Typing tool
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Typing tool
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Complete norovirus genomes
| MW305494 | GI.3 | |
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| GI.P3 |
ORF1: 1..5368
ORF2: 5352..6983
ORF3: 6983..7630
LOCUS MW305494 7705 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GI isolate Arg4372 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305494
VERSION MW305494.1
KEYWORDS .
SOURCE Norovirus GI
ORGANISM Norovirus GI
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7705)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7705)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7705
/organism="Norovirus GI"
/mol_type="genomic RNA"
/isolate="Arg4372"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122928"
/country="Argentina"
/collection_date="2004"
/note="genotype: GI.3[GI.P3]"
gene <1..5368
/gene="ORF1"
CDS <1..5368
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QPJ58818.1"
/translation="ADVSNNNANTNNDNIGSRLMAKIRGRIGPQRGETTTKIKDANMA
LDLLRRSQTPSPSRQESPPKGQRDRPPRTASEVRRVMGWDVEPEHQESTAKAWCDLTQ
EEKEEIMRNNEKLFDAGGVTPSTLPSTFERAGPVDSPGEQQPVTWSASSGVDIGIDDL
TTVRGPFWNMCPLPPLDARNNGPAKEPLIGDMIEFYEGHIFHYAIYIGQGKTIGVHSP
QAAFSIPRITIHPLVAWWRVCYVPTNQQRLTYDQLKELENEPWPYASITNNCYEFCCR
VMALDDTWLERRLVSTGKFNHPTQDWSQDTPDFHQDSKLEMVRDAVLSAINGLVSQPF
KNILTKIKPLNVLNLLSNCDWTFMGVVELIVLLAELFDVFWTPPDISSFIASLLPEFH
LQGPEDLARDLVPLILGGIGLAIGFTRDKVTKVMKSAVDGLRSATQLGQYGLEIFSII
KKYFFGGDQTEKTLRGIEDAVIDMEVLSSTNVTQLVKDKKLARTYMNVLDNEEEKARK
LSVRSADPHIVTSVNNLISRISMARSALAKAQAEMTSRPRPVVIMMCGPPGIGKTKAA
EHLAGRLAAEIRPGGKVGLVPRESIDHWDGYHGEDVLLWDDYGMSKITEDCNKLQAIA
DTAPLSLNCDRIENKGMQFSSDAIIITTNAPGPAPVDFVNLGPVCRRVDFLVYCSAPE
IEQMRRTHPGDANAIKDLYKRDYSHLKMELAPQGGFDSQGNTPFGKGIMKPTTLNRLL
IQATALAMERQDEFQLQGAVYNFDEDRVSAFTSLARANGLGLVSMATLGKRLRSVKSM
EGLRNALVGYKIGECDIIWNTRVYSIKSDGSTVTIKEKQAPTSSQHQAICTATLALSR
LRAARALAYASCLQSAVLSILQVAGSALVVSRAVKRMFGTRTEQPMLEGKHKEHNCRV
HRAEAAGHGPIGHDGVIERYGLCESEQEEEGEQTVELPTANKEGKNKGKTKKGRGRKS
NFNAFSRRGLSDEEYEEYKKIREEKSGNYSIQEYLEDRQRYEEELAEVQAGGDGGIGE
TEAEIRHRVFYKSKSGMRKQRQEERRQLGLVSGSEIRKRKPIDWTPPKNDWSEDTRTV
NYDEHISFEAPPSIWSRVVKFGSGWGFWVSSTVFITTTHVIPPGAKEIFGENLGNVAI
HRVGEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCTIMIKRDSGELLPLAVRMGAVASM
KIQGKLMHGQSGMLLTGANAKGMDLGTIPGDCGAPYVHKRGNDWVVCGVHAAATKSGN
TVVCAIQGGDGEATLEGGDQNKGHYAGHPILRYGNGPSLSTKTKFWKSTPQPLPPGTY
EPAYLGGRDPRVEGGPSLQQVLRDQLKPFAEPRGRLPEAGLLEAAVETVSNAIEQVMD
TPVAWSYSDACMSLDKTTSSGYPHHKKKNDDWNGNSFVRELGDQAAHANSMYELGKSM
KPVYTAALKDELVKPDKVYTKIKKRLLWGADLGTVIRAARAFGPFCEAIKSHVIKLPI
KVGMNAIEDGPLIYAEHSKYKFHYDADYTAWDSTQNREIMMESFNIMCKLTANPSLAA
VVAQDLLSPSEMDVGDYVISVKDGLPSGFPCTSQVNSINHWILTLCALSEVTGLSPDV
IQSQSYFSFYGDDEIVSTDIEFDPIRLTQVLKEYGLKPTRPDKTDGPIVVRQQVDGLV
FLRRTISKDAIGYQGRLDRNSIERQLWWTRGPNHEDPFETLVPHSQRKVQLISLLGEA
ALHGEKFYRKIASRVIQEVKEGGLEIYIPGWQAMFRWMRFHDLSLWTGDRNLLPDYVN
DDGV"
mat_peptide <1..1183
/gene="ORF1"
/product="p48"
mat_peptide 1184..2272
/gene="ORF1"
/product="NTPase"
mat_peptide 2273..2872
/gene="ORF1"
/product="p22"
mat_peptide 2873..3292
/gene="ORF1"
/product="VPg"
mat_peptide 3293..3835
/gene="ORF1"
/product="Pro"
mat_peptide 3836..5365
/gene="ORF1"
/product="RdRp"
gene 5352..6983
/gene="ORF2"
CDS 5352..6983
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58819.1"
/translation="MMMASKDAPTNMDGTSGAGQLVPEVSAAEPISMEPVAGAATAAA
TAGQVNMIDPWIMSNYVQAPQGEFTISPNNTPGDILFDLQLGPHLNPFLSHLAQMYNG
WVGNMKVRVLLAGNAFTAGKIIISCVPPGFAAQNISIAQATMFPHVIADVRVLEPIEV
PLEDVRNVLFHNNDSTPTMRLICMLYTPLRASGSSSGTDPFVIAGRVLTCPSPDFNFL
FLVPPNVEQKTKPFSVPNLPLNVLSNSRVPSLIKSMMVSQDHGQMVQFQNGRVTLDGQ
LQGTTPTSASQLCKIRGTVYHATGGQGLNLTEIDGTPYHAFESPAPIGFPDVGECDWH
INASPANTFTNGSIIQRIDVVQDSTFAPHLGTIHYTNANYDANVSLICSLEWLSPPSN
GAPKVNPWAIPRYGSTLTEAAQLAPPIYPPGFGEAIVFFMSDFPIANGSDGLSVPCTI
PQEFVTHFVNEQAPTRGEAALLHYVDPDTHRNLGEFKLYPEGFMTCVPNSSGSGPQTL
PINGVFTFISWVSRFYQLKPVGTTGPVRRLGIRRS"
gene 6983..7630
/gene="ORF3"
CDS 6983..7630
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58820.1"
/translation="MAQAIFGAIAATAAGSAVGAGIQAGTEAALQHQRFQQDLTLQSN
TFKHDKEMLGLQVGASTALLQNSLNTRYNMLTNAGLSSSDAARMVVGAPATRIVDWNG
TRVSAPRSTATTLRSGGFMTIPTLYKGKQQQKAPTEIGLSNPNYGSTVSSRVADWVSS
QNSSRSSLGPYHPNALQTAWVTPPGSSSTSTISSVSTAPRYFNTDRLPLFANMRK"
ORIGIN
1 tgctgatgtc agcaataaca atgctaacac caacaatgat aacattggat cccgccttat
61 ggcgaagatc cgtgggcgta taggcccaca acgtggcgaa acaaccacaa agataaaaga
121 tgccaatatg gcacttgacc tgttgcgccg gtcacagaca ccttctccat cccggcaaga
181 gagccccccc aagggccaga gagaccgccc ccctcggacc gcctctgagg tgaggagagt
241 gatgggatgg gatgttgaac cagaacatca agagagcacg gccaaagcat ggtgtgatct
301 cacacaagaa gagaaggagg agataatgcg caacaatgaa aagctttttg atgctggggg
361 agttactcca tcaaccttac ctagcacatt tgaaagagct ggcccagttg acagccccgg
421 tgaacagcaa cctgtaacgt ggtctgccag tagtggggtt gatatcggca ttgacgacct
481 aactactgtt cgtggcccat tctggaacat gtgtcccctt ccaccattgg atgcccggaa
541 caatggcccc gctaaagagc ccctcattgg ggacatgata gagttttacg agggccacat
601 atttcattat gccatctata ttggacaggg taagaccatt ggggttcact caccgcaagc
661 agctttctcc atacctagaa taactattca tcctctagtg gcctggtggc gcgtgtgtta
721 tgtcccaact aaccaacagc gcctcaccta tgaccaactc aaagaattag agaacgaacc
781 atggccctat gcctccatca caaacaactg ctatgaattc tgttgcagag tgatggcact
841 tgacgacacc tggcttgaga ggaggctagt cagcacagga aagttcaacc atcccacaca
901 agattggtca caggacaccc cagatttcca ccaagattct aaacttgaga tggtgagaga
961 cgctgtgcta tcagctatta atggccttgt gtcacaaccc ttcaaaaaca ttttaacaaa
1021 gattaaacca ttgaatgttc tcaatctctt gtcaaattgt gattggactt tcatgggggt
1081 tgtagaatta attgtactcc tagcagagct ttttgatgta ttctggaccc caccagatat
1141 ttcaagcttc attgcctcat tactacctga attccaccta cagggcccag aagacctggc
1201 tagggacttg gtccccctca tcttaggtgg cataggcctg gctatcggct ttacaagaga
1261 taaagtgaca aaggtgatga agagcgccgt cgacgggctg cgatcggcaa cacagcttgg
1321 gcagtacgga ctggagatat tctcaatcat taagaaatac ttctttggtg gggaccaaac
1381 agaaaagacc ttgcgaggta tagaggatgc agtgatagac atggaagtgt tgtccagcac
1441 taatgtgaca caattagtca aagataagaa actggctaga acatacatga atgtactgga
1501 taatgaagag gaaaaggcaa gaaaactctc agtccgcagt gctgacccac acatagtgac
1561 ctcagtcaac aacttgatat cacggatttc catggcaaga tcagccttgg ctaaagccca
1621 ggccgaaatg acatctcgcc cacgcccagt ggtcataatg atgtgtggcc ctcccggcat
1681 cggaaagacc aaggccgccg agcacctggc cggtcgattg gccgctgaaa ttagaccagg
1741 aggtaaggtt ggtcttgtgc cccgggagtc catagaccac tgggacggat atcatggtga
1801 ggatgtctta ttgtgggatg attatggcat gtcaaagata acagaggact gcaacaagct
1861 gcaggccata gctgacactg cacccctatc gctcaactgt gacaggatag agaacaaagg
1921 tatgcaattc tcctcagatg caataattat aaccactaat gctcctggtc ctgccccagt
1981 ggactttgtc aacctgggtc ctgtgtgcag gcgagtggac ttcctagtct actgctctgc
2041 ccctgaaatt gagcaaatga gaagaaccca ccctggtgat gccaatgcta ttaaggatct
2101 gtataaaaga gactattcac acttaaaaat ggaattggcc ccacagggtg gctttgatag
2161 tcagggtaac acaccatttg ggaaaggcat catgaagccc acaactctca ataggctact
2221 cattcaggca acagcattgg ctatggagcg gcaagatgag ttccaactcc aaggggctgt
2281 ctacaacttt gatgaggata gggtgtccgc ctttacaagc ctggcccgcg ccaacggctt
2341 agggctcgtg agcatggcaa cgctgggtaa aaggctcaga agcgtcaagt ccatggaggg
2401 tctgcgcaat gcattagtgg gctataagat aggagagtgt gacataatct ggaacaccag
2461 ggtgtattca atcaagagtg acggtagtac cgtcacaatt aaagaaaaac aggccccaac
2521 ctcctctcag catcaggcca tctgcacagc cactctcgcg ctctctagat tgcgagctgc
2581 cagagctctt gcgtatgcct cctgtctgca aagtgcagtg ctatcaatac tccaggtggc
2641 tggctctgcc ctagtggtga gtagggctgt gaaacgcatg tttggcacac gcactgagca
2701 acctatgtta gagggcaagc acaaagagca caactgtaga gtgcaccgtg cagaagcagc
2761 cggccatggc cccattggac atgatggggt cattgaacgc tatggcttgt gtgagagtga
2821 gcaagaagaa gaaggtgagc aaacggttga gttaccaact gccaataaag aaggtaaaaa
2881 caagggcaag accaaaaagg gccgtgggcg gaaatccaac ttcaacgctt tctcaagacg
2941 cggcctcagt gatgaagaat atgaagaata caaaaagatt agagaagaga aaagtggtaa
3001 ctacagcatc caggagtacc tcgaggatcg ccagcgttac gaggaagaac ttgctgaagt
3061 gcaggccggc ggggatggtg gaatcggtga gactgaggcg gagatccgcc atcgagtttt
3121 ctacaagtca aagtccggca tgaggaaaca acgccaagaa gagcggcgtc aactgggcct
3181 cgtcagcggc tctgagattc gcaagcgcaa gcccatagac tggacccctc ctaagaatga
3241 ttggtcagaa gacaccagaa ctgttaacta tgatgaacac atcagttttg aggcccctcc
3301 ctcaatttgg agtagggtgg tgaagtttgg tagtggctgg ggtttttggg tgagttcaac
3361 agtgttcata actacaaccc atgttatacc acctggagct aaagaaatct ttggtgaaaa
3421 ccttggcaat gtggccattc acagggttgg tgaatttacc caattccgct tctccaaaaa
3481 gatgaggcct gacctcactg gcatggttct agaagagggt tgcccagaag gaacagtgtg
3541 cactataatg atcaaaagag actctggtga gctattgcca cttgctgttc ggatgggggc
3601 agtggcttca atgaagatcc aaggtaaact tatgcatggg cagtcaggga tgctgctcac
3661 cggtgccaat gccaaaggca tggacctcgg aactatacct ggtgactgtg gggctcccta
3721 tgtccacaaa agaggaaacg attgggtagt atgtggggtc catgcggctg ccacaaaatc
3781 aggcaacact gtggtgtgtg ctatacaggg tggagacggt gaggccacgc tggagggtgg
3841 cgaccaaaat aagggacact acgcagggca tccaatattg agatatggaa atggcccctc
3901 gctgtcaacc aagacaaaat tctggaagtc caccccccag ccattgcccc ccggcacata
3961 tgaaccagct taccttggtg gtagggaccc tagagttgag gggggcccat ccttacaaca
4021 ggtgttaagg gaccagttga aaccattcgc cgagccccgt ggcaggttac ccgaagcggg
4081 cctgttggaa gcagcagttg aaacggtctc taatgcaatt gaacaggtca tggacacacc
4141 agtggcatgg agttatagtg acgcttgcat gtcactagac aagacaacca gttccggtta
4201 ccctcatcat aaaaagaaga atgatgattg gaatggaaat tcatttgtga gagaactggg
4261 tgaccaggcg gcgcatgcca atagcatgta tgaacttggc aagtccatga agcctgtgta
4321 cacagcagcc ctcaaagacg agctagtcaa gccagataag gtgtacacta aaatcaaaaa
4381 gagattgctt tggggcgcgg atcttggcac cgtcatccgc gctgccagag cttttgggcc
4441 attctgtgaa gccataaaat cccatgtaat caaactgcct attaaggtgg gcatgaacgc
4501 catagaggat ggccctttga tctatgcaga gcactctaag tataaattcc actatgatgc
4561 tgactacaca gcttgggact caacacaaaa cagggagatc atgatggaat cttttaacat
4621 tatgtgcaag ctcacagcca acccttcctt ggccgcagta gtggcacaag atctgctctc
4681 tccatctgaa atggacgttg gtgattatgt gatcagtgtt aaagatggct taccatctgg
4741 tttcccatgc acttcacaag tgaatagcat caaccactgg atcctgaccc tatgtgcatt
4801 gtcagaagtc actggcttgt cccctgatgt gatacaatca cagtcttatt tctcatttta
4861 tggtgatgat gagattgttt caacagacat agagtttgac ccaatcagat taacacaagt
4921 actgaaggag tatggtttga aacccacaag acctgataaa actgatggcc caattgttgt
4981 tagacagcag gtggatggcc tggttttcct ccgccgcacc atctctaagg atgccattgg
5041 gtaccaggga cggctcgacc gtaactccat tgaaagacag ctttggtgga cccgcggacc
5101 aaaccacgag gacccgtttg aaacgctagt cccacactcg cagaggaagg ttcagctgat
5161 atctctgctg ggtgaagcag cactccatgg tgagaaattc tataggaaaa tagccagtag
5221 ggtcattcaa gaagtcaagg agggggggct tgaaatctac atccctggtt ggcaggccat
5281 gttccgctgg atgcgattcc atgatttgag cttgtggaca ggagaccgca atctcctgcc
5341 cgattatgta aatgatgatg gcgtctaagg acgccccgac aaacatggat ggcaccagtg
5401 gtgccggtca gctggttcca gaggttagtg cagctgaacc tatatcaatg gaacctgtgg
5461 ctggtgctgc tacggcagca gcaaccgcag gccaagttaa tatgattgac ccctggatta
5521 tgagtaatta tgttcaagcc cctcaaggag aattcacaat ttcccctaac aatacccccg
5581 gggacatatt gtttgattta cagttaggcc ctcatttaaa cccatttcta tcacacctgg
5641 cccagatgta taatgggtgg gttggcaata tgaaagtcag agtgctgctt gctggtaatg
5701 cttttacagc gggtaagata ataattagtt gtgttccccc aggcttcgca gcccagaata
5761 tttcaatagc ccaagccaca atgtttcctc acgttattgc tgatgtacga gtgctagaac
5821 cgattgaggt cccattagag gatgtgagga atgtgctttt ccataacaat gattccaccc
5881 caactatgag attgatttgt atgctgtaca cccctctccg tgccagtggt agttcttccg
5941 gcactgaccc atttgttata gctggccggg ttctcacctg ccccagccct gatttcaact
6001 ttttgttcct tgtgccccct aatgttgagc agaaaactaa gccatttagt gtgcccaatc
6061 taccccttaa tgttctttca aattctagag ttccctcttt gataaagtcc atgatggtct
6121 cccaagacca tgggcagatg gtgcaattcc aaaatggcag ggtcacattg gatgggcagc
6181 tccaaggcac cacccccact tcagccagtc aactttgtaa gattcggggg acggtctacc
6241 atgcaactgg tggccaaggg ctcaacttga ctgagataga tggtaccccc taccatgcat
6301 ttgagagccc cgccccaatt ggctttcccg atgtgggtga gtgtgattgg cacattaatg
6361 catctcctgc caatactttt acaaatggta gcattataca aagaattgat gtggttcagg
6421 attctacttt tgccccccat ctaggcacta tccattacac caatgctaat tatgatgcta
6481 atgttagtct gatttgctcg cttgaatggc tttctccccc aagtaatggt gccccaaagg
6541 taaatccatg ggctattcct cggtatggtt caactctaac tgaggctgct cagctggccc
6601 caccaatata cccccctggt tttggcgagg caattgtttt ctttatgtct gatttcccca
6661 tagctaatgg ttcagatggc ctgagtgtcc cttgcaccat accacaagag tttgtgaccc
6721 attttgtcaa tgagcaagca ccaacccgtg gggaagccgc cctccttcat tatgttgacc
6781 cagatacaca tcgcaatctg ggtgagttca aattataccc tgaaggattc atgacttgtg
6841 tgccaaactc tagtggcagt ggtccccaaa cgctgcccat caatggggtt ttcactttca
6901 tttcttgggt ttcccgtttt taccagttga agcctgtggg aacgaccgga ccggttcgta
6961 ggcttggaat caggagatca taatggccca agcaatattt ggagcaatag ctgcgacggc
7021 tgctggcagt gctgtaggtg cgggcatcca agctggtact gaggctgcgc tccaacacca
7081 gcgctttcag caggacttaa cgttgcagag taatactttt aaacatgata aggaaatgtt
7141 ggggttgcag gttggtgcct ccactgccct cttacaaaat agtctcaaca cccgctacaa
7201 catgctcact aatgctggcc tctcgtcctc ggacgcagcc cgcatggtgg ttggcgcgcc
7261 tgccacgcgt attgtggact ggaatggcac cagagtatcg gcaccacggt ccactgccac
7321 cacgctgagg tctggtggtt tcatgacaat cccaacttta tacaaaggca aacaacagca
7381 gaaagctcca actgaaattg gcttatctaa cccaaattat gggtcaactg tatcttcaag
7441 ggttgctgat tgggtttcct ctcaaaattc ttcccgttcg tccttgggcc cgtaccaccc
7501 taatgcattg caaacagcat gggtgacacc acctggctca agttctacct ctactatttc
7561 ttctgtgtct accgcaccta gatatttcaa tactgatagg ttgcctctat tcgcaaatat
7621 gagaaaatag ttttgtaata tgaaatgtgg gcatcatatt caattggatt tgattaattg
7681 ctaatctggt ctaattatca atttg
//