Typing tool
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Typing tool
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Complete norovirus genomes
| MW305506 | GI.3 | |
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| GI.P10 |
ORF1: 1..5368
ORF2: 5352..6980
ORF3: 6980..7621
LOCUS MW305506 7702 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GI isolate DS275 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305506
VERSION MW305506.1
KEYWORDS .
SOURCE Norovirus GI
ORGANISM Norovirus GI
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7702)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7702)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7702
/organism="Norovirus GI"
/mol_type="genomic RNA"
/isolate="DS275"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122928"
/country="Saudi Arabia"
/collection_date="1990"
/note="genotype: GI.3[GI.P10]"
gene <1..5368
/gene="ORF1"
CDS <1..5368
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QPJ58854.1"
/translation="ADVSNNKANTNNENIGSRLMARLRGHIGPQRGEATTKIKDANMA
LDLLRRSQTPSPTRHNHPPKDQRDRPPRTVMEVKRTMGWDDEPQQKESTARAWCDLTK
EEKEEIMRNNERLFDAGGVTPSTVPSTFERDNSNGAVDEHQAVSWSAANGVDIGVGDL
TTVRGPYWNLCPLPPLDTRNNGPAKEPLIGDMIEFYEGHIFHYAIYIGQGKTIGVHSP
QAAFSIPRITIHPLVAWWRVCYVPTSQQRLTYDQLKELENEPWPYASITNNCYEFCCR
VMALDDTWLQRKLITTGKFNHPTQEWSQDTPDFHQDSKLEMVRDAVLSAINGLVSQPF
KNILSKIKPLNLINLLSNCDWTFMGVVELIVLMAELFDVFWTPPDISSFIASLLPEFH
LQGPEDLAKDLVPLILGGIGLAIGFTRDKVTKVMKSAVDGLRSATQLGQYGLEIFSII
KKYFFGGDQTERTLRGIEDAVIDMEVLSSTNVTQLVRDKKLAKAYMNVLDNEEEKARK
LSVRSADPHIVTSVNNLISRISMARSALAKAQAEMTSRIRPVVIMMCGPPGIGKTKAA
EHLASRLANEIRPGGKVGLVPRESIDHWDGYHGEEVLLWDDYGMSKITEDCNKLQAIA
DTAPLSLNCDRIENKGMQFVSDAIIITTNAPGPAPVDFVNLGPVCRRVDFLVYCSAPE
IEQMRRAHPGDANVIKDLYKKDFSHLKMEIAPQGGFDNQGNTPFGKGTMKTTTLNRLL
IQATALTMERQDEFQLQGAVYNFDEDRVAAFTSMARANGLGLISMATLGKKLRSVKTM
EGLRNALVGYKIEECDIIWNTRTYSIKSDGKAVTVKEKQSPSSAQHQAVCTATLALSR
LRAARALAYASCLQSAVLSVLQVAGSAVVVSRAVKRMFGTRTDQPALEGGHKEHNCRV
HRAEAAGRGPIGHDGVIERYGLCESEQEGEDEQTLELPTASKEGKNKGKTKKGRGRKS
NFNAFSRRGLSDEEYEEYKKIREEKSGNYSIQEYLEDRQRYEEELAEVQAGGDGGIGE
TEAEIRHRVFYKSKAGMRKQRQEERRQLGLVSGSEIRKRKPIDWTPPKNDWSEDTRTV
NYDEHISFEAPPSIWSRVVKFGSGWGFWVSSTVFITTTHVIPPGSKEVFGEDLKNVAI
HRVGEFTQFRFSKKMRPDLSGMVLEEGCPEGTVCTIMIKRDSGELLPLAVRMGAVASM
KIQGKLMHGQSGMLLTGANAKGMDLGTIPGDCGAPYVHKRGNDWVVCGVHAAATKSGN
TVVCAIQGGEGEATLEGGDQNKGHYAGHPILRYGNGPSLSTKTKFWKSTPQPLPPGTY
EPAYLGGRDPRVEGGPSLQQVLRDQLKPFAEPRGRLPEAGLLEAAVETVTNAIEQVMD
TPVAWSFSDACMSLDKTTSSGYPHHKRKNDDWNGTAFVRELGDQAAHANNMFELGKSM
KPVYTAALKDELVKPDKVYNKIKKRLLWGADLGTVIRAARAFGPFCEAIKPHVIKLPI
KVGMNAIEDGPLIYAEHAKYKHHFDADYTAWDSTQNREIMMESFNIMCKLTANPSLAA
VVAQDLLSPSEMDVGDYVISVKDGLPSGFPCTSQVNSINHWILTLCALSEVTGLSPDV
LQSQSYFSFYGDDEIVSTDVEFDPIKLTQVLKEYGLKPTRPDKTDGPIVVKQQVDGLV
FLRRTISKDAIGYQGRLDRNSIERQLWWTRGPNHDDPFETLVPHPQRKVQLISLLGEA
ALHGEKFYRKIASRVIQEVKEGGLEIYIPGWQAMFRWMRFHDLSMWTGDRDLLPDYVN
DDGV"
mat_peptide <1..1183
/gene="ORF1"
/product="p48"
mat_peptide 1184..2272
/gene="ORF1"
/product="NTPase"
mat_peptide 2273..2872
/gene="ORF1"
/product="p22"
mat_peptide 2873..3292
/gene="ORF1"
/product="VPg"
mat_peptide 3293..3835
/gene="ORF1"
/product="Pro"
mat_peptide 3836..5365
/gene="ORF1"
/product="RdRp"
gene 5352..6980
/gene="ORF2"
CDS 5352..6980
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58855.1"
/translation="MMMASKDAPTNMDGTSGAGQLVPEANTAEPIAMDPVVGAATAVA
TAGQVNMIDPWIMSNFVQAPQGEFTISPNNTPGDILFDLQLGPQLNPFLSHLAQMYNG
WVGNMRVKILLAGNAFTAGKIIISCIPPGFTSQSVSIAQMTMFPHIIADVRVLEPIEI
PLEDVRNVLFHTNDNRPTMRLVCMLYTPLRANGSSSGTDPFVIAGRVLTCPDSTFNFL
FLVPPNVEQKTKQFSVPNLPLNSLSNSRVPSLIKSMMISRDQAQVIQFQNGRVTLDGQ
LQGTTPTSASQLFKLRGTVFTASGGKGLNLTELDGTPYHAFESPAPIGFPDIGDCDWH
LIAVPTTTFPNDGHNREIAVTQGPAFAPHLGSIHFTGGDLNNNDNVICSINWISPIDA
VKKVNPWVIPNYGSTLTEAAQLAPPIYPPGFGETIVFFMSDGPIANGLNGLSVPCTLP
QEFVTHFVNEQAPTRGEAALLHYIDPDTHRNLGEFKIYPEGFMTCVPNASGSGPQTLP
INGVFTFVSWVSRFYQLKPVGTAGAVRRLGIRRS"
gene 6980..7621
/gene="ORF3"
CDS 6980..7621
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58856.1"
/translation="MAQAILGAIAATAAGSAVGAGIQAGTEAALQHQRFQQDLTLQSN
TFKHDKEMLGLQVEASTALLQNSLGARYSMLTNAGLTSADAARAVAGAPVTRVVDWNG
TRIAAPTSTQTTLRSGGFMSVPIVYRGKQQQPSGGFHNPNYDAQSTSTRTSQWVSSQS
SSLSTLSPYHPNALRTAWVTPPGSTSTSTLSSNSTITRFFNTERLPLFANMRK"
ORIGIN
1 tgctgatgtc agcaataaca aagctaacac caacaatgaa aatattggat ctcgcctcat
61 ggcgagactc cgtgggcata taggcccaca acgtggtgaa gccaccacaa aaatcaaaga
121 tgccaatatg gcattggacc tgttacgccg gtcacagaca ccctctccta cccggcacaa
181 ccaccccccc aaagaccaaa gagaccgccc accacggact gttatggagg tgaaaagaac
241 tatgggttgg gatgatgaac cacaacaaaa agagagcaca gctagggcat ggtgtgatct
301 cacaaaagag gagaaagagg agataatgcg taacaacgag agactgtttg atgctggtgg
361 ggtaacccct tcaaccgtgc ccagcacatt tgagagagac aactcgaatg gagctgttga
421 tgaacaccag gctgtgtcct ggtctgctgc taatggagtt gatattgggg ttggagacct
481 aacaaccgtt cgcgggcctt actggaacct atgccccctt ccaccattgg acacccgtaa
541 caatggcccc gcaaaggaac ctcttatagg agacatgata gagttttatg aggggcatat
601 ctttcactat gcaatttata ttgggcaagg taaaaccatt ggagtccact caccgcaagc
661 agctttttcc atacccagaa taaccatcca cccactggtg gcatggtggc gtgtatgtta
721 tgttcccacc agccaacaac gccttactta tgatcagctc aaagaattgg agaatgaacc
781 atggccctat gcctccataa ccaacaactg ctatgagttt tgttgtaggg tgatggcgct
841 tgatgacacg tggcttcaga gaaagttgat caccactgga aaattcaacc atcccacaca
901 ggaatggtca caggataccc ctgacttcca ccaagattca aaacttgaga tggtcaggga
961 tgctgtgctg tcagcgataa atggccttgt gtctcaaccc tttaaaaata tcctatcaaa
1021 aatcaagccc ctaaacctta ttaatctcct ctctaattgt gattggacct tcatgggggt
1081 tgttgagttg atcgtactaa tggctgaatt gtttgatgtg ttttggacgc cacctgacat
1141 atcaagtttt atagcctcac tactaccaga attccaccta caaggcccag aggatctggc
1201 taaagatctg gtccccctca tacttggcgg cattggtttg gcaataggct ttacaaggga
1261 caaggtcaca aaagttatga aaagcgcggt tgacggacta cgttcagcca cgcagcttgg
1321 gcagtatggc ttggagatat tttcaattat aaagaaatac ttctttggag gtgaccagac
1381 agagcgaaca ctgcggggta ttgaggatgc agtcatagac atggaggtgc tgtccagtac
1441 aaatgtgaca caattggtta gggataagaa actagccaag gcttacatga atgtattgga
1501 caatgaagag gagaaagcta gaaaactgtc agtccgaagc gctgacccgc atatagtgac
1561 ctctgttaac aacttgatat cccgaatctc tatggcaagg tcagcattag ccaaagccca
1621 ggcagaaatg acatctcgca tacgccctgt ggtcataatg atgtgtggcc cccctggcat
1681 tggaaaaaca aaggctgccg aacacctagc cagccgacta gcaaatgaga taaggccagg
1741 tggtaaggtc ggtcttgtgc cacgtgaatc cattgatcac tgggacggtt accatggtga
1801 agaggtccta ctttgggatg actatggcat gtcaaaaatt actgaagact gcaacaaatt
1861 gcaagcaatt gcggacactg caccgctttc ccttaattgt gacagaattg agaataaagg
1921 catgcaattt gtgtcagatg caatcattat aaccaccaat gcgcctggcc cggccccagt
1981 tgatttcgta aatcttgggc ctgtgtgtag gcgagtagac ttcctggtct actgttctgc
2041 cccagagatt gagcagatgc gaagggcaca tccaggtgat gccaatgtaa tcaaggattt
2101 atataagaag gacttctcac acttgaagat ggaaatagcc cctcaggggg gctttgataa
2161 ccaaggtaac acaccatttg gaaagggcac catgaagacc accacgctta atagactact
2221 catacaagcc acagccttga ccatggaacg acaagatgag ttccaattgc aaggggcagt
2281 ctataacttt gatgaggata gagtggccgc cttcactagc atggcccgag ccaatggctt
2341 agggcttatc agtatggcaa ctctgggaaa gaaactgaga agtgttaaaa ccatggaggg
2401 attgcgtaat gcactggtgg gctataaaat tgaagaatgt gatataatct ggaacacccg
2461 aacctactca attaagagtg atggtaaagc tgtcacagtg aaagagaaac aaagtccatc
2521 atcggctcag catcaagccg tctgcacggc cactctcgct ctatccaggt tgcgtgcggc
2581 ccgagcattg gcctatgcct cttgccttca gagtgcggtt ttgtccgtgc tccaagtggc
2641 cggctctgct gtggtggtaa gtagagcagt taagcgcatg tttggtacgc gcacagacca
2701 accagctctt gaaggtggcc ataaggaaca caactgtagg gttcatcgtg cagaggctgc
2761 aggtcgtggc cccataggac acgacggtgt cattgagcgc tacggcctgt gcgagagtga
2821 acaagaagga gaagatgagc aaacattgga gctgccaact gctagtaagg agggcaagaa
2881 taagggcaaa accaagaagg gccgaggtcg taagtccaac ttcaatgcct tctcaagacg
2941 tggcctcagt gatgaagagt atgaggaata caagaagatc agggaagaaa agagtggcaa
3001 ctacagcatc caagagtatc tcgaggaccg ccagcgatat gaagaagaac tagcagaggt
3061 tcaggctggc ggtgatggcg ggataggtga gactgaagca gaaatccgcc acagggtgtt
3121 ctacaagtcc aaggctggca tgagaaagca gcgccaagag gaacggcggc agttggggct
3181 tgtcagcggg tctgagatcc gcaagcgtaa gcccatagac tggacccctc ccaagaatga
3241 ctggtctgaa gacacaagga cggtcaatta tgatgaacac atcagctttg aagccccacc
3301 atcaatatgg agcagagttg taaaatttgg cagtggatgg ggcttttggg tcagttcaac
3361 agtcttcatc accaccaccc atgtaatccc accaggctcc aaagaagtct ttggagagga
3421 tcttaaaaat gtggccattc acagggttgg tgagttcacc caattccgct tttccaaaaa
3481 gatgagacct gatcttagtg gtatggtact ggaagaaggt tgcccagagg gtacagtctg
3541 caccataatg atcaagagag actctggtga gttattacca ctggctgtgc gcatgggcgc
3601 ggtggcctca atgaaaatcc aagggaaact catgcatgga cagtcaggga tgcttctcac
3661 cggggccaat gccaaaggca tggaccttgg gactatacct ggagactgtg gagcacccta
3721 tgtgcacaaa agagggaacg attgggttgt ttgtggcgtg catgctgcag ccacaaagtc
3781 aggcaacacc gtggtgtgcg ccatacaagg tggagaaggt gaggccacat tagaaggtgg
3841 tgaccagaac aagggccact atgcagggca ccccatactc agatatggta atgggccctc
3901 attgtcaacc aaaaccaaat tttggaaatc aaccccccaa ccactgcccc ctggaacata
3961 cgagccggcc tacctcggtg gaagggaccc aagggtggaa ggaggtccat cactgcaaca
4021 agttctgagg gaccaactta aaccctttgc tgagcctcgt ggtagactgc ctgaagcggg
4081 cctcttggaa gccgcagtgg aaacagttac caatgccatt gagcaagtca tggacacacc
4141 agtggcttgg agtttcagtg atgcatgcat gtccctggat aagactacca gctctggcta
4201 tccccaccat aagagaaaga atgatgactg gaatggcacc gcattcgtgc gggaactggg
4261 ggatcaggca gcccacgcca ataacatgtt tgagcttgga aaatccatga aacctgtata
4321 cactgcagca cttaaagatg aacttgttaa accagacaag gtgtacaata agatcaagaa
4381 gaggctgctg tggggggcgg accttggcac agtcattcgt gccgctagag cttttggtcc
4441 attttgtgaa gccataaaac ctcacgttat aaagttacct atcaaagttg gcatgaatgc
4501 tattgaagat ggccccctaa tttatgcaga gcatgccaaa tacaagcacc actttgatgc
4561 tgattacacg gcctgggatt ccactcaaaa cagggaaatt atgatggaat cctttaatat
4621 catgtgtaaa cttaccgcca acccttccct ggccgcagta gtggcacaag atttactttc
4681 cccttctgaa atggatgttg gggattatgt aatcagtgtg aaagacggtc tgccatcagg
4741 ctttccgtgt acctcacaag tcaacagcat aaatcattgg atcctcactc tgtgtgcatt
4801 atcagaagtc actgggctct ccccagacgt gttgcagtca caatcgtact tctccttcta
4861 tggagatgac gagatagtct ccacagatgt tgaatttgac ccaatcaaac taacacaagt
4921 gctcaaagaa tatggtctaa aacctacaag acctgacaaa acagacggcc ctatagtagt
4981 caaacagcaa gtggatggcc ttgtctttct tcgacgcact atctcaaaag atgccattgg
5041 ttaccaaggt cgtctcgacc gaaactccat tgagaggcag ctttggtgga cgcgtggtcc
5101 caaccacgat gatccatttg agacattggt tccacacccg cagaggaaag tccaactgat
5161 atctctgctt ggtgaggctg ccctccatgg tgagaaattc tacagaaaga tagcaagcag
5221 agtcatccag gaagtcaaag aaggggggtt agagatttac atccctgggt ggcaggccat
5281 gttccgctgg atgcgcttcc atgatctaag catgtggaca ggggatcgcg atctcctgcc
5341 cgattatgta aatgatgatg gcgtctaagg acgccccaac aaacatggat ggcaccagtg
5401 gtgccggcca gctggtacca gaggcaaaca cagctgagcc tattgctatg gacccagtag
5461 ttggtgctgc tacggcagtt gccactgctg gccaagtaaa tatgattgac ccctggatta
5521 tgagtaattt tgttcaagca ccccaaggag aatttacaat ttcacccaat aacacacctg
5581 gtgatatttt atttgattta caattgggac ctcaattaaa tccctttttg tctcatttag
5641 cacaaatgta taatggttgg gttggaaaca tgagagtaaa gattttgttg gctgggaatg
5701 cgttcacagc aggcaaaata atcatcagtt gtattccccc tggtttcacc tcccaaagtg
5761 tgtccatagc acagatgact atgtttcccc atataatcgc tgatgttagg gttctagaac
5821 caattgaaat tcccctggag gacgtgagga atgttctgtt tcataccaat gacaaccggc
5881 caactatgcg gctggtatgc atgctttaca cgccacttag ggccaatggc agttcttctg
5941 gcactgatcc ttttgtcatt gcaggcaggg tcctgacttg ccctgattct actttcaact
6001 ttttgttttt agtgccccca aatgtggaac agaagaccaa acagtttagt gtacccaatc
6061 tccctctcaa ttctctttct aactctaggg tgcctagttt gatcaagtcc atgatgattt
6121 ctcgtgatca agcccaagtg atccagttcc agaatggtcg ggttacatta gatggacagt
6181 tacagggtac aaccccgact tctgctagcc aactcttcaa gctccggggc actgttttta
6241 ctgcgtctgg tggcaaagga ctaaacctga cagagcttga cggcacaccc taccatgcct
6301 ttgagagtcc cgcacccata gggttccctg atattggtga ttgtgattgg catctcattg
6361 ctgtccccac taccactttt ccaaatgacg gccataatcg tgagatagca gtcactcaag
6421 ggccagcatt tgcacctcat ctaggttcta tacatttcac aggaggtgac ctcaataata
6481 atgataatgt tatctgttca ataaattgga tctcccccat tgatgcagtg aaaaaggtaa
6541 acccatgggt cattccaaat tatggttcaa ccctaacaga agcagcccaa ttggctcccc
6601 caatataccc cccaggcttt ggtgagacca ttgttttctt catgtctgat ggccctattg
6661 ccaatggact gaatgggctg agtgttccat gcacgctacc acaagaattt gtgacccact
6721 ttgtcaatga acaagctcca acccggggtg aagctgcatt attgcattac attgacccag
6781 atactcatcg caatttaggt gagttcaaaa tttaccctga aggatttatg acttgtgtgc
6841 ctaatgccag tgggagtggt cctcaaactt tgccaatcaa tggtgttttc acttttgttt
6901 cttgggtttc ccggttctat caactaaagc ctgtgggaac ggccggtgcg gtccgtaggc
6961 ttggaatccg cagatcataa tggcccaagc catcttggga gcgattgcag ccacagctgc
7021 aggcagtgct gttggcgcag gcatccaggc tggcacggag gccgcgcttc agcatcagcg
7081 tttccaacag gatttaaccc tccagagtaa tacttttaag catgacaaag aaatgttagg
7141 gctacaagtt gaagcttcaa cagctctttt gcagaacagc ttgggagccc gctacagcat
7201 gctcaccaat gctggcctca cctcagctga cgctgccaga gctgttgccg gggctccggt
7261 gacccgggta gttgattgga acggcacacg cattgcagcc cccacatcaa cccagaccac
7321 tcttaggtca ggtggtttca tgagtgtgcc aatagtgtac agaggaaaac aacagcaacc
7381 atctggtggc ttccacaacc ccaactacga cgcgcagtct acatctactc gcacgtctca
7441 gtgggtgtct tcgcagtcct cttctttgtc aaccctttca ccatatcatc ctaatgctct
7501 ccgaaccgcc tgggttactc cccctggttc aacatctaca tctacacttt cttcaaattc
7561 tactattact agattcttta atactgaaag attgcctcta ttcgcaaata tgaggaaata
7621 gttttgtaat atgaaatgtg ggcatcatat tcaattggct taattaataa ttaataattt
7681 ggtctgatta gtatttgatg tt
//