Typing tool
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Typing tool
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Complete norovirus genomes
| MW305491 | GI.3 | |
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| GI.P13 |
ORF1: 1..5368
ORF2: 5352..6986
ORF3: 6986..7633
LOCUS MW305491 7695 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GI isolate B8 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305491
VERSION MW305491.1
KEYWORDS .
SOURCE Norovirus GI
ORGANISM Norovirus GI
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7695)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7695)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7695
/organism="Norovirus GI"
/mol_type="genomic RNA"
/isolate="B8"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122928"
/country="Central African Republic"
/collection_date="09-Aug-1977"
/note="genotype: GI.3[GI.PNA]"
gene <1..5368
/gene="ORF1"
CDS <1..5368
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QPJ58809.1"
/translation="ADVSNNNANTNNENIGSRLMARLRGRVGPQRGENTTKIKDANMA
LDLLRRSQTPSPSRQDHPPKDQRDRPPRTALEVRKTMGWDEEPRQQESTAKAWCDLTK
EEKEEIMRNNEKLFDAGGVAPAILPSTFERATPQENTDECQAVTWSASDGVDIGVDSL
KTVRGPPWNMCPLPPLEARNSGPAREPLIGDMVEFYEGHIFHYAIYIGQGKTIGVHSP
QAAFSIPRITIHPLVAWWRVCYTPTDQQRLTYDQLRELENEPWPYASVTNNCYEFCCK
VMALDDSWLQRKLITTGKFNHPTQEWSKDTPDFHQDSKLEMVRDAVLSAINGLVSQPF
KNILSKIKPLNLINLLSNCDWTFMGVVELIVLVAELFDVFWTPPDISSFIASLLPDFH
LQGPEDLAKDLVPLILGGIGLAIGFTRDRVTKVMKSAVDGLRSATQLGQYGLEIFSII
KKYFFGGDQTERTLRGIEDAVIDMEVLSSTNVTQLVRDKKSAKAYMNVLDIEEEKARK
LSVRSADPHIVTSVNNLISRISMARSALAKAQAEMTSRIRPVVIMMCGPPGIGKTKAA
EHLASRLASEIRPGGKVGLVPRESIDHWDGYHGEEVLLWDDYGMSKITEDCNKLQAIA
DTAPLSLNCDRIENKGMQFVSDAIIITTNAPGPAPVDFVNLGPVCRRVDFLVYCSAPE
IEQTRRAHPGDANAIKDLYKRDFSHLKMDLAPQGGFDNQGNTPFGKGVMKPTTLNRLL
IQATALTMERQDEFQLQGMVYNFDEDRVAAFTSLARANGLGLISMATLGKKLRGVKTM
EGLRNALVGYRIEECDIIWNTRAYSIKSDGKCVTVKERQSQTSSQHQAVSTATLALSR
LRAARAIAYASCLQSAVLSILQVAGSAVVVSRAVKRMFGTSTEQPALEGGHKEHNCRV
HRAQAAGHGPIGHDGIIERYGLCESEQEDESDQVMELPSANREGKNKGKTKKGRGRKS
NFNAFSRRGLSDEEYEEYKKIREEKSGNYSIQEYLEDRQRYEEELAEVQAGGDGGIGE
TEAEIRHRIFYKSKSGMRKQRQEERRQLGLVSGSEIRKRKPIDWTPPKNDWSEDTRSV
NYDEHISFEAPPSIWSRVVKFGSGWGFWVSSTVFITTTHVIPPGAKEIFGEAISNVAI
HRVGEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCTIMIKRDSGELLPLAVRMGAVASM
KIQGKLMHGQSGMLLTGANAKGMDLGTIPGDCGAPYVHKRGNDWVVCGVHAAATKSGN
TVVCAIQGGEGEATLEGGGQNKGHYAGHPILRYGNGPSLSTKTKFWKSNPQPLPPGTY
EPAYLGGRDPRVEGGPSLQQVLRDQLKPFAEPRGRLPEAGLLEAAVETVTNAIEQVMD
TPVAWSYSDACMSLDKTTSSGYPHHKRKNDDWNGSSFVRELGDQAAHANSMYELGKPM
KPVYTAALKDELVKPDKVYNKIKKRLLWGADLGTVIRAARAFGPFCEAIKPHVLKLPI
KVGMNAIEDGPLIYAEHSKYKYHYDADYTAWDSTQNREIMMESFNIMCKLTANPSLAA
VVAQDLLSPSEMDVGDYVISVKDGLPSGFPCTSQVNSINHWILTLCALSEVTGLAPDV
IQSQSYFSFYGDDEIVSTDIEFDPSRLTQVLKEYGLKPTRPDKTDGPIIIRQQVDGLV
FLRRTISKDAIGYQGRLDRNSIERQLWWTRGPNHEDPFETLVPHTQRKVQLISLLGEA
ALHGEKFYRKIASRVIQEVKEGGLEIYIPGWQAMFRWMRFHDLSLWTGDRDLLPDYVN
DDGV"
mat_peptide <1..1183
/gene="ORF1"
/product="p48"
mat_peptide 1184..2272
/gene="ORF1"
/product="NTPase"
mat_peptide 2273..2872
/gene="ORF1"
/product="p22"
mat_peptide 2873..3292
/gene="ORF1"
/product="VPg"
mat_peptide 3293..3835
/gene="ORF1"
/product="Pro"
mat_peptide 3836..5365
/gene="ORF1"
/product="RdRp"
gene 5352..6986
/gene="ORF2"
CDS 5352..6986
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58810.1"
/translation="MMMASKDAPTNMDGTSGAGQLVPEANTAEPISMEPVAGAATAAA
TAGQVNMIDPWIMNNYVQAPQGEFTISPNNTPGDILFDLQLGPHLNPFLSHLAQMYNG
WVGNMKVKVLLAGNAFTAGKIIISCIPPGFASQNISIAQATMFPHVIADVRVLEPIEV
PLEDVRNVLFHNNDNTPTMRLVCMLYTPLRASGSSSGTDPFVIAGRVLTCPSPDFSFL
FLVPPNVEQKTKPFSVPNLPLNVLSNSRVPSLIKSMMVSQDHGQMVQFQNGRVTLDGQ
LQGTTPTSASQLCKMRGTVYHASGGQGLNLTEIDGTPYHAFESPAPIGFPDIGDSDWH
INASPATTFDSGESIKRLDMEQGSSFAPHLGTVHYTNADYPANTDLICSLEWLSPPSG
GTPNKVNPWTIPRYGSTLTEAAQLAPPIYPPGFGEAIVFFMSDFPIANGQDGLKVPCT
IPQEFVTHFVNEQAPTRGEAALLHYVDPDTHRNLGEFKLYPEGFMTCVPNSSGSGPQT
LPINGVFTFVSWVSRFYQLKPVGTTGPVRRLGIRRS"
gene 6986..7633
/gene="ORF3"
CDS 6986..7633
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58811.1"
/translation="MAQAIFGAIAATAAGSAVGAGIQAGTEAALQHQRFQQDLTLQNN
TFKHDKEMLGLQVGASTALLQNSLTTRYNMLTNAGLSSSDAARMVVGAPTTRVVDWNG
TRISAPQSTATTLRSGGFMTIPTLYKGKQQQKAPTEIGLSNPNYGSSALSRTADWVSS
QNSSRSSLGPYHPNALQTTWVTPPGSSSTSTISSVSTAPRYFNTDRLPLFANMRK"
ORIGIN
1 tgctgatgtc agcaataaca atgctaacac caacaatgaa aacattgggt ctcgccttat
61 ggcgagactc cgcggacgtg taggtccgca gcgtggtgaa aacaccacaa aaataaagga
121 cgccaatatg gcgctcgacc ttttgcgccg gtcacagaca ccttccccat cccggcaaga
181 ccacccccca aaagatcaga gagatcgtcc accgcgcact gctctggagg tgaggaagac
241 aatggggtgg gatgaagagc caaggcaaca ggagagcacc gctaaggcgt ggtgcgacct
301 cacaaaggag gaaaaagagg agataatgcg caacaacgag aagctctttg atgctggggg
361 ggttgcccct gcaattttgc caagcacgtt cgagagggcc acgccacaag aaaacaccga
421 cgagtgtcag gcagtcacct ggtccgccag tgatggtgtg gacattggtg tggacagttt
481 aaaaacagtc cgtggccctc cttggaatat gtgccccctg ccacctttag aggctcgcaa
541 tagcggacct gcaagagagc cccttatagg ggatatggtt gagttttatg agggtcacat
601 ttttcattat gccatttaca ttgggcaagg aaagaccatt ggtgttcatt caccacaggc
661 agccttttct atacctagaa taactatcca tccattagtg gcttggtggc gagtgtgtta
721 cacacccaca gatcaacaga gacttactta tgaccaatta agagaactgg agaatgaacc
781 atggccctat gcctcagtca ccaataactg ttatgagttc tgctgcaagg taatggcact
841 tgatgactct tggctccaac ggaaattgat cactactgga aaatttaacc accctacaca
901 ggaatggtca aaagacaccc ccgactttca ccaagattca aagcttgaga tggttcggga
961 tgctgtgcta tcggccatta acggtcttgt gtcacaacct tttaaaaaca tcttgtcaaa
1021 aatcaagccc ctgaatctga ttaacctatt gtcaaattgt gactggactt ttatgggggt
1081 tgtggagctg atagtgcttg tggctgaact atttgatgta ttttggacac caccagacat
1141 ctccagtttt atcgcatcac tattgcctga ttttcatctt cagggtccag aggatttggc
1201 aaaggatctg gtccccctta tactaggtgg aattggcctc gcgattggct tcacaagaga
1261 cagagtcacc aaggttatga agagtgctgt tgacggattg cgttcggcaa cacagcttgg
1321 gcaatatgga ttagagatat tctcaattat taagaaatac ttctttgggg gtgaccagac
1381 agagagaacc ttacgaggca ttgaagatgc tgtgatagac atggaagttc tgtccagtac
1441 aaatgtgaca caattagtta gagataagaa atcagctaaa gcatatatga atgtattgga
1501 cattgaggag gaaaaggcca gaaaactttc agtccgtagc gctgacccgc acatagtaac
1561 ctcagtcaat aatttgatat ctcgcatctc catggcaagg tcagctttag ctaaagccca
1621 ggcagaaatg acatcccgta tacgcccagt agtgatcatg atgtgtggcc ccccaggcat
1681 tggcaaaaca aaagctgccg agcacttagc cagtcgattg gcctccgaaa tcaggccagg
1741 tggtaaggtt ggactcgtgc ctcgcgagtc catagaccat tgggacggct atcatggtga
1801 agaggtcctg ttatgggatg actatggcat gtcaaagata acagaagatt gcaacaagtt
1861 acaagccatt gctgacactg caccattgtc actgaactgt gataggatag agaacaaagg
1921 tatgcagttc gtctctgatg caataattat aacaaccaat gcccctggtc cagccccagt
1981 cgacttcgtc aatttggggc ccgtgtgcag acgagttgac tttctagtct actgttccgc
2041 acccgaaatt gaacagacac ggagggccca cccaggcgat gccaatgcta taaaagacct
2101 gtataagaga gacttctcac acctaaaaat ggatctggct ccacaagggg gttttgacaa
2161 tcagggtaac acgccctttg gtaagggtgt aatgaaaccc accaccctta accggctgct
2221 gatccaagcc actgcgctga ctatggaaag gcaagatgaa tttcaactcc aaggcatggt
2281 ttacaatttt gatgaggata gggtggcagc attcaccagc ttggctcgtg ccaacggatt
2341 agggcttatt agtatggcaa ctctgggcaa gaaactaaga ggtgttaaga ccatggaagg
2401 actgcgcaat gcgctggtgg ggtaccgaat agaagagtgt gacataattt ggaacactag
2461 agcctactca attaagagtg atggcaaatg tgtgacagtc aaggaaaggc aaagtcaaac
2521 ctcatcccaa catcaagctg tcagcacggc caccctcgcg ctctccaggc tgcgagctgc
2581 tcgagcgata gcatacgcat cctgcctaca aagcgccgtt ctttccatac ttcaggtggc
2641 tggctccgct gtggtggtta gcagggcagt gaaacgcatg tttggtacga gcaccgaaca
2701 gcccgcattg gagggcggac ataaagaaca caactgcagg gtccatcggg cacaggccgc
2761 aggccatggt cccatagggc atgatgggat cattgagcgc tatggtttgt gtgagagcga
2821 gcaagaggat gaaagtgatc aagtcatgga actgccatca gccaacaggg aaggtaaaaa
2881 caagggcaag accaagaagg gccgtggccg caagtccaac ttcaatgctt tttcacgacg
2941 tgggctcagt gatgaagaat atgaggagta caagaagatc agagaagaga agagtggtaa
3001 ttacagcatt caagagtacc ttgaagatcg ccaacgctac gaggaagaac ttgccgaagt
3061 acaagcaggc ggggatggtg gaattggtga aactgaggca gaaatccgcc accggatctt
3121 ctataagtca aaatctggca tgagaaagca gcgccaagaa gagaggcgac aattagggct
3181 tgttagtggt tctgagattc gcaagcgcaa gcctatagat tggacccccc ctaaaaatga
3241 ctggtctgaa gacaccaggt cagtcaatta tgatgaacac attagctttg aggccccccc
3301 ctcaatttgg agcagagttg tcaaatttgg tagcggttgg ggattttggg tgagctcaac
3361 agtgttcatc actacaacac atgttatacc acctggagct aaggagatct tcggggaagc
3421 cattagtaat gttgccatcc acagagttgg tgaattcact cagttccgtt tctccaaaaa
3481 gatgagacct gacctcacag gtatggtctt ggaagaagga tgcccagagg gcacagtatg
3541 taccattatg ataaaaaggg actctggtga gctgttacca cttgctgttc gtatgggagc
3601 agtggcctca atgaagattc aagggaaact catgcatggg cagtcaggga tgttacttac
3661 tggtgccaat gctaagggca tggaccttgg gaccatacct ggtgactgtg gggcacctta
3721 tgtccataag agagggaatg actgggtggt ctgtggggtg catgcggcgg ccacaaaatc
3781 aggcaacact gtagtatgtg ccatacaggg tggtgaaggt gaagccacat tagagggtgg
3841 tggccagaac aagggtcatt atgcagggca cccaatatta agatatggaa atggtccttc
3901 actgtcgacc aaaacgaaat tctggaaatc aaacccccaa cctttacccc ctggcacata
3961 tgaaccagct tatctcggtg gtagagaccc cagagttgaa gggggcccgt ccttgcagca
4021 agtgttaagg gaccaactaa aaccatttgc tgagccgcgt ggcaggttac ccgaagcggg
4081 actactggaa gccgcagttg aaactgtcac caatgcaatc gaacaggtta tggacacacc
4141 agtggcatgg agctacagcg acgcctgtat gtctctagac aaaacaacca gctctggcta
4201 cccccaccac aaaagaaaga atgatgattg gaacgggagt tcatttgtga gagagctggg
4261 agaccaagca gcgcatgcta acagtatgta cgagcttggt aaacccatga agcctgtata
4321 cacagctgcg ctcaaagatg agctcgtcaa accagacaag gtatataaca agattaaaaa
4381 gaggttactc tggggagcag atctcggcac tgtcatccgt gctgctaggg catttgggcc
4441 attctgtgag gccataaaac cccatgtgct caaactgccc attaaagtgg gtatgaatgc
4501 catagaggat ggccccctga tttatgcaga acactccaag tataagtatc attatgatgc
4561 tgattacaca gcctgggact caacacaaaa cagggagatc atgatggagt cctttaacat
4621 catgtgtaag ctcactgcta atccttccct agccgcggta gtggcacaag acctgctttc
4681 cccatctgaa atggatgttg gtgactacgt gatcagcgtc aaagatggtc taccgtctgg
4741 cttcccatgt acttcacaag tgaacagtat caaccactgg atcttgacct tgtgtgcctt
4801 gtcagaagtc actggtctgg ctcctgacgt aatacagtca cagtcttact tttcattcta
4861 tggtgatgat gagatagttt caacagacat cgaatttgac ccaagcagat taacacaggt
4921 gttaaaagag tatggcctaa aacccacaag acccgacaaa actgatggcc caattatcat
4981 tagacaacag gtcgatggtt tggtcttcct ccgacgcacc atctcaaaag atgccatcgg
5041 gtaccagggg cggcttgacc gcaattccat tgagaggcaa ctttggtgga cccgtgggcc
5101 caatcatgaa gacccattcg agaccttagt cccacacaca caaaggaagg ttcagctgat
5161 atctctgctg ggcgaagctg cactccatgg ggaaaagttc tacagaaaga tagctagcag
5221 ggtaatccaa gaggttaaag agggaggatt ggaaatttac atccctgggt ggcaggccat
5281 gttccgctgg atgcgattcc atgatttgag tttgtggaca ggagaccgcg atctcttgcc
5341 cgattatgta aatgatgatg gcgtctaagg acgccccaac aaacatggat ggcaccagtg
5401 gtgccggcca gctggtacca gaggcaaata cagctgagcc tatatcaatg gagcccgtgg
5461 ctggggcagc gacagctgcc gcaaccgctg gccaagttaa tatgattgac ccctggatta
5521 tgaataatta tgtgcaagcc cctcaaggtg aattcaccat atcaccaaac aatacaccag
5581 gtgatatttt atttgattta caactaggcc cccaccttaa tccatttcta tctcatttgg
5641 cccaaatgta caatggctgg gtgggcaata tgaaggtgaa agttctattg gcaggcaacg
5701 ctttcacagc aggaaaaata atcattagct gcatacctcc tggttttgct tcacaaaata
5761 tctccatagc ccaagccaca atgttccccc acgttatagc tgatgtcagg gtcctggagc
5821 ccatcgaggt tccgttggag gacgtaagga atgtgttatt ccacaacaat gacaatacac
5881 caactatgag gctggtatgc atgctctaca cccccttgcg cgccagcggg agttcatctg
5941 ggacagaccc ctttgtaatt gctgggcgtg tgctgacttg ccctagtcca gatttcagct
6001 ttttattttt agttcccccc aacgtagaac aaaagactaa accttttagt gttccaaatc
6061 ttccactcaa tgttctttca aactcgagag taccatccct aataaaatcc atgatggtgt
6121 cacaggacca cggacaaatg gtgcaatttc aaaatggcag agtcacgctg gacggacagc
6181 tccagggcac tacgccaacc tcagccagcc aactctgcaa gatgcggggg acggtttatc
6241 acgcctctgg tggccaaggg ctcaatttga ctgaaattga tggcactccc taccacgcct
6301 ttgaaagccc agcccctatt ggtttccctg acataggaga cagcgattgg cacattaatg
6361 cttcacctgc caccaccttt gacagcggtg aaagcatcaa aaggctagac atggaacagg
6421 gctcctcatt cgccccacat ttgggtactg tgcactacac aaatgctgac tatcctgcca
6481 atactgactt aatttgctca ttggaatggc tgtccccccc tagtgggggc accccaaaca
6541 aagtcaaccc ttggaccatc ccgcggtacg gttcaacctt aactgaagcc gcccaattgg
6601 ccccaccaat ttaccccccc ggttttggtg aagcaatagt tttcttcatg tctgatttcc
6661 ctatagcaaa tggtcaagat ggattgaaag taccctgcac tataccccag gaatttgtaa
6721 cccattttgt caatgaacaa gcaccaaccc gtggggaggc tgccctcctt cattatgttg
6781 accctgatac acatcgcaac ttgggtgagt tcaaattata ccctgaagga tttatgactt
6841 gtgtgccaaa ctccagtggc agcggtcccc aaacgctgcc cattaatggg gtcttcactt
6901 ttgtctcttg ggtttcccgt ttctatcaat taaagcctgt gggaacgacc ggaccggttc
6961 gtaggctcgg aatcaggaga tcataatggc ccaggcaata tttggagcaa tagctgcaac
7021 ggccgctggt agtgctgtgg gtgcgggcat ccaagctggc actgaggccg cactccaaca
7081 tcagcgcttc cagcaggact taacgttgca gaacaacact ttcaagcatg ataaggaaat
7141 gttaggactg caggttggtg cttccaccgc ccttttacaa aacagcctca ccacccgcta
7201 caacatgctt accaatgctg gcctctcatc ctcagacgca gcacgcatgg tggttggcgc
7261 gccaaccaca cgcgtcgtgg actggaacgg taccaggata tcagcaccac aatccactgc
7321 tactacactg aggtctggcg ggtttatgac aattccaact ttatataagg gcaaacaaca
7381 gcagaaagct ccaactgaaa ttggcttatc taatccaaat tatgggtcat ctgccctctc
7441 aagaactgct gattgggttt cttctcaaaa ttcttctcgc tcttccttgg gcccatacca
7501 ccctaatgcc ttgcagacaa catgggtgac accacctggc tcaagttcta cttctactat
7561 ttcttctgtg tctactgcac ctagatattt taatactgat aggttgcctc tattcgcaaa
7621 tatgaggaaa taattttgta atatgaaatg tgggcatcat attcaattga atttaattaa
7681 tcatttggtc taatt
//