Typing tool
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Typing tool
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Complete norovirus genomes
| MW305487 | GI.5 | |
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| GI.P5 |
ORF1: 1..5333
ORF2: 5317..6948
ORF3: 6948..7574
LOCUS MW305487 7664 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GI isolate PNV011143 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305487
VERSION MW305487.1
KEYWORDS .
SOURCE Norovirus GI
ORGANISM Norovirus GI
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7664)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7664)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7664
/organism="Norovirus GI"
/mol_type="genomic RNA"
/isolate="PNV011143"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122928"
/country="Peru"
/collection_date="11-Oct-2008"
/note="genotype: GI.5[GI.P5]"
gene <1..5333
/gene="ORF1"
CDS <1..5333
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ58797.1"
/translation="TAASKNCASDNSNTIKNRLLAKLKNIGNNNQPIKIENTHMALGL
IGRGSSPTPPTEPPKQQRDRAPRSAAETQQALGWVEQPLDQNLPTWEELSEAEKRDIM
ARNENWFDAGGLAPASIPSTHERAQDDEPSGLQIKWSANAGVDLGVGDLTSVTGPAWN
MCPMPPMDQRNSGPAKEPLIGDMLEFYEGRIYHYAIYIGQGKSIGVHSPQAAFSIARI
TIHPIAAWWRVCYVPSAEQRLNYDQLKELENEPWPYAAVTNNCYEFCCRVMGVQDTWL
ERRLIDSGRFNHPTQDWSKDTPDFQQDSKLEIVRDAVLAAINGLVSKPFKDLLGKLKP
LNVLNLLSNCDWTFMGVVETVILLMELFGIFWNPPDVSSFIASLLPDMHLQGPEDLAR
DLIPLILGGIGLAIGFTKDKVTKVMKSAVEGLRAATQLGQYGLEIFAVLKKYFFGGDQ
TEKTLKDIEAAVIDMEVISTTAITQLVRDKQSARTYMAILDAEEEKARKLSVKHADPH
VVSTTNALIARISLARSALAKAQAEMTNRVKPVVIMMCGPPGIGKTKAAEYLAKRLAN
EIRPGGKVGLVPREAVDHWDGYHGEEVMLWDDYGMSKIADDCNKLQAIADTAPLTLNC
DRIEKKGLQFVSDAIIITTNAPGPAPVDFVNLGPVCRRVDFLVYCSAPDVEQTRRTNP
GDTGALKDCFKSDFSHLKMELAPQGGFDNQGNTPFGKGVMRPTTLNRLLIQAVALTME
RQDEFQMQGPTYDFDVDRIAAFTSLARANGLGLIDMAKLGKKLRGVDSIHGLKNALNG
YTITPCSIKWQARIYNIESDGTTVKIKEDTAAQTQRQHTIDTAVLALTRLRAARAAAY
ASCLQSAITTILQMAGSALVINRAVKRMFGTHTNTISLEGPPREHRCRVHVAKANGGG
PIGHDDVIERFGLCETEEDDDSQELKVSLPTATHEGKNKGKTKKGRGRRANYNAFSRR
GLSDEEYEEYKKIREEKNGNYSIQEYLEDRQRYEEEMAEVQAGGDGGIGETEMEIRHR
VFYKSKTRKNRQEERHQLGLVTGSDIRKRKPIDWTPPKNEWADDDREVDYNEKISFEA
PPTLWSRVVKFGSGWGFWVSPTVFITTTHVIPTNVREFFGEPLDTIAIHRAGEFTQLR
FSRKIRPDLTGMVLEEGCPEGVVCSILIKRDSGELLPLAVRMGAIASMKIQGRLVHGQ
SGMLLTGANAKGMDLGTLPGDCGAPYVYKRNNDWVVCGVHAAATKSGNTVVCAVQAGE
GETTLEGGDKGHYAGHEIIKHSKGPALSSKTKFWRSTTDPLPPGVYEPAYLGGRDPRV
KGGPSLQQVLRDQLKPFAEPRGRMPEPGLLEAAVETVTSVLEQVMDTPVPWTYADACQ
SLDKTTSSGHPYHKRKNDDWNGTAFVGELGEQAAHANNMYEQGKSMKPLYTAALKDEL
VKPEKVYQKIKKRLLWGADLSTVIRAARAFGPFCDAIKPHVIKLPIKVGMNSIEDGPM
IYAEHARFKNHFDADYSAWDSTQNRQIMTESFSIMCRLTATPELASVVAKDLLAPSEM
DVGDYIIRVKEGLPSGFPCTSQVNSINHWLITLCALSEVTGLSPDVIQSQSYFSFYGD
DEIVSTDIDFDPARLTQVLKEYGLRPTRPDKSEGPIVLRRQIDGLVFLRRTISKDAAG
FQGRLDRGSIERQLWWTRGPNHDDPNETLIPHPQRKVQLISLLGEASLHGEKFYRKIA
AKVIQEIKTGGLEMYVPGWQAMFRWMRFHDLGLWTGDRNLLPEFVNDDGV"
mat_peptide <1..1157
/gene="ORF1"
/product="p48"
mat_peptide 1158..2246
/gene="ORF1"
/product="NTPase"
mat_peptide 2247..2849
/gene="ORF1"
/product="p22"
mat_peptide 2850..3263
/gene="ORF1"
/product="VPg"
mat_peptide 3264..3806
/gene="ORF1"
/product="Pro"
mat_peptide 3807..5330
/gene="ORF1"
/product="RdRp"
gene 5317..6948
/gene="ORF2"
CDS 5317..6948
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58798.1"
/translation="MMMASKDAPPSADGANGAGQLVPEVNNAEPLPLDPVAGASTALA
TAGQVNMIDPWIFNNFVQAPQGEFTISPNNTPGDILFDLQLGPHLNPFLAHLSQMYNG
WVGNMRVRVILAGNAFTAGKVIICCVPPGFQSRTLSIAQATLFPHVIADVRTLEPIEI
PLEDVRNTLYHTNDNQPTMRLLCMLYTPLRTGGGSGGTDAFVVAGRVLTCPSSDFNFL
FLVPPTVEQKTRPFSVPNIPLQLLSNSRVPNLIQSMVLSPDQAQNVQFQNGRCTTDGQ
LLGTTPVSVSQILKFRGKVSAGSKVINLTELDGSPFLAFEAPAPTGFPDLGTSDWHVE
MSLNSNSQSSGNPILLRDIQPNSSDFVPHLGSVSVTAAIEVAGDYTGTIQWTSQPSNV
TPVPDVNFWTIPHYGSNLAEASQLAPVVYPPGFGEAIVYFMSPIPGPNTAHKPNLVPC
LLPQEFVTHFVSEQAPSMGEAALVHYVDPDTNRNLGEFKLYPEGFITCVPNGTGPQQL
PLNGVFVFASWVSRFYQLKPVGTASSARGRLGVRR"
gene 6948..7574
/gene="ORF3"
CDS 6948..7574
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58799.1"
/translation="MAQAIIGAIAASAAGSALGAGIQAGAEAALQSQRFQQDLTLQQN
SFKHDKEMMSYQVEMSNALLAKNLNTRYALLQSGGLSSADAARAVAGAPVTRIVDWNG
TRVAAPNSSATTLRSGGFMSVPIPVQPKQKPPTTSGFNNPAYGETMSRVSSWVQSQNS
SRSMPPFHNSALRTVWVTPPGSTSSSSVSSVPMGVFNTDRLPLFANRR"
ORIGIN
1 ctactgctgc tagcaaaaat tgtgctagtg acaatagcaa tacaattaag aatcgcttat
61 tagcgaaact taaaaatata ggcaataaca accagcctat aaaaatagaa aacacccata
121 tggccttagg actcattggc agaggttcat caccaacccc tcccactgag ccccccaagc
181 agcagcgtga ccgtgcacca cggagtgctg ctgagacaca acaggccttg gggtgggttg
241 aacaaccact agatcagaat ctaccaacct gggaagaact gagtgaagct gagaaacgtg
301 acatcatggc aaggaacgag aactggttcg atgctggtgg cctggcacca gcatccatcc
361 ccagtacgca tgagcgtgcc caagatgatg agccatcagg actccaaata aaatggagtg
421 ccaatgctgg tgttgatctt ggggttgggg acctcacatc tgttactggc cccgcgtgga
481 acatgtgccc tatgccgcca atggaccagc gcaatagtgg gcctgcaaaa gaaccactca
541 ttggcgacat gcttgagttt tatgagggac gtatatacca ctatgccata tacatcgggc
601 aaggtaaatc cattggagtc cattcaccac aggcagcttt ctctatagcc aggataacaa
661 tacatcccat tgctgcttgg tggcgagtgt gctatgtccc aagtgctgag cagagactaa
721 attatgacca acttaaagaa cttgagaatg agccatggcc gtatgccgca gtcaccaata
781 attgctatga attttgttgt cgagtcatgg gcgtgcaaga cacttggctc gagcgtcggc
841 tcatagattc aggccgcttt aatcatccca cacaagattg gtctaaggac accccagact
901 tccagcaaga tagcaagtta gagatagtca gagatgctgt tttggcagcc ataaatggcc
961 tagtttcaaa accatttaaa gacctcttgg ggaagttgaa acctctaaat gttctcaacc
1021 tactttccaa ttgtgactgg accttcatgg gggtcgtgga gactgtgatc ctcttgatgg
1081 aactcttcgg gatattctgg aacccacctg atgtgtccag ctttattgca tcactcttac
1141 cagacatgca cttgcagggc cctgaggatt tggctagaga cttgatacct ctaatactcg
1201 gtggcatagg tcttgccatc gggttcacca aggacaaggt cacaaaagtt atgaaaagtg
1261 cagtggaggg tctacgggcc gcaacccaac ttggccagta cggtcttgag atctttgccg
1321 tgctaaagaa gtacttcttt ggaggtgacc aaacagagaa gacactaaaa gacattgaag
1381 cggcagtgat agacatggaa gtcatttcaa ccacagccat aacacaattg gttagagaca
1441 agcaatcagc caggacatat atggctattc tagatgcaga agaggagaaa gccagaaagc
1501 tctcagtgaa gcatgctgac ccccatgtgg tatccactac caatgccctc attgcacgca
1561 tatcgctagc ccgttctgca ttggctaagg cgcaagcaga gatgaccaat agagttaaac
1621 ctgtggtcat catgatgtgt ggtccgccag gcattgggaa aactaaggca gcagagtacc
1681 tggcaaaacg gctagccaat gaaataagac cgggaggcaa ggttggtctt gtaccgcgtg
1741 aggctgtgga ccattgggat gggtaccatg gagaggaagt catgctgtgg gatgactacg
1801 ggatgtcgaa gattgctgat gactgcaaca agttacaggc aattgctgat acggcccctt
1861 tgacattgaa ttgtgatagg atagaaaaga aaggactcca atttgtatct gatgccataa
1921 ttataaccac caacgcccct ggcccagcac cagtggattt tgtcaacctt ggtcccgtgt
1981 gccggcgagt ggacttcctc gtctattgtt cggcccccga tgtcgagcag acccgtcgca
2041 ctaatcctgg tgacactggg gccctcaagg actgcttcaa aagtgacttc tcacatttaa
2101 aaatggaact cgccccccaa ggcgggtttg acaaccaggg taacaccccg tttggcaagg
2161 gggtcatgcg cccaactaca ctcaataggt tgttaataca ggcagttgcc ctcaccatgg
2221 agcggcaaga tgagttccaa atgcaaggac caacttatga ctttgatgtt gatagaatcg
2281 cagctttcac cagcttggca cgtgccaatg gccttggcct tattgacatg gccaagcttg
2341 ggaagaaact gcggggtgtg gattccatcc atggtcttaa gaatgcactc aatgggtaca
2401 ccataacacc ctgtagcata aaatggcagg caagaatcta taatatagaa tctgatggca
2461 cgacagtaaa aattaaagag gacactgcag cacagactca acgccaacac acaattgaca
2521 ccgcggtgtt ggccttaacc cgcttaagag ctgctagggc tgcagcatat gcatcatgtc
2581 tacaaagtgc aattacaacc attctccaga tggcaggctc agcacttgtc attaatcgag
2641 ctgtcaaacg catgtttggt acccacacta acaccatctc attggaaggt ccccccagag
2701 aacaccgttg tagggtccac gtggccaaag ccaatggtgg cggcccaatt gggcacgatg
2761 atgtaataga gagatttggc ctgtgtgaaa ctgaagaaga tgatgacagc caggagctta
2821 aagtcagcct gcccactgcc acccatgaag gtaagaacaa gggtaagacg aagaaaggca
2881 gaggtagacg tgccaattac aacgctttct caaggagggg cctcagtgat gaggaatatg
2941 aggagtacaa gaagatcaga gaagaaaaga atggcaatta cagtatacaa gagtaccttg
3001 aggacagaca gcgctatgaa gaagagatgg ccgaagtcca ggctggaggg gatggcggca
3061 ttggagaaac cgagatggag atccggcatc gtgtcttcta taaatccaaa actaggaaga
3121 accggcagga agagcgccac cagttaggtc ttgttactgg gagtgatatc aggaagagaa
3181 agccaattga ttggacgccc cccaaaaatg agtgggctga tgatgatagg gaagtggatt
3241 acaatgagaa aattagcttt gaggcaccac ccacactctg gagccgtgtc gtgaagtttg
3301 gttccggctg gggattctgg gtcagcccta cagtcttcat tactacaacc catgtcatcc
3361 caacaaatgt gagggaattc tttggagagc cacttgacac catcgccatc catcgagctg
3421 gtgaatttac acagctaagg ttttctagaa aaataaggcc tgatttaacc ggcatggttc
3481 ttgaagaagg ttgcccagaa ggtgtggtct gttcaatcct cataaaaagg gactctggag
3541 aacttctccc attggctgtt cggatgggtg ccattgcctc aatgaagatt caagggcgcc
3601 tggtccatgg ccaatcaggg atgctgctga caggggctaa tgctaagggc atggaccttg
3661 gtactctccc cggtgactgt ggggctccgt atgtctacaa aaggaacaat gattgggtag
3721 tctgtggtgt ccacgctgca gccacaaaat ctgggaatac agttgtgtgt gcagtgcagg
3781 caggtgaggg ggagaccaca ctggaaggag gggacaaggg ccattatgcc ggacatgaaa
3841 taatcaagca tagtaaggga ccagcactat ctagcaaaac caaattttgg cggtcaacta
3901 ctgatcctct accaccaggg gtgtatgagc cagcttacct tggaggtcgc gaccctaggg
3961 ttaaaggcgg cccatcacta caacaagtat tgagggatca gttgaaacca tttgctgaac
4021 cgcgtgggcg tatgcctgaa cctggtttac tagaggcagc tgttgagaca gtcacatcag
4081 tattagagca ggtcatggat accccagttc cctggactta tgccgatgca tgtcagtcac
4141 tggataaaac tactagttct ggccatccat accataagag gaaaaatgat gactggaatg
4201 ggactgcatt tgttggggaa ttgggagaac aggcagccca tgcaaataac atgtatgaac
4261 agggcaagtc aatgaaaccc ctttacacag ctgcactcaa ggatgaattg gtcaaacctg
4321 agaaagtgta ccagaagatt aagaagcggc ttttgtgggg cgctgatctc tcaacagtga
4381 tccgcgctgc tagagccttt ggtccattct gtgatgcaat aaagccccat gtcataaagc
4441 tccccatcaa ggttggaatg aattcaattg aggacggtcc aatgatttat gctgagcatg
4501 caagatttaa gaaccacttt gatgctgatt attctgcatg ggattcaaca caaaatagac
4561 agatcatgac tgagtcattt tcaataatgt gccgcctcac ggccacacca gagctggctt
4621 cagtggtggc taaagacctt ctcgcaccat cagagatgga tgttggggat tatatcataa
4681 gggtcaaaga aggcctccct tcaggcttcc cctgcacttc acaagtcaac agcataaacc
4741 actggctgat caccctctgt gctctctctg aggttactgg actttctcct gatgtaatac
4801 aatcacagtc atacttttca ttttatggtg atgatgaaat agtgtctact gatattgatt
4861 ttgacccagc acgcctaacc caggtgctca aagaatatgg tctccgccct acacgcccag
4921 ataagagcga agggccaata gtattaagga ggcagattga tgggttggtg tttctcagga
4981 ggaccatatc aaaagatgca gctggttttc aaggccgatt ggacagaggt tctattgaga
5041 gacaactttg gtggactcgt ggcccaaacc acgatgaccc caatgagact ctgatacccc
5101 acccacaaag gaaggtgcag ctcatatcac tacttggtga ggcctcactc catggtgaaa
5161 aattttacag aaaaattgcc gctaaggtta tccaagaaat taagactggc ggcttagaaa
5221 tgtatgtgcc aggctggcag gccatgttcc gttggatgcg ctttcatgac ctcggattgt
5281 ggacagggga tcgcaatctc ttgcccgaat tcgtaaatga tgatggcgtc taaggacgcc
5341 ccaccaagcg cagatggcgc gaatggcgcc ggtcagcttg tgccggaggt taataatgct
5401 gaaccactgc cacttgaccc agtggcgggg gcttctactg cccttgccac tgctggacaa
5461 gttaacatga ttgacccatg gatcttcaac aactttgttc aggcccctca gggtgaattt
5521 actatttctc caaataatac ccccggtgat attttgtttg atttacaatt gggaccacat
5581 ttaaatcctt ttctagcaca tttgtctcag atgtataatg gctgggttgg caatatgcgg
5641 gttagggtta tcttggccgg caatgccttc actgctggta aagttataat ttgttgtgtc
5701 ccccctggct ttcaatctag aaccctttct atagctcagg ccacactctt tcctcatgtc
5761 atagctgatg tgcgaacttt ggaaccaatt gagatccctc tagaggatgt taggaatact
5821 ctctatcata ctaatgataa tcaaccaaca atgcgcttac tgtgtatgct ttacacacca
5881 ctgcgcaccg gtggcggttc tggtggcaca gatgcgtttg ttgtggcggg ccgagtctta
5941 acttgcccta gttctgattt taacttttta ttcctggtcc ctcccactgt ggagcagaag
6001 acacgcccct tcagtgtacc taacataccc ttgcagttgc tgtctaattc ccgtgttccc
6061 aacctcatac agagcatggt tctctcgcct gatcaggctc agaatgtcca atttcagaat
6121 ggccgctgta ccaccgatgg gcagctcctg ggcacaacac ctgtctcagt tagtcagatt
6181 ttaaagttta gaggaaaggt atcagctggc tctaaagtta ttaatcttac tgaactggat
6241 ggttccccct ttttagcttt tgaggcccca gcacccacag gctttcctga cctggggacc
6301 agtgattggc atgttgaaat gagcctcaac tcaaatagcc agagttctgg caatccaatc
6361 ctactaaggg acatacaacc aaattcttca gacttcgtgc cacatttggg tagtgtatcc
6421 gtcactgctg caattgaagt ggctggagat tacactggta caattcaatg gacctctcaa
6481 ccatccaatg tcactccagt ccctgatgtt aatttctgga ctatccccca ctatggatca
6541 aatttggcag aagcctccca gttggcccct gtggtatacc ccccgggatt tggtgaagct
6601 atagtgtatt ttatgtctcc cataccaggc ccaaacactg cacacaaacc caatttagta
6661 ccctgcctac tcccacaaga atttgtaact cattttgtca gtgagcaagc tccatccatg
6721 ggtgaggcag ctcttgtcca ttacgtggac ccagacacca accgcaattt gggcgagttc
6781 aaactgtatc ctgaaggttt tattacttgt gtgccaaatg gtactggccc acaacaactc
6841 ccccttaatg gagtctttgt ctttgcttct tgggtttcca gattttatca attaaagcct
6901 gtgggaacgg ccagttcggc cagaggtagg cttggagtta gaagataatg gctcaagcca
6961 tcattggagc cattgctgca tcagcggctg ggagtgccct tggagctggt atccaagcag
7021 gtgctgaggc cgccctccag agccaaaggt ttcagcagga cctcactctt caacaaaatt
7081 cttttaaaca tgataaggag atgatgtcat atcaagttga aatgtctaat gctttgctag
7141 ctaaaaatct taatactcgc tatgctttac ttcaatctgg tggtctatct agtgctgatg
7201 ctgcccgtgc tgtggcaggt gcgcctgtca caaggattgt tgattggaac ggtacaaggg
7261 tggcagcccc aaactcctct gcaacaactc ttagatctgg tggattcatg tctgtcccca
7321 tacctgttca acccaaacag aagccaccta ccacctcagg gtttaacaat ccagcatatg
7381 gagaaactat gtcaagggtt tcctcttggg ttcagtccca gaattcgagt agaagtatgc
7441 ctccttttca caattctgcc cttaggactg tttgggtcac accaccaggt tcaacttctt
7501 cttcatctgt ttcatctgtg cctatgggtg tgtttaatac cgacaggctc cccctattcg
7561 caaataggag gtaatattgt tgtaataaga ataataatgt gggcatctta ttcaatttgg
7621 tctaattaat tatatgatta ggtttgattt ggacaattga tgtt
//