Typing tool
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Typing tool
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Complete norovirus genomes
| MW305504 | GI.4 | |
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| GI.P4 |
ORF1: 1..5326
ORF2: 5310..6944
ORF3: 6944..7570
LOCUS MW305504 7660 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GI isolate 11692 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305504
VERSION MW305504.1
KEYWORDS .
SOURCE Norovirus GI
ORGANISM Norovirus GI
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7660)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7660)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7660
/organism="Norovirus GI"
/mol_type="genomic RNA"
/isolate="11692"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122928"
/geo_loc_name="Japan"
/collection_date="22-Jan-2013"
/note="genotype: GI.4[GI.P4]"
gene <1..5326
/gene="ORF1"
CDS <1..5326
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QPJ58848.1"
/translation="TAASAENTSDNSESIKNRFFTRLKNLGSNNKPIKIENTHMALNL
ISRGPSPAPQERPPKDQRDKPPRNVTETQQAMGWVDPPVDQNLPTWEELSQTEKQEIL
KNNSNWFDAGGLAPASIPSGYVKNTEQQPPDHQVKWSVNNGVDLGVDSLTTVPGPTWN
LCPMPPIDQRNNGPAKEPLIGDMIEFYEGHIYHYAIYIGQGKTVGVHSPQAAFSIARI
TIHPIAAWWRVCYVPTPDQRLNYDQLKELENEPWPYAAVTNNCYEFCCRILNLQDTWL
ERRLVTSSRFNHPTQDWSRDTPDFQQDSKLEIVRDAVLAAINGLVSKPFKDLLNKLKP
LNVLNLLSNCDWTFMGVVETIILLMELFGIFWNPPDVSSFIASLLPDMHLQGPEDLAK
DLIPLVLGGVGLAIGFTKDKVTKVMKSAVEGLRAATQLGQYGLEIFAVLKKYFFGGDQ
TEKTLKDIETAVIDMEVISTTAVTQLVRDKQAARTYMNILDAEEEKARKLSVRHADPH
VVSTTNALISRISLARSALAKAQAEMTNRVKPVVIMMCGPPGIGKTKAAEYLAKRLAN
EIRPGGKVGLVPREAVDHWDGYHGEEVMLWDDYGMSKIADDCNKLQAIADTAPLTLNC
DRIEKKGLQFVSDAIVITTNAPGPAPVDFVNLGPVCRRVDFLVYCTAPDVEQTRRTNP
GDTGALKDCFKSDFSHLKMELAPQGGFDNQGNTPFGKGTMRPTTLNRLLIQAVALTME
RQDEFQMQGRVYDFDADRVSAFTSLARANGLGLISMASLGKKLRGVDSVHGLKNALSG
YTITPCSIKWQARVYDIESDGTNVHIKENTSAQTQRQQSIDTAALALTRLKAARAAAY
AACIQSAITTILQMAGSAIVINRAVKRMFGAHPSTIALEGPPREHRCRAHLAKAAGGG
PIGHDDVIDKYGLCETEEEGTSEEMNVELPTATSEGKNKGKTKKGRGRRANYNAFSRR
GLSDEEYEEYKKIREEKNGNYSIQEYLEDRQRYEEELAEVQAGGDGGIGETEMEIRHK
IFYKSKKGRQNERRQLGLVTGSDIRKRKPIDWTPPKNDWADDNREVDYNEKLSFEAPP
TLWSRVVRFGSGWGFWVSPTVFITTTHVIPSGVREFFGEPIESIAIHRAGEFTQFRFS
RKVRPDLTGMVLEEGCPEGVVCSILIKRDSGELLPLAVRMGAIASMKIQGRLVHGQSG
MLLTGANAKGMDLGTLPGDCGAPYVYKRNNDWVVCGVHAAATKSGNTVVCAVQAGEGE
TTLEGGDKGHYAGHEIIKHSKGPALSTKTKFWRSTPEPLPPGVYEPAYLGGRDPRVKG
GPSLQQVLRDQLKPFAEPRGRMPEPGLLEAAVETVTSMLEQTMDTPTPWSFSDACQSL
DKTTSSGHPYHKRKNDDWNGTSFVGELGEQAAHANNMYELGKSMKPLYTAALKDELVK
PEKVYQKIKKRLLWGADLSTVIRAARAFGPFCDAIKPHVIKLPIKVGMNSIEDGPMIY
AEHAKYKNHFDADYSAWDSTQNRQIMTESFAIMCRLTASPELASVVAKDLLAPSEMDV
GDYIIRVKEGLPSGFPCTSQVNSINHWLITLCAMSEVTGLSPDVIQSQSYFSFYGDDE
IVSTDIDFDPARLTQVLKEYGLRPTRPDKSEGPIILRRQVDGLVFLRRTISKDAAGFQ
GRLDRGSIERQLWWTRGPNHDDPSETLIPHPQRKVQLISLLGEASLHGEKFYRKISSK
VIQEIKTGGLEMYVPGWQAMFRWMRFHDLGLWTGDRNLLPEFVNDDGV"
mat_peptide <1..1156
/gene="ORF1"
/product="p48"
mat_peptide 1157..2245
/gene="ORF1"
/product="NTPase"
mat_peptide 2246..2848
/gene="ORF1"
/product="p22"
mat_peptide 2849..3256
/gene="ORF1"
/product="VPg"
mat_peptide 3257..3799
/gene="ORF1"
/product="Pro"
mat_peptide 3800..5323
/gene="ORF1"
/product="RdRp"
gene 5310..6944
/gene="ORF2"
CDS 5310..6944
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58849.1"
/translation="MMMASKDATPSADGATGAGQLVPEVNTADPIPIDPVAGSSTALA
TAGQVNLIDPWIINNFVQAPQGEFTISPNNTPGDVLFDLQLGPHLNPFLSHLSQMYNG
WVGNMRVRVVLAGNAFTAGKVIICCVPPGFQSRTLSIAQATLFPHVIADVRTLDPVEV
PLEDVRNVLYHNNDTQPTMRLLCMLYTPLRTGGASGGTDSFVVAGRVLTCPGPDFNFL
FLVPPTVEQKTRPFTVPNIPLKYLSNSRIPNPIEGMSLSPDQTQNVQFQNGRCTIDGQ
PLGTTPVSVSQLCKFRGRITSGQKVLNLTELDGSPFMAFAAPAPAGFPDLGSCDWHIE
MSKIPNSSTQSNPIVVNSVKPNSQQFVPHLSSITLDDNVSSGGDYIGTIQWTSPPSDS
GGANTNFWKIPDYGSSLAEASQLAPAVYPPGFNEVIVYFMASIPGPNQSGSPNLVPCL
LPQEYITHFISEQAPIQGEAALLHYVDPDTNRNLGEFKLYPGGYLTCVPNSSSTGPQQ
LPLDGVFVFASWVSRFYQLKPVGTAGPARGRLGVRR"
gene 6944..7570
/gene="ORF3"
CDS 6944..7570
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58850.1"
/translation="MAQAIIGAIAASAAGSALGAGIQAGAEAALQAQRYQQDLTLQQN
SFNHDKEMLGYQVEMSNKLLAKNLNTRYSLLQAGGLSSSDAARAVAGAPVTRLVDWGG
VRVAAPQSSATTLRSGNFMAVPLPAQPKQKPLASEGYSNPAYDPMQRTASWVQSQNSS
RTWSPYHRQALQTVWVTPPGSTSSSSVSTAPRGYFNTDRLPLFANLRR"
ORIGIN
1 tactgctgct agtgctgaaa acactagtga caatagtgaa tctataaaga accgtttctt
61 cacaagattg aagaatttag gttctaacaa taaacctata aaaattgaaa acacccatat
121 ggccctcaac ttgattagta gagggccatc tccagcccca caagaaaggc cccccaaaga
181 tcagagggac aaacccccaa ggaatgtgac tgaaactcaa caggcaatgg ggtgggttga
241 cccccccgtg gatcagaact taccaacctg ggaggaattg agtcaaacag aaaaacaaga
301 gatactcaag aacaattcaa actggttcga tgctggtgga ctggcaccag ctagtatccc
361 ttctggttat gtgaagaata cagagcagca accccctgac caccaggtta aatggagtgt
421 aaacaacggg gttgatctgg gggtggacag tctaactact gtgccaggtc caacatggaa
481 cctgtgcccc atgccaccaa ttgatcaacg aaacaatggc cctgcaaaag agccacttat
541 tggtgatatg atagaattct atgagggaca catttaccat tatgcaatat atattggcca
601 aggaaaaact gttggggtcc actcacctca agcggccttt tcaatagcca gaataaccat
661 acaccccatt gctgcttggt ggagggtttg ttatgtgcca acacctgatc agagattaaa
721 ttatgaccaa ctcaaagagc ttgagaatga gccatggcca tatgctgcag tcaccaataa
781 ttgctatgag ttttgctgca gaatcctcaa cctgcaggat acttggttgg agcgccgtct
841 agttacgtcc agtcgtttta accatccaac acaagactgg tctagggaca cgcctgactt
901 tcaacaagat agcaaactag aaatagtcag ggatgctgtg cttgctgcaa ttaatggctt
961 ggtatcaaaa ccctttaaag accttctaaa taaacttaag ccactcaacg tgcttaacct
1021 actctccaac tgcgattgga catttatggg agtagtggag acaataatat tacttatgga
1081 actatttggg atcttctgga acccccctga tgtgtccagc ttcatagcct cactactacc
1141 cgatatgcat ctgcaagggc cagaagatct ggctaaagat ttgataccac tggtgttggg
1201 gggtgtagga cttgcaattg gatttaccaa ggacaaggtt acaaaggtca tgaagagcgc
1261 tgttgaagga cttagggcag ccacacaatt gggccagtat ggcctagaga tatttgcagt
1321 cttaaagaaa tacttctttg gtggagacca aacagagaag actttaaagg acattgagac
1381 agccgtgatt gacatggagg tcatttcaac aactgctgtc actcaattag tcagggacaa
1441 gcaggctgcc cgaacctaca tgaacatctt ggatgctgaa gaagaaaagg caagaaagct
1501 ttcagtcagg catgcagacc cccatgtcgt gtccacgact aatgccctga tctcacgcat
1561 ttctttggct cgctctgcac ttgccaaggc acaagctgag atgaccaata gagttaaacc
1621 agtagtaata atgatgtgtg gccccccagg tataggcaag acaaaggcag ctgagtacct
1681 tgctaagaga ttggctaatg agatacggcc tggtggaaaa gtgggtctcg tgccaaggga
1741 agctgtggat cactgggatg gatatcatgg tgaagaggtt atgctgtggg atgattatgg
1801 catgtcaaaa atagccgatg actgtaataa gttgcaggcc atagccgaca cagctccact
1861 caccttgaat tgtgaccgga ttgagaagaa agggttacag ttcgtctctg atgccatagt
1921 gataacaaca aatgccccag gtccagcccc tgttgacttt gtcaatcttg gcccagtgtg
1981 ccgacgggta gacttcctgg tttattgcac cgcacctgac gttgaacaaa cacgtcgcac
2041 caaccctgga gacactggag cccttaagga ttgtttcaaa agtgacttct cccatctaaa
2101 aatggagttg gccccacagg gcggatttga taatcaaggg aacaccccat ttggcaaagg
2161 gactatgcgg cccaccacgt taaaccgtct tctcatacaa gctgtggcgc taaccatgga
2221 gcgtcaggat gaattccaga tgcaaggtcg agtgtatgat tttgacgctg acagggtatc
2281 cgctttcacc agtctagcga gagccaatgg tctgggcctc attagcatgg cctctctagg
2341 aaagaaattg aggggtgtgg actcagtcca tggcctcaag aatgcattat caggctacac
2401 cataacccct tgtagtataa aatggcaagc cagagtgtat gacattgaat cggatggcac
2461 taatgtacac ataaaggaaa acacctcagc ccagacacaa cgccagcagt caattgacac
2521 agcagctcta gcactcacta gactcaaggc agcacgggca gcagcgtatg cagcttgcat
2581 acaaagcgca ataacaacta tcttgcagat ggctgggtca gccatcgtta taaatcgtgc
2641 tgtcaaaagg atgtttggag cacacccaag caccatagcc ctcgaaggac caccaagaga
2701 acaccggtgt agagctcacc tggccaaagc tgcaggtggt ggaccaatag gtcatgatga
2761 tgtcattgat aagtatggtc tatgtgagac tgaagaagag ggcaccagtg aggagatgaa
2821 tgtggagctt cccaccgcca cttctgaggg taaaaataaa ggtaaaacca agaaaggaag
2881 aggcagaaga gccaactaca atgctttttc aaggcgaggt ctgagtgatg aagaatacga
2941 ggagtataag aagatcaggg aagaaaagaa tggtaactac agtattcagg aataccttga
3001 agacagacaa cgctatgaag aagaactcgc agaagtgcaa gctggtggtg atggaggcat
3061 tggtgagaca gaaatggaga tccgacacaa gatcttctat aaatccaaaa agggccgcca
3121 aaatgaacgc cgccagttag gattagtcac tggtagtgac attagaaaga gaaaaccaat
3181 tgattggacc ccccccaaga atgattgggc agatgataat agggaagtgg attacaatga
3241 aaaactcagt tttgaagccc caccaaccct ctggagccgg gttgtgagat ttggctctgg
3301 gtggggcttt tgggtgagcc cgactgtttt tatcaccacc acccacgtta taccatctgg
3361 agtgcgtgaa ttctttggag aacccatcga atccattgca atccaccgtg ctggtgaatt
3421 tacacaattc aggttttcac gcaaagtccg cccagatttg actggaatgg tgttggagga
3481 aggctgccct gaaggtgtcg tgtgttccat cctcattaaa cgcgactctg gtgagctact
3541 accccttgct gttcgaatgg gcgctatagc gtccatgaag atccaaggga ggttagtgca
3601 tggtcaatct gggatgctgc ttactggggc caacgccaag gggatggact taggtaccct
3661 accaggtgat tgtggtgccc cttatgtgta caagaggaac aacgactggg tggtttgtgg
3721 tgtacatgca gctgccacga aatcaggcaa cactgtggtg tgtgctgtcc aggctgggga
3781 gggtgaaacc accttagagg gaggtgataa aggccactat gctggtcatg agataatcaa
3841 gcacagtaag ggcccagctt tatcaaccaa gaccaagttt tggaggtcaa cccctgaacc
3901 actgccgcca ggtgtttatg aaccagcata ccttgggggc cgtgacccaa gggtaaaagg
3961 tggaccttcc ctacaacaag tcctgcgtga ccagctgaaa ccgttcgctg agccacgagg
4021 tcgaatgcca gaacctggtc tacttgaggc agccgtcgaa actgtcacat ccatgcttga
4081 acaaacaatg gacacaccaa ccccttggtc tttctctgat gcatgtcagt cactcgacaa
4141 aaccacaagt tcggggcacc cataccataa aaggaaaaat gatgattgga atggaacttc
4201 atttgttggg gagcttggag aacaggcggc acatgccaac aacatgtatg agttaggtaa
4261 gtccatgaaa ccactttaca ctgcagccct aaaagatgag ttagtcaagc ctgagaaagt
4321 ctatcaaaag atcaagaaaa ggctcctctg gggtgctgat ctctcaacag ttataagagc
4381 tgccagagcc tttggaccat tttgtgacgc cataaagcct catgtcatta aactccccat
4441 caaggttggt atgaactcca tagaagatgg cccaatgatt tatgcagaac atgcaaagta
4501 taagaatcat tttgatgcag attattcggc ctgggattct acacaaaata gacagatcat
4561 gactgagtcc tttgcaatca tgtgccgcct cacggcgtca cctgagttgg cctctgttgt
4621 agccaaagat ctacttgcac cctcagaaat ggatgttggt gactacatca tccgtgtgaa
4681 ggaaggcttg ccatcagggt tcccttgcac gtcacaggtg aatagtataa atcattggtt
4741 aatcacattg tgtgctatgt ctgaagtcac aggcttatca cccgatgtca tacaatccca
4801 gtcttacttt tctttctatg gtgatgatga aatagtctca acagatattg attttgaccc
4861 cgcccgcctc actcaagtac ttaaagaata tggattgaga cccacccgac cagacaagtc
4921 agaaggaccc atcatactta gaagacaggt ggatggtctt gttttcttaa ggaggacaat
4981 ctcaaaagat gctgcgggct tccaggggag gctggatagg ggctcaattg aaaggcagct
5041 ctggtggact cgaggcccta accatgatga ccccagtgag actctaatcc cacaccccca
5101 gaggaaagtt cagcttatat cccttcttgg cgaggcttcc ctccacggtg agaaatttta
5161 caggaaaatc tccagtaaag ttatacagga gataaagact ggtggtttgg aaatgtatgt
5221 gccaggctgg caggccatgt tccgctggat gcgcttccat gacctcggat tgtggacagg
5281 agatcgcaat ctcctgcccg aattcgtaaa tgatgatggc gtctaaggac gctacaccaa
5341 gcgcagatgg cgccactggc gccggccagc tggtaccgga ggttaataca gctgacccta
5401 tacccattga ccctgtggct ggctcctcta cagcacttgc cactgcaggc caagttaatt
5461 tgattgatcc ctggataatc aataattttg tgcaagcccc ccagggtgaa ttcacaatat
5521 ccccaaacaa tacccccggt gatgtgcttt ttgatttgca gttaggacct catttaaacc
5581 ctttcctctc ccatctctct cagatgtaca atggctgggt gggcaacatg cgagtgcgtg
5641 ttgtcttggc tggtaatgct ttcacggctg ggaaggttat aatttgttgt gtcccccctg
5701 gctttcaatc tcgtactctt tccatagctc aggctacttt attcccccac gttattgctg
5761 atgttaggac ccttgaccct gtagaagtgc ctcttgaaga tgttaggaac gtgttgtatc
5821 ataataatga cacccaaccc accatgcgcc tcctttgcat gctgtacacc cctctccgca
5881 ccgggggagc gtctggtggg actgattctt tcgtggtagc tgggcgtgta cttacttgcc
5941 caggccctga ctttaacttc ttattcttgg tccctcctac agtcgagcaa aagactcgcc
6001 ctttcactgt gcctaatatc cctttgaagt atctatctaa ctccagaatc ccaaacccca
6061 ttgaaggtat gtcattgtca cctgatcaga ctcaaaatgt ccaattccag aatggcaggt
6121 gcacaattga cggtcaaccc ctcgggacta cacctgtctc ggttagccag ttatgtaagt
6181 ttaggggtag gataacatct ggacagaagg tgctcaattt gacagagttg gatggttcac
6241 cttttatggc ctttgctgcc cctgctcctg cgggcttccc agatcttggg tcctgtgatt
6301 ggcatattga gatgagtaaa atcccaaatt ctagcaccca gagtaatcca atagtggtca
6361 attctgtcaa gcccaatagt caacagtttg tccctcattt gtcaagcatc acccttgatg
6421 acaatgtttc tagtgggggt gattatattg gtactataca atggacctct cctccttctg
6481 attctggcgg agccaataca aacttttgga aaatccctga ctatgggtct agcttggctg
6541 aagcttcaca gttggccccc gctgtctatc cacctggttt caatgaagtg attgtgtatt
6601 ttatggcatc tatacctggc cctaatcaat ctgggtcccc taatttggtg ccatgcctac
6661 tcccccagga atatataaca catttcatta gtgaacaggc ccccattcag ggtgaggctg
6721 ccttactcca ttatgtggac ccagacacca atcgtaattt gggtgagttt aaattgtatc
6781 ctggtggtta tttaacctgt gttcctaata gttctagtac tggacctcaa cagcttcctc
6841 ttgatggtgt ttttgtcttt gcttcttggg tctctagatt ttatcaatta aagcctgtgg
6901 gaacagccgg accggctaga ggtaggcttg gtgtccgtag ataatggccc aagccattat
6961 aggagccatt gccgcctctg cagccggcag cgccctgggt gctggcatcc aggccggtgc
7021 tgaagctgcg ttacaggcac agagatatca acaagatttg actttgcagc aaaattcttt
7081 taatcatgat aaagaaatgt taggttatca agtggaaatg tccaataagt tgttagctaa
7141 gaatcttaat acccgctatt ctcttctcca ggcgggtggc ctctcatcct ctgatgcggc
7201 tagggctgtg gccggggccc ctgtcaccag gctggtcgac tggggtggag tgcgtgttgc
7261 agcaccacaa tcgtctgcca ccacattgag atctggcaat ttcatggcag tgccgctccc
7321 agctcagcca aagcagaagc cccttgccag tgagggttat tccaaccccg cttatgaccc
7381 tatgcagcgt acagcttctt gggttcaatc tcaaaattcc agtcggactt ggtctcctta
7441 ccataggcag gcccttcaga ctgtgtgggt gaccccccct ggctctacct cttcttcttc
7501 tgtttctacc gcccctcggg ggtactttaa tacagatagg ttgcctctgt tcgcaaactt
7561 gaggcgttaa tgttgtaata agattagtga gcatcctatt caagtttggc tttgtataat
7621 ttggttatat ttggctttta attttgattt ggttgatgtt
//