Typing tool
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Typing tool
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Complete norovirus genomes
| MW305500 | GI.3 | |
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| GI.P3 |
ORF1: 1..5368
ORF2: 5352..6989
ORF3: 6989..7636
LOCUS MW305500 7706 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GI isolate Arg14665 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305500
VERSION MW305500.1
KEYWORDS .
SOURCE Norovirus GI
ORGANISM Norovirus GI
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7706)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7706)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7706
/organism="Norovirus GI"
/mol_type="genomic RNA"
/isolate="Arg14665"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122928"
/country="Argentina"
/collection_date="2016"
/note="genotype: GI.3[GI.P3]"
gene <1..5368
/gene="ORF1"
CDS <1..5368
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QPJ58836.1"
/translation="ADVSNNNANTNNDNIGSRLMARIRGRMGPQRGETTTKIIDANMA
LNLLRRSQTPSPSRQESPPKSQRDRPPRTASEVKKVLGWDVEPEHQESTAKAWCDLTQ
EEKEEIMRNNEKLFDAGGITPSTLPSTFERADPVDSPVEQQPVTWSASGGVDIGVNDL
TTVSGPFWNMCPLPPLDARNNGPAKEPIIGDMIEFYEGHIFHYAIYIGQGKTIGVHSP
QAAFSIPRITIHPLVAWWRVCYVPTNQQRLTYDQLKELENEPWPYASITNNCYEFCCR
VMALDDTWLERRLVSTGKFNHPTQDWSQDTPDFHQDSKLEVVRDAVLSAINGLVSQPF
KNILSKIKPLNVLNLLSNCDWTFMGVVELIVLLAELFDVFWTPPDISSFIASLLPEFH
LQGPEDLARDLVPLILGGIGLAIGFTRDKVTKVMKSAVDGLRSATQLGQYGLEIFSII
KKYFFGGDQTEKTLRGIEDAVIDMEVLSSTNVTQLVKDKKLARTYMNVLDNEEEKARK
LSVRSADPHIVTSVNNLISRISMARSALAKAQAEMTSRPRPVVIMMCGPPGIGKTKAA
EHLAGRLANEIRPGGKVGLVPRESIDHWDGYHGEDVLLWDDYGMSKITEDCNKLQAIA
DTAPLSLNCDRIENKGMQFSSDAIIITTNAPGPAPVDFVNLGPVCRRVDFLVYCSAPE
IEQMRRTHPGDANAIKDLYKRDYSHLKMELAPQGGFDSQGNTPFGKGIMKPTTLNRLL
IQATALAMERQDEFQLQGAVYNFDEDRVSAFTSLARANGLGLLSMATLGKRLRSVKSM
EGLRNALVGYKIGECDIIWNTRVYSIKSDGSTVTIKEKQTPTSPQYQAISTATLALSR
LRAARALAYASCLQSAVLSILQVAGSALVVSRAVKRMFGTRTEQPMLEGKHKEHNCRV
HRAEAAGHGPIGHDGVIERYGLCESEQEEEGEQTVELPTANKEGKNKGKTKKGRGRKS
NFNAFSRRGLSDEEYEEYKKIREEKSGNYSIQEYLEDRQRYEEELAEVQAGGDGGIGE
TEAEIRHRVFYKSKSGMRKQRQEERRQLGLVSGSEIRKRKPIDWTPPKNDWSEDTRTV
NYDEHISFEAPPSIWSRVVKFGSGWGFWVSSTVFITTTHVIPPGAKEVFGEDLSNVAI
HRVGEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCTIMIKRDSGELLPLAVRMGAVASM
KIQGKLMHGQSGMLLTGANAKGMDLGTIPGDCGAPYVHKRGNDWVVCGVHAAATKSGN
TVVCAIQGGDGEATLEGGGQNKGHYAGHPILRYGNGPSLSTKTKFWKSTPQPLPPGTY
EPAYLGGRDPRVEGGPSLQQVLRDQLKPFAEPRGRLPEAGLLEAAVETVTNAIEQVMD
TPVAWSYSDACMSLDKTTSSGHPHHKKKNDDWNGNSFVRELGDQAAHANSMYELGKSM
KPVYTAALKDELVKPDKVYTKIKKRLLWGADLGTVIRAARAFGPFCEAIKPHVIKLPI
KVGMNAIEDGPLIYAEHSKYKFHYDADYTAWDSTQNREIMMESFNIMCKLTANPSLAA
VVAQDLLSPSEMDVGDYVISVKDGLPSGFPCTSQVNSINHWILTLCALSEVTGLSPDV
IQSQSYFSFYGDDEIVSTDIEFDPIRLTQILKEYGLKPTRPDKTDGPIIIRQQVDGLV
FLRRTISKDAIGYQGRLDRNSIERQLWWTRGPNHEDPFETLVPHTQRKVQLISLLGEA
ALHGEKFYRKIAGRVIQEVKEGGLEIYIPGWQAMFRWMRFHDLSLWTGDRDLLPDYVN
DDGV"
mat_peptide <1..1183
/gene="ORF1"
/product="p48"
mat_peptide 1184..2272
/gene="ORF1"
/product="NTPase"
mat_peptide 2273..2872
/gene="ORF1"
/product="p22"
mat_peptide 2873..3292
/gene="ORF1"
/product="VPg"
mat_peptide 3293..3835
/gene="ORF1"
/product="Pro"
mat_peptide 3836..5365
/gene="ORF1"
/product="RdRp"
gene 5352..6989
/gene="ORF2"
CDS 5352..6989
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58837.1"
/translation="MMMASKDAPTNMDGTSGAGQLVPEANTAEPISMEPVAGAATAAA
TAGQVNMIDPWIMNNYVQAPQGEFTISPNNTPGDILFDLQLGPHLNPFLSHLAQMYNG
WVGNMKVKVLLAGNAFTAGKIIISCIPPGFAAQNISIAQATMFPHVIADVRVLEPIEV
PLEDVRNVLFHNNDNTPTMRLVCMLYTPLRASGSSSGTDPFVIAGRVLTCPSPDFSFL
FLVPPNVEQKTKPFSVPNLPLNTLSNSRVPSLIKSMMVSRDHGQMVQFQNGRVTLDGQ
LQGTTPTSASQLCKIRGSVFHANGGNGYNLTELDGSPYHAFESPAPIGFPDLGECDWH
MEASPTTQFNIGDVIKQINVKQESAFAPHLGTVQVDGLSDVSVNTNMIAKLGWVSPVS
DRHKRDVDPWVIPRYGSTLTEAAQLAPPIYPPGFGEAIVFFMSDFPIAHGTNGLSVPC
TIPQEFVTHFVNEQAPTRGEAALLHYLDPDTNRNLGEFKLYPDGFMTCVPNSSGTGPQ
TLPINGVFVFVSWVSRFYQLKPVGTAGPARRLGIRRS"
gene 6989..7636
/gene="ORF3"
CDS 6989..7636
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58838.1"
/translation="MAQAILGAIAATAAGSAVGAGIQAGTEAALQHQRFQQDLTLQKN
SFIHDKEMMGLQVEASTALLQNSLGTRYNMLTKAGMTSADAARMVVGAPATRVVDWNG
TRIAAPMSTATTLRSGGFMTVPTVYRGSKNKQSIGGGFSNVNYDPSVSSSRTSQWVSS
QNSMRSTLEPFHPGALRTTWVTPPGSTSTSTISTVSTVPKFFNTERLPLFANRGK"
ORIGIN
1 tgctgatgtc agcaataaca atgctaacac caacaatgat aacattggat cccgcctcat
61 ggcgaggatc cgtgggcgca tgggcccaca acgtggtgaa acaaccacaa aaataataga
121 cgccaatatg gcgcttaatc tgctacgccg gtcacaaaca ccttccccat cccggcaaga
181 gagccctcct aagagccaga gagaccgccc ccctcggact gcttctgagg tgaagaaagt
241 gttggggtgg gatgttgaac cagaacacca ggaaagcacg gccaaggcat ggtgcgacct
301 cacgcaagaa gagaaggagg agataatgcg caataatgaa aagctcttcg atgctggggg
361 aatcactcca tcaactttgc ctagcacgtt tgaaagggcc gacccagttg atagccccgt
421 tgaacagcaa cctgtgacat ggtctgccag tggtggggtc gatattggtg tcaatgattt
481 gaccaccgtc agtggcccat tttggaatat gtgccccctt ccgccactgg atgctcggaa
541 taatggcccc gctaaggagc ccatcatagg agatatgata gagttctacg agggtcacat
601 attccattat gccatctaca ttggacaagg taagaccatt ggggtccact caccgcaagc
661 agctttctcc ataccaagga taaccatcca tcctctggta gcttggtggc gcgtgtgcta
721 cgttccaact aaccagcagc gcctcactta tgatcagctc aaagagttgg agaatgagcc
781 atggccctac gcttccatta caaacaattg ctatgagttt tgctgcagag tgatggcact
841 tgacgacaca tggcttgaaa ggaggttagt cagcactgga aaattcaatc accccacaca
901 agattggtca caggacaccc cggattttca ccaggactcg aaacttgagg tggtaagaga
961 tgccgtgcta tcagctatta atggccttgt gtcacagccc tttaaaaaca ttttgtcaaa
1021 gatcaaacca ttaaacgtcc tcaatctctt gtcaaattgt gactggacct tcatgggggt
1081 tgtggaactg attgtgctcc tagcggagtt gtttgatgtg ttctggaccc caccagacat
1141 ctcaagtttc attgcctcac tactacctga atttcacctg cagggcccag aagacctagc
1201 tagggacttg gtccctctca tcctaggtgg cataggcctg gctattggct ttacaagaga
1261 caaagtgacg aaagtgatga agagtgccgt cgatgggttg agatcagcga cacagctcgg
1321 gcagtacgga ctggaaatat tctcaatcat caagaaatat ttctttggtg gggatcaaac
1381 ggaaaagacc ctgcggggta ttgaggatgc agtgatagac atggaggtgt tgtctagcac
1441 caatgtgaca caattggtta aagataagaa attggccaga acctacatga atgtgctaga
1501 caatgaagag gaaaaagcaa ggaaactctc agtccgtagt gctgatccgc acatagtgac
1561 ctcagtcaac aatctgatat cacgaatatc tatggcaaga tcagccttgg ccaaagccca
1621 ggctgagatg acatctcgcc cacgccctgt ggttataatg atgtgtggcc cccccggcat
1681 cggaaaaacc aaggccgccg aacacctggc tggccgattg gcaaacgaga ttagaccagg
1741 aggtaaggtt ggacttgtgc cccgggaatc catagatcac tgggacggat accatggcga
1801 ggacgtccta ctatgggatg actatggcat gtcaaagata acagaggact gtaataagct
1861 acaagccata gctgacactg cacccctatc acttaattgt gacaggatag agaacaaagg
1921 catgcaattc tcctcagatg caataatcat aaccaccaat gcccctggcc cggccccggt
1981 ggactttgtc aacctaggcc ctgtgtgcag gcgagtggac tttttagttt actgttctgc
2041 ccctgaaatt gagcaaatga ggaggaccca ccctggtgat gccaatgcca tcaaagacct
2101 atacaaaagg gactactcac acttaaaaat ggaattggcc ccacaaggtg gttttgatag
2161 tcagggtaac acaccatttg ggaagggcat catgaaaccc acaaccctca ataggctact
2221 cattcaggca acagcattag ctatggagcg gcaagacgag ttccagctcc aaggggctgt
2281 ctacaacttt gatgaagaca gggtgtccgc cttcacaagc ctggcccgag ctaacggctt
2341 ggggctttta agcatggcaa cattgggtaa aaggctcaga agtgtcaagt ctatggaggg
2401 cctgcgtaac gcattagtgg gctacaaaat aggagagtgt gatataatct ggaacactag
2461 agtgtattca attaaaagtg atggtagtac tgtcacaatc aaggaaaaac aaaccccaac
2521 ttcaccccaa taccaagcca ttagcacagc cactcttgca ctctctaggt tgcgggccgc
2581 tagggctctc gcgtacgcct cctgcctgca gagtgcagtg ctgtcaatac ttcaagtagc
2641 tggctctgcc ctggtggtga gcagggccgt taagcgcatg tttggcacgc gcactgaaca
2701 acctatgttg gaaggcaagc acaaagaaca caactgtaga gtgcaccgcg cagaggcagc
2761 tggccatggt cctattgggc atgatggagt catcgaacgc tatggcctct gtgagagtga
2821 gcaagaagaa gaaggcgagc aaacagttga gctacccact gccaataaag aaggcaaaaa
2881 caagggcaag accaaaaagg gccgtggacg aaaatccaat tttaatgctt tctcaagacg
2941 aggcctcagt gatgaagagt atgaagaata caagaagatc agagaagaaa agagtggtaa
3001 ttacagcatc caggagtacc tcgaggaccg ccaacgatat gaggaagagc ttgctgaagt
3061 gcaggctggt ggggatggtg gaattggtga gactgaagca gagattcgcc atcgggtttt
3121 ctataaatca aaatccggca tgagaaagca acgccaagaa gaacggcgtc agttgggtct
3181 cgttagcggc tctgagatcc gcaaacgcaa gcccatagac tggacccccc ctaagaatga
3241 ttggtcagaa gacaccagga ctgtcaacta tgatgaacac attagctttg aagcccctcc
3301 ctcaatttgg agtagggtgg tgaagtttgg cagtggttgg ggtttttggg tgagctcaac
3361 agtgttcata accacgaccc atgtcatacc acctggggcc aaagaagtct ttggtgaaga
3421 cctcagtaac gtggccatcc atagagttgg tgagttcacc cagttccgtt tctccaaaaa
3481 gatgagacct gacctcaccg gcatggtttt agaagaaggt tgcccagagg gaacagtgtg
3541 caccataatg atcaagagag attctggtga gttgttgccg ctcgccgttc ggatgggggc
3601 agtggcatca atgaagatcc aaggcaaact tatgcacggg caatcaggaa tgttactcac
3661 cggtgctaat gccaaaggta tggaccttgg gactataccc ggtgattgtg gggcacccta
3721 tgtccacaag aggggaaatg actgggtggt ctgtggagta catgcagccg ccacaaaatc
3781 aggcaacact gtagtgtgcg ccatacaagg tggcgatggt gaagccactc tggaaggcgg
3841 cggtcaaaac aagggccact atgcagggca tccgatacta aggtatggga atggcccttc
3901 attatcaacc aaaacaaaat tttggaaatc aaccccccag cctttgcctc ctggtacata
3961 tgagccagct taccttggag gcagagaccc cagagttgag gggggcccat ctttacagca
4021 ggtgttaagg gaccagttaa aaccatttgc cgagccccgt ggcagattac ccgaagcggg
4081 cttgttggaa gctgcagttg aaacggtcac caatgctatt gaacaggtca tggacacacc
4141 ggtggcatgg agctatagtg atgcttgtat gtcactagat aagacaacca gttccggcca
4201 cccccatcac aagaagaaaa atgatgattg gaatgggaat tcatttgtga gagaattggg
4261 tgaccaggcg gcacacgcta acagcatgta tgagcttggt aagtccatga aacctgtgta
4321 tacagcagcc ctaaaggatg agctagtcaa accagataag gtgtacacaa aaatcaaaaa
4381 gagactgctt tggggcgcgg acctcggtac cgtcattcgc gctgccagag catttggacc
4441 attttgtgag gccataaaac cccatgtaat taagttgcct atcaaggtgg gtatgaatgc
4501 catagaggat ggccccttga tttatgctga gcactccaaa tataaatttc attatgatgc
4561 tgactataca gcttgggact caacacaaaa cagggaaatc atgatggaat ctttcaacat
4621 tatgtgcaag cttacagcca atccctcctt ggccgcagtg gtggcacagg atctactctc
4681 cccatctgaa atggatgttg gtgactatgt gatcagtgtc aaagatggtt taccatctgg
4741 ctttccatgc acttcacagg tgaacagtat caaccactgg atactaaccc tgtgtgcact
4801 gtcagaagtc actggcttgt ccccagatgt gatacagtca caatcctact tctcatttta
4861 tggtgatgat gaaatagtct caacagatat agaatttgac ccaattagat tgacacaaat
4921 actgaaggaa tatggtttga agcctacaag acctgacaaa actgatggcc caatcattat
4981 tagacagcag gttgacggcc tggtcttcct ccggcgcacc atttctaagg atgccattgg
5041 ataccaggga cgactcgacc gtaattctat tgaaaggcag ctttggtgga ctcgtggacc
5101 aaaccatgag gacccatttg agacactggt cccacataca cagagaaagg tccaactaat
5161 atccttgcta ggtgaagcag cactccacgg tgaaaagttc tacaggaaga tagctggtag
5221 ggtcattcaa gaggtcaaag agggagggct tgaaatctac attcctggtt ggcaggccat
5281 gttccgctgg atgcgattcc atgatctaag tttatggaca ggagaccgcg atctcctgcc
5341 cgattatgta aatgatgatg gcgtctaagg acgccccaac aaacatggat ggcaccagtg
5401 gtgccggcca gctggtacca gaggcaaaca cagctgagcc tatatcaatg gagcccgtgg
5461 ctggggcagc aacagctgcc gcaactgctg gccaagttaa tatgattgac ccctggataa
5521 tgaacaatta tgtacaggcc ccccaaggtg aatttaccat atcgcctaat aacacaccag
5581 gtgatatttt gtttgattta caattaggcc cccaccttaa ccctttctta tctcatttgg
5641 cccaaatgta taatggttgg gttggcaata tgaaagtgaa ggttctattg gctggtaatg
5701 ctttcacggc tggtaaaata attattagtt gcataccccc tggctttgcc gcacaaaata
5761 tttctattgc ccaggccacc atgttccccc atgtcatagc tgatgttagg gttttggaac
5821 ccattgaggt gccattggaa gatgtgagga atgtgctctt ccacaacaat gacaacacgc
5881 caactatgcg gttggtgtgc atgctataca cccccttgcg ggccagtggt agctcgtctg
5941 gaacagaccc ctttgtgatt gctgggcgtg ttttgacatg cccaagtcct gattttagct
6001 ttttgttttt ggtccccccc aatgtagagc aaaagactaa acctttcagt gtcccaaacc
6061 ttccattgaa taccctttca aattcgagag ttccttctct aatcaaatca atgatggtgt
6121 ccagggacca tgggcagatg gtccagtttc aaaatggtag ggtcacccta gatgggcagc
6181 tgcaaggcac cacacccaca tcagctagtc agctgtgcaa aatcaggggc agtgtctttc
6241 atgccaatgg tgggaatggg tacaacttga cagaactgga tgggagccca taccacgcat
6301 ttgagagccc cgcaccaata gggtttccag atctaggtga atgtgattgg cacatggagg
6361 cttctcctac cacccagttt aatattggag atgttataaa acaaattaat gttaaacaag
6421 agtcagcatt tgccccccac cttggcaccg tacaggtaga cggcctgagt gatgtgagtg
6481 tcaacaccaa catgatagct aaattgggat gggtgtctcc cgtcagtgat agacacaaaa
6541 gggatgtcga cccgtgggtc ataccacgct atggttcaac tctgactgag gccgcccagt
6601 tagccccccc aatatatccc ccaggctttg gtgaggccat tgtgtttttc atgtcagatt
6661 ttcccattgc ccatggcacc aatggcttga gtgtgccttg cactataccc caagaatttg
6721 tcacccattt tgtcaatgaa caggccccca ctagagggga agcagctttg ctacactatc
6781 tggaccctga tactaataga aatcttggtg agtttaaatt atatcctgat ggcttcatga
6841 catgtgtgcc taactccagt ggcactggtc cacaaactct cccaatcaat ggtgtctttg
6901 tctttgtgtc ctgggtttct agattttacc aattaaagcc tgtgggaaca gccggcccgg
6961 ctcgtaggct tgggattagg agatcataat ggctcaagcc atacttggag ccatagcagc
7021 aacagcagcc ggtagtgctg ttggtgctgg tatacaagct ggaaccgaag ctgccctaca
7081 gcatcaaaga tttcagcaag atttgacctt acaaaagaat tccttcattc atgataaaga
7141 gatgatgggc ttacaggtag aggcttcaac tgcgctcctc caaaacagct tgggtacgag
7201 gtacaatatg ttgaccaaag cagggatgac atccgcagac gcggcacgta tggtagtggg
7261 ggcacctgcg actcgtgtcg ttgactggaa cgggactagg atcgccgcac ccatgtcaac
7321 tgcgacgaca cttaggtctg gtggtttcat gaccgtacca actgtttata ggggtagtaa
7381 aaataaacaa tcaattggtg gtggtttttc taatgtaaat tatgatccct cagtctcctc
7441 ttcccgcact tctcaatggg tctcttctca aaattcaatg cgttccactc tggaaccatt
7501 tcatccaggt gctctgagaa ctacatgggt caccccacct gggtcaactt ctacttctac
7561 aatttctaca gtttctactg tgccaaaatt ctttaataca gaaaggttac ccttattcgc
7621 aaacaggggt aagtgatttt gtaatatgaa ttagtgggca tcatattcaa tttggaatca
7681 attagatatt tagattggca gatgat
//