatgg gttgtacgtg gagcgtggcc
421 ttgtgcttgg ggtgcacaaa ccacccgctg cgataagcct cgctaaaatt gagttaacac
481 cattgtctct ttattggagg gttgtttaca ctccccagta cttaatagct ccagacactt
541 tgaagaacct gaatggagaa tcattcccat acacggcttt tgacaacaac tgctatgctt
601 tttgctgctg ggttttggac cttaatgatt cttggctcag caggagaatg attcaaagga
661 ccactggttt cttcaggcct taccaggagt ggaacagaaa gccattacca accatggacg
721 agcccaagat caagaaagtt gcaaacgctg tcctatgtgc tctctcttca ctcttcacca
781 gacccattaa agacatcatc ggcaagctaa aaccaatgaa catccttaac atactggcaa
841 cttgtgactg gacatttgca ggcatagtgg aatcccttat tcttcttgct gaactctttg
901 gggtgttctg gacgccccca gatgtgtctg cgatgatcgc tcccttgctc ggtgatttcg
961 aaatgcaggg ccctgaagat cttgccgtgg agctcgtgcc cgtggtaatg ggagggatag
1021 gtctggtgtt gggattcacc aaggaaaaga tcggcaagat gctttcatca gctgcatcca
1081 cgctcagggc ttgtaaagat ctaggggctt atggattgga aatactcaaa ttagttatga
1141 aatggttctt ccctaagaaa gaagaggcca acgagctggc catggtaagg gccattgagg
1201 atgctgtgtt agaccttgag gcaatagaaa acaaccatat gaccactctt ctcaaggaca
1261 aagacagtct tgccacatac atgagaaccc tcgacttgga ggaagagaaa gcaagaaagc
1321 tctccaccaa atctgcatca ccagacatcg tgggcacaat aaactcactg ttggcaagga
1381 ttgcagcagc ccggtcacta gtccacaaag caaaagaaga gctgtcaagc agacaaagac
1441 ctgttgtcgt tatgatatct ggcaggccgg gcatagggaa aactcaccta gccagagagc
1501 tggccaagaa agttgcatca acactggcag gtgaccaaag gattggcctg gtgcccagga
1561 atggtgtgga ccattgggat gcctacaaag gagaaagagt ggtgctgtgg gacgactatg
1621 gcatgagcaa ccccatacag gatgccctaa gactccaaga actggctgat acctgccctc
1681 taacacttaa ctgtgacaga attgaaaaca agggaaaggt gtttgatagc gatgccataa
1741 taataacaac caacctctcg aatccagcac ccttagacta tgttaacttc gaggcctgct
1801 ccaggcgcat agacttctta gtatatgcag atgcgccaga tattgagaag gccaaacgag
1861 atttccctgg ccagccagac atgtggaaag accattacag accagacttc tcacacatca
1921 agctccaact ggccccacag ggcggttttg acaagaacgg caacacccca cacggtaagg
1981 gtgtgatgaa gtccttgact gttgggtcat tgatcgccag agcctctggc ctgctccatg
2041 aaagaatgga tgaatttgag ctacagggcc ctggtctgtc aactttcaac tttgaccgca
2101 acaaggtcgc tgcctttaga caactggcag ctgaaaataa gtatggcatg ttggacacac
2161 tgagagtagg aaaccagcta aagggtgtca aaaccatgga tgagctgaag cgagccatca
2221 ataacatcac catcaagaag tgcttgatag tgtataatgg atgcacctac actatggaat
2281 ctgatggacg tggtaaagtg ttagttgaca aagtgcaaaa cacaacagtt caaaccaaca
2341 atgagcttgc gggggccctg caccacctca ggtctgcaag aataagatac tatgtcaagt
2401 gtttccaaga ggcaatctac tccctactcc aaattgctgg tgcagctttt gtcacctcac
2461 gcatagtgag gcgcatgaat atctcaaacc tatggtcgaa gccacctgct gaagacaatg
2521 atgaatcaga ggacaaagga gggtgtccca aacccagaga tgaggatgag ttcaccgtcg
2581 attccaaaga catcaaagtg gaaggaaaga aaggcaagaa caaatctggg agaggaaaga
2641 aacacacagc tttctccagc aagggcctca gtgatgaaga atatgatgag tacaaaagaa
2701 tcagagaaga aagaaatggc aagtactcga tagaagagta tctccaagat agggacaggt
2761 attatgagga acttgccatt gctaaagcca ctgaggaaga cttttgtgaa gaggaggagg
2821 ccaaaatccg ccagaggatc ttccgtccta ccaggaaaca acggaaggag gagagagtca
2881 ccctcggact cgtcacgggg tcagaaatca ggaagaggaa cccggatgac ttcaaaccaa
2941 gaggaaaact gtgggctgat gatgacagga gtgtggatta taatgagaaa ataagttttg
3001 aagcaccacc aagcatctgg tcaagaatag ttaattttgg ttcaggctgg gggttctggg
3061 tgtccccaag ccttttcata acctcaaccc acgtgatacc gaaggggatc acggaggctt
3121 ttggtgtgcc catcaatcaa atacaaattc acaagtcagg agagttctgt cgcctgaggt
3181 tcccaaaacc catcaggacg gatgtgagtg ggatgatctt agaagaaggt gcccctgagg
3241 gaaccgtcgc aaccatcctt gtcaaacggc cgacagggga gttgatgccc ttggctgcta
3301 gaatgggaac ccatgccaca atgaagatcc aagggagaat ggtgggtggt cagatgggca
3361 tgttgctcac cggctcaaac gccaagggca tggacctcgg cacaacacca ggtgattgtg
3421 ggtgccctta catatacaag agaggcaacg actttgtggt catcggcgta cacaccgcag
3481 cagcacgtgg aggcaacaca gtcatatgtg ccacacaagg aagtgaaggt gaagccactc
3541 ttgaaggagg agacaacaag ggtacttact gtggagcccc tatcctgggt cctggcaacg
3601 caccaaaatt gagcaccaaa acaaaattct ggagatcttc caatgcacca ctcccaccag
3661 gcacctatga gccagcgtac ctaggtggaa aagacccacg agtgaaaggg ggtccgtcct
3721 tgcaacaagt catgagagat cagctcaagc ctttcactga acccagaggg aaaccaccaa
3781 acccaagtat tctggaatct gcaaagagaa ccatcatcaa cgttttggaa caaactattg
3841 acccacccca aaagtggaca tatgcccagg catgtgcatc tcttgacaaa acaacttcca
3901 gcggttaccc acatcatgtc cgcaagaatg actactggag tggtgagaca ttcacaggta
3961 aactggcaga tcaagcttca aaggcaaatc ttatgtatga agaaggaaaa cacatgacac
4021 cggtgtacac cgcggccctc aaggatgaac tagtcaaaac tgacaaaatc tatggtaaga
4081 tcaagaagag gctactgtgg ggttctgacc tttccaccat gatccgatgt gctagggcat
4141 tcggtggcct catggaagaa ctcaaagcac actgcatcac ccttcctgtc agagttggca
4201 tgaacatgaa tgaagatgga ccaataatat ttgagaaaca ctccagatac aactaccatt
4261 atgatgcaga ctactcccgt tgggattcca cacaacaacg ggcggtgctt gcgtcagcac
4321 ttgaaatcat ggtgagattt tctgctgagc cacaattagc gcaaaaagtg gctgaggacc
4381 tgctttcacc aagtgtggtt gatgtgggtg atttcaaaat tacaatcaat gagggccttc
4441 catccggcgt gccatgcacg tcccagtgga actcaatctc ccactggttg ctcacattgt
4501 gtgccttatc tgaggtgaca ggactaggtc ctgacatcat acaggccaac tccatgttct
4561 ccttctatgg tgatgatgaa attgtgagca ctgacataaa attggaccca gaaaagttaa
4621 ctgcaaagct cagagagtat ggcctcaagc ccactcgtcc tgacaaaact gaggggccat
4681 tggtgattag tgaagactta aacgggttga cattccttcg ccgcactgtg acccgtgatc
4741 cagcaggctg gtttggaaaa ctagatcaaa gctctatcct caggcaattg tattggacaa
4801 aaggacccaa ccatgaagac cccagtgaaa ccatgatacc acatgcacag aggcccgtac
4861 aactcatggc actactggga gaatcctccc tacatggacc ctcattttat agcaaagtta
4921 gtaaattggt tatatctgaa cttaaggagg gaggaatgga tttttatgtg cccagacaag
4981 agtcaatgtt cagatggatg aggttctcag atctaagcac atgggagggc gatcgcaatc
5041 tggctcccag ttttgtgaat gaagatggcg tcgaatgacg ccgctccatc taatgatggt
5101 gctgcgggcc tcgtcccaga gatcaacacc gagacccttc ccctagaacc agtggctggt
5161 gcagctcttg ctgcggctgt cactggtcaa aataatataa ttgatccctg gattagaaca
5221 aattttgtac aagcacccaa tggggagttc actgtttcac ctaggaattc cccaggagaa
5281 atcctcctaa atttagaatt aggtcctgac ttaaatccct atttggcaca cttatctaga
5341 atgtacaatg ggtatgctgg tggagtggag gtccaggttc tcctagcagg gaatgcgttc
5401 accgctggaa agatcctctt cgctgccgta ccgccaaatt ttccagtcga attcttaagt
5461 cctgcccaaa ttactatgct cccacatttg atagttgacg tcaggaccct tgaaccaatt
5521 atgatacccc tccccgacgt gagaaacacc ttcttccatt acaacaatag gccctctgag
5581 cgtatgcgtt tggtggccat gttgtacaca cccctgagat ccaacggctc aggtgatgac
5641 gtcttcacag tttcatgtag agtgttaact agacccactc cagattttga attcacctac
5701 ctagttccac cctcagtaga gtctaagaca aagcctttct ctcttcccat cttaaccatt
5761 tctgaattga ctaattcaag gtttccagca cccattgatt cattgtttac cgcccaaaat
5821 aacaatctta atgtccaatg tcaaaatggt cggtgcacac tagatggtga gttgcaggga
5881 accacccagc tgctcccaac tggaatatgt gccttcagag ggaaaatatc agcagatgtg
5941 gaaagcagcc accaagacag gtggcacatg cagttgacaa atctcaatgg caccccattt
6001 gatccaacag atgatgtccc agctccgctt ggcactcctg acttcacagg tctactgttt
6061 ggagttgcaa gccaaagaaa cgttggtgga acaggtaaca acaccaccag ggcccacgag
6121 gtagtgatag caacaactag tacacaattt gtgccaaaat tgggttctat taattttggg
6181 agtgaaagtg acgattttca agtgggccca ccaaccaaat tcacaccagt tggaatcaaa
6241 attgaaaccg ggcatccttt tagacaatgg gacctaccta actattctgg agcactgacc
6301 ctcaacatga accttgctcc acctgttgcc ccaaacttcc caggtgagca gctgctcttc
6361 tttagatcaa atgttccttg tgctggtggt gttagtgagg gtattattga ctgcctgctg
6421 cctcaagagt ggatacaaca tttctaccag gagtccgctc catcccaatc agatgtggca
6481 ctgatcagat atgtcaaccc tgacacgggc cgcactctct ttgaggcaaa actccacagg
6541 actggttata ttactgttgc tcactctggt gattatcctc ttgttgttcc ttctaatggc
6601 tattttaggt ttgattcttg ggtaaatcaa ttttactcac tcgcccccat gggaactggg
6661 aatgggcgca ggagagtgca gtaatggcag gagcttttat agcaggtctt gcaggtgaca
6721 tgctcacctc tgctgtaggc tcactggcga atgctggagc aaatgccata acacagaaaa
6781 ttgactttga aaacaacaaa caacttcaag cagcctcctt tcaacatgat aaagatatgc
6841 tccgcgcaca agtggatgca actaaacagc tgcaggcaga aatgattgcc atcaaacagg
6901 ggatcttgac cgctggcggc ttctcccctg ctgacgcagc aagaggggct gtaggagcac
6961 ccatgaccaa ggtgcttgac tggtctggca cacgctattg ggcaccaaat tctaccaaaa
7021 caacaagtta ctccgggcag ttcacaccga cgcctgtgca cataccaaat tttaacagta
7081 aacccaggcc tcctgccaaa acccagcctt cttcttcttc ttctggtagt gtttatagcc
7141 tttcaaccca atcaacttca ctccctggac cttcttcttc aggttcatct gtttcttctg
7201 tctcaacaca atcaacaaaa ttgagttcag tttcttctat gagtagaaca gcagattggg
7261 ttaatcaaca aaggaacctt agcccttaca tgagcggggc ccttaatatt tctcatgtga
7321 cacctccatc aagcagggct tcaagttcgg gaacagtctc aactgtgccc aaagaagttt
7381 tggactcctg gacatctgca ttcaatacac gcagacagcc gctcttcgca cacctcagag
7441 tgagggggga gtcacgtgtt tagtgaaaag aatcaattag ttttaattgg gttaaacttt
7501 aattg
//