Typing tool
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Typing tool
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Complete norovirus genomes
| MW305499 | GI.4 | |
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| GI.P4 |
ORF1: 1..5326
ORF2: 5310..6944
ORF3: 6944..7570
LOCUS MW305499 7660 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GI isolate Arg13668 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305499
VERSION MW305499.1
KEYWORDS .
SOURCE Norovirus GI
ORGANISM Norovirus GI
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7660)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7660)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7660
/organism="Norovirus GI"
/mol_type="genomic RNA"
/isolate="Arg13668"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122928"
/geo_loc_name="Argentina"
/collection_date="2015"
/note="genotype: GI.4[GI.P4]"
gene <1..5326
/gene="ORF1"
CDS <1..5326
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QPJ58833.1"
/translation="TAASAENTSDNSDSIKNRFFTRLKNLGSNNKPIKIENTHMALNL
ISRGPSPIPQDKPPKDQRDKPPRNVAETQQAMGWIDPPMDQNLPTWEELSQTEKQEIL
KNNSNWFDAGGLAPASIPTGYVKNTDQQPPDHQVKWSASDGVDLGVGNLTTVPGPAWN
LCPMPPIDQRNNGPAKEPLIGDMIEFYEGHIYHYAIYIGQGKTVGVHSPQAAFSIARI
TIHPIAAWWRVCYVPTPDQRLNYDQLKELENEPWPYAAVTNNCYEFCCRILNLQDSWL
ERRLVTSGRFNHPAQDWSRDTPDFQQDSKLEIVRDAVLAAINGLVSKPFKDLLNKLKP
LNVLNLLSNCDWTFMGVVETIILLMELFGVFWNPPDVSSFIASLLPDMHLQGPEDLAK
DLIPLVLGGVGLAIGFTKDKVTKVMKSAVEGLRAATQLGQYGLEIFAVLKKYFFGGDQ
TEKTLKDIETAVIDMEVISTTAVTQLVRDKQAARTYMNILDAEEEKARKLSVRHADPH
VVSTTNALISRISLARSALAKAQAEMTNRVKPVVIMMCGPPGIGKTKAAEYLAKRLAN
EIRPGGKVGLVPREAVDHWDGYHGEEVMLWDDYGMSKIADDCNKLQAIADTAPLTLNC
DRIEKKGLQFVSDAIVITTNAPGPAPVDFVNLGPVCRRVDFLVYCTAPDVEQTRRTNP
GDTGALKDCFKSDFSHLKMELAPQGGFDNQGNTPFGKGTMRPTTLNRLLIQAVALTME
RQDEFQMQGQVYDFDADRISAFTSLARANGLGLISMASLGKKLRGVDSVHGLKNALSG
YTITPCSIKWQARVYDIESDGTNVRIKENTSAQTQRQQSIDTAALALTRLKAARAAAY
AACIQSAITTVLQMAGSAIVINRAVKRMFGAHSSTIALEGPPREHRCRAHLAKAAGGG
PIGHDDVIDKYGLCETEEEGTSEEINVELPTATSEGKNKGKTKKGRGRRANYNAFSRR
GLSDEEYEEYKKIREEKNGNYSIQEYLEDRQRYEEELAEVQAGGDGGIGETEMEIRHK
IFYKSKKGRQNERRQLGLVTGSDIRKRKPIDWTPPKNDWADDNREVDYNEKLSFEAPP
TLWSRVVRFGSGWGFWVSPTVFITTTHVIPSGAREFFGEPIESIAIHRAGEFTQFRFS
HKVRPDLTGMVLEEGCPEGVVCSILIKRDSGELLPLAVRMGAIASMKIQGRLVHGQSG
MLLTGANAKGMDLGTLPGDCGAPYVYKRNNDWVVCGVHAAATKSGNTVVCAVQAGEGE
TTLEGGDKGHYAGHEIIKHSKGPALSTKTKFWRSTPEPLPPGVYEPAYLGGRDPRVKG
GPSLQQVLRDQLKPFAEPRGRMPEPGLLEAAVETVTSMLEQTMDTPTPWSFSDACQSL
DKTTSSGHPYHKRKNDDWNGTSFVGELGEQAAHANNMYELGKSMKPLYTAALKDELVK
PEKVYQKIKKRLLWGADLSTVIRAARAFGPFCDAIKPHVIKLPIKVGMNSIEDGPMIY
AEHAKYKNHFDADYSAWDSTQNRQIMTESFAIMCRLTASPELASVVAKDLLAPSEMDV
GDYIIRVKEGLPSGFPCTSQVNSINHWLITLCAMSEVTGLSPDVIQSQSYFSFYGDDE
IVSTDIDFDPARLTQVLKEYGLRPTRPDKSEGPIILRRQVDGLVFLRRTISKDAAGFQ
GRLDRGSIERQLWWTRGPNHDDPSETLIPHPQRKVQLISLLGEASLHGEKFYRKISSK
VIQEIRTGGLEMYVPGWQAMFRWMRFHDLGLWTGDRNLLPEFVNDDGV"
mat_peptide <1..1156
/gene="ORF1"
/product="p48"
mat_peptide 1157..2245
/gene="ORF1"
/product="NTPase"
mat_peptide 2246..2848
/gene="ORF1"
/product="p22"
mat_peptide 2849..3256
/gene="ORF1"
/product="VPg"
mat_peptide 3257..3799
/gene="ORF1"
/product="Pro"
mat_peptide 3800..5323
/gene="ORF1"
/product="RdRp"
gene 5310..6944
/gene="ORF2"
CDS 5310..6944
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58834.1"
/translation="MMMASKDATPSADGATGAGQLVPEVNTADPIPIDPVAGSSTALA
TAGQVNLIDPWIINNFVQAPQGEFTISPNNTPGDVLFDLQLGPHLNPFLSHLSQMYNG
WVGNMRVRVVLAGNAFTAGKVIICCVPPGFQSRTLSIAQATLFPHVIADVRTLDPVEV
PLEDVRNVLYHNNDTQPTMRLLCMLYTPLRTGGASGGTDSFVVAGRVLTCPGPDFNFL
FLVPPTVEQKTRPFTVPNIPLKYLSNSRIPNPIEGMSLSPDQTQNVQFQNGRCTIDGQ
PLGTTPVSVSQLCKFRGRITSGQRVLNLTELDGSPFMAFAAPAPAGFPDLGSCDWHIE
MSKIPNSSTQNNPIVVNSVKPNSQQFVPHLSSITLDDNVSSGGDYIGTIQWTSPPSDS
GGANTNFWKIPDYGSSLAEASQLAPAVYPPGFNEVIVYFMASIPGPNQSGSPNLVPCL
LPQEYITHFISEQAPIQGEAALLHYVDPDTNRNLGEFKLYPGGYLTCVPNSSSTGPQQ
LPLDGVFVFASWVSRFYQLKPVGTAGPARGRLGVRR"
gene 6944..7570
/gene="ORF3"
CDS 6944..7570
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58835.1"
/translation="MAQAIIGAIAASAAGSALGAGIQAGAEAALQAQRYQQDLTLQQN
SFNHDKEMLGYQVEMSNKLLAKNLNTRYSLLQAGGLSPSDAARAVAGAPVTRLVDWGG
VRVAAPQSSATTLRSGNFMAVPLPAQPKQKPLASEGYSNPAYDPMQRTASWVQSQNSS
RNWSPYHRQALQTVWVTPPGSTSSSSVSTAPRGYFNTDRLPLFANLRR"
ORIGIN
1 tactgctgct agtgctgaaa acactagtga caatagtgat tctataaaga accgtttctt
61 cacaaggttg aagaatttag gttctaacaa taagcctata aaaattgaga acacccatat
121 ggcccttaac ttaattagta ggggcccatc cccaattcca caagataagc cccctaaaga
181 ccagagggat aaacccccaa ggaatgtggc tgagacccag caggcaatgg gatggattga
241 cccccccatg gaccagaatc taccaacctg ggaggagttg agccaaacgg aaaaacaaga
301 gatactcaaa aataattcaa actggtttga tgctggtggt ttggcaccag ctagcatccc
361 tactggttat gtaaagaata cagaccaaca accccctgac caccaagtca agtggagtgc
421 cagtgatggg gttgatctcg gggtaggcaa tctaacaact gtgccaggtc cagcatggaa
481 tctgtgcccc atgccaccaa ttgaccaacg caacaatggt ccagcaaagg aaccacttat
541 tggtgacatg atagaattct atgagggaca catttaccat tatgcaatat acattggcca
601 aggaaaaact gttggggttc actcacctca agcggccttt tcaatagcca ggataactat
661 acaccccatc gccgcttggt ggagggtttg ttatgtgcca acacccgatc agaggttaaa
721 ttatgaccaa ctcaaggaac ttgagaatga gccatggcca tatgctgcag ttactaataa
781 ttgctatgag ttctgctgca ggattctcaa tcttcaggac tcttggttgg aacgtcgttt
841 ggttacatct ggccgtttca accacccagc acaagactgg tctagggaca cgcctgactt
901 ccagcaagat agcaagttag aaatagtcag ggatgccgtg cttgctgcta tcaatggctt
961 ggtatcaaaa cctttcaaag acctcctaaa caaacttaag ccactcaacg tgctcaacct
1021 actctctaac tgtgattgga catttatggg ggtggttgag acgataatac tacttatgga
1081 actgtttggg gtcttctgga atccccctga tgtgtccagc ttcatagcct cattattgcc
1141 tgatatgcac ttgcaaggac cagaagatct ggctaaagac ttgataccgt tggtattggg
1201 gggtgtgggg cttgcaattg ggttcaccaa ggacaaagtc acaaaggtca tgaagagtgc
1261 tgttgaaggg ctcagggcag ccacacaatt gggtcagtat ggcctagaga tatttgcagt
1321 cttaaagaaa tatttctttg gtggagacca aacagagaag accttaaaag atattgagac
1381 agccgtaatt gacatggagg tcatctcaac aactgctgtt actcaactag tcagggacaa
1441 acaggctgcc cggacctaca tgaacatctt agatgctgaa gaagagaagg caagaaagct
1501 ttcagttaga catgcagacc cccatgttgt gtccacgacc aatgccctga tctcacgtat
1561 ttcattggct cgctccgcac ttgctaaggc acaagctgag atgaccaata gagttaaacc
1621 agtagtgata atgatgtgtg gtcccccagg tataggcaag acaaaggcag ccgaatacct
1681 tgctaagaga ctggccaatg agatacggcc tggaggaaaa gtgggcctcg tgccaaggga
1741 ggctgtggat cactgggatg ggtatcatgg tgaagaggtt atgctatggg atgactatgg
1801 tatgtctaag atagctgatg actgtaataa attacaggct atagccgaca cagctccact
1861 cactttgaat tgtgaccgga ttgaaaagaa agggttgcaa tttgtctctg atgccatagt
1921 gataacaaca aatgccccag gaccagcccc agttgacttt gtcaatcttg gcccagtgtg
1981 tcgccgggta gatttcctgg tttattgcac tgcacctgac gttgaacaaa cacgtcgcac
2041 taaccctgga gacaccgggg cccttaagga ttgctttaaa agtgacttct ctcatctaaa
2101 aatggagttg gctccacagg gcgggttcga caatcaaggg aacactccat ttggcaaagg
2161 gaccatgcgg cctaccacat taaaccgcct ccttatacag gccgtggcac taaccatgga
2221 gcgtcaggat gagttccaga tgcaaggtca agtgtacgat tttgatgctg acaggatctc
2281 tgccttcacc agtttagcaa gagccaatgg tttgggtctc attagcatgg cctctctagg
2341 aaagaaatta aggggtgtgg attcggttca tggcctcaag aatgcactat caggctatac
2401 cataaccccc tgtagcataa agtggcaagc tagagtgtat gacattgaat cagatggtac
2461 caatgtgcgc ataaaggaaa acacctcagc ccagacacaa cgccagcaat caattgacac
2521 agcagcctta gcacttacca ggcttaaagc agcacgggca gcagcatatg cagcttgcat
2581 acaaagcgca ataacaactg tcctgcagat ggctgggtca gccatcgtta taaatcgtgc
2641 tgttaaaagg atgttcggtg cacactcgag cactatagcc cttgagggac ccccaagaga
2701 acatcggtgc agggctcact tagccaaggc tgcaggtggt gggccaatag gccatgatga
2761 tgtcattgat aagtatggcc tatgtgagac tgaagaagag ggtaccagtg aggagataaa
2821 tgtggagtta cccaccgcca cttccgaagg caaaaacaaa ggaaagacca agaaaggaag
2881 gggcaggaga gccaactaca atgctttttc acggcgtggc ctgagtgatg aggagtatga
2941 ggagtataag aagattaggg aagaaaagaa tggcaactac agcattcaag agtaccttga
3001 agacaggcaa cgctatgaag aagagcttgc agaagtgcaa gctggtggtg atggaggcat
3061 tggtgagaca gaaatggaga tccgacataa aatcttttac aagtccaaaa agggccgcca
3121 gaatgaacgc cgccaattag ggttagtcac tggtagtgat atcagaaaga gaaaaccaat
3181 tgattggacc ccccccaaaa acgattgggc agatgataat agggaagtgg attacaatga
3241 aaaactcagt tttgaagccc caccaaccct ctggagccgg gttgtaagat ttggctccgg
3301 gtggggcttt tgggtgagcc cgactgtttt tatcaccacc actcatgtca taccatctgg
3361 ggcgcgtgag ttctttgggg aacccatcga gtccattgca atccatcgtg ctggtgaatt
3421 cacacaattc agattttcac acaaggtccg cccggatctg actggaatgg tgctggagga
3481 aggctgtcct gagggtgtcg tgtgttctat tctcattaaa cgtgactctg gtgagctgct
3541 accccttgct gtccgaatgg gtgctatagc gtccatgaag attcagggaa ggctagtgca
3601 tggtcagtct gggatgctgc ttactggagc taacgctaag gggatggatt taggcaccct
3661 accaggtgat tgtggtgccc cttatgtgta caaaaggaat aatgactggg tggtttgtgg
3721 tgtacatgca gccgctacaa agtcaggtaa cactgtggtg tgtgctgtcc aggctggaga
3781 gggtgaaacc accctagagg gtggtgacaa aggccactat gcaggccatg aaataattaa
3841 gcatagtaag ggaccagctt tgtctactaa gaccaagttt tggaggtcaa cccctgaacc
3901 attgccgcca ggtgtttatg aaccagcata ccttgggggt cgtgatccaa gggtaaaagg
3961 tgggccctct ctgcagcaag tcttgcgtga tcagttgaaa ccatttgctg agccgcgagg
4021 tcgaatgcca gagcctggtc tacttgaggc agctgttgaa actgtcacgt ccatgcttga
4081 acaaacaatg gatacaccaa ccccctggtc tttttctgat gcatgtcaat cacttgacaa
4141 aaccacaagt tcgggacacc catatcataa aaggaaaaat gatgattgga atggaacttc
4201 atttgttgga gagcttggag aacaggcagc acatgccaac aacatgtatg aattaggtaa
4261 atctatgaaa ccactataca ctgcagccct aaaggacgag ttagttaagc ccgagaaagt
4321 ttatcaaaag atcaagaaga ggcttctctg gggtgctgat ctctcaacag ttataagagc
4381 tgccagggcc tttgggccat tttgtgatgc cataaagcct catgtcatta aactccccat
4441 caaagtaggt atgaactcca tagaggatgg cccaatgatt tatgcagagc atgcaaaata
4501 taagaaccat tttgatgcag attattcggc ctgggattcc acgcagaata gacagattat
4561 gactgaatcc tttgcaatca tgtgccgcct cacggcatca ccggaattgg cttctgttgt
4621 ggctaaagat ctgctagcgc cttcagaaat ggatgttggt gattacatca tccgtgtaaa
4681 agaaggcttg ccatcaggat tcccttgcac atctcaggtg aatagtataa accactggct
4741 gatcacactg tgtgccatgt ctgaagtcac gggtttgtca cccgatgtca tacaatccca
4801 atcttacttt tctttctatg gtgatgatga gatagtctca acagacattg attttgaccc
4861 cgctcgcctc acccaagtgc ttaaggaata tgggttaaga cccaccagac cagacaagtc
4921 agaagggccc atcatactca gaagacaggt ggatggcctt gtattcttaa ggaggacaat
4981 ttccaaagat gctgcaggct ttcagggaag gctagatagg ggctcaattg aaaggcagct
5041 gtggtggact cggggcccta accatgatga tcccagtgaa actctgattc cacaccccca
5101 gaggaaagtc cagcttatat cccttcttgg tgaagcctcc ctccatggtg agaagtttta
5161 cagaaaaatc tccagtaaag ttatacagga gataaggacc ggtggcttag aaatgtatgt
5221 accaggttgg caggccatgt tccgctggat gcgcttccat gatctcggat tgtggacagg
5281 agatcgcaat ctcctgcccg aattcgtaaa tgatgatggc gtctaaggac gctacaccaa
5341 gcgcagatgg cgccactggc gccggccagc tggtaccgga ggttaataca gctgacccta
5401 tacccattga ccctgtggct ggctcctcta cagcccttgc cactgcgggc caagttaatt
5461 tgattgaccc ctggataatc aataattttg tgcaagcccc tcagggcgag ttcacaatat
5521 ccccaaataa tacccccggt gacgtgctat ttgatttgca gttagggcct catctgaatc
5581 ctttcctttc ccatctttct cagatgtaca atggctgggt gggcaacatg cgagtgcgcg
5641 ttgttttggc tggtaatgct tttacagctg gaaaggttat aatttgttgt gttccccctg
5701 gctttcaatc tcgcactctt tccatagctc aggctacttt atttccccat gttattgctg
5761 atgtcaggac ccttgatcct gtagaagtgc cccttgaaga tgttaggaat gtattgtatc
5821 acaataatga cactcaacct accatgcgcc tcctttgcat gttatacacc cctcttcgaa
5881 ctgggggggc gtctggtggg actgattctt ttgtggtggc tgggcgtgtg cttacttgcc
5941 caggccctga ctttaacttc ttattcttag ttcctcctac agtcgagcaa aagactcgcc
6001 ctttcactgt gcctaatatc cctttgaagt acctgtctaa ttctaggatc ccaaacccta
6061 ttgagggtat gtctttgtca cctgaccaga ctcaaaatgt tcaattccag aatggtaggt
6121 gtacaattga tggtcagccc ctcgggacca cacctgtctc agttagccag ttatgtaagt
6181 ttaggggtag gattacatct ggacagaggg tgctcaattt gacagaatta gatggttcac
6241 cttttatggc ttttgccgct cccgcccccg cgggctttcc agatcttgga tcttgtgatt
6301 ggcatattga aatgagtaaa atcccaaact ccagcaccca gaacaatcca atagtagtca
6361 attctgtcaa acccaatagt caacagtttg tcccgcattt gtcaagcatc acccttgatg
6421 ataatgtttc tagtgggggc gactatattg gcactataca atggacctct cctccttctg
6481 attccggcgg tgccaacaca aacttttgga agattcctga ctatgggtct agcctagcag
6541 aagcctcaca gctggccccc gctgtctatc cacctggttt caatgaggtg attgtgtact
6601 ttatggcatc tatacctggc cccaatcaat ctggttcccc taatttggtg ccatgccttc
6661 tcccccagga atatataaca cattttatca gtgagcaggc ccccattcag ggtgaggccg
6721 ccttactcca ttatgtagat ccagacacca atcgcaattt gggtgagttc aagttgtatc
6781 ctggtggtta tctgacttgt gttcctaata gttctagtac aggacctcaa cagcttcctc
6841 ttgatggtgt gtttgtcttt gcttcttggg tttctagatt ttatcaatta aagcctgtgg
6901 gaacagccgg accggctaga ggtaggcttg gtgtccgcag ataatggccc aagccattat
6961 aggagccatt gctgcctccg cggctggcag tgccctgggt gctggcatcc aggctggtgc
7021 tgaggctgcg ttacaggcac agagatatca acaagatttg actttacagc aaaattcttt
7081 caatcatgat aaagagatgt taggttatca agtagagatg tctaataagc tattagctaa
7141 aaatcttaat acccgctatt ctcttctcca ggcgggtggt ctctccccct ctgatgcggc
7201 tagggctgtg gccggggccc ctgtcactag gttggttgac tggggtggag tccgtgttgc
7261 ggcacctcaa tcatctgcca ccacactgag atctggcaat tttatggcag tgccactccc
7321 agcccagcca aagcagaaac ctcttgctag tgagggatat tctaatccag cttatgaccc
7381 catgcagcgt acagcttctt gggttcaatc ccaaaattcc agccggaatt ggtccccata
7441 ccacaggcaa gccctccaaa ctgtgtgggt gaccccccct ggttctactt cttcttcttc
7501 tgtttctact gcccctcgag ggtattttaa tacagataga ttgcctctgt tcgcaaactt
7561 gaggcgctaa tgttgtaata agattagtga gcatcctatt caaatttggc tttatataat
7621 ttgattgtat ttggctttta attttgattt gattgatgtt
//