Typing tool
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Typing tool
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Complete norovirus genomes
| MW305489 | GI.3 | |
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| GI.P3 |
ORF1: 1..5368
ORF2: 5352..6989
ORF3: 6989..7636
LOCUS MW305489 7709 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GI isolate 9-2 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305489
VERSION MW305489.1
KEYWORDS .
SOURCE Norovirus GI
ORGANISM Norovirus GI
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7709)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7709)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7709
/organism="Norovirus GI"
/mol_type="genomic RNA"
/isolate="9-2"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122928"
/country="USA"
/collection_date="18-Jan-1988"
/note="genotype: GI.3[GI.P3]"
gene <1..5368
/gene="ORF1"
CDS <1..5368
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QPJ58803.1"
/translation="ADVSNNNANTNNDNIGSRLMARIRGRIGPQRGETTTKIKDANMA
LDLLRRSQTPSPSRQESPPKSQRDRPPRTASEVKRVMGWDVEPEHQESTAKAWCDLTQ
EEKEEIMRNNEKLFDAGGITPSTLPSTFERADPIDNPGEQQPVTWSASGGVDIGINDL
TTVRGPFWNMCPLPPLDARNNGPAKEPLIGDMIEFYEGHIFHYAIYIGQGKTIGVHSP
QAAFSIPRITIHPLVAWWRVCYVPTNQQRLTYDQLKELENEPWPYASITNNCYEFCCR
VMALDDTWLERRLVSTGKFNHPTQDWSQDTPDFHQDSKLEIVRDAVLSAINGLVSQPF
KNILSKIKPLNVLNLLSNCDWTFMGVVELIVLLAELFDVFWTPPDVSSFIASLLPEFH
LQGPEDLARDLVPLVLGGIGLAIGFTRDKVTKVMKSAVDGLRSATQLGQYGLEIFSII
KKYFFGGDQTEKTLRGIEDAVIDMEVLSSTNVTQLVKDKKLARTYMNVLDNEEEKARK
LSVRSADPHIVTSVNNLISRISMARSALAKAQAEMTSRPRPVVIMMCGPPGIGKTKAA
EHLAGRLAAEIRPGGKVGLVPRESIDHWDGYHGEDVLLWDDYGMSKITEDCNKLQAIA
DTAPLSLNCDRIENKGMQFSSDAIIITTNAPGPAPVDFVNLGPVCRRVDFLVYCSAPE
IEQMRRAHPGDANAIKDLYKRDYSHLKMELAPQGGFDSQGNTPFGKGIMKPTTLNRLL
IQATALAMERQDEFQLQGAVYNFDEDRVSAFTSLARANGLGLISMATLGKRLRSVKSM
EGLRNALVGYKIGECDIIWNTRVYSIKSDGSTVTIKEKQTPTSPQHQAICTATLALSR
LRAARALAYASCLQSAVLSILQVAGSALVVSRAVKRMFGTRTEQPMLEGKHKEHNCRV
HRAEAAGHGPIGHDGVIERYGLCESEQEEEGEQTVELPTANKEGKNKGKTKKGRGRKS
NFNAFSRRGLSDEEYEEYKKIREEKSGNYSIQEYLEDRQRYEEELAEVQAGGDGGIGE
TEAEIRHRVFYKSKSGMRKQRQEERRQLGLVSGSEIRKRKPIDWTPPKNDWSEDTRTV
NYDEQISFEAPPSIWSRVVKFGSGWGFWVSSTVFITTTHVIPPGAKEIFGENLSNVAI
HRVGEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCTIMIKRDSGELLPLAVRMGAVASM
KIQGKLMHGQSGMLLTGANAKGMDLGTIPGDCGAPYVHKRGNDWVVCGVHAAATKSGN
TVVCAIQGGDGEATLEGGGQNKGHYAGHPILRYGNGPSLSTKTKFWKSTPQPLPPGTY
EPAYLGGRDPRVEGGPSLQQVLRDQLKPFAEPRGRLPEAGLLEAAVETVTNAIEQVMD
TPVAWSYNDACMSLDKTTSSGYPHHKKKNDDWNGNSFVRELGDQAAHANSMYELGKSM
KPVYTAALKDELVKPDKVYTKIKKRLLWGADLGTVIRAARAFGPFCEAIKPHVIKLPI
KVGMNAIEDGPLIYAEHSKYKFHYDADYTAWDSTQNREIMMESFNIMCKLTANPSLAA
VVAQDLLSPSEMDVGDYVISVKDGLPSGFPCTSQVNSINHWILTLCAMSEVTGLSPDV
IQSQSYFSFYGDDEIVSTDIEFDPIRLTQILKEYGLKPTRPDKTDGPIIVRQQVDGLV
FLRRTISKDAIGYQGRLDRNSIERQLWWTRGPNHEDPFETLVPHSQRKIQLISLLGEA
ALHGEKFYRKIASRVIQEVKEGGLEIYIPGWQAMFRWMRFHDLSLWTGDRDLLPDYVN
DDGV"
mat_peptide <1..1183
/gene="ORF1"
/product="p48"
mat_peptide 1184..2272
/gene="ORF1"
/product="NTPase"
mat_peptide 2273..2872
/gene="ORF1"
/product="p22"
mat_peptide 2873..3292
/gene="ORF1"
/product="VPg"
mat_peptide 3293..3835
/gene="ORF1"
/product="Pro"
mat_peptide 3836..5365
/gene="ORF1"
/product="RdRp"
gene 5352..6989
/gene="ORF2"
CDS 5352..6989
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58804.1"
/translation="MMMASKDAPTNMDGTSGAGQLVPEANTAEPISMEPVAGAATAAA
TAGQVNMIDPWIMNNYVQAPQGEFTISPNNTPGDILFDLQLGPHLNPFLSHLAQMYNG
WVGNMKVKVLLAGNAFTAGKIIISCIPPGFAAQNISIAQATMFPHVIADVRVLEPIEV
PLEDVRNVLFHNNDNAPTMRLVCMLYTPLRASGSSSGTDPFVIAGRVLTCPSPDFSFL
FLVPPNVEQKTKPFSVPNLPLNTLSNSRVPSLIKSMMVSRDHGQMVQFQNGRVTLDGQ
LQGTTPTSASQLCKIRGNVFHANGGNGYNLTELDGSPYHAFEGPAPIGFPDLGECDWH
MEASPTTQFDTGEVIKQINVKQESAFAPHLGTIQADGLDGVSVNTNMIAKLGWVSPVS
DGHKGNVDPWVIPRYGSTLTEAAQLAPPIYPPGFGEAIVFFMSDFPIAHGVNGLSVPC
TIPQEFVTHFVNEQAPTRGEAALLHYLDPDTNRNLGEFKLYPEGFMTCVPNSSGTGPQ
TLPINGVFVFVSWVSRFYQLKPVGTAGPARRLGIRRS"
gene 6989..7636
/gene="ORF3"
CDS 6989..7636
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58805.1"
/translation="MAQAILGAIAATAAGSAVGAGIQAGTEAALQHQRFQQDLTLQKN
SFNHDKEMMGLQVEASTALLQNSLGTRYNMLTRAGMTSADAARMVVGAPTTRVIDWNG
TRVAAPMSTATTLRSGGFMTVPTVYRGGKNKQSIGGGFSNVNYDPSISSSRTSQWVSS
QNSMRSTMEPFHPGALRTTWVTPPGSTSTSTISTVSTVPKFFNTERLPLFANRGK"
ORIGIN
1 tgctgatgtc agcaataaca atgctaacac caacaatgat aacattggat cccgcctcat
61 ggcgaggatc cgtgggcgta taggcccaca acgtggcgaa acaaccacaa agataaaaga
121 tgccaatatg gcacttgacc tgctgcgccg gtcacaaaca ccttccccat cccggcaaga
181 gagccccccc aagagtcaga gagaccgccc ccctcggacc gcctctgagg taaagagggt
241 gatgggatgg gatgttgaac cagaacatca ggagagcacg gctaaggcat ggtgcgacct
301 cacgcaagaa gagaaggagg agataatgcg caataatgaa aagctcttcg acgctggggg
361 aattactcca tcgactttgc ctagcacgtt tgagagggct gacccaattg acaaccccgg
421 tgaacagcaa cctgtaacat ggtctgccag tggtggggtc gacattggca tcaacgatct
481 aaccactgtc cgtggcccat tctggaacat gtgccccctt ccaccattgg atgcccggaa
541 caatggcccc gctaaagagc cccttatagg ggacatgata gaattttatg aaggtcacat
601 attccattat gccatatata ttggacaggg taagaccatt ggggttcact caccgcaagc
661 agctttctcc atacctagga taactatcca tcctctagtg gcttggtggc gcgtgtgtta
721 cgtcccaact aatcaacagc gcctcacata tgaccaactc aaagaattag agaatgagcc
781 atggccctat gcttccatca caaacaattg ctatgagttt tgctgtaggg tgatggcact
841 tgacgacacc tggcttgaga ggaggttggt cagcactgga aaattcaacc atcccacaca
901 agattggtca caggataccc cagattttca ccaagactca aagcttgaga tagtaagaga
961 tgctgtgtta tcagctatca atggccttgt atcacaaccc tttaaaaaca ttttatcaaa
1021 gatcaaacca ttgaacgttc tcaatctctt gtcaaattgt gattggactt ttatgggggt
1081 ggtagaacta attgtactcc tagcagagct gtttgatgta ttctggactc caccagatgt
1141 ttcaagcttc attgcctcac tactacctga attccaccta cagggcccag aagacctagc
1201 tagggacttg gtccctctcg ttctaggtgg cataggcctg gctattggct tcacaagaga
1261 taaagtgaca aaagtgatga agagcgccgt cgatgggctg cgatcggcga cgcagcttgg
1321 gcagtacggg ctggaaatat tctcaatcat taagaaatat ttctttggtg gggaccaaac
1381 agaaaagacc ttgcggggta tagaggacgc agtgatagat atggaggtgt tatccagtac
1441 caatgtgaca caactagtta aagataagaa gctggccaga acatacatga atgtgttaga
1501 caatgaagag gaaaaggcaa ggaaactctc agtccgtagt gctgacccac acatagtgac
1561 ctcagtcaac aatttgatat cacggatttc tatggcaagg tcagccttgg ctaaagctca
1621 ggctgaaatg acatctcgcc ctcgcccagt ggtcataatg atgtgtggtc cccccggcat
1681 cggaaaaacc aaggccgccg agcacctggc cggccgactg gctgctgaaa tcagaccagg
1741 aggtaaggtt ggtcttgtgc cccgggaatc tatagatcat tgggacggat accatggtga
1801 ggatgtctta ttatgggatg actatggcat gtcaaaaata acagaggatt gtaacaagtt
1861 gcaagccata gctgacactg cacctctatc actcaattgt gacaggatag agaacaaagg
1921 catgcagttt tcttcagatg caataatcat aaccactaac gcccctggtc cggccccagt
1981 ggactttgtc aacctaggcc ctgtgtgcag gcgagtggat ttcctagttt actgctctgc
2041 ccctgaaatt gagcaaatga gaagagccca tcctggtgat gccaatgcta ttaaggactt
2101 atataaaagg gactattcac acctaaaaat ggaattagcc ccacagggtg gctttgatag
2161 ccaaggcaac acaccatttg ggaaaggtat tatgaagccc acaaccctca ataggctact
2221 tattcaggca acagcattag ctatggagcg gcaagatgag ttccagctcc aaggggctgt
2281 ctataacttt gatgaagaca gggtgtccgc ctttacaagc ttggcccgcg ctaatggttt
2341 ggggctcata agcatggcaa cactgggaaa aaggctcaga agtgtcaaat ccatggaggg
2401 cctgcgcaat gcattagtgg gctacaaaat aggagagtgt gacataatct ggaataccag
2461 agtgtattca atcaaaagtg acggcagcac tgtcacaatt aaggagaaac aaaccccaac
2521 ttcacctcaa caccaggcca tctgtacagc cactcttgca ctctctaggt tgcgggccgc
2581 tagagctctt gcgtacgcct cctgcctgca aagtgcagtg ctatcaatac tccaggtggc
2641 tggctctgcc ctggtggtga gtagggctgt gaagcgcatg tttggtacgc gcactgaaca
2701 acctatgtta gaaggcaagc ataaagagca caactgtaga gtgcaccgcg cagaggcagc
2761 cggccatggt cccattgggc atgacggggt cattgaacgc tacggcctgt gtgagagtga
2821 acaagaagaa gaaggcgagc aaacggttga gttacccact gctaataaag aaggtaaaaa
2881 caagggcaag accaaaaagg gccgtggacg gaaatccaat ttcaatgctt tctcaagacg
2941 tggcctcagt gatgaagagt atgaagagta caagaagatt agagaagaga agagtggcaa
3001 ttacagcatc caggagtacc tcgaggatcg ccagcgctat gaggaagaac ttgctgaagt
3061 gcaggctggt ggggatggtg gaattggtga gactgaggca gagattcgcc accgggtttt
3121 ctataagtca aaatccggca tgagaaagca acgccaagaa gagcggcgtc agctgggtct
3181 cgttagcggc tctgagattc gcaagcgcaa gcccatagac tggactcctc ctaagaatga
3241 ttggtcagaa gacaccagaa ctgtcaacta tgatgaacaa atcagttttg aggcccctcc
3301 ttcaatttgg agtagggtgg tgaagtttgg tagtggctgg ggtttttggg tgagctcaac
3361 agtgttcata accacaaccc atgtcatacc acctggggct aaagaaatct ttggtgaaaa
3421 tcttagcaat gtggccatcc acagggttgg tgagttcacc caattccgtt tctccaaaaa
3481 gatgagacct gacctcactg gtatggtctt agaagagggt tgcccagagg gaacagtgtg
3541 caccataatg atcaagagag attctggtga gctgttgcca ctcgccgtcc ggatgggggc
3601 agtggcttca atgaagatcc aaggtaaact tatgcatgga caatcaggaa tgttgctcac
3661 cggtgccaat gccaaaggca tggacctcgg aactatacct ggtgactgtg gggcacccta
3721 tgtccacaag agagggaacg attgggtagt atgtggagtc catgcagccg ccacaaaatc
3781 aggcaacact gtggtgtgtg ctatacaggg tggtgacggt gaagccacac tagagggtgg
3841 cggccaaaac aagggtcact atgcagggca tccaatacta aggtatggga atggcccttc
3901 tctatcaacc aagacaaaat tctggaagtc caccccccag cctttgcccc ccggtacgta
3961 tgagccagct tatcttggtg gcagagaccc tagagttgag gggggcccat ccttacagca
4021 agtgttgagg gaccagttga aaccattcgc cgagccccgt ggtaggttgc ccgaagcggg
4081 cctgttggaa gctgcagttg aaacggtcac taatgcaatt gaacaggtca tggacacacc
4141 ggtggcttgg agctacaatg atgcttgcat gtccctagat aagacaacca gttctggcta
4201 cccccaccac aagaagaaga atgatgactg gaatggaaat tcatttgtga gagaactggg
4261 cgaccaggcg gcgcatgcta atagcatgta tgaacttgga aagtccatga aacccgtgta
4321 cacagcggcc ctcaaagatg agttagtcaa gccagataag gtgtacacta aaatcaaaaa
4381 gagactgctt tggggcgcgg atcttggcac cgtcatccgt gctgccagag cttttgggcc
4441 attctgtgaa gctataaaac cccatgtgat aaaattgcct attaaggtgg gtatgaatgc
4501 catagaggat ggtcctttga tttatgcaga gcactctaaa tataagtttc attatgacgc
4561 tgactacaca gcttgggact caacacaaaa cagggagatt atgatggagt ctttcaatat
4621 tatgtgcaaa ctcacagcca acccttcctt ggccgcagta gtggcacagg atctgctctc
4681 cccatctgaa atggacgttg gcgattatgt gatcagtgtt aaagatggtc tgccatctgg
4741 ctttccatgc acctcacaag tgaatagcat caaccactgg atcctaactc tatgtgcaat
4801 gtcagaagtt actggcttgt cccctgatgt aatacaatca cagtcttatt tctcatttta
4861 tggtgatgat gaaatagtct cgacagacat agaatttgac ccaatcagat tgacacaaat
4921 actgaaggag tatggcttga aacccacaag acctgacaaa actgatggcc caattattgt
4981 cagacagcag gtggatggtc tggttttcct ccggcgcacc atctctaagg acgccattgg
5041 ataccagggg cgactcgacc gcaactccat tgaaagacag ctttggtgga cccgcgggcc
5101 aaaccacgag gacccattcg agacgctagt cccacactcg cagagaaaga tccagctaat
5161 ctccttgctg ggtgaagcag cactccatgg tgaaaaattc tacagaaaga tagccagtag
5221 ggttattcaa gaagtcaagg agggggggct tgagatttac attcctggtt ggcaggccat
5281 gttccgctgg atgcgattcc atgatttgag tttgtggaca ggagaccgcg atctcctgcc
5341 cgattatgta aatgatgatg gcgtctaagg acgccccaac aaacatggat ggcaccagtg
5401 gtgccggcca gctggtacca gaggcaaata cagctgagcc tatatcaatg gagcctgtgg
5461 ctggggcagc aacagctgcc gcaaccgctg gccaagttaa tatgattgac ccctggataa
5521 tgaataatta tgtacaagcc cctcaaggtg aattcactat atcgcctaac aatacaccag
5581 gtgatatttt atttgacctg caattaggcc cccaccttaa tcctttctta tcccatttgg
5641 cccaaatgta caatggttgg gttggcaata tgaaagtgaa ggtcctattg gctggtaatg
5701 ccttcacggc tggtaaaata attattagtt gtataccccc tggctttgct gcgcaaaata
5761 tctctattgc tcaggctaca atgttccccc acgtcatagc tgatgttagg gttttggaac
5821 ccattgaggt acccttggaa gatgtgagga atgtactgtt ccataacaat gacaacgcac
5881 caaccatgag gttggtgtgt atgctctaca ctcccttgcg agccagtggt agctcatctg
5941 gaactgatcc ctttgtgatt gctgggcgtg ttctgacatg cccaagccct gattttagct
6001 ttttgttctt ggttccccct aatgtagaac agaagactaa acctttcagt gtcccaaatc
6061 ttccattgaa tactctttca aattcaagag tcccttccct aattaaatca atgatggtgt
6121 ccagagacca tgggcagatg gtccagtttc aaaacggtag ggtcacccta gatgggcaac
6181 tgcagggtac cacgcccaca tcagctagcc agctgtgcaa aatcagaggt aatgtcttcc
6241 acgctaatgg tgggaacgga tacaacttaa ctgaactgga tgggagccca taccatgcat
6301 ttgagggccc tgcgccaata gggtttccag acctaggtga atgtgattgg cacatggaag
6361 cctcccccac cacccaattc gacactggtg aagttataaa acaaattaat gtcaaacaag
6421 aatcagcatt tgctccccac cttggtacca tacaagcaga cggcctggat ggtgtgagcg
6481 tcaacactaa catgatagct aaattgggat gggtgtctcc tgtcagtgac ggacataaag
6541 gtaatgtcga cccgtgggtc attccacgat atggatcgac tttgactgag gccgcccaat
6601 tagcccctcc aatatatccc cctggttttg gtgaggccat tgtgtttttc atgtcagatt
6661 ttcccattgc ccatggcgtc aatggcttga gtgtgccttg caccatacct caagaatttg
6721 ttacccattt tgttaatgaa caggccccta ctagggggga agcagcccta ttgcattatt
6781 tagaccctga caccaataga aatcttggtg agtttaaatt ataccctgag ggctttatga
6841 cgtgtgtgcc taattccagt ggcactggtc ctcaaaccct ccctatcaat ggtgtttttg
6901 ttttcgtgtc ctgggtatcc agattctatc agttgaagcc tgtgggaaca gccggcccgg
6961 ctcgtaggct tgggattagg agatcataat ggctcaagct atacttggag ccatagcagc
7021 aacggcagct ggcagcgctg ttggtgctgg catacaagct ggaaccgaag ctgccctaca
7081 acaccagagg ttccagcaag acttgaccct acagaagaac tccttcaatc atgacaaaga
7141 gatgatgggc ctacaggttg aggcttcaac tgcactcctc caaaacagtt tgggcacacg
7201 gtacaatatg ctgaccagag cagggatgac atctgcagat gcggcacgca tggttgtggg
7261 ggcgcctaca acacgtgtca ttgattggaa tgggactagg gtcgccgcac ccatgtcaac
7321 cgcaacgaca cttaggtctg gtggtttcat gaccgtgcca actgtttata ggggtggcaa
7381 gaataaacaa tcaattggtg gtggcttttc taatgtaaat tatgatccct caatttcctc
7441 ttctcggact tctcaatggg tttcttcaca aaattcaatg cgttccacta tggaaccatt
7501 tcatccaggt gccctgagaa ccacatgggt cactccacct gggtcaactt ctacttctac
7561 aatttccaca gtttctactg tgccaaaatt ctttaataca gaaagattac ccttgttcgc
7621 gaacaggggt aagtgatttt gtaatatgaa ttagtgggca tcatattcaa tttggaatca
7681 attagatgtt tagattggca gatgatgtt
//