Typing tool
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Typing tool
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Complete norovirus genomes
| MW305498 | GI.6 | |
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| GI.P11 |
ORF1: 1..5335
ORF2: 5319..6941
ORF3: 6941..7570
LOCUS MW305498 7659 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GI isolate Arg11085 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305498
VERSION MW305498.1
KEYWORDS .
SOURCE Norovirus GI
ORGANISM Norovirus GI
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7659)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7659)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7659
/organism="Norovirus GI"
/mol_type="genomic RNA"
/isolate="Arg11085"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122928"
/country="Argentina"
/collection_date="2013"
/note="genotype: GI.6[GI.P11]"
gene <1..5335
/gene="ORF1"
CDS <1..5335
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QPJ58830.1"
/translation="NVASNNNANNTSATSRFLSRFKGLGGGASPPNPIKIKSTEMALG
LIGKTTQEAVGASDLPPKQQRDRPPRTQEEVQYGMGWTERPVDQNVKSWEELDTSTKE
EILDSHKEWFDAGGLGPCTMPSTCEQAKDDSPPGEQVRWSARDGVNLGVNRLTTVSGP
EWNLCPLPPIDLRNMEPASEPTIGDMIEFYEGHIYHYSIYIGQGKTVGVHSPQAAFSV
ARVTIQPIAAWWRVCYIPQPKHRLSYDQLRELENEPWPYAAITNNCFEFCCQVMNLED
TWLQRRLITSGRFHHPSQSWSQQTPEFQQDSKLELVRDAILAAVNGLVSQPFKNFLGK
LKPLNVLNILSNCDWTFMGVVEMVILLLELFGVFWNPPDVSNFIASLLPDFHLQGPED
LARDLVPVILGGIGLAIGFTRDKVTKVMKSAVDGLRAATQLGQYGLEIFSLLKKYFFG
GDQTERTLKGIEAAVIDMEVLSSTSVTQLVRDKQAAKAYMNILDNEEEKARKLSAKNA
DPHVISSTNALISRIAMARSALAKAQAEMTSRMRPVVIMMCGPPGIGKTKAAEHLAKR
LANEIRPGGKVGLVPREAVDHWDGYHGEEVMLWDDYGMTKIQDDCNKLQAIADSAPLT
LNCDRIENKGMQFVSDAIVITTNAPGPAPVDFVNLGPVCRRVDFLVYCSAPEVEQIRR
VSPGDTSALKDCFKSDFSHLKMELAPQGGFDNQGNTPFGKGVMKPTTINRLLIQAVAL
TMERQDEFRLQGKMYDFDDDRVSAFTTMARDNGLGILSMASLGKKLRGVTSMDGLKNA
LKGYKIGACTIKWQAKVYSLESDGNSVNIREEKNVLTQQQQSVCAASIALTRLRAARA
VAYASCIQSAITSILQIAASALVVNRAVKRMFGTRTAALSLEGPPKEHKCRVHQAKAA
GKGPIGHDDMVDKYGLCETEEDEEVAHTEIPSATMEGKNKGKNKKGRGRKNNYNAFSR
RGLNDEEYEEYKKIREEKGGNYSIQEYLEDRQRYEEELAEVQAGGDGGIGETEMEIRH
RVFYKSKSKKHHQEERRQLGLVTGSDIRKRKPIDWTPPKSAWADDEREVDYNERINFE
APPTLWSRVTKFGSGWGFWVSPTVFITTTHVIPTSAKEFFGESLASIAIHRAGEFTLF
RFSKKIRPDLTGMILEEGCPEGTVCSVLIKRDSGELLPLAVRMGAIASMRIQGRLVHG
QSGMLLTGANAKGMDLGTIPGDCGAPYVYKRANDWVVCGVHAAATKSGNTVVCAVQAS
EGETTLEGGDKGHYAGHEIIKHGCGPALSTKTKFWKSSPEPLPPGVYEPAYLGGRDPR
VSGGPSLQQVLRDQLKPFAEPRGRMPEPGLLEAAVETVTSSLEQVMDTPVPWSYSDAC
QSLDKTTSSGFPHHKKKNDDWNGTAFIRELGEQAAHANNMYEQAKSMKPMYTAALKDE
LVKPEKVYQKVKKRLLWGADLGTVIRAARAFGPFCDAIKSHTIKLPIKVGMNSIEDGP
LIYAEHSKYKYHFDADYTAWDSTQNRQIMTESFSIMCRLTASPELASVVAQDLLAPSE
MDVGDYVIRVKEGLPSGFPCTSQVNSINHWLITLCALSEVTGLSPDVIQSMSYFSFYG
DDEIVSTDIEFDPAKLTQVLKEYGLKPTRPDKSEGPIIVRKSVDGLVFLRRTISRDAA
GFQGRLDRASIERQIYWTRGPNHSDPFETLVPHQQRKIQLISLLGEASLHGEKFYRKI
SSKVIQEIKTGGLEMYVPGWQAMFRWMRFHDLGLWTGDRNLLPEFVNDDGV"
mat_peptide <1..1165
/gene="ORF1"
/product="p48"
mat_peptide 1166..2254
/gene="ORF1"
/product="NTPase"
mat_peptide 2255..2851
/gene="ORF1"
/product="p22"
mat_peptide 2852..3265
/gene="ORF1"
/product="VPg"
mat_peptide 3266..3808
/gene="ORF1"
/product="Pro"
mat_peptide 3809..5332
/gene="ORF1"
/product="RdRp"
gene 5319..6941
/gene="ORF2"
CDS 5319..6941
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58831.1"
/translation="MMMASKDAPTSPDGASGAGQLVPEANTAEQISMDPVAGASTAVA
TAGQVNMIDPWIFNNFVQAPQGEFTISPNNTPGDILFDLQLGPHLNPFLAHLSQMYNG
WVGNMRVRILLAGNAFTAGKIIICCVPPGFDARILTIAQATLFPHLIADVRTLEPVEL
PLEDVRNVLFHNSSQPQPTMRLVAMLYTPLRTGGGSGGTDAFVVAGRVLTCPAPDFSF
LFLVPPSVEQKTRVFSVPNIPLKDLSNSRVPVPVQGMFMSPDVNQSVQFQNGRCQIDG
QLQGTTPVSLSQLCKIRGKTSSNARVLNLSEVDGTPFIPLESPAPVGFPDLGGCDWHV
NFTFQAQNQDPSQSVTFATNDASFVPYLGSISPHNGGDFHAGDIIGSLGWISAPSDNS
QLNVWTIPKYGSSLPDVTHLAPAVFPPGFGEVILYFYSTFPGSGQSSQLQVPCLLPQE
FITHFCNEQAPIAGEAALLHYVDPDTGRNLGEFKLYPDGFMTCVPNSVSSGPQTLPIN
GVFVFVSWVSRFYQLKPVGTASAARRLGLRRI"
gene 6941..7570
/gene="ORF3"
CDS 6941..7570
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58832.1"
/translation="MAQAVIGAIAASAAGSILGAGIQAGAEAGLQAQRYQQDLQLQQN
SFKHDKEMLGYQVQASNALLAKNLNTRYALLQAGGLSSADAARAVAGAPVTRIVDWNG
TRIAAPSSSTTTLRSGGFMAVPMPLPLKTKQPVMSGQDNPNYAASSISRTASWVQSQN
SMRSVSPFHSDALRTVWVTPPGSSSTSSVQSSFYGVFNTDRLPLFANRR"
ORIGIN
1 taatgttgca agcaataaca acgctaacaa cactagtgct acatctcgat ttttgtcgag
61 atttaagggt ttaggtggtg gcgcgagccc ccctaacccc ataaagatca aaagcacaga
121 aatggccttg ggtttgattg gcaagacaac ccaagaggca gtaggtgcca gtgacctacc
181 gcctaaacag caaagagacc ggccccccag aacccaagag gaagttcagt acggcatggg
241 gtggactgaa aggcccgtgg accagaatgt taagtcatgg gaggaacttg acacctccac
301 caaggaagag attttggaca gccacaaaga atggttcgat gccggcggtt tgggcccgtg
361 cactatgccc tcaacttgtg aacaggctaa agatgatagc ccacctggtg agcaagtcag
421 atggtcagcg cgtgatggag tcaaccttgg agtgaaccgt ctcacgacgg tgagtggccc
481 cgagtggaac ctctgccctc taccccccat tgacctaagg aatatggaac cagctagtga
541 acccaccatt ggagacatga tagagtttta tgaaggccac atctaccact actccatata
601 cattgggcaa ggaaagacag ttggtgtgca ttccccacag gcagcattct cagtggctag
661 agtgaccatc caacctatag ctgcttggtg gagggtttgt tatatacccc agcccaaaca
721 tagactgagt tatgaccaac ttagggaatt ggaaaatgaa ccttggccgt atgcagctat
781 caccaacaat tgttttgagt tttgctgtca agttatgaac cttgaggaca catggttgca
841 gaggcggcta ataacatcag gtagattcca ccacccttcc cagtcctggt cacaacagac
901 ccctgaattt cagcaggaca gtaaactgga actggttagg gatgctatat tggccgcggt
961 gaatggcctt gtttcacaac ccttcaaaaa tttcttgggc aagctcaagc ctcttaatgt
1021 attaaacatc ctatctaact gtgactggac ttttatgggg gtggtggaga tggttatact
1081 acttcttgag ctctttggcg tgttctggaa cccgcccgat gtgtctaatt ttatagcatc
1141 tctcctccct gacttccacc ttcaggggcc agaagacctg gcccgggatt tggtgccagt
1201 cattcttggt ggcataggac tagccattgg atttaccaga gataaagtca ccaaggtcat
1261 gaagagtgct gtggatggac tccgggccgc tacacagctg gggcaatacg ggttggaaat
1321 attctcactc ctcaagaagt atttctttgg tggggatcag actgaacgaa ccctcaaagg
1381 cattgaagca gcagtcatag atatggaggt tttgtcctct acatcagtga cacaactggt
1441 gagagacaag caggcagcta aagcttacat gaacatcctg gataatgaag aggaaaaagc
1501 tagaaaactc tctgctaaga atgctgaccc ccatgtaata tcctcaacaa atgccctaat
1561 atcacgtata gccatggcgc gatccgctct ggctaaggct caagctgaga tgaccagccg
1621 aatgaggcca gttgtcatca tgatgtgtgg acctcctgga attggcaaga ctaaagcagc
1681 ggaacacttg gcaaaacgcc tagctaatga gatcaggcct ggcggcaaag tgggactggt
1741 accacgtgag gctgttgacc actgggatgg ctaccatggt gaggaagtga tgctatggga
1801 tgactatggt atgacaaaga tacaagatga ctgcaacaag ctccaggcta ttgctgactc
1861 tgccccactc actctcaatt gtgataggat tgaaaataaa gggatgcagt ttgtgtcaga
1921 tgcaatagtc atcaccacca acgctccagg gcctgcccct gtggactttg tcaaccttgg
1981 ccctgtgtgt agacgggttg acttcctggt ctactgttcc gccccagagg tagagcagat
2041 aaggagagtc agccctggag acacgtcggc acttaaagac tgcttcaagt cagatttctc
2101 ccacctgaag atggagttag ctcctcaagg ggggtttgac aaccagggga acacaccatt
2161 cggcaagggt gtcatgaaac caacaaccat caacaggctc ctcatacaag ctgtggctct
2221 caccatggag agacaggatg agttccgtct ccaagggaag atgtatgatt ttgatgatga
2281 tagggtgtca gcctttacca ccatggcacg cgataatgga ttgggcatcc tgagcatggc
2341 gagcctaggt aagaagctgc gcggtgtcac atcgatggat ggtctgaaga atgctttgaa
2401 agggtataaa attggtgcgt gcacaatcaa gtggcaggct aaggtgtatt cactagagtc
2461 agatggcaac agtgttaaca tcagggagga gaagaatgtt ttaactcaac aacagcagtc
2521 ggtgtgcgct gcctctattg cactcacccg tctgcgggcc gcacgcgcgg tggcgtatgc
2581 gtcatgcatt caatcagcca taacctccat actacaaatt gctgcctctg ccctagtggt
2641 caacagggcc gtgaaaagaa tgtttggcac acgcactgct gctttgtctc tagagggccc
2701 ccccaaagaa cacaaatgca gagtccacca ggctaaagcc gcaggaaaag ggcccattgg
2761 ccatgatgac atggttgaca aatatggtct atgtgagact gaggaggatg aagaagtagc
2821 ccacactgag ataccatctg ccaccatgga aggtaagaac aaaggaaaga acaagaaagg
2881 gcgcggccga aagaacaact acaacgcctt ttcccgtaga gggctcaatg acgaagagta
2941 cgaggagtat aagaaaatac gggaagagaa gggtggaaat tacagcattc aggagtacct
3001 agaggataga caaaggtatg aagaggagct tgctgaggtt caagcaggtg gagatggagg
3061 gatcggtgaa actgaaatgg aaatccgcca tagagtgttc tacaagtcta agagcaagaa
3121 gcaccaccag gaagaacgac gccaactggg attagtcaca ggttctgaca tccggaaaag
3181 aaaaccaatt gactggaccc cccctaagtc agcatgggca gatgatgagc gtgaagtgga
3241 ctacaatgag aggatcaact ttgaggcgcc ccccactttg tggagccggg tcacaaagtt
3301 tggatctggg tggggcttct gggtcagtcc cacagtcttc ataaccacaa cgcacgttat
3361 accaaccagt gcaaaagagt tctttggtga atcccttgcc agcatagcca tccacagagc
3421 cggagaattc accctcttca ggttctctaa gaaaatcagg cccgatctca cgggtatgat
3481 tcttgaggaa ggttgcccag agggtacggt gtgctcagta ttgataaaaa gggactccgg
3541 tgagctacta ccactagctg taagaatggg cgcaatagca tcaatgcgca tacagggtcg
3601 ccttgtccat ggccagtctg gtatgttgct cactggggcg aatgctaagg gcatggacct
3661 cggaactatt ccaggggatt gtggagctcc ctatgtctat aagagagcaa atgactgggt
3721 ggtttgtggt gtgcacgctg ctgccactaa gtcaggcaac acagtagtgt gcgccgtcca
3781 ggctagtgaa ggggaaacca cacttgaggg gggtgacaaa ggtcactacg ccggacatga
3841 gataatcaag catggatgtg ggccagccct gtcaaccaaa acaaagttct ggaaatcgtc
3901 ccctgaacca ctaccccctg gagtctatga acctgcatac ctcggtggcc gggatcctag
3961 agtgagtggt ggcccctcgc tccaacaggt attacgggat cagttaaagc catttgctga
4021 gccacggggg cgtatgccgg aaccaggtct cctggaggcc gcagttgaga ctgtgacctc
4081 atcactggag caggttatgg ataccccagt gccgtggagt tacagcgatg catgtcaatc
4141 cctagacaaa actactagtt ctggttttcc ccatcacaag aagaagaatg atgattggaa
4201 cggcaccgcc ttcattagag agttgggaga gcaggcagcg cacgccaata atatgtacga
4261 acaagctaag agcatgaaac ccatgtacac ggcggcgctt aaggatgaat tagtgaaacc
4321 agaaaaagtg taccaaaaag tgaagaagcg cttgctttgg ggggcagatc taggaacagt
4381 gatccgggcc gcacgggcct ttggcccatt ctgtgatgct ataaagtccc acacaattaa
4441 actacctatc aaagttggaa tgaattcaat cgaggatggg ccattaattt atgcagagca
4501 ttcaaaatat aaatatcact ttgatgcaga ctatacggct tgggactcaa cacaaaatag
4561 gcaaattatg actgaatcat tctcaatcat gtgtcggcta actgcttctc cagaattggc
4621 ctcagtggtg gcacaagatc tgcttgcacc ttcagaaatg gacgttggtg actacgtcat
4681 aagagtgaag gaaggcctcc catctggctt tccatgcaca tcacaggtca atagcataaa
4741 ccattggttg ataactttgt gcgccctctc tgaggtgact ggcctgtcac cagatgttat
4801 ccagtccatg tcatactttt ctttctatgg tgatgatgaa atagtttcca ctgacataga
4861 atttgaccca gcaaagctga cacaagtcct taaagagtat ggcctcaaac ccacccgccc
4921 tgacaagagt gaaggtccaa taattgtgag gaagagcgtg gatggcctgg tcttcttacg
4981 tcgcaccatt tcccgcgacg ccgcggggtt ccaggggcga ctggaccgag catctattga
5041 aaggcagatc tactggacca gagggcccaa tcactcagac ccctttgaaa ccttggtgcc
5101 ccaccagcaa agaaaaatcc agctgatatc actgttaggt gaggcctcat tgcatggtga
5161 gaaattctac aggaagatct caagcaaagt catccaagag attaagacag ggggtcttga
5221 aatgtatgtg ccagggtggc aagccatgtt ccgctggatg cggttccacg accttggcct
5281 gtggacagga gatcgcaatc tcctgcccga attcgtaaat gatgatggcg tctaaggacg
5341 ccccaacatc ccctgatggc gccagtggcg ccggccagct ggtaccggag gctaatacag
5401 ctgagcaaat ttcaatggac cctgttgcgg gtgcttcaac agcagtcgcg acagctgggc
5461 aagttaatat gattgaccca tggattttca ataactttgt ccaggcacct caaggagaat
5521 tcactatttc ccctaataat acccccggtg acattttgtt tgatttacaa ttaggacccc
5581 accttaatcc atttctagcc catctttcac agatgtacaa tggttgggtc ggcaatatgc
5641 gtgtgcgcat actgttggcc gggaatgcct tcacagctgg aaagataatc atttgctgtg
5701 tcccccctgg ttttgatgcc agaatactca caatagccca agcaactctc ttcccacact
5761 taattgctga tgtaaggacc cttgagcctg tggagcttcc tttggaggat gtgcgcaatg
5821 ttctcttcca caacagtagc caaccgcagc caacaatgcg gctggttgcc atgttgtaca
5881 ctcccctccg cactggtggt ggttccggag gcactgatgc ctttgtggtg gcgggtaggg
5941 tgctcacgtg ccccgccccc gactttagtt ttctgtttct agtcccccct tccgttgaac
6001 aaaagaccag agttttcagt gtccccaata tacccctgaa ggatctctca aattcccgtg
6061 tccctgtgcc tgtacagggc atgtttatgt ccccagatgt taatcaatca gtccagtttc
6121 agaatggacg ctgccaaatt gatggccaac tccaaggcac cactccagtc tcgctcagcc
6181 aactctgcaa gattaggggt aaaacttcta gtaatgctag ggtgctcaac ttaagtgagg
6241 tagatggcac acccttcatc ccacttgaat caccagcgcc agttggtttt cccgacttgg
6301 gaggttgtga ctggcatgta aatttcactt tccaggctca aaatcaggac ccatctcaaa
6361 gtgtaacctt tgcaactaat gatgccagct ttgttcccta tctaggtagt atctctcctc
6421 acaatggggg agattttcat gcaggtgaca tcataggtag ccttggttgg atttcagccc
6481 cgtctgataa ttcacaactt aatgtttgga caataccaaa gtatggatct agtctcccag
6541 atgtcactca tcttgcccct gctgtgtttc ccccaggctt tggggaggtg atcttgtact
6601 tctactctac cttcccaggt tctggacaat ccagccaact tcaagtccca tgtttgttgc
6661 ctcaggagtt catcacccac ttctgcaacg aacaggctcc catcgctggg gaggctgccc
6721 tcctccacta cgtggaccct gatacggggc gaaacttggg agaatttaaa ctttaccctg
6781 atgggtttat gacctgtgtc cccaatagtg ttagtagtgg ccctcaaacc cttcctatca
6841 atggagtctt tgtctttgtt tcatgggtat ctagattcta tcaactcaag cctgtgggaa
6901 cggcctcagc ggctagaagg cttggattgc ggcgcatata atggcccaag ctgtcatcgg
6961 tgccatagcc gcatctgccg ctggtagcat actaggggca ggcatacagg ctggtgctga
7021 ggctggtctc caggctcaac ggtatcagca ggatctgcag ttgcaacaaa attctttcaa
7081 gcatgataag gaaatgttag gctaccaagt tcaggctagt aatgctcttt tagctaagaa
7141 tcttaacact agatatgctc ttctgcaggc agggggccta tctagcgctg atgctgctcg
7201 ggcagtggct ggtgctcctg tcacccgtat agtggactgg aatggcacgc gcatcgcagc
7261 gcccagttca agcaccacta cactcagatc tggtggtttt atggctgtcc ctatgccact
7321 gcctttaaag accaagcaac cagtgatgtc tgggcaggat aatccaaatt atgctgcttc
7381 ttctatctct agaactgctt catgggtgca atctcaaaat tctatgaggt ctgtttctcc
7441 ttttcacagt gatgctttga gaaccgtttg ggttacacca cccggttcat catcaacttc
7501 atctgtgcaa tctagtttct atggtgtttt taatacagat agattgcctc tgttcgcaaa
7561 cagaaggtaa taaaattttg taataggatg ccagtgggca ccatattcag atttgatttt
7621 aattggattg ttttaattaa atttggctta attggtgtt
//