Typing tool
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Typing tool
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Complete norovirus genomes
| MW305496 | GI.5 | |
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| GI.P5 |
ORF1: 1..5332
ORF2: 5316..6947
ORF3: 6947..7573
LOCUS MW305496 7641 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GI isolate Arg10030 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305496
VERSION MW305496.1
KEYWORDS .
SOURCE Norovirus GI
ORGANISM Norovirus GI
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7641)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7641)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7641
/organism="Norovirus GI"
/mol_type="genomic RNA"
/isolate="Arg10030"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122928"
/country="Argentina"
/collection_date="2012"
/note="genotype: GI.5[GI.P5]"
gene <1..5332
/gene="ORF1"
CDS <1..5332
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QPJ58824.1"
/translation="TAASKNSASDNSNTIKGRLLAKLKNIGNNNQPIKIENTHMALGL
IGRGPSPAPPVEPPKQQRDRAPRSTAETQQAMGWVEQPLDQNLPTWEELSEAEKREII
AQNENWFDAGGLAPASIPSTHERAQNDEPPGHQIRWSANDGVDLGVGDLTSVTGPAWN
MCPMPPMDQRNSGPAKEPLIGDMLEFYEGRIYHYAIYIGQGKTIGVHSPQAAFSIARI
TIHPIAAWWRVCYVPSAEQRLNYDQLKELENEPWPYAAVTNNCYEFCCRVMGVQDSWL
ERRLISSGRFNHPTQDWSKDTPDFQQDSKLEIVRDAVLAAINGLVSQPFKNLLGKLKP
LNVLNLLSNCDWTFMGVVETVILLMELFGVFWNPPDVSSFIASLLPDMHLQGPEDLAR
DLIPLILGGIGLAIGFTKDKVTKVMKSAVDGLRAATQLGQYGLEIFAVLKKYFFGGDQ
TEKTLKDIEAAVIDMEVISTTAITQLVRDKQSARTYMAILDAEEEKARKLSVKNADPH
VVSSTNALIARIALARSALAKAQAEMTNRVKPVVIMMCGPPGIGKTRAAEYLAKRLAN
EIRPGGKVGLVPREAVDHWDGYHGEEVMLWDDYGMSKIADDCHKLQAIADTAPLTLNC
DRIEKKGLQFVSDAIIITTNAPGPAPVDFVNLGPVCRRVDFLVYCSAPDVEQTRRTNP
GDTGALKGCFKDDFSHLKMEIAPQGGFDNQGNTPFGKGVMRPTTLNRLLIQAVALTME
RQDEFQMQGPTYDFDADRIAAFTSLARANGLGLIDMAKLGKRLRGVDSIHGLKNALNG
YTITPCSIKWQARIYNIESDGTTVKIKEDTAAQTQRQHTIDTAVLALTRLRAARAAAY
ASCLQSAITSILQMAGSALVIHRAVKRMFGTHTNTISLEGPPREHHCRVHVAKANGGG
PIGHDDVIERFGLCETEEEDDSQELKVSLPTATQEGKNKGKTKKGRGRRANYNAFSRR
GLSDEEYEEYKKIRDEKNGNYSIQEYLEDRQRYEEEMAEVQAGGDGGIGETEMEIRHR
VFYKSKTKKNRQEERHKLGLVTGSDIRKRKPIDWTPPKNEWADDDREVDYSEKISFEA
PPTLWSRVVKFGSGWGFWVSPTVFITTTHVIPTSAREFFGEPLDTIAIHRAGEFTQLR
FSRKIRPDLTGMVLEEGCPEGVVCSILIKRDSGELLPLAVRMGAIASMKIQGRLVHGQ
SGMLLTGANAKGMDLGTLPGDCGAPYVYKRNNDWVVCGVHAAATKSGNTVVCAVQAGE
GETTLEGGDKGHYAGHEIIKHSKGPALSSKTKFWRSTTEPLPPGVYEPAYLGGRDPRV
KGGPSLQQVLRDQLKPFAEPRGRMPEPGLLEAAVETVTSALEQVMDTPIPWTYADACQ
SLDKTTSSGHPYHKRKNDDWNGTAFVGELGEQAAHANNMYEQGKSMKPLYTAALKDEL
VKPEKVYQKIKKRLLWGADLSTVIRAARAFGPFCDAIKSHVIKLPIKVGMNSIEDGPM
IYAEHARYKNHFDADYSAWDSTQNRQIMTESFSIMCRLTASPELASVVAKDLLAPSEM
DVGDYIIRVKEGLPSGFPCTSQVNSINHWLITLCALSEITGLSPDVIQSQSYFSFYGD
DEIVSTDIDFDPARLTQVLKEYGLRPTRPDKSEGPIVLRKQIDGLVFLRRTISKDAAG
FQGRLDRGSIERQLWWTRGPNHDDPNETLIPHQQRKVQLISLLGEASLHGEKFYRKIA
AKVIQEIKTGGLEMYVPGWQAMFRWMRFHDLGLWTGDRNLLPEFVNDDGV"
mat_peptide <1..1156
/gene="ORF1"
/product="p48"
mat_peptide 1157..2245
/gene="ORF1"
/product="NTPase"
mat_peptide 2246..2848
/gene="ORF1"
/product="p22"
mat_peptide 2849..3262
/gene="ORF1"
/product="VPg"
mat_peptide 3263..3805
/gene="ORF1"
/product="Pro"
mat_peptide 3806..5329
/gene="ORF1"
/product="RdRp"
gene 5316..6947
/gene="ORF2"
CDS 5316..6947
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58825.1"
/translation="MMMASKDAPSSADGANGAGQLVPEVNNAEPLPLDPVAGASTALA
TAGQVNMIDPWIFNNFVQAPQGEFTISPNNTPGDILFDLQLGPHLNPFLAHLSQMYNG
WVGNMRVRLILAGNAFTAGKVIICCVPPGFQSRTLSIAQATLFPHVIADVRTLEPIEI
PLEDVRNTLYHNNDNQPTMRLLCMLYTPLRTGGGSGGTDAFVVAGRVLTCPSPDFNFL
FLVPPTVEQKTRPFSLPNIPLHLQSNSRVPNPIQSMVISPDQAQNTQFQNGRCTTDGQ
LLGTTPVSASQILKFRGKVSPGSKVINLTELDGSPFLAFEAPAPTGFPDLGTCDWHVE
LSLNSSGQSSGNPIVSRDIQPNSSDFVPHLGSVAVTAAIETAGDYTGTIQWISQPSNV
SPVPNVNLWTIPNYGSNLAEASQLAPVVYPPGFGEAVVYFMSHIPGPNTEHKPNLVPC
LLPQEFITHFVSEQAPPMGEAALIHYVDPDTNRNLGEFKLYPEGIITCVPNGTGPQQL
PLNGVFVFASWVSRFYQLKPVGTASSARGRLGVRR"
gene 6947..7573
/gene="ORF3"
CDS 6947..7573
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58826.1"
/translation="MAQAIIGAIAASAAGSALGAGIQAGAEAALQSQRFQQDLTLQQN
SFKHDKEMMSYQVEMSNALLAKNLSTRYALLQSGGLSSADAARAVAGAPVTRIVDWNG
TRVAAPNSSATTLRSGGFMSVPIPIQPKQKPPTISGFNNPAYGETMSRVSSWVQSQNS
SRSMPPFHSSALRTVWVTPPGSTSSSSVSSVPMGVFNTDRLPLFANRR"
ORIGIN
1 tactgctgct agcaaaaatt ctgctagcga caatagtaac acaattaagg gtcgcttatt
61 agcgaaactt aagaatatag gcaataacaa tcagcctata aagatagaaa atactcatat
121 ggccttaggg ctcattggta gaggtccatc accagcccct cccgttgagc cccccaaaca
181 acagcgtgac cgtgcaccac ggagtactgc tgagacccaa caggccatgg ggtgggttga
241 acaaccatta gatcagaacc tgccgacctg ggaagaactg agtgaagcag agaaacgcga
301 aatcatagca cagaatgaga actggtttga tgctggtggc ttggcaccag catccatccc
361 tagcacacat gagcgtgccc aaaatgatga gccaccaggg caccaaataa gatggagcgc
421 caatgatggc gttgatcttg gggttggtga cctcacctct gtcactggcc ctgcatggaa
481 catgtgtccc atgccaccaa tggatcaacg caatagtggg cccgcaaaag aaccactcat
541 tggcgacatg cttgaattct atgaggggcg catataccac tatgccatat acatcgggca
601 gggcaaaacc attggagtcc attcaccaca ggcagccttc tctatagcca ggataacaat
661 acatcccatt gctgcgtggt ggcgagtgtg ctatgtccca agtgctgaac aaagactaaa
721 ttatgaccaa cttaaagaac ttgagaatga accatggccg tacgccgcag ttaccaacaa
781 ttgctacgag ttttgttgtc gcgtcatggg cgtccaagac agttggctcg agcgtcggct
841 cataagttcg ggccgcttca atcaccccac acaggattgg tctaaagaca ctccagattt
901 ccaacaagac agtaaattag agatagtcag ggatgctgtt ttggcagcca taaacggcct
961 tgtttcacaa ccatttaaaa accttttggg gaagttgaag cccctgaatg ttctcaacct
1021 actctccaat tgtgactgga ccttcatggg ggtcgtggag actgtgatcc ttctgatgga
1081 gctctttgga gtattctgga acccacctga tgtatccagc tttattgcct cgctcttacc
1141 agacatgcac ttgcagggcc ctgaggattt ggctagagac ttgatacctt taatactcgg
1201 tggcataggg cttgccatcg ggttcaccaa ggacaaggta acaaaagtta tgaaaagtgc
1261 agtagatggt ctacgggctg caactcaact tggccaatac ggtcttgaga tctttgccgt
1321 attaaagaaa tacttctttg gaggtgacca gacagagaag acacttaaag acattgaggc
1381 ggcagtgata gatatggaag tcatctcaac tacagccata acacaactgg ttagagataa
1441 gcaatcagcc agaacatata tggccatcct agatgcagag gaggagaaag ccagaaagct
1501 ctcagtgaag aatgctgatc cccatgtggt atcctctacc aatgccctta ttgcacgcat
1561 agcgctagcc cgttccgctt tggctaaggc gcaggcagag atgaccaata gggtcaaacc
1621 tgtggtcatc atgatgtgtg gtccgccagg cattggtaaa actagggcag cagaatacct
1681 ggcaaaacgg ttggccaatg aaataaggcc tggaggcaaa gttggccttg taccacgtga
1741 ggctgtggat cattgggatg ggtaccatgg tgaggaggtc atgttgtggg atgactatgg
1801 tatgtcgaag attgctgacg actgtcacaa gctacaggca attgctgaca cggccccttt
1861 gacattgaac tgcgacagga tagagaagaa agggctccaa tttgtatctg atgccataat
1921 tataaccacc aacgccccag gcccagcacc agtggatttt gtcaaccttg gtcctgtgtg
1981 ccggcgagta gacttcctcg tctattgttc ggcccccgac gtcgaacaga cccgtcgcac
2041 taatcctggt gacactgggg cccttaaggg ctgcttcaaa gatgacttct cacatttaaa
2101 aatggagatt gccccccaag gtggatttga taatcagggt aataccccgt ttggcaaagg
2161 ggttatgcgc ccaaccacac tcaacaggct gttaatacag gcagtcgccc tcaccatgga
2221 gcggcaagat gagtttcaaa tgcaaggacc aacttatgac tttgatgctg atagaattgc
2281 agcttttacc agcttggcac gtgccaatgg ccttggcctt attgacatgg ccaaacttgg
2341 gaagagactg cggggtgtag attccattca tggccttaag aatgcactta atgggtacac
2401 cataacaccc tgtagcataa aatggcaagc aagaatttac aacatagaat ctgatggcac
2461 aacagtaaag attaaagaag acactgcagc gcagacccaa cgccagcata caattgatac
2521 tgcagtattg gccctaaccc gcttaagggc tgctagggct gcagcatatg catcatgcct
2581 gcaaagtgca attacatcta ttctccaaat ggcgggctca gcacttgtca tccatcgagc
2641 tgtcaaacgc atgtttggca ctcacaccaa taccatctca ctggaaggcc cccctagaga
2701 acaccattgc agggttcacg tggcgaaagc taatgggggc ggcccgattg gacacgatga
2761 tgtaatagag agatttggcc tgtgtgagac tgaggaagaa gatgacagcc aggagcttaa
2821 agttagccta cccactgcca cccaagaagg taagaacaag ggcaagacga agaaaggcag
2881 aggtaggcgc gccaattata atgctttctc aaggagggga ctcagtgatg aggagtatga
2941 ggaatacaag aagatcagag acgaaaagaa tggcaactac agtatacaag agtaccttga
3001 ggacaggcag cgttatgaag aagagatggc cgaagtccag gctggagggg atggcggcat
3061 tggagagacc gaaatggaga tccggcatcg tgttttctat aaatccaaaa ccaaaaagaa
3121 ccggcaggaa gagcgccaca agttggggct tgttactggg agtgacatca ggaagagaaa
3181 accaattgat tggacacccc ctaaaaatga gtgggctgat gatgacaggg aagtggatta
3241 cagtgagaaa atcagctttg aagcgccacc cacactctgg agccgtgttg taaagtttgg
3301 ttctggttgg ggattctggg tcagccctac agttttcatc accacaacac atgttatccc
3361 aacaagtgcg agagaattct ttggggagcc actcgacacc attgccatcc atcgagctgg
3421 tgaattcaca cagctaagat tttccagaaa gataagacct gacttgaccg gcatggtcct
3481 tgaagaaggt tgcccagaag gtgttgtctg ttcaatcctc ataaaaagag actctggaga
3541 actcctcccg ttggctgttc ggatgggtgc cattgcttcg atgaagattc aagggcgtct
3601 agtccatggg caatcaggaa tgttgctgac aggagccaat gctaagggca tggaccttgg
3661 caccctccct ggtgattgtg gggccccgta tgtctacaaa aggaacaatg actgggtagt
3721 ctgtggtgtc cacgccgcag ccacaaaatc tggaaacaca gttgtgtgtg cagtgcaagc
3781 aggtgaaggg gagaccacac tggaaggagg agataaggga cattatgccg ggcatgaaat
3841 aattaagcat agtaagggac cagcactatc tagtaaaacc aaattttggc ggtcaaccac
3901 tgaaccccta ccaccaggag tgtatgagcc agcttacctt ggaggtcgcg accctagggt
3961 taaaggcggc ccgtcactgc aacaagtgtt gagggaccag ctgaagccat ttgctgaacc
4021 gcgtgggcgt atgcctgaac ctggcctact agaggcagct gttgagacag tcacgtcagc
4081 gctggagcag gtcatggata ccccaatccc ctggacttat gctgatgcat gccagtcatt
4141 ggataagacc accagttctg gccacccata ccataagagg aaaaatgatg actggaatgg
4201 gactgcgttt gtgggggaat tgggggaaca ggcagcccat gcaaataaca tgtatgaaca
4261 gggcaagtca atgaaacccc tttacacagc cgcactcaag gatgaattgg tcaaacctga
4321 gaaagtgtat cagaagatta aaaagcggct tctttggggc gctgatctat caacagtaat
4381 ccgtgccgct agagcctttg gcccattttg tgatgcaata aagtcccatg tcataaagct
4441 tcccatcaag gttgggatga attcaattga ggatggtcca atgatttatg ccgagcatgc
4501 aagatataag aaccactttg atgctgatta ctctgcgtgg gactcaacac agaacaggca
4561 aatcatgact gagtcatttt caataatgtg tcgcctcacg gcctcaccag agctggcctc
4621 agtggtggct aaagaccttc tcgcaccatc tgagatggat gttggggact acatcataag
4681 agttaaagaa ggtctccctt caggcttccc ctgcacttca caagttaata gcataaacca
4741 ttggctaatc actctttgtg ccctctctga gattactgga ctctctcctg atgtcataca
4801 atcacagtca tacttctcat tttatggtga tgatgaaatt gtgtccactg atattgattt
4861 tgacccagca cgcctaaccc aagtgcttaa agagtatggt cttcgcccta cacgtccaga
4921 caagagtgaa ggaccaatag tgttaaggaa gcaaattgat gggctagtgt ttctcaggag
4981 gaccatatca aaagatgcag ctggtttcca aggccgatta gacagaggtt ctattgagag
5041 gcagctttgg tggactcgtg gcccaaacca cgacgacccc aatgagaccc tgatacccca
5101 ccaacaaaga aaggttcagc tcatatcact acttggtgaa gcctcactcc atggtgaaaa
5161 attctacaga aaaattgccg ctaaggttat ccaagaaatc aagactggtg gcttagaaat
5221 gtatgtgcca ggctggcagg ccatgttccg ttggatgcgc tttcacgacc tcggattgtg
5281 gacaggagat cgcaatcttc tgcccgaatt cgtaaatgat gatggcgtct aaggacgccc
5341 catcaagcgc agatggcgcg aatggcgccg gtcagcttgt gccggaggtt aataatgctg
5401 aaccactgcc acttgatcca gtggcggggg cttccactgc ccttgccact gctggacaag
5461 ttaatatgat tgacccatgg atctttaata attttgttca ggcccctcag ggtgaattca
5521 ctatttctcc aaacaatacc cccggcgata ttttgtttga tttgcaatta ggtccacatc
5581 taaatccttt tctagcacat ttgtctcaga tgtataatgg ctgggttggt aacatgcggg
5641 tcaggcttat cttggccggt aatgccttca ctgctggtaa agtcataatc tgttgtgttc
5701 cccctggttt tcaatctaga accctttcca tagctcaggc cacactcttt ccccatgtca
5761 tagctgatgt gcgaactctg gaaccaatcg agatcccttt agaagatgtt aggaacactc
5821 tctatcataa taatgacaat caaccaacaa tgcgcttgct gtgcatgctc tacacgccac
5881 tacgcaccgg tggcggttct ggcggcacag acgcgtttgt tgtggcaggt cgagttttaa
5941 cttgccctag tcctgatttt aatttcttgt tcctagtccc acccactgta gagcagaaga
6001 cacgcccctt tagcctgccc aatataccct tgcacttgca gtctaattcc cgtgtcccca
6061 atcccataca gagcatggtt atttcgcctg atcaggctca gaatacccaa ttccagaatg
6121 gccgctgcac caccgatggg caactcttgg gtacaacacc tgtctcagct agtcagatct
6181 taaagtttag aggaaaggta tcacctggtt ccaaagttat caatctcact gagttggatg
6241 gttccccttt tctggctttt gaggcccctg cacccacggg ctttcctgac ttgggaactt
6301 gcgattggca tgttgaattg agccttaact caagtggcca aagttctggc aatccaattg
6361 tatcaaggga catacaacca aattcttcag attttgtgcc acacttgggc agtgtggccg
6421 tcaccgctgc aattgaaaca gctggggatt atactggcac aatccagtgg atctcccagc
6481 catccaatgt ctccccagtt cccaatgtca acctgtggac tatccccaat tatggatcaa
6541 atttggcaga agcctcccag ttggcccctg tggtttaccc cccgggattt ggtgaagccg
6601 tagtatactt tatgtctcac ataccgggcc caaatactga acacaaaccc aatctggtac
6661 cctgcctact tccacaagaa tttataactc attttgtcag tgaacaagcc ccacccatgg
6721 gtgaggcagc tcttatccat tatgtggatc cagatactaa tcgtaatctg ggtgagttca
6781 aattgtatcc tgagggtatt atcacctgtg tgccgaatgg cactggtcca caacaactcc
6841 ccctcaatgg ggtctttgtc tttgcttcct gggtttctag attttaccaa ttaaagcctg
6901 tgggaacggc cagttcggcc agaggtaggc ttggagtcag aagataatgg ctcaagccat
6961 aattggagct attgctgcat cagcggctgg aagtgccctt ggagctggta tccaagcggg
7021 tgctgaggcc gccctccaga gccagagatt ccagcaggac cttacccttc aacaaaattc
7081 ttttaaacat gataaggaaa tgatgtcata tcaagttgaa atgtctaatg ctttgctagc
7141 taaaaatctc agcactcgct atgctttgct ccaatctgga ggtctatcta gtgctgatgc
7201 tgctcgtgct gtggcaggtg cgcctgtcac aaggattgtt gattggaatg gcacgagagt
7261 agcagcccca aattcctctg caacaactct cagatctggt ggattcatgt ctgttcctat
7321 acctattcag cccaaacaaa agccccctac catctcagga tttaacaatc cagcatatgg
7381 agaaactatg tcaagagttt cctcctgggt ccagtcccag aattcaagta ggagtatgcc
7441 tcctttccat agttctgccc tcaggactgt ttgggttaca ccaccaggtt caacttcttc
7501 ttcatctgtt tcatctgtgc ctatgggcgt gttcaacacc gataggcttc ccctattcgc
7561 aaataggaga taatattgtt gtaataagaa taacaatgtg ggcatcttat tcaatttggt
7621 ctaattaatt tcataattag g
//