Typing tool
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Typing tool
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Complete norovirus genomes
| MW305486 | GI.7 | |
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| GI.P7 |
ORF1: 1..5061
ORF2: 5045..6661
ORF3: 6661..7308
LOCUS MW305486 7322 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GI isolate PNV013852 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305486
VERSION MW305486.1
KEYWORDS .
SOURCE Norovirus GI
ORGANISM Norovirus GI
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7322)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7322)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7322
/organism="Norovirus GI"
/mol_type="genomic RNA"
/isolate="PNV013852"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122928"
/geo_loc_name="Peru"
/collection_date="28-Jan-2009"
/note="genotype: GI.7[GI.P7]"
gene <1..5061
/gene="ORF1"
CDS <1..5061
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="QPJ58794.1"
/translation="EEKKEILDNNERLFDAGGVTPSTVPSTFERCETSERVDGCHPVK
WSESAGVDLGVDSLTTVTGPVWNMCPLPPIDSRNNGPASEPRIGDMIEFYEGHIFHYA
IYLGQGKTIGVHSPQAAFSIARITIHPMAAWWRVCYEPTDQQRLSYDQLKELENEPWP
YASITNNCYEFCCRVMSLDDTWLQRKLVTSGRFNHPTQEWSKETPDFHQDSKLEIVRD
AILSAINGLVSQPFKNILSKIKPLNLLSLLSNCDWTFMGVVELVVLLAELFDIFWTPP
DISNFIASLLPDFHLQGPEDLARDLVPLILGGVGLAIGFTRDKITKVMKSAVDGLRSA
TQLGQYGLEVFSIIKKYFFGGDQTEKTLKGIENAVIDMEVLSSTNVTQLVRDKKLAKT
YMNILDNEEEKARKLSVRSADPHVVTTVNNLISRISMARSALAKAQAEMTNRARPVVI
MMCGPPGIGKTKAAEHLANRLAGEIRPGGKVGLVPRESIDHWDGYHGEEVLLWDDYGM
SKITEDCNKLQAIADTAPLTLNCDRIENKGMQFVSDAIIITTNAPGPAPVDFVNLGPV
CRRVDFLVYCTAPEIEQTRRAHPGDTNAIKNLFKPDFSHLKMEIAPQGGFDNQGNTPF
GKGAMKSTTLNRLLIQAVALTMERQDEFQMQGAVYNFDEDRVTAFTSLARANGLGLLS
MAALGKKLRSVNNMEGLRNALKGYKITECDIVWNNRTYTIKGDGSNVSVTEKQAAANL
QQQAISSVTLALSRLRAARALAYASCLQSAVTTILQMAGSAVVISRAVKRMFGTHTNQ
PALEGKPREHNCRVHRAEREGRGPIGHDGIIERYGLCETDQEEEEKIEMEVPTADKEG
KNKGKNKKGRGRKNNYNAFSRRGLSDEEYEEYKKVREEKGGNYSIQEYLEDRQRYEEE
LAEVQAGGDGGIGETEAEIRHRVFYKSKSGMRKQRQEERRQLGLVTGTEIRKRKPIDW
TPPKNDWSEDTRQVNYDEHISFEAPPSIWSRVVKFGSGWGFWVSSTVFITTTHVIPPD
AKEIFGEKLSDIAIHRVGEFTQFRFSKKMRPDLSGMVLEEGCPEGTVCTIMVKRDSGE
LLPLAVRMGAVASMKIQGKLMHGQSGMLLTGANAKGMDLGTIPGDCGAPYVHKRGNDW
VVCGVHAAATKSGNTVVCAIQSGEGEATLEGGGQNKGHYAGHPILRYGNGPSLSTKTK
FWKSTPQPLPPGTYEPAYLGGRDPRVDGGPSLQQVLRDQLKPFAEPRGRLPEPSLLEA
AVETVTNVLEQTMDTPVPWSYSDACMSLDKTTSSGYPHHKRKNDDWNGNAFVRELGEQ
AAHANNMYELGKSVKPVYTAALKDELVKPEKVYTKIKKRLLWGADLGTVIRAARAFGP
FCEAIKPHVIKLPIKVGMNAIEDGPLIYAEHAKYRYHFDADYTAWDSTQNREIMLESF
NIMCKLTANPSLAAVVAQDLLSPSEMDVGDYVISVKDGLPSGFPCTSQVNSINHWIYT
LCALSEVTGLAPDVLQSQSYFSFYGDDEIVSTDVEFDPIKLTQVLREYGLKPTRPDKS
EGPIIVKQQIDGLVFLRRTISKDAAGYQGRLDRNSIERQLWWTRGPNHDDPFETLIPH
QQRKIQLISLLGEAALHGEKFYRKIANRVIQEVKEGGLELYIPGWQAMFRWMRFHDLS
MWTGDRNLLPDYVNDDGV"
mat_peptide <1..876
/gene="ORF1"
/product="p48"
mat_peptide 877..1965
/gene="ORF1"
/product="NTPase"
mat_peptide 1966..2565
/gene="ORF1"
/product="p22"
mat_peptide 2566..2985
/gene="ORF1"
/product="VPg"
mat_peptide 2986..3528
/gene="ORF1"
/product="Pro"
mat_peptide 3529..5058
/gene="ORF1"
/product="RdRp"
gene 5045..6661
/gene="ORF2"
CDS 5045..6661
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58795.1"
/translation="MMMASKDAPSNMDGTSGAGQLVPEVNAAEPLPLEPVVGAATAAA
TAGQVNMIDPWIMNNFVQAPEGEFTISPNNTPGDILFDLRLGPHLNPFLLHLSQMYNG
WVGNMRVRVMLAGNAFSAGKIIICCVPPGFESQNISIGQATMFPHVIADVRVLEPIEV
PLDDVRNVLFHTNENRPTMRLLCMLYTPLRAGGASSGTDPFVIAGRVLTCPAPDFNFL
FLVPPSVEQKTRQLTIPNIPLNNLANSRVPAMINKMTVSADQNQVVQFQNGRCTLEGQ
LLGTTPVSANQVARIRGKVFSTNSGTGLNLTEIDGTPYHAFESPAPLGFPDIGDCDWH
VYAFKVNQNTGDPMYRLDITQGNSFAPHLGSIEFSSEQHPSGDQLGTLTWISPLNNAS
RVDPWKIPSYGSTLTESTNLAPPIFPPGFGEAIVYFMSDFPIVSGNTAQIPCTLPQEF
VSSFVEQQAPIRGEAALLHYVDPDTHRNLGEFKLYPDGFITCVPNTGGGPQNLPSNGV
FIFSSWVSRYYQLKPVGTAGPVRRLGVRRV"
gene 6661..7308
/gene="ORF3"
CDS 6661..7308
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58796.1"
/translation="MAQAIIGAIAATAAGSAVGAGIQAGTEAALQYQRFQQDLTLQEN
SFKHDERMLGLQIEGSNALLQKNLSTRYNLLVGAGLSSADAARSIAGAPMTKLVDWNG
VRIAAPASTATTLRSGNFMSIPVTPKKEPQKLSARSVGLSNPNYDSSTMISRTTQWVE
SQNSIRNLSPFHSSALRTTWVTPPGSTSTSTFSTVSSAPRYFNTERLPLFANNRK"
ORIGIN
1 gaagaaaaga aggagatcct ggacaacaac gagcgcctct ttgacgctgg cggtgtgact
61 ccttcgacag taccaagcac ttttgagaga tgtgaaacat ctgagcgagt cgacggctgc
121 caccctgtca aatggagcga gtctgcggga gtggatttag gcgtggattc cctaaccact
181 gtcacaggtc cagtgtggaa catgtgcccc cttccaccga ttgattcacg taacaatggc
241 cctgcaagtg agccacgcat tggagacatg atagaatttt atgaagggca tatattccat
301 tacgccatat atcttggtca agggaagacc ataggagtcc actcccctca ggcagctttc
361 tccatagctc gtataaccat acaccctatg gcagcatggt ggcgtgtctg ctatgaacca
421 acagatcagc aacgcctcag ctatgaccaa ttaaaggaac ttgagaatga accgtggccc
481 tacgcatcca taacgaataa ttgttatgag ttctgttgcc gtgtcatgtc cctggacgac
541 acctggttac aacgaaagtt ggtgacatcc ggtaggttta atcaccccac ccaggagtgg
601 tccaaggaaa cacctgattt ccatcaagat tcaaaattgg aaatagtgag agatgcaata
661 ctatccgcca taaacggctt ggtctctcaa ccttttaaga atatcctctc aaaaattaag
721 ccactgaatt tgttgtcttt gctatcaaat tgtgactgga ctttcatggg ggtcgtcgag
781 ctagtggtgc tactggctga actgtttgac atattctgga ccccacctga tatctccaac
841 ttcatagcat ctctcctgcc tgactttcac ctgcaagggc cagaggattt ggcaagagac
901 ctggtcccat taatattggg gggtgttggc ctggctattg gtttcactag agacaaaatc
961 acaaaggtca tgaagagtgc cgttgatggc ctgcgctcag ccacgcagct tggacaatat
1021 ggccttgagg tgttctcgat cataaagaag tatttctttg gtggagacca aactgagaaa
1081 accctcaagg gcatagagaa tgcagtcata gatatggagg tcctgtcgag caccaatgtc
1141 acacaactgg tgcgcgacaa gaagttggcc aaaacataca tgaatatcct ggacaatgag
1201 gaggaaaagg caaggaaact ttcagtgcgc agtgcagatc cacatgttgt gacaacagtc
1261 aacaacctca tttcgcgcat atccatggcg cgatcagctc tcgccaaagc tcaggctgag
1321 atgactaatc gggcacgccc cgtggtcata atgatgtgtg gaccaccagg tataggaaaa
1381 accaaagctg ctgaacacct ggccaaccgc ctggctggtg agataagacc agggggaaaa
1441 gtgggtttag tgcctagaga atccattgac cattgggatg gctaccatgg ggaagaagtc
1501 ctgctgtggg atgactacgg catgtccaag ataacagagg attgcaataa actacaagcc
1561 atagctgaca ctgctccact cacactcaac tgtgacagga tagagaacaa gggtatgcaa
1621 tttgtgtcag atgcaataat aataacaaca aatgcccccg ggccagcccc cgtcgacttt
1681 gttaatcttg gtccagtatg tcgacgtgta gacttcttgg tgtactgcac cgcccccgaa
1741 attgaacaga ccaggagagc ccaccctggg gacaccaatg ctatcaagaa tttgttcaaa
1801 ccagactttt cccatttaaa aatggagata gcaccacaag gggggtttga caaccaaggt
1861 aacaccccct ttgggaaggg tgctatgaaa tcgaccacac tcaataggct actcatacag
1921 gcagtcgctt tgacaatgga aagacaagat gagttccaga tgcagggggc agtgtataac
1981 tttgatgagg atcgggtcac agctttcact agcctggccc gggccaacgg actaggactt
2041 ttgagcatgg ccgcactcgg taaaaagttg cggagcgtta acaatatgga aggactccgc
2101 aacgccctca aagggtacaa gatcactgaa tgtgacattg tgtggaacaa caggacttac
2161 accattaagg gagatggatc aaatgtgagc gtcacagaaa agcaggcagc tgccaatctt
2221 cagcaacaag ccatcagctc agttactctg gcactttcta ggttacgcgc cgcacgagcg
2281 ttggcgtatg catcatgtct ccagagcgca gtaaccacca tcttgcaaat ggctgggtct
2341 gcagtggtga tcagcagggc agtcaaacgc atgtttggga cccatactaa ccagccagca
2401 ctggagggca aacccaggga acacaactgc agggtccacc gtgccgaaag ggaaggtcgt
2461 ggccctattg gtcatgatgg catcatagaa cggtacggtc tgtgtgagac tgaccaagaa
2521 gaagaagaaa agatcgagat ggaagtgcca actgcagaca aagaaggcaa gaacaaaggc
2581 aagaacaaga aggggcgagg taggaaaaat aactacaacg ccttctctag gcgaggccta
2641 agtgatgagg agtatgaaga atacaagaag gttagagaag agaagggtgg taactacagc
2701 atccaagaat acctcgagga ccgccaacga tatgaagaag agttggctga ggtccaagcg
2761 ggtggagatg gcgggatcgg tgaaacagag gcagagatcc gccatcgtgt tttctacaaa
2821 tccaagagtg gcatgcgaaa acaacgtcaa gaggagcgcc gacagcttgg attagtcaca
2881 ggcactgaaa tcagaaagcg caagcccata gattggacac cacctaagaa tgactggtca
2941 gaagacacca ggcaggtcaa ctatgatgag catatcagct ttgaagcccc accttctatt
3001 tggagtagag tggtcaaatt tggcagtgga tggggctttt gggtgagttc aacagttttt
3061 atcacaacca cacacgtcat accaccagat gctaaagaaa tttttgggga aaaactttca
3121 gatatagcaa tacacagagt tggggagttc acacaattta gattctctaa gaaaatgaga
3181 cctgacctca gtggtatggt ccttgaggag ggttgcccgg agggaacggt gtgcactata
3241 atggtgaaga gagattcagg tgaactgcta cctctagctg tgcgcatggg agctgttgca
3301 tccatgaaga tacaaggtaa gctcatgcat ggtcaatctg gtatgttgct aaccggtgca
3361 aatgcaaagg gaatggacct tggcaccatc cctggtgact gtggagctcc atatgtgcat
3421 aagaggggaa atgactgggt agtgtgtgga gtgcacgcgg ccgcaaccaa gtcgggcaac
3481 accgtagtgt gtgcaataca gtcaggtgaa ggtgaagcta cccttgaagg gggcggacaa
3541 aacaaggggc attatgcagg ccacccaatt ttaaggtatg gcaatgggcc ctctctctcc
3601 acaaaaacca aattctggaa atcgaccccc caaccactcc cgcctggaac ctatgaacca
3661 gcttacctag gtggacgtga ccccagggta gacggtggtc catctcttca acaagtccta
3721 cgtgaccaac tcaagccttt tgctgagccc cgtggtagac tgccagagcc gagcttgctc
3781 gaagcagctg tggagactgt tacaaatgtt ttagaacaaa ccatggacac acctgtgcct
3841 tggagttaca gtgacgcctg tatgtctctt gacaagacca ccagctcagg ttatccgcac
3901 cataagcgca agaatgatga ttggaatggc aatgcgtttg tgcgtgaact tggggaacag
3961 gcagctcatg ccaataatat gtacgaattg ggcaagtcag ttaaaccagt ttacacagca
4021 gcacttaaag atgaattggt aaaacctgaa aaagtgtaca caaaaataaa aaagagactg
4081 ctttggggtg cggaccttgg tacagtcatt cgggccgctc gagccttcgg cccattttgt
4141 gaggcgataa agccacatgt gataaaattg ccgatcaagg ttggcatgaa tgcaattgaa
4201 gatggccccc tcatatatgc tgaacatgca aagtatagat atcattttga tgcagattac
4261 acagcctggg actcaactca gaatagagaa atcatgctag aatctttcaa cattatgtgt
4321 aagctcacag ccaatccatc actggccgct gttgtggcac aggacctact gtccccatca
4381 gaaatggatg tgggggatta tgtgattagt gttaaggatg gcctcccctc agggttccca
4441 tgcacctcac aagtgaacag cataaaccac tggatttaca ctctgtgtgc cctgtcagag
4501 gtcacaggcc tggcccctga tgtcctgcaa tcccagtctt acttttcctt ctacggggat
4561 gatgagatag tatcaactga tgtggaattt gacccaataa agctcaccca agtgctcaga
4621 gaatatggtt tgaagcccac ccgacctgac aaatcagaag ggcccattat agtgaaacaa
4681 cagatagatg ggctggtctt tctcagacgt accatatcaa aagacgctgc cggttaccag
4741 gggcgtttag atcgcaactc cattgaaagg caactgtggt ggactcgggg accaaatcat
4801 gatgacccct ttgagactct gataccccat caacaaagga aaattcaact gatatccctg
4861 cttggtgagg ctgcactcca tggagagaaa ttttacagga agattgctaa tagggtgata
4921 caggaagtta aggagggtgg gcttgagctc tacataccag gttggcaggc catgtttcgc
4981 tggatgcgat ttcatgactt gagcatgtgg acaggagatc gcaatctact gcctgattat
5041 gtaaatgatg atggcgtcta aggacgcccc ctcaaacatg gatggcacca gtggtgccgg
5101 tcagctggtt ccagaggtta atgcagctga acctctaccc cttgaaccgg tggtgggcgc
5161 cgcaaccgcg gcggccactg ctggacaggt taatatgata gacccctgga ttatgaataa
5221 ttttgtccaa gcccctgaag gcgaatttac tatttcaccc aacaacaccc ctggagatat
5281 tttatttgac ttgcgtctgg gaccacacct taaccccttt ctcctgcatt tgtcccagat
5341 gtataatggt tgggttggga atatgagagt tagggtcatg cttgcaggga acgcgttctc
5401 cgctggtaag atcataattt gttgtgtccc acctggcttt gaatcccaga acatatcaat
5461 tggacaagcc acaatgttcc cccatgtcat agctgatgtg agagtcctgg agcccataga
5521 ggtccccctt gatgatgtgc gcaatgtcct gttccacaca aatgagaacc gcccaaccat
5581 gcgactgctc tgtatgttat acacacctct ccgtgctgga ggagcttcat caggcacaga
5641 cccttttgtc attgctggcc gtgtgttaac ttgtcccgct cctgatttca attttctgtt
5701 tcttgtgccc cccagtgtag aacagaaaac caggcaattg actataccca atataccctt
5761 gaacaatttg gctaactcca gagtgcctgc aatgataaac aagatgacag tctctgctga
5821 tcagaatcag gtggtccagt ttcaaaatgg ccgttgcaca cttgaaggac aactcttagg
5881 tacaacccct gtttcagcca accaagttgc ccgcatacgt ggcaaagtct tctccaccaa
5941 ctccgggacg gggcttaatt taactgaaat agatggaacc ccctaccatg catttgagag
6001 cccggccccc ctcggttttc ctgacatagg tgattgtgat tggcacgtgt atgcctttaa
6061 ggtaaatcaa aatacagggg atcccatgta cagattggat ataacacaag gaaactcatt
6121 tgcaccgcat cttggctcca ttgagtttag ttctgaacag cacccatcgg gggaccaact
6181 aggcacactt acttggatct cccctctcaa caatgcttct agggttgacc cctggaaaat
6241 cccatcatat ggttcaacat tgactgagtc caccaacttg gcaccaccca tctttccacc
6301 aggttttggt gaggctatag tttattttat gtcagatttt cctattgtgt caggtaatac
6361 tgcccaaatc ccctgtaccc tgccccaaga atttgtttca tcctttgtgg aacaacaggc
6421 accgatccga ggtgaagctg ctctactgca ttatgtggac ccagataccc atcgcaatct
6481 gggagaattc aaattgtacc ctgatgggtt catcacttgt gtgccaaaca cgggtggcgg
6541 cccccaaaat ctcccatcga atggtgtctt tatcttctct tcttgggttt ctagatatta
6601 tcaattaaag cctgtgggaa cagccggtcc ggttaggagg cttggtgtga gaagggtata
6661 atggcccaag ccatcatagg agctattgcc gccaccgctg ctggcagcgc agtgggggca
6721 ggtatccaag ctggaactga ggcagccttg caataccaaa ggtttcagca agatctcacc
6781 ctgcaggaga attcttttaa gcatgatgaa aggatgttgg gtctacaaat tgaggggtct
6841 aatgctttgc tacaaaagaa tctttctacc cgctataatc tcttagttgg tgcaggcctt
6901 tcctcagctg atgctgcaag gtccattgct ggggccccaa tgacaaaact cgtggactgg
6961 aatggggtga gaatcgctgc ccccgcatcc actgccacca ccctccgttc tggcaacttc
7021 atgagcatac cagtcacacc caaaaaggag ccccaaaaac tgtcagcacg ttctgtaggc
7081 ctctccaatc ccaattatga ttcatctact atgatttcta ggacaactca atgggtggag
7141 tcgcaaaatt caatcaggaa tttgtcacct ttccatagct cggctctgag gactacttgg
7201 gtaactcctc ctggttctac ttctacttca actttttcta ctgtttcttc ggcgccacgg
7261 tacttcaaca ccgagcgtct tcctttgttc gcaaacaata ggaaatagtt tttgtaatat
7321 aa
//