Typing tool
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Typing tool
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Complete norovirus genomes
| MW305507 | GI.3 | |
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| GI.P10 |
ORF1: 1..5368
ORF2: 5352..6986
ORF3: 6986..7630
LOCUS MW305507 7692 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GI isolate DS395 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305507
VERSION MW305507.1
KEYWORDS .
SOURCE Norovirus GI
ORGANISM Norovirus GI
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7692)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7692)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7692
/organism="Norovirus GI"
/mol_type="genomic RNA"
/isolate="DS395"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122928"
/country="Saudi Arabia"
/collection_date="1990"
/note="genotype: GI.3[GI.P10]"
gene <1..5368
/gene="ORF1"
CDS <1..5368
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QPJ58857.1"
/translation="ADVSNNKANTNNENIGSRLMARLRGHLGPQRGEATTKIKDANMA
LDLLRRSQTPSPTRHNHPPKDQRDRPPRTAMEVKRTMGWDDEPEQEESTARAWCDLTK
EEKEEIMRNNERLFDAGGVTPSTVPSTFERDNSNGTVDEHQTVSWSATNGVDIGVGDL
TTVRGPYWNLCPLPPLDTRNNGPAKEPLIGDMIEFYEGHIFHYAIYIGQGKTIGVHSP
QAAFSIPRITIHPLVAWWRVCYVPTNQQRLTYDQLKELENEPWPYASITNNCYEFCCR
VMALDDTWLQRKLVITGKFNHPTQEWSQDTPDFHQDSKLEMVRDAVLSAINGLVSQPF
KNILSKIKPLNLINLLSNCDWTFMGVVELIVLMAELFDVFWTPPDISSFIASLLPEFH
LQGPEDLAKDLVPLILGGIGLAIGFTRDKVTKVMKSAVDGLRSATQLGQYGLEIFSII
KKYFFGGDQTERTLRGIENAVIDMEVLSSTNVTQLVRDKKLAKAYMNVLDNEEEKARK
LSVRSADPHIVTSVNNLISRISMARSALAKAQAEMTSRIRPVVIMMCGPPGIGKTKAA
EHLASRLANEIRPGGKVGLVPRESIDHWDGYHGEEVLLWDDYGMSKITEDCNKLQAIA
DTAPLSLNCDRIENKGMQFVSDAIIITTNAPGPAPVDFVNLGPVCRRVDFLVYCSAPE
IEQMRRAHPGDTNAIKDLYKKDFSHLKMEIAPQGGFDNQGNTPFGKGTMRTTTLNRLL
IQATALTMERQDEFQLQGAVYNFDEDRVAAFTSMARANGLGLISMATLGKKLRSVKTM
EGLRNALVGYRIEECDIIWNTRTYSIKSDGKAVTVKEKQSPSSAQHQAVCTATLALSR
LRAARALAYASCFQSAVLSVLQVAGSAVVVSRAVKRMFGTRTDQPALEGGHKEHNCRV
HRAEAAGRGPIGHDGVIERYGLCESEQEGEDEQTLELPTASKEGKNKGKTKKGRGRKS
NFNAFSRRGLSDEEYEEYKKIREEKSGNYSIQEYLEDRQRYEEELAEVQAGGDGGIGE
TEAEIRHRVFYKSKAGMRKQRQEERRQLGLVSGSEIRKRKPIDWTPPKNDWSEDTRTV
NYDEHISFEAPPSIWSRVVKFGSGWGFWVSSTVFITTTHVIPPGSKEVFGEDLKNVAI
HRVGEFTQFRFSKKMRPDLSGMVLEEGCPEGTVCTIMIKRDSGELLPLAVRMGAVASM
KIQGKLMHGQSGMLLTGANAKGMDLGTIPGDCGAPYVHKRGNDWVVCGVHAAATKSGN
TVVCAIQGGEGEATLEGGGQNKGHYAGHPILRYGNGPSLSTKTKFWKSTPQPLPPGTY
EPAYLGGRDPRVEGGPSLQQVLRDQLKPFAEPRGRLPEAGLLEAAVETVTNAIEQVMD
TPVAWSFSDACMSLDKTTSSGYPHHRRKNDDWNGTAFVRELGDQAAHANNMFELGKSM
KPVYTAALKDELVKPDKVYNKIKKRLLWGADLGTVIRAARAFGPFCEAIKPHVIKLPI
KVGMNAIEDGPLIYAEHAKYKYHFDADYTAWDSTQNREIMMESFNIMCKLTANPSLAA
VVAQDLLSPSEMDVGDYVISVKDGLPSGFPCTSQVNSINHWILTLCALSEVTGLSPDV
LQSQSYFSFYGDDEIVSTDVEFDPIKLTQVLKEYGLKPTRPDKTDGPIVVKQQVDGLV
FLRRTISKDAIGYQGRLDRNSIERQLWWTRGPNHDDPFETLVPHPQRKVQLISLLGEA
ALHGEKFYRKIASRVIQEVKEGGLEIYIPGWQAMFRWMRFHDLSMWTGDRDLLPDYVN
DDGV"
mat_peptide <1..1183
/gene="ORF1"
/product="p48"
mat_peptide 1184..2272
/gene="ORF1"
/product="NTPase"
mat_peptide 2273..2872
/gene="ORF1"
/product="p22"
mat_peptide 2873..3292
/gene="ORF1"
/product="VPg"
mat_peptide 3293..3835
/gene="ORF1"
/product="Pro"
mat_peptide 3836..5365
/gene="ORF1"
/product="RdRp"
gene 5352..6986
/gene="ORF2"
CDS 5352..6986
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58858.1"
/translation="MMMASKDAPTNMDGTSGAGQLVPEANTAEPISMEPVAGAATAAA
TAGQVNMIDPWIMNNYVQAPQGEFTISPNNTPGDILFDLQLGPHLNPFLSHLAQMYNG
WVGNMRVKVLLAGNAFTAGKIIISCIPPGFAAQNISIAQATMFPHVIADVRVLEPIEV
PLEDVRNVLFHNNDSSPTMRLVCMLYTPLRASGSSSGTDPFVIAGRVLTCPSPDFSFL
FLVPPNVEQKTKPFSVPNLPLNTLSNSRVPSLINAMMISRDHGQMVQFQNGRVTLDGQ
LQGTTPTSLSQLCKIRGKVFHASGGNGLNLTELDGSAYHAFESPAPIGFPDIGDCDWH
MNATATNNFTGSSNEYQILIKQESAFAPHLGHVQADNLSAGANTDLIVSLSWISPVSD
QHRHDVDPWVIPRYGSSLTEAAQLAPPIYPPGFGEAIVFFMSDFPVVSGVNGMRIPCT
LPQEYVAHFVNEQAPTRGEAALLHYVDPDTHRNLGEFKMYPEGFMTCVPNSSGSGPQT
LPINGVFTFVSWVSRFYQLKPVGTAGPARRLGIRRS"
gene 6986..7630
/gene="ORF3"
CDS 6986..7630
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58859.1"
/translation="MAQAIFGAIAATAAGSAVGAGIQAGTEAALQHQRFQQDLTLQSN
SFKHDKEMIGLQVGASTALLQNSLNTRYNLLTQAGMSTTDAARAVVGAPTTRVVDWNG
TRIAAPMSSATTLRSGGFMTVPTIYRGSKTNSQLSSGFSNANYMPSSVSRTSEWVSSQ
NSSRSSLGPYHPNALQTAWVTPPGSTSTSSLSSASTAPRYFNTERLPLFANLRK"
ORIGIN
1 tgctgatgtc agcaataaca aagctaacac caacaatgaa aacattgggt ctcgcctcat
61 ggcgaggctt cgtgggcatt taggcccaca gcgtggtgaa gccaccacaa aaatcaaaga
121 tgccaatatg gcattggatt tgttacgccg gtcacaaaca ccctccccta cccggcataa
181 ccaccccccc aaagaccaga gagaccgccc gccacggact gccatggagg tgaaaagaac
241 tatgggttgg gatgatgagc cagaacaaga agagagcaca gctagggcat ggtgtgatct
301 tacaaaagag gagaaagagg agataatgcg caacaacgag aggttgtttg atgctggtgg
361 ggtgactcct tcaaccgtgc ccagcacatt tgagagagat aattcgaatg gtactgttga
421 tgaacaccag actgtgtcct ggtctgctac taatggagtt gatattgggg ttggagacct
481 gacaaccgtt cgcgggcctt attggaatct atgccccctt ccaccattgg acacccgtaa
541 caatggcccc gcaaaggaac ctcttatagg agatatgata gagttttatg aagggcatat
601 ctttcactat gcaatctata ttgggcaagg taaaaccatt ggagtccact caccgcaagc
661 agctttttct atacccagaa ttaccatcca cccactggtt gcatggtggc gtgtgtgtta
721 tgttcccacc aaccaacaac gcctcacata tgatcagctg aaagaattgg agaatgaacc
781 atggccctat gcctccataa ccaacaattg ctatgagttc tgttgcagag tgatggcact
841 tgatgacacg tggcttcaga gaaagttggt catcactggg aaattcaacc atcccacaca
901 ggaatggtca caggacaccc ctgacttcca ccaagactca aaacttgaga tggttaggga
961 tgctgtgctg tcagcgataa atggccttgt gtctcaaccc tttaaaaata ttctatcaaa
1021 aatcaagcct ctaaacctca ttaacctcct ttctaattgt gactggacct ttatgggggt
1081 tgttgagctg atcgtgctaa tggctgaatt atttgatgtg ttttggacac cacctgacat
1141 ttcaagcttt atagcctcac tgctaccaga attccacttg caaggtccag aagatctggc
1201 taaagaccta gtccctctca tacttggtgg tattggtttg gcaataggct ttacaaggga
1261 caaggttaca aaagttatga aaagcgcggt tgacggacta cgctcagcca cgcaacttgg
1321 gcagtatggc ttggagatat tctcaattat aaagaagtac ttctttggag gtgaccaaac
1381 agagcgaaca ctgcggggca ttgagaatgc agtgatagac atggaggtgc tgtccagtac
1441 aaatgtgaca caactggtta gggataagaa actagccaag gcatacatga atgtattgga
1501 caatgaagag gaaaaggcta gaaagctgtc agtccgaagt gctgacccgc acatagtgac
1561 ctctgttaac aacttgatat cccgaatctc tatggcaagg tcagcattag ccaaagcaca
1621 ggcagaaatg acatctcgca tacgccctgt ggtcataatg atgtgtggcc cccctggtat
1681 tggaaaaaca aaggctgccg aacacctagc cagccgacta gcaaatgaga taaggccagg
1741 tggcaaggtc ggtcttgtgc cacgtgaatc tattgatcac tgggacggtt atcatggtga
1801 agaggtccta ctttgggatg actatggtat gtcaaaaatt actgaagact gcaacaagtt
1861 gcaagcgatt gcggacactg caccactttc ccttaattgt gacagaattg agaataaagg
1921 tatgcaattt gtctcagatg caatcattat aaccaccaat gcgcctggcc cggccccagt
1981 tgattttgta aatcttgggc ctgtgtgtag gcgagtggac ttcctggtct actgttctgc
2041 cccagagatt gagcagatgc gaagggcaca tccaggtgac accaatgcaa tcaaggattt
2101 gtataagaag gatttctcac acttgaagat ggaaatagcc ccccaggggg gctttgataa
2161 ccaaggtaac acaccatttg ggaagggcac catgaggacc accacgctca atagactact
2221 catacaggcc acagctttga ccatggaaag acaagatgag ttccaattac aaggagcagt
2281 ctataatttt gatgaggata gagtggctgc cttcactagc atggcccgag ccaatggttt
2341 agggcttatt agcatggcaa ctctgggtaa gaaactgaga agtgtcaaga ccatggaggg
2401 attgcgcaat gcactagtgg gctatagaat tgaagaatgt gatataatct ggaacacccg
2461 aacctactca attaagagtg atggtaaagc tgttacagtt aaagagaaac aaagtccatc
2521 atcggctcag caccaagccg tctgtacggc cactctcgct ctatccaggt tgcgtgcggc
2581 ccgagcattg gcttatgcct cttgttttca gagtgcggtt ttgtccgtgc tccaagtggc
2641 cggctccgct gtggtagtaa gtagagcagt caagcgcatg ttcggtacgc gcacagatca
2701 accagctctt gaaggtggtc acaaggaaca caactgtagg gtccatcgtg cagaggctgc
2761 aggtcgtggc cccataggac acgacggtgt cattgagcgc tacggcttgt gtgagagtga
2821 acaagaaggt gaagatgagc aaacattgga gctgccaact gctagtaaag agggcaagaa
2881 taagggcaaa accaaaaagg gccgaggtcg taagtccaac ttcaatgcct tctcaagacg
2941 tggcctcagt gatgaagagt atgaggaata caagaagatc agggaagaaa agagtggtaa
3001 ctacagcatc caagagtatc tcgaggaccg ccaacgatac gaagaggaac tagcagaggt
3061 tcaggctggc ggcgatggcg ggataggtga gactgaagca gaaatccgcc acagggtgtt
3121 ctacaaatcc aaggctggca tgaggaaaca gcgccaagag gaacggcgac aattggggct
3181 tgttagcggg tctgagatcc gcaagcgtaa gcccatagat tggacccctc ccaaaaacga
3241 ctggtctgaa gacacaagga cggtcaatta tgatgaacac atcagctttg aagccccgcc
3301 atcaatatgg agcagagttg taaagtttgg aagtggatgg ggtttctggg tcagctcaac
3361 agttttcatc accaccaccc atgtaatccc accaggctcc aaagaagttt ttggagagga
3421 tctcaaaaac gtggccattc atagggttgg tgagtttacc caattccgct tctccaaaaa
3481 gatgagacct gaccttagtg gtatggtgtt ggaagaaggt tgcccagaag gcacagtctg
3541 caccattatg atcaaaagag actctggtga gttgttacca ctagccgtgc gcatgggcgc
3601 tgtggcatca atgaaaatcc aagggaaact tatgcatggg cagtcaggga tgctcctcac
3661 cggagccaat gccaagggta tggaccttgg aactatacct ggagactgtg gagcgcctta
3721 tgtgcacaaa agagggaatg attgggttgt atgtggcgtg catgcagcag ccacaaaatc
3781 aggtaacacc gtggtgtgcg ccatacaagg tggagaaggt gaggccactc tggaaggcgg
3841 tggccagaac aagggccact atgcaggaca ccccatactc agatatggta atggaccctc
3901 actgtcaact aaaaccaagt tctggaaatc aaccccccaa ccactgcccc ctggaacata
3961 cgagccggct tacctcggtg gaagggatcc gagagtggaa ggaggtccat cactacaaca
4021 ggttttgaga gaccagctta aaccctttgc tgagcctcgc ggtaggctgc ctgaagcagg
4081 tcttttggaa gccgcagtgg aaacagtcac caatgccatt gaacaagtca tggacacacc
4141 agtggcttgg agtttcagcg atgcatgcat gtccctggat aagaccacta gttctggcta
4201 tccccatcat aggagaaaga atgatgactg gaatggcacc gcattcgtgc gggagctggg
4261 ggatcaggca gcccacgcca ataacatgtt tgagcttgga aaatctatga aacctgtata
4321 cactgcagca cttaaagatg agcttgttaa accagacaag gtgtacaata agatcaagaa
4381 gaggctgctg tggggggcgg accttggcac agttattcgt gccgctagag cttttggtcc
4441 attttgtgaa gccataaaac ctcatgttat aaagttacct atcaaagttg gtatgaatgc
4501 tattgaagat ggccccctaa tctatgcaga gcatgccaaa tacaagtacc actttgatgc
4561 tgattacacg gcctgggatt ccactcaaaa cagggaaatc atgatggagt cctttaacat
4621 catgtgtaaa ctcactgcca acccttccct ggctgcggta gtggcacaag acttactttc
4681 tccttctgaa atggatgttg gagattatgt aatcagtgtg aaagacggcc tgccatcagg
4741 cttcccgtgt acctcacaag tcaacagcat aaatcactgg attctcaccc tgtgtgcatt
4801 gtcagaagtc accgggctct ccccagatgt gttgcagtca cagtcgtatt tttccttcta
4861 tggggatgat gagatagtct ccacagatgt tgaatttgac ccaattaaat tgacacaagt
4921 gctcaaagaa tatggtctaa aacccacaag acccgacaaa acagacggcc ccatagtggt
4981 caaacaacaa gtggatggcc ttgtctttct tcgacgaact atctcaaaag atgccattgg
5041 ttatcaaggt cgtctcgacc gaaactccat tgagaggcag ctttggtgga cgcgtggtcc
5101 caatcacgat gatccatttg agaccttggt tccacatccg cagagaaaag tccagctgat
5161 atctctgctt ggtgaggctg ctctccatgg tgagaaattc tacagaaaga tagcaagcag
5221 agtcatccag gaagttaaag aaggggggtt agaaatttac atccctgggt ggcaggccat
5281 gttccgctgg atgcgcttcc atgatctgag catgtggaca ggggatcgcg atctcctgcc
5341 cgattatgta aatgatgatg gcgtctaagg acgccccaac aaacatggat ggcaccagtg
5401 gtgccggcca gctggtacca gaggcaaaca cagctgagcc tatttcaatg gagccagtgg
5461 ctggggctgc gacagcagcc gcaactgctg gacaagtaaa tatgattgac ccctggataa
5521 tgaataatta tgtacaagct cctcaaggag aatttaccat atcgcccaac aatacacccg
5581 gtgacatttt atttgacctg caattgggcc cacacctcaa tcctttcttg tcccatttag
5641 ctcaaatgta caatggttgg gttggaaata tgagagtgaa ggtgcttttg gctggtaatg
5701 cttttacagc tgggaaaatt ataattagtt gcataccccc tggctttgct gcgcaaaata
5761 tttccatagc tcaagctaca atgttccccc atgtcattgc agatgttagg gtgcttgaac
5821 ctatagaggt ccctcttgaa gatgttagaa atgtgctttt ccacaataat gatagttccc
5881 ccactatgag attggtctgc atgttgtata cacctcttag ggctagtggt agttcttcag
5941 gcactgaccc atttgtcatt gcaggaaggg tcctgacttg cccgagccca gattttagtt
6001 tcttatttct tgtccccccg aatgtagaac agaaaactaa gcccttttct gtgcccaact
6061 tgccactaaa tacactctct aactcaaggg ttccttcact catcaatgct atgatgattt
6121 ctagagacca tgggcagatg gtgcagttcc aaaatggcag agtcacgctt gatggccagt
6181 tgcagggtac aacccctact tcactgagcc agctatgcaa gattagaggg aaagtcttcc
6241 atgccagtgg gggcaatggt ctgaatctga ctgaattaga tggttctgct tatcatgctt
6301 ttgaaagtcc tgctccaatt gggtttccgg acatcggtga ctgtgactgg cacatgaacg
6361 ccacagccac taacaatttc actgggtcca gcaatgaata tcaaatactc attaaacaag
6421 aatcagcatt tgctccccac cttggccatg tgcaggctga taatctgtca gcaggcgcca
6481 acactgatct tatagtgtcc ttgagttgga tatcccctgt ttcagaccaa cataggcatg
6541 acgtggatcc atgggtcata ccacgttatg gttcttccct cactgaagct gcccaattgg
6601 ccccgcccat ttaccctcct ggctttggtg aagctatagt gttctttatg tctgactttc
6661 cagtggtgtc aggtgttaat ggtatgagga ttccatgcac actacctcag gaatatgtgg
6721 ctcattttgt aaacgagcag gctcccactc gaggtgaagc agctcttttg cattatgttg
6781 atcctgacac tcacagaaac ctaggtgagt ttaaaatgta tcctgagggt ttcatgacct
6841 gtgtgcccaa ttccagtgga tctggtcctc aaaccttacc tattaatgga gtctttacct
6901 ttgtttcttg ggtttctcgt ttctatcaat taaagcctgt gggaactgct ggtccagcac
6961 gtaggcttgg catcagaaga tcataatggc tcaagctatc tttggagcta ttgctgccac
7021 tgccgctggt agcgccgtcg gggctggtat ccaagctgga actgaggctg ctctccagca
7081 tcagcgtttt caacaggatc ttaccttaca aagtaattct tttaagcatg ataaagaaat
7141 gattgggctt caggtaggtg cctctacagc attattgcaa aatagtttga acactcggta
7201 caatttatta acacaggcag gcatgtcaac aactgatgca gccagggctg tggttggtgc
7261 gccaactaca cgagtggtag actggaatgg caccagaatt gcagccccta tgtcctccgc
7321 caccactttg agatcaggtg gcttcatgac agtaccaaca atttacagag gctctaagac
7381 caattcacaa ttgtcaagtg gtttttctaa tgctaattat atgcctagta gtgtatctag
7441 aacttctgaa tgggtttctt ctcaaaattc ctccagatct tccttgggtc cttaccaccc
7501 aaatgcattg caaactgctt gggttacccc tccagggtca acctctactt cttctttatc
7561 atccgcctct acggcaccaa gatattttaa tacagaaagg cttcctttat tcgcaaactt
7621 aaggaagtaa aatttttgta atatgaatta gtgggcatca tattcaattg gaattttaaa
7681 ttagttttaa tt
//