Typing tool
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Typing tool
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Complete norovirus genomes
| MW305493 | GI.3 | |
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| GI.P3 |
ORF1: 1..5374
ORF2: 5358..6992
ORF3: 6992..7639
LOCUS MW305493 7659 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GI isolate C91 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305493
VERSION MW305493.1
KEYWORDS .
SOURCE Norovirus GI
ORGANISM Norovirus GI
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7659)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7659)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7659
/organism="Norovirus GI"
/mol_type="genomic RNA"
/isolate="C91"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122928"
/country="French Guiana"
/collection_date="14-Mar-1978"
/note="genotype: GI.3[GI.P13]"
gene <1..5374
/gene="ORF1"
CDS <1..5374
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QPJ58815.1"
/translation="ADVSNNNANTNNENIGSRLMAKIRGRIGPQRGETTTKIKDANMA
LELLRRSQTPSPSRQDNNCPPKAQRDRPPRTASEVKRAMGWDTEPEHQESTARAWCDL
SKEEKEEIMRNNEKLFDAGGVTPSTLPSTFERADSSCVTNEQQAVTWSASDGVNIGVN
DLTTVRGPFWNMCPLPPMEARNSGPAKEPRIGDMIEFYEGHIFHYAIYIGQGKTIGVH
SPQAAFSIPRITIHPLVAWWRVCYVPTDQQRLTYDQLKELENEPWPYASITNNCYEFC
CKVMALDDNWLQRKLVNSGKFNHPTQDWSQDTPDFHQDSKLEMVRDAVLSAINGLVSQ
PFKNILSKIKPLNVLNLLSNCDWTFMGVVELIVLLAELFDVFWTPPDISSFIASLLPD
FHLQGPEDLARDLVPLILGGIGLAIGFTRDRITKVMKSAVDGLRSATQLGQYGLEIFS
IIKKYFFGGDQTEKTLRGIEDAVIDMEVLSSTNVTQLVKDKKLAKAYMNVLDNEEEKA
RRLSVRSADPHIVTSVNNLISRISMARSALAKAQAEMTSRPRPVVIMMCGPPGIGKTK
AAEHLANRLATEIRPGGKVGLVPRESIDHWDGYHGEDVLLWDDYGMSKITEDCNKLQA
IADTAPLSLNCDRIENKGMQFSSDAIIITTNAPGPAPVDFVNLGPVCRRVDFLVYCSA
PEIEQTRRAHPGDANAIKDLYKKDFSHLKMELAPQGGFDSQGNTPFGKGVMKTTTLNR
LLIQATALAMERQDEFQLQGAVYNFDEDRVTAFTNLARANGLGLISMATLGKKLRSVK
SMEGLRNALVGYKIGECDIIWNTRVYSIKSDGSTITVKERQAPSSPQRQAISTATLAL
SRLRAARALAYASCLQSAVLSILQVAGSALVVSRAVKRMFGTRTEQPMLEGKHKEHNC
RVHRAEAAGHGPIGHDGIIERYGLCESEQDGEDDQIVELPTADKEGKNKGKTKKGRGR
KSNFNAFSRRGLSDEEYEEYKKVREEKGGNYSIQEYLEDRQRYEEELAEVQAGGDGGI
GETEAEIRHRVFYKSKSGMRKQRQEERRQLGLVSGTEIRKRKPIDWTPPKNDWSEDTR
TVNYDEHISFEAPPSIWSRVVKFGSGWGFWVSSTVFITTTHVIPPGAKEIFGESLSNV
AIHRVGEFTQFRFSKKMRPDLSGMVLEEGCPEGTVCTIMIKRDSGELLPLAVRMGAVA
SMKIQGKLMHGQSGMLLTGANAKGMDLGTIPGDCGAPYVHKRGNDWVVCGVHAAATKS
GNTVVCAIQGGEGEATLEGGGQNKGHYAGHPILRYGNGPSLSTKTKFWKSNPQPLPPG
TYEPAYLGGRDPRVEGGPSLQQVLRDQLKPFAEPRGRLPEAGLLEAAVETVTNAIEQV
MDTPVAWSYNDACMSLDKTTSSGYPHHKRKNDDWNGSSFVRELGDQAAHANSMYELGK
PMKPVYTAALKDELVKPDKVYNKIKKRLLWGADLGTVIRAARAFGPFCEAIKPHVIKL
PIKVGMNAIEDGPLIYAEHSKYKYHYDADYTAWDSTQNREIMMESFNIMCKLTANPSL
AAVVAQDLLSPSEMDVGDYVISVKDGLPSGFPCTSQVNSINHWILTLCALSEVTGLAP
DVIQSQSYFSFYGDDEIVSTDIEFDSNRLTQVLKEYGLKPTRPDKTDGPIIIRQQVDG
LVFLRRTISKDAIGYQGRLDRNSIERQLWWTRGPNHEDPFETLVPHAQRKVQLISLLG
EAALHGEKFYRKIASRVIQEVKEGGLEIYIPGWQAMFRWMRFHDLSLWTGDRDLLPDY
VNDDGV"
mat_peptide <1..1189
/gene="ORF1"
/product="p48"
mat_peptide 1190..2278
/gene="ORF1"
/product="NTPase"
mat_peptide 2279..2878
/gene="ORF1"
/product="p22"
mat_peptide 2879..3298
/gene="ORF1"
/product="VPg"
mat_peptide 3299..3841
/gene="ORF1"
/product="Pro"
mat_peptide 3842..5371
/gene="ORF1"
/product="RdRp"
gene 5358..6992
/gene="ORF2"
CDS 5358..6992
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58816.1"
/translation="MMMASKDAPTNMDGTSGAGQLVPEANTAEPISMEPVAGAATAAA
TAGQVNMIDPWIMNNYVQAPQGEFTISPNNTPGDILFDLQLGPHLNPFLSHLAQMYNG
WVGNMKVKVLLAGNAFTAGKIIISCIPPGFASQNISIAQATMFPHVIADVRVLEPIEV
PLEDVRNVLFHNNDNTPTMRLVCMLYTPLRASGSSSGTDPFVIAGRVLTCPSPDFSFL
FLVPPNVEQKTKPFSVPNLPLNVLSNSRVPSLIKFMMVSQDHGQMVQFQNGRVTLDGQ
LQGTTPTSASQLCKMRGTVYHASGGQGLNLTEIDGTPYHAFESPAPIGFPDLGDSDWH
INASPATTFNTGESVKRLDMEQGSSFAPHLGTVHYTNADYDANTDLICSLEWLSPPSG
GTPNKVNPWAIPRYGSTLTEAAQLAPPIYPPGFGEAIVFFMSDFPIANGQDGLKVPCT
IPQEFVTHFVNEQAPTRGEAALLHYVDPDTHRNLGEFKLYPEGFMTCVPNSSGSGPQT
LPINGVFTFVSWVSRFYQLKPVGTTGPVRRLGIRRS"
gene 6992..7639
/gene="ORF3"
CDS 6992..7639
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58817.1"
/translation="MAQAIFGAIAATAAGSAVGAGIQAGTEAALQHQRFQQDLTLQSN
TFKHDKEMLGLQVGASTALLQNSLSTRYNMLTNAGLSSSDAARMVVGAPATRVVDWNG
TRISAPQSTATTLRSGGFMTIPTLYKGKQQQKAPTEIGLSNPNYGSSASSRTADWVLS
QNSSRSSLGPYHPNALQTTWVTPPGSSSTSTISSVSTAPRYFNIDRLPLFANMRK"
ORIGIN
1 tgctgatgtt agcaacaaca atgccaacac caacaatgaa aacattggat cccgccttat
61 ggcgaagatc cgtgggcgta taggcccaca acgtggtgaa acaaccacga agatcaagga
121 tgccaatatg gcacttgaac tgttacgccg gtcacaaaca ccatccccat ctcgacaaga
181 taacaactgc ccccctaaag ctcaaaggga ccgccccccg cggaccgcct cagaggtgaa
241 gagggcaatg ggatgggata ctgagccaga acatcaagaa agcacagcta gagcatggtg
301 tgacctctca aaagaagaga aggaggaaat aatgcgcaac aatgaaaaac tttttgatgc
361 tggaggtgtt actccttcga ccttgcccag cacatttgag agggctgatt caagctgtgt
421 cactaatgaa caacaggctg tgacatggtc tgctagtgat ggggttaata ttggcgttaa
481 tgacttgacc accgttcgtg gcccgttttg gaacatgtgc cccctcccac caatggaagc
541 ccgtaacagt ggccctgcta aggaaccccg tataggggac atgatagaat tctatgaggg
601 ccatatattc cattatgcta tttatattgg gcaaggcaag accattggag ttcactcacc
661 acaagccgct ttctccatac ccagaataac catccaccct ttagtggctt ggtggcgtgt
721 gtgttatgtt cccactgacc agcagcgcct cacctatgat caacttaagg aattagaaaa
781 tgaaccatgg ccctatgcct ctattaccaa caactgctat gagttctgtt gcaaggtgat
841 ggcacttgac gacaactggc tccaaagaaa attggtcaac agtgggaagt tcaaccaccc
901 cacacaggac tggtcacaag acaccccaga tttccatcag gattcaaaac ttgagatggt
961 gagagacgcc gtgttatcag ccattaatgg tcttgtgtcg caacccttca aaaacatttt
1021 gtcaaagatc aaaccattaa atgtgctcaa tctcctatca aattgtgatt ggaccttcat
1081 gggtgtcgta gagctgatcg tgctcttggc agaattattt gatgtgttct ggaccccacc
1141 agacatctca agttttattg cttcactact acctgatttt cacctgcagg gccctgagga
1201 cttggccaga gacttggtcc ccctcatatt gggtggtatt ggtctagcaa ttggttttac
1261 aagggacaga ataacaaagg tgatgaagag tgccgttgat gggctgcggt cagcaacaca
1321 gcttgggcag tatgggttag agatattttc aattattaag aaatatttct ttggagggga
1381 ccaaacagaa aagaccctgc ggggtattga agatgcagtg atagatatgg aagtgttatc
1441 cagcaccaat gtgacacaat tggttaaaga caaaaagtta gccaaagcat acatgaatgt
1501 gctagacaat gaggaagaaa aggcaagaag actctcagtt cgcagtgctg acccacatat
1561 agtgacatct gttaacaact tgatatcacg tatatccatg gcaaggtcag ctctggctaa
1621 ggcccaggct gaaatgacat cccgcccacg accagtagtc ataatgatgt gtggtcctcc
1681 tggtattggg aagaccaagg ctgccgagca cctagctaac cggttggcta ctgaaatcag
1741 gcctgggggc aaagttggcc ttgtaccccg agagtctata gatcattggg atggatacca
1801 tggtgaggat gttctactct gggatgacta tggcatgtca aagataacag aggattgcaa
1861 caagctacag gccatagctg acactgcacc actttcactt aattgtgaca ggatagaaaa
1921 taagggcatg cagttctcct ctgatgcaat aatcataacc accaatgctc ctggcccagc
1981 cccagtagac tttgtcaacc taggccctgt atgcaggcgg gtggactttt tagtctactg
2041 ttctgctcct gagattgagc agacgcggag ggctcatcca ggtgacgcta atgccatcaa
2101 ggacctgtac aaaaaggact tctcacacct taaaatggag ttagctccac agggtggctt
2161 cgacagtcag ggcaacacac cgtttgggaa gggtgttatg aagaccacaa ctctcaacag
2221 gttgttgatt caggccacag cattagctat ggaacgacaa gatgagttcc aactccaagg
2281 agccgtctac aactttgatg aggacagagt gaccgctttc accaacctag ctcgcgccaa
2341 tggcttgggg ctcataagca tggcaacatt aggcaagaaa ttgaggagtg tcaaatctat
2401 ggaaggtctg cgcaatgcat tggtgggata caagattggg gagtgcgaca taatctggaa
2461 caccagagtg tactcaatta agagtgatgg gagcaccatt acggtcaaag aaagacaagc
2521 cccatcctca ccccaacgtc aagctatctc cacagccacc cttgcgctct ccaggctgcg
2581 agctgctaga gcccttgcgt acgcctcctg cttgcaaagt gcagtactat caatactaca
2641 ggttgctggc tctgccttag tggtgagcag ggctgtgaaa cgcatgtttg gcacacgcac
2701 cgaacaaccc atgttggaag gtaagcacaa ggaacacaat tgcagggtac atcgtgcaga
2761 ggccgccggt catggtccca ttggtcatga tgggatcata gaacgctatg gtctgtgtga
2821 gagcgaacag gatggggaag atgaccagat tgtggaattg cccaccgccg ataaagaagg
2881 caagaacaaa ggtaagacca aaaagggccg cgggcggaaa tccaacttca atgccttttc
2941 gaggcgtggc ctcagtgatg aggaatatga ggagtacaag aaggttaggg aagagaaggg
3001 tggcaactac agtatacaag agtatcttga ggatcgccag cgctatgaag aggaacttgc
3061 tgaggtgcag gctggtggag atggtggaat cggtgaaact gaagcagaga tccgccaccg
3121 ggttttctac aaatcaaaat ctggcatgag aaaacaacga caagaggaac ggcgccagct
3181 aggtctcgtg agcggcactg aaatccgcaa gcgtaagccc atagattgga ctccccccaa
3241 aaacgattgg tcagaggata ctagaactgt caattatgat gaacacatca gcttcgaagc
3301 cccgccctca atttggagca gagtggtaaa atttggtagt ggttggggtt tttgggtgag
3361 ttcgacagtg tttatcacca caacccatgt tataccacct ggggctaaag agatctttgg
3421 tgagagcctc agtaatgttg ccattcatag ggttggtgaa ttcacccaat tccgcttctc
3481 caaaaaaatg agacctgacc tctctggcat ggtcttggaa gaaggctgtc cagaaggcac
3541 agtgtgtacc ataatgataa aaagagattc tggtgagctg ttgccacttg ctgttcgtat
3601 gggagcagtg gcttcaatga aaattcaagg aaaactcatg catgggcagt caggaatgtt
3661 actcactggt gccaatgcca agggtatgga ccttgggacc atacctggtg actgtggggc
3721 accctatgtc cataagagag ggaatgactg ggtagtctgt ggggtacatg cagcagccac
3781 gaaatcaggc aacactgtgg tatgcgccat acagggtggt gaaggtgaag ccacattaga
3841 gggtggcggc caaaataagg gacactatgc tgggcacccg atattgagat atggaaatgg
3901 tccttcactg tcaactaaaa caaaattttg gaaatcaaac ccccaacctt taccccctgg
3961 cacgtatgaa ccagcttacc tcggtggcag agaccccaga gttgaggggg gcccatcctt
4021 acagcaggta ttgagggacc aactaaaacc atttgctgag cctcgtggca gattacccga
4081 agcgggatta ctggaagccg cagttgagac tgtcaccaat gcaattgaac aggttatgga
4141 cacaccagta gcgtggagct acaacgacgc ctgcatgtct ttagacaaga caactagctc
4201 tggctacccc caccacaaaa gaaagaatga tgattggaac gggagttcat ttgtgagaga
4261 actgggagac caagcagcac atgctaatag catgtacgag cttggtaagc ccatgaagcc
4321 tgtttacaca gcagcactca aagatgaact cgtcaaacca gacaaggtat acaacaagat
4381 taagaagagg ttactttggg gagcagacct cggtactgtc atccgtgccg ctagggcttt
4441 tggaccgttc tgtgaggcca taaaacccca tgtgatcaag ttgcccatta aggtgggtat
4501 gaacgccata gaggatggcc ctctaattta tgcagagcac tctaagtaca aatatcatta
4561 tgatgctgac tacacagcat gggactcaac acaaaacaga gagattatga tggagtcctt
4621 taacatcatg tgcaagctta ctgctaatcc ttccctagcc gcagtagtgg cacaagatct
4681 gctttcccca tctgagatgg atgtcggtga ctatgtgatc agtgtcaagg atggtctgcc
4741 atctggcttt ccatgcacct cacaagtgaa cagcatcaac cactggatat tgaccttgtg
4801 tgccttgtca gaagtcactg gtctggctcc tgatgtaata cagtcacaat cttacttttc
4861 attctatggt gatgatgaga tagtttcaac ggatattgaa ttcgattcaa acagattgac
4921 acaagtgtta aaagagtatg gcctaaaacc cacaaggcct gacaaaactg atggtccaat
4981 cataattaga caacaggttg atggcttggt cttcctccga cgcaccatct caaaagatgc
5041 tatcgggtat caggggcggc ttgatcgcaa ttccattgaa aggcagttgt ggtggacccg
5101 tgggcccaat catgaagacc catttgagac cctagtccca cacgcgcaaa ggaaggtcca
5161 gttgatatct ttattgggtg aagctgcact ccatggtgaa aagttctaca gaaagatagc
5221 cagcagggta atccaagagg ttaaagaggg aggactggaa atttacatcc ctggctggca
5281 ggccatgttc cgctggatgc gattccatga tttgagtttg tggacaggag accgcgatct
5341 cttgcccgat tatgtaaatg atgatggcgt ctaaggacgc cccaacaaac atggatggca
5401 ccagtggtgc cggccagctg gtaccagagg cgaatacagc tgagcctata tcaatggagc
5461 ccgtggctgg ggcagcaaca gctgccgcaa ccgccggcca agttaatatg attgacccct
5521 ggattatgaa taattatgtg caagcccctc aaggcgaatt caccatatca ccaaataata
5581 cacctggtga tattttattt gatttacaac taggccccca cctcaatccc tttctgtctc
5641 atttggccca aatgtataat ggctgggtag gtaatatgaa agtaaaagtt ctattggcag
5701 gtaacgcttt cacagcgggg aaaataatca ttagctgcat acctcctggc tttgcttcac
5761 aaaatatctc tatagctcaa gctacaatgt tcccccatgt tatagctgat gttagggtct
5821 tggagcccat tgaggtcccg ttggaggatg taagaaatgt gttattccat aacaatgaca
5881 acacaccaac catgaggctg gtatgcatgc tctacacccc cttgcgtgcc agtggaagtt
5941 catctgggac ggaccccttt gtgatagctg ggcgtgtgtt gacttgtcct agtccagact
6001 ttagctttct atttttggtt ccccccaatg tagaacaaaa gactaaaccc tttagtgtcc
6061 caaacctccc acttaatgtt ctttcaaact caagggtgcc atctctaata aaattcatga
6121 tggtgtcaca ggaccacggg caaatggtgc aattccaaaa tggcagagtc acgctggacg
6181 gacagctcca gggcactaca ccaacatcgg ccagccaact ctgtaagatg cgggggacgg
6241 tctatcacgc ctccggtggc caagggctca acttgactga aattgatggc actccttatc
6301 atgcatttga aagcccagcc cccattggtt tccctgattt aggagatagt gattggcaca
6361 ttaatgcttc acctgccacc accttcaaca ctggtgaaag tgtcaagagg ctggatatgg
6421 aacaaggttc ctcattcgcc ccgcatttgg gcactgtgca ttataccaat gctgactatg
6481 acgccaacac tgatttaatc tgctcattgg aatggctgtc cccccccagt gggggtaccc
6541 caaacaaagt caatccctgg gccataccac ggtacggttc gaccttaacc gaagccgctc
6601 aattggcccc accaatctac ccccctggct ttggtgaagc aatagttttc tttatgtctg
6661 attttcctat agcaaatggt caagatggat taaaagtacc ctgcactata ccccaagagt
6721 ttgtaaccca ttttgttaat gaacaagcac caacccgtgg ggaggctgcc ctcctccatt
6781 atgttgaccc tgacacacac cgcaatttgg gtgagttcaa attataccct gaagggttca
6841 tgacttgtgt accaaactcc agtggcagcg gtccccaaac gttgcccatt aatggggtct
6901 tcacttttgt ctcttgggtt tcccgtttct atcaattaaa gcctgtggga acgaccggac
6961 cggttcgtag gcttggaatc aggagatcat aatggcccaa gcaatatttg gagcaatagc
7021 agcaacggct gctggtagtg ctgtgggtgc gggcatccag gctggcactg aggccgcgct
7081 ccagcatcag cgcttccagc aggacttaac gctgcagagc aacactttca aacatgataa
7141 agaaatgtta ggattacagg ttggtgcttc cactgcccta ttacaaaata gtctcagcac
7201 ccgctacaac atgctgacca atgctggcct ctcgtcctca gacgcagcac gtatggtggt
7261 tggcgcgcca gccacacgtg ttgttgactg gaacggcact aggatatcag caccacaatc
7321 cactgccact acgctgaggt ctggcgggtt catgacaatt ccaactttat ataagggcaa
7381 acaacagcag aaagctccaa ctgagattgg cttatccaac ccaaattatg ggtcatctgc
7441 atcttcaagg actgctgatt gggttctttc tcaaaattct tctcgttctt ctttgggccc
7501 ataccacccc aatgccttac agacaacatg ggtgacacca cctggctcaa gttctacttc
7561 tactatttct tctgtgtcta ctgcacctag atattttaat attgataggt tgcctctatt
7621 cgcaaatatg aggaaataat tttgtaatat gaaatgtgg
//