Typing tool
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Typing tool
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Complete norovirus genomes
| MW305508 | GI.7 | |
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| GI.P7 |
ORF1: 1..5362
ORF2: 5346..6965
ORF3: 6965..7612
LOCUS MW305508 7612 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GI isolate DS386 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305508
VERSION MW305508.1
KEYWORDS .
SOURCE Norovirus GI
ORGANISM Norovirus GI
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7612)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7612)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7612
/organism="Norovirus GI"
/mol_type="genomic RNA"
/isolate="DS386"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122928"
/geo_loc_name="Saudi Arabia"
/collection_date="1990"
/note="genotype: GI.7[GI.P7]"
gene <1..5362
/gene="ORF1"
CDS <1..5362
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QPJ58860.1"
/translation="ADVSKQNANTNNENIGSRLMARLKERISSQRGEGTTKIKNTEMA
LELIRRSQTPSPTRSDPPPKSQRDRPPRTVSEVKQALGWGDSTHKDYGARAWCDLTAE
EKKEILDNNERLFDAGGVTPSTVPSTFERYEAFDQTNDGHSVRWNESTGVDLGVGSLT
TVAGPVWNMCPLPPIDSRNNGPASEPRIGDMIEFYEGHIFHYAIYLGQGKTIGVHSPQ
AAFSIARITIHPMAAWWRVCYEPTDHQRLSYDQLKELENEPWPYASITNNCYEFCCRV
MSLDDSWLQRKLVTSGRFNHPTQEWSRDTPDFHQDSKLEIVRDAILSAINGLVSQPFK
NILSKIKPLNLLSLLSNCDWTFMGVVELVVLMAELFDIFWTPPDVSNFIASLLPDFHL
QGPEDLAKDLVPLILGGIGLAIGFTRDKITKVMKSAVDGLRSATQLGQYGLEIFSIIK
KYFFGGDQTEKTLKGIENAVIDMEVLSSTNVTQLVRDKKLAKTYMNILDNEEEKARKL
SVRSADPHVVTTVNNLISRISMARSALAKAQAEMTSRARPVVIMMCGPPGIGKTKAAE
HLANRLAGEIRPGGKVGLVPRESIDHWDGYHGEEVLLWDDYGMSKITEDCNKLQAIAD
TAPFTLNCDRIENKGMQFVSDAIIITTNAPGPAPVDFVNLGPVCRRVDFLVYCTAPEI
EQTRRTHPGDTNAIKDLFKPDFSHLKMEIAPQGGFDNQGNTPFGKGAMKPTTLNRLLI
QAVALTMERQDEFQMQGAVYNFDEDRVTAFTSLARANGLGLLSMAALGKKLRSVNNME
GLRNALKGYKITECDIVWNNRTYTIKGDGSNVGVTEKQVVASLQQQAVSSVTLALSRL
RAARALAYASCFQSAVVTILQMAGSAVVISRAVKRMFGTHTNQPALEGKPKEHNCRVH
RAEREGHGPIGHDGIIERYGLCESDQDEEKIVMEVPTADKEGKNKGKNKKGRGRKNNY
NAFSRRGLSDEEYEEYKKVREEKGGNYSIQEYLEDRQRYEEELAEVQAGGDGGIGETE
AEIRHRVFYKSKSGMRKQRQEERRQLGLVTGAEIRKRKPIDWTPPKNDWSEDTREVNY
DEHISFEAPPSIWSRVVKFGSGWGFWVSSTVFITTTHVIPPDAKEIFGEKLSDIAIHR
VGEFTQFRFSKKMRPDLSGMVLEEGCPEGTVCTIMVKRDSGELLPLAVRMGAVASMKI
QGKLMHGQSGMLLTGANAKGMDLGTIPGDCGAPYVHKRGNDWVVCGVHAAATKSGNTV
VCAIQSGEGEATLEGGGQNKGHYAGHPILRYGSGPSLSTKTKFWKSTPQPLPPGTYEP
AYLGGRDPRVDGGPSLQQVLRDQLKPFAEPRGRMPEPSLLEAAVETVTNVLEQTMDTP
VPWSYSDACMSLDKTTSSGHPYHKRKNDDWNGSAFVRELGEQAAHANNMYELGKSVKP
VYTAALKDELVKPEKVYTKIKKRLLWGADLGTVIRAARAFGPFCEAIKPHVIKLPIKV
GMNAIEDGPLIYAEHAKYKYHFDADYTAWDSTQNREIMLESFNIMCKLTANPSLAAVV
AQDLLSPSEMDVGDYVISVKDGLPSGFPCTSQVNSINHWIYTLCALSEVTGLAPDVLQ
SQSYFSFYGDDEIVSTDVEFDPIKLTQVLREYGLKPTRPDKSEGPIIVKQQIDGLVFL
RRTISKDAAGYQGRLDRNSIERQLWWTRGPNHDDPFETLIPHQQRKIQLISLLGEAAL
HGEKFYRKIANRVIQEVKEGGLELYIPGWQAMFRWMRFHDLSLWTGDRNLLPDYVNDD
GV"
mat_peptide <1..1180
/gene="ORF1"
/product="p48"
mat_peptide 1181..2269
/gene="ORF1"
/product="NTPase"
mat_peptide 2270..2866
/gene="ORF1"
/product="p22"
mat_peptide 2867..3286
/gene="ORF1"
/product="VPg"
mat_peptide 3287..3829
/gene="ORF1"
/product="Pro"
mat_peptide 3830..5359
/gene="ORF1"
/product="RdRp"
gene 5346..6965
/gene="ORF2"
CDS 5346..6965
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58861.1"
/translation="MMMASKDAPSNMDGTSGAGQLVPEVNAAEPLPLEPVVGAATAAA
TAGQVNLIDPWIMNNFVQAPEGEFTISPNNTPGDILFDLHLGPHLNPFLQHLSQMYNG
WVGNMRVRVMLAGNAFTAGKIIICCVPPGFASQNISIGQATMFPHVIADVRVLEPIEI
PLDDVRNVLFHTNENRPTMRLLCMLYTPLRAGGASSGTDPFVIAGRVLTCPSPDFNFL
FLVPPSVEQKTRQLTVPNIPLNNLANSRVPAMINKMTVSTDQNQVVQFQNGRCTLEGQ
LLGTTPVSASQVARIRGKVFSTASGKGLNLTELDGTPYHAFESPAPLGFPDIGACDWH
VSTFKVDQNLSGDPMSRLDIKQNAPFAPHLGSIEFTSDQDPTGDQLGTLAWVSPSTSG
ARVDPWKIPSYGSTVTESTHLAPPIFPPGFGEAIVYFMSDFPIVSGNTAQVPCTLPQE
FVSHFVEQQAPIRGEAALLHYVDPDTHRNLGEFKLYPDGFITCVPNTGGGPQNLPTNG
VFVFSSWVSRYYQLKPVGTAGPARRLGVRRV"
gene 6965..7612
/gene="ORF3"
CDS 6965..7612
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58862.1"
/translation="MAQAIIGAIAATAAGSAVGAGIQAGTEAALQYQRFQQDLTLQEN
SFKHDERMLGLQIEGSNALLQKNLSTRYNLLVGAGLSSADAARSIVGAPVTKIVDWNG
VRIAAPTSTATTLRSGNFMNIPVTLKKESQNLSARSVGLSNPNYDSSTMVSRTTQWVE
SQNSIRNLSPFHSSALRTTWVTPPGSTSTSTFSTVSSAPRFFNTERLPLFANNRK"
ORIGIN
1 tgctgatgtc agcaaacaaa atgctaacac caacaacgaa aacatcggtt ctcgcctcat
61 ggcgagactg aaggagcgta taagctccca acgtggtgaa ggcaccacaa agattaagaa
121 cactgaaatg gcattggaac tgatacgtag gtcccaaaca ccatccccaa cgcgctcgga
181 tcctcctccc aaatcacagc gtgaccgccc tccaagaact gtatcagaag taaagcaagc
241 attaggttgg ggtgattcca cccataagga ttatggggcc cgagcatggt gtgacctaac
301 agctgaagag aagaaagaga tcttggataa taacgagcgc ctctttgatg ctggcggtgt
361 gactccatca acagtgccga gtacttttga aagatatgag gcatttgatc aaactaatga
421 tggccattct gttagatgga acgaatccac gggagtagat ctaggtgtgg gttctctaac
481 cacagttgca ggtccagtgt ggaatatgtg tcctcttcca ccgattgatt cacgcaataa
541 tggtcctgca agtgaaccac gcatcgggga catgatagaa ttctatgaag gacacatatt
601 tcattatgcc atatatcttg gccaagggaa gaccataggg gtccactccc cccaggcagc
661 cttctccata gcacgcatta ccatacaccc catggcagca tggtggcgtg tctgctatga
721 accaacagac catcaacgcc tcagctatga ccaattaaaa gagctcgaga atgaaccatg
781 gccttatgca tccataacaa ataattgtta tgagttttgt tgccgtgtca tgtccctgga
841 cgactcttgg ttacagcgaa aattggtgac ctctggtagg ttcaatcacc ccactcagga
901 gtggtctagg gatacaccgg acttccatca agattcaaaa ttagagatag tgagagacgc
961 aattctgtct gctataaatg gcctagtctc tcaacctttc aaaaacattc tttccaagat
1021 taaaccatta aacttgttat ccttgttgtc aaattgtgat tggactttta tgggggtcgt
1081 ggagctggta gtgctaatgg ctgaactatt tgacatcttc tggacccctc ctgatgtctc
1141 caactttata gcatctcttt tgcccgactt tcacctacaa ggaccagagg atttggcaaa
1201 agatctggtc ccgctgatat tggggggcat tggcctggcc attggattca ccagagacaa
1261 gataacaaaa gtcatgaaga gtgctgttga tggcctgcgc tcagctacgc aactcgggca
1321 atatggcctt gagatattct caatcattaa aaagtatttc tttggtggag atcaaactga
1381 gaaaaccctc aagggcatag agaatgccgt catagacatg gaagtcttat cgagtaccaa
1441 tgtcactcag ttggtgcgcg ataagaaatt ggctaaaact tacatgaaca tcctagacaa
1501 tgaagaggaa aaagcaagaa aactctcagt acgtagtgct gatccacatg ttgtgacaac
1561 agttaacaat ctcatttcgc gcatatccat ggcgcgttca gccctcgcca aggcccaagc
1621 tgaaatgacc agtcgggcgc gcccggtggt cataatgatg tgtgggccac caggcatagg
1681 aaagactaag gctgctgagc atttagccaa ccgcttggct ggtgaaataa gaccaggggg
1741 caaagtgggc ttggtaccta gagaatccat tgaccattgg gatggctatc acggggaaga
1801 ggttctatta tgggatgact atggcatgtc caaaataaca gaagattgca ataaactaca
1861 ggccatagcc gacactgccc cgttcacact caactgtgat aggatagaga ataaaggcat
1921 gcaatttgta tctgatgcaa taataataac aacaaacgcc cctgggccag cccctgttga
1981 ctttgtcaac cttggtccag tatgtcggcg tgtggacttt ctagtgtact gcaccgcacc
2041 cgaaattgaa caaaccagga gaacccatcc tggagacacc aatgctatca aagacttatt
2101 caaaccagac ttttcccatt taaaaatgga gatagcgcca caaggggggt ttgataacca
2161 aggcaacacc ccttttggga agggtgctat gaagccaacc acacttaata gactacttat
2221 acaggctgtt gcattaacaa tggaaagaca agatgagttc cagatgcaag gggcggtgta
2281 caactttgat gaggaccggg tgacagcttt caccagcttg gctcgggcca atgggctagg
2341 actcttaagc atggcagcac ttggcaaaaa gttgcgaagt gtcaacaaca tggaaggact
2401 tcgcaatgcc ctcaaggggt acaagatcac tgagtgtgat attgtgtgga acaatagaac
2461 ttataccatt aagggagatg gatcaaatgt gggtgttact gagaaacagg tggtggcctc
2521 tcttcagcaa caagccgtca gctcagttac tttggcactt tccagattgc gcgccgcgcg
2581 agcgttggcg tatgcatctt gctttcagag tgcagtggtt accatcctac aaatggctgg
2641 gtctgcagtg gtgatcagca gagcagttaa gcgcatgttt gggacccata cgaaccagcc
2701 ggccctggag ggtaaaccca aggaacacaa ttgcagggtc caccgtgccg aaagggaagg
2761 ccatggacct attggtcatg atggtatcat agaacgatac ggcctgtgtg agagcgatca
2821 agatgaagaa aagatcgtga tggaagtgcc caccgctgac aaagaaggta aaaacaaagg
2881 taagaacaag aaagggcgag gtaggaaaaa caattacaac gccttttcca gacgaggcct
2941 aagtgatgag gagtatgagg aatataaaaa ggttagagaa gaaaagggag gcaactacag
3001 tatccaagaa taccttgagg atcgtcagcg ctacgaagaa gaactcgctg aggtccaagc
3061 tggtggagat ggcgggatcg gtgagacaga agcagagatt cgccatcggg tcttctataa
3121 atccaagagt ggcatgcgca aacagcgcca agaggagcgc cgacaacttg gattagttac
3181 aggtgctgaa atcagaaaac gtaaacccat agattggaca ccgcctaaaa atgactggtc
3241 agaagatact agggaagtca attatgatga acacatcagt tttgaagccc caccctctat
3301 ttggagtaga gttgtaaaat ttggcagtgg atggggcttc tgggtgagct caacagtttt
3361 tatcacaacc acacacgtca taccaccgga tgctaaagaa atttttggag aaaaactttc
3421 agatatagca atacacagag ttggggaatt cacacaattt agattctcta agaaaatgag
3481 acctgatctc agtggtatgg tgctggaaga gggctgccca gaaggaactg tgtgcaccat
3541 aatggtaaag agagattcag gtgagctgct accactggct gtacgcatgg gagctgtcgc
3601 atctatgaag atacagggaa aactcatgca tggtcaatct ggcatgttgc taactggtgc
3661 gaatgcaaaa ggaatggatt taggtactat ccctggtgat tgtggagctc catatgtgca
3721 caagagagga aatgattggg tggtgtgtgg agtgcacgca gctgcaacca agtcaggtaa
3781 tactgttgtt tgtgcaatac agtcaggtga aggtgaagcc acccttgaag ggggcggaca
3841 aaataaagga cattatgcag gccacccaat tctgaggtat ggcagtggac cctctctatc
3901 tacaaagact aaattctgga aatcaactcc ccaacccctc ccacctggaa cctacgagcc
3961 agcttacttg ggtgggcgtg accccagagt ggatggtgga ccatcacttc aacaggtcct
4021 gcgcgatcag ctcaaacctt ttgctgaacc tcgtggtagg atgccagaac caagcttact
4081 agaagcagct gtagagactg tcacaaacgt cttagagcaa accatggaca cacctgtacc
4141 atggagctac agtgatgctt gtatgtcact tgacaagacc accagctcgg gccatccata
4201 tcataaacgc aaaaatgatg attggaatgg cagtgcattt gtgcgtgagc ttggggaaca
4261 ggcagctcac gccaacaaca tgtatgaact aggcaaatca gttaaaccag tttacactgc
4321 agcactcaaa gatgaactgg taaaacctga aaaagtgtac acaaaaataa agaaaagact
4381 gctttggggt gcagaccttg gcacagtcat tcgagctgct cgagcatttg gcccattctg
4441 tgaagctata aaaccacatg taataaaact gccgatcaaa gttggcatga atgcaattga
4501 agatggcccc ctcatatatg ctgaacatgc taaatataag tatcactttg atgcagacta
4561 tacagcttgg gattcaaccc agaacagaga aatcatgtta gaatctttta acatcatgtg
4621 caaactcacg gctaatccat cattggccgc cgttgtcgcg caggacttac tgtccccatc
4681 ggaaatggat gtgggggatt acgtgattag tgtcaaagat ggtctcccct cagggttccc
4741 atgcacctca caagtgaata gcataaacca ttggatttat actctgtgtg ctctgtcgga
4801 ggtcacgggc ttggctcctg atgttttgca gtcccaatct tatttttcct tctatgggga
4861 tgatgaaatt gtatcaactg atgtggaatt tgacccaata aaactcaccc aagtgcttag
4921 ggaatatggt ttgaagccca ctcggcctga caaatcagaa gggcctatca tagtgaaaca
4981 gcaaatagat gggctagttt tcctgaggcg cactatatca aaagatgctg ccggttacca
5041 ggggcgtctg gaccgcaact ctattgaaag acaactgtgg tggactcggg gcccaaacca
5101 tgatgacccc tttgaaacac tgatacccca tcaacaaaga aagattcaat tgatttcctt
5161 acttggtgag gctgcacttc acggagagaa attctacagg aagattgcca acagagttat
5221 acaggaagtc aaggaagggg ggcttgagct ctacatacca ggttggcagg ccatgttccg
5281 ctggatgcgt ttccatgact tgagtttgtg gacaggagat cgcaatcttc tgcccgatta
5341 tgtaaatgat gatggcgtct aaggacgccc cctcaaacat ggatggcact agtggtgccg
5401 gtcagctggt tccagaggtt aatgcagctg aacccctacc tcttgaaccg gtagtgggcg
5461 ccgcaaccgc ggcggccact gctggacaag ttaatttaat agacccctgg attatgaata
5521 attttgtcca agcccctgag ggcgaattta ccatttcacc caacaatacc cctggagata
5581 ttttgtttga tctgcatttg ggaccacatc ttaatccctt cctccaacat ttatcccaaa
5641 tgtataatgg ctgggtgggg aacatgagag tcagagtcat gcttgcgggg aatgcgttca
5701 ctgctggtaa aatcataatt tgttgtgtcc caccaggttt tgcatcccaa aacatatcaa
5761 ttggacaagc cacgatgttc cctcatgtca tagcagatgt gagggtgctg gagcctattg
5821 aaatccccct tgatgatgta cgcaatgtct tatttcacac caatgagaac cgccccacca
5881 tgcggttgct ctgcatgctg tacacacccc tccgtgctgg aggtgcttca tcaggcacag
5941 atccttttgt cattgcaggt cgtgtgctaa cttgcccttc ccccgatttc aattttctgt
6001 ttcttgtgcc tcctagtgtg gaacagaaaa ctaggcaatt aactgtgccc aatataccct
6061 tgaataattt ggctaactcc agagtgcccg caatgataaa taagatgaca gtttctactg
6121 atcaaaatca ggtagtccag ttccaaaatg gtcgttgcac actcgaaggg caactcttgg
6181 gcacaacccc tgtttcagct agtcaagtgg cccgcatacg cggcaaagtt ttctccactg
6241 catcagggaa aggactcaac ctaactgagc tggatggaac cccttaccat gcatttgaga
6301 gtccagcccc cctcggtttc cctgacatag gagcttgtga ttggcatgtg tcaactttca
6361 aagtggatca aaatctttcg ggggatccca tgtccaggtt agatataaag caaaatgccc
6421 catttgcacc acatctaggt tccattgagt tcacctctga ccaagaccca actggggacc
6481 aattaggcac actagcctgg gtctccccct ccactagcgg agctagggtt gatccctgga
6541 agattccatc atatggctca acagtgactg agtccactca cctggcacca cctattttcc
6601 caccgggttt tggtgaagcc atagtctatt tcatgtcaga ttttcctatt gtgtcaggta
6661 acactgctca agttccctgc accctacccc aggaatttgt ttcacacttt gtagaacaac
6721 aggcaccaat ccgaggtgaa gccgccctac tgcattatgt agacccagac acccaccgca
6781 atttgggaga gtttaaatta taccctgatg ggttcatcac ctgtgtgcca aatacaggcg
6841 gtggccccca aaaccttcct acaaatggag tttttgtctt ttcttcttgg gtttctagat
6901 attatcaatt aaagcctgtg ggaacagccg gtccggctag gaggcttggt gtgaggagag
6961 tataatggcc caagccatta taggagctat tgccgccacc gctgctggca gcgcagtggg
7021 ggcaggtatc caagctggga cagaagcagc cttgcaatac cagaggtttc aacaggatct
7081 caccttacag gagaactctt ttaaacatga tgaaaggatg ttgggtttgc agattgaggg
7141 atcaaatgct ctattacaaa agaatctttc tacccgctat aatctattag ttggtgcagg
7201 tctttcttca gccgatgctg caaggtccat cgtcggggcc cccgtaacaa agattgtgga
7261 ttggaatggg gtgaggatcg ccgcccctac gtccactgcc accacccttc gatctggcaa
7321 ttttatgaac ataccagtca cacttaaaaa ggagtcccaa aacctgtcag cacgttctgt
7381 aggtctttcc aatcctaatt acgactcatc cacaatggtc tctagaacaa cccaatgggt
7441 ggagtcacaa aattcaatta gaaatttatc acctttccat agttcagccc tgaggaccac
7501 atgggtgact cctcctggct ctacttctac ttcaactttt tccactgttt cttcggcgcc
7561 acggttcttt aatactgagc gccttccttt gttcgcaaac aataggaaat ag
//