Typing tool
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Typing tool
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Complete norovirus genomes
| MW305484 | GI.8 | |
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| GI.P8 |
ORF1: 1..5368
ORF2: 5352..6983
ORF3: 6983..7624
LOCUS MW305484 7703 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GI isolate PNV009733 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305484
VERSION MW305484.1
KEYWORDS .
SOURCE Norovirus GI
ORGANISM Norovirus GI
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7703)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7703)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7703
/organism="Norovirus GI"
/mol_type="genomic RNA"
/isolate="PNV009733"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122928"
/country="Peru"
/collection_date="25-Aug-2008"
/note="genotype: GI.8[GI.P8]"
gene <1..5368
/gene="ORF1"
CDS <1..5368
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QPJ58788.1"
/translation="ADVSNNNANTNNENIGSRLMARIRGRIGPQRGETTTKIKDASMA
LDLLRRSQTPSPARQESPPKDQRDRPPRTVSEVKRAMKWDVEPEHRESTARAWCDLSK
EEKEEIMRNNEKLFDAGGVTPSTLPSTFERAETNNDVSDQQAVSWSANDGVNIGVSDL
TTVHGPFWNMCPLPPLDARNNGPAKEPLIGDMIEFYEGHIFHYAIYIGQGKTIGVHSP
QAAFSIPRITIHPLVAWWRVCYVPNDRQRLTYDQLKELENEPWPYAAVTNNCYEFCCR
VMALDDTWLQRRLVSTGKFNHPTQDWSQDTPDFHQDSKLEMVRDAVLSAINGLVSQPF
KNILSKIKPLNVLNLLSNCDWTFMGVVELIVLMAELFDIFWTPPDISSFIASLLPDFH
LQGPEDLARDLVPLILGGIGLAIGFTRDKITKVMKSAVDGLRSATQLGQYGLEIFSII
KKYFFGGDQTEKTLRGIEDAVIDMEVLSSTNVTQLVKDKKLARTYMNVLDNEEEKARK
LSVRSADPHIVTSVNNLISRISMARSALAKAQAEMTSRPRPVVIMMCGPPGIGKTKAA
EHLAGRLAAEIRPGGKVGLVPRESIDHWDGYHGEDVLLWDDYGMSKITEDCNKLQAIA
DTAPLSLNCDRIENKGMQFSSDAIIITTNAPGPAPVDFVNLGPVCRRVDFLVYCSAPE
IEQMRRAHPGDTNAIKDLYKKDFTHLKMELAPQGGFDSQGNTPFGKGVMKPTTLNRLL
IQATALAMERQDEFQLQGATYNFDEDRVAAFTNLARANGLGLISMATLGKKLRGVKSM
EGLRNALLGYKIEECDIVWNTRMYSIKSDGNTVTIKEKQAPTSPQHQAICTATLALSR
LRAARALAYASCLQSAVLSILQVAGSAVVVSRAVKRMFGTRTEQPMLEGKHKEHNCRV
HRAEAAGHGPIGHDGVIERYGLCESEQEEESVQTVELPTASEEGKNKGKTKKGRGRKS
NFNAFSRRGLSDEEYEEYKKIREEKSGNYSIQEYLEDRQRYEEELAEVQAGGDGGIGE
TEAEIRHRVFYKSKSGMRKQRQEERRQLGLVSGTEIRKRKPIDWTPPKNDWSEDTRTV
NYDEHISFEAPPSIWSRVVKFGSGWGFWVSSTVFITTTHVIPPGAKEVFGESISNVAI
HRVGEFTQFRFPKKMRPDLSGMVLEEGCPEGTVCTIMIKRDSGELLPLAVRMGAVASM
KIQGKLMHGQSGMLLTGANAKGMDLGTIPGDCGAPYVHKRGNDWVVCGVHAAATKSGN
TVVCAIQGGEGEATLEGGDRNKGHYAGHPILRYGNGPSLSTKTKFWKSTPQPLPPGTY
EPAYLGGRDPRVEGGPSLQQVLRDQLKPFAEPRGRLPEAGLLEAAVETVTNALEQVMD
TPVAWSFSDACMSLDKTTSSGYPHHKRKNDDWNGSSFVRELGDQAAHANNMYELGKPM
KPVYTAALKDELVKPDKVYNKIKKRLLWGADLGTVIRAARAFGPFCEAIKPHVIKLPI
KVGMNAIEDGPLIYAEHSKYKYHYDADYTAWDSTQNREIMMESFNIMCKLTANPSLAA
VVAQDLLSPSEMDVGDYVISVKDGLPSGFPCTSQVNSINHWIMTLCALSEVTGLSPDV
IQSQSYFSFYGDDEIVSTDIEFDPAKLTQILKEYGLKPTRPDKTDGPIIVRQQVDGLV
FLRRTISKDAIGYQGRLDRNSIERQLWWTRGPNHEDPFETLVPHSQRKVQLISLLGEA
ALHGEKFYRKIASRVIQEVKEGGLEIYIPGWQAMFRWMRFHDLSLWTGDRDLLPDYVN
DDGV"
mat_peptide <1..1183
/gene="ORF1"
/product="p48"
mat_peptide 1184..2272
/gene="ORF1"
/product="NTPase"
mat_peptide 2273..2872
/gene="ORF1"
/product="p22"
mat_peptide 2873..3292
/gene="ORF1"
/product="VPg"
mat_peptide 3293..3835
/gene="ORF1"
/product="Pro"
mat_peptide 3836..5365
/gene="ORF1"
/product="RdRp"
gene 5352..6983
/gene="ORF2"
CDS 5352..6983
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58789.1"
/translation="MMMASKDAPTNMDGTSGAGQLVPEANTAEPLPIKPVAGAATAVA
TAGQVNMIDPWIMNNFVQAPQGEFTISPNNTPGDILFDLQLGPHLNPFLAHLSRMYNG
WVGNMQVRIMLAGNAFSAGKIIVCCIPPGFSSQSISIAQATMFPHVIADVRVLEPIDV
PLDDVRNVLFHNNDNPQTMRLLCMLYTPLRSGGTSSGTDPFVIAGRVLTCPTPDFSFL
FLVPPDIEQRTKPFSVPNIPMNLMSNSRVSMLIDGMMVSNDQNQVPQFQNGRVTLDGQ
LQGTTTVSAACVARMRGRIFNNNGNYGVNLTELDGNPYHAFDSPAPLGFPDFGNCDLH
MTFVKINPNELSSGDPSGKVVIHSYDATFAPHLGTVKLENDDELARFVGKEVVLELTW
VSNREGATLNLWAVPNYGSNLTQASQLAPPIYPPGFGEAIVYFTSTFPTVSNPKVPCT
LPQEFVSHFVNEQAPTRGDAALLHYVDPDTHRNLGEFKMYPEGYMTCVPNAGGGPQTL
PINGVFVFISWVSRYYQLKPVGTAGAARRLGLRRS"
gene 6983..7624
/gene="ORF3"
CDS 6983..7624
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58790.1"
/translation="MAQAVLGAIAATAAGSAVGAGIEAGTQAALQHQRYQQDLNMQSL
SFQHDKEMLGLQVDASNALLQRNLATRYNLLSAAGLSSADAARMIAGAPPTKVVDWNG
VRISAPTSSAITLKSGSFMSVPVMNYKTNKNVTGIDNPNYAPSGSSMVSRTSQWVESQ
NSLRSLDPFHRSALQTTWVTPPGSTSVSTVSSTSTIPRYFNTERLPLFANLRK"
ORIGIN
1 tgctgatgtc agcaataaca atgctaacac caacaatgaa aatattgggt cccgccttat
61 ggcgaggatc cgtgggcgca taggtccaca acgtggtgaa acaactacaa agattaagga
121 tgccagtatg gcacttgacc tgctacgccg gtcacaaaca ccctccccag ctcgacaaga
181 gagtcccccc aaagatcaga gagatcgtcc tccacgaacc gtttcagagg ttaaaagggc
241 catgaagtgg gatgttgaac cagaacaccg ggaaagtaca gcaagagcct ggtgcgatct
301 ctcgaaggaa gaaaaagagg agataatgcg caacaatgag aagctatttg atgctggggg
361 agtcactcca tcaactctac ccagcacatt tgaaagggct gaaacaaaca atgatgttag
421 tgaccaacaa gctgtatcat ggtctgctaa tgatggagtg aatattggcg ttagtgatct
481 gaccactgtc catggaccat tttggaatat gtgccccctc ccaccattgg acgctcgcaa
541 caatggtcct gccaaagagc ccctcatagg ggatatgata gagttctatg aaggccacat
601 attccactac gccatttata tagggcaagg taagactatt ggggtccact cgccacaggc
661 tgctttttcc atacccagaa taaccatcca ccctttggtg gcttggtggc gcgtgtgtta
721 tgttcccaat gaccgtcaac gcctcaccta tgatcaactt aaagaattgg agaatgaacc
781 atggccatat gccgctgtta ctaacaactg ctatgaattt tgttgtagag tgatggcgct
841 agatgacact tggctccaaa ggagactggt tagcactgga aagttcaacc accccacaca
901 ggattggtca caagacaccc cagacttcca ccaagattcg aagttagaaa tggtgagaga
961 tgctgtactg tcagccatta acggtcttgt gtcacaaccc ttcaaaaaca ttctttcaaa
1021 gatcaagcca ttaaatgtgc tcaatctttt atcaaactgt gattggacct tcatgggggt
1081 tgtagagctg atcgtcctca tggcagaatt gttcgatata ttctggactc caccagatat
1141 ctcgagcttt attgcatcgc tattgccaga ttttcatctt caaggcccag aggacttagc
1201 tagggacctg gtcccactca tactaggtgg cattggccta gcaattggct ttacaagaga
1261 caagataaca aaagtgatga agagtgccgt tgatggtctg cggtcagcga cacagcttgg
1321 acagtatgga ttagaaatat tctcaatcat aaagaaatac ttctttggag gtgaccagac
1381 agaaaagacc ctccggggca tcgaggatgc agtgatagac atggaggtat tgtccagcac
1441 caacgtaaca caattggtca aggacaagaa gttggccaga acttacatga atgtactgga
1501 taatgaggaa gaaaaggcta gaaaactctc agtccgcagt gctgacccac acatagtaac
1561 ctcagtcaac aacttgatat ctcgcatttc aatggcaaga tcagccctgg ccaaggccca
1621 agcagaaatg acatcccgcc cacgcccagt ggtcataatg atgtgtggtc cccctggcat
1681 tgggaaaacg aaagctgctg agcacctggc gggccgattg gctgccgaaa taagaccagg
1741 gggaaaagtc ggtcttgtgc cgcgagagtc catagaccac tgggacggtt atcatggtga
1801 ggacgttctg ctctgggatg attatggtat gtcaaaaata acagaagatt gcaataaatt
1861 gcaagccata gctgacactg caccactgtc actcaattgc gacaggatag aaaacaaagg
1921 catgcagttc tcctctgatg caataattat taccaccaat gctcctggtc cagctccagt
1981 tgactttgtt aatctgggtc ctgtgtgcag gcgggtggac tttttagtat actgctctgc
2041 tccagaaatt gaacaaatgc ggagggccca cccaggtgac actaatgcta ttaaggacct
2101 gtacaagaaa gatttcacgc acctcaagat ggaattagct ccacaaggtg gctttgatag
2161 ccagggcaac acgccgtttg gaaaaggtgt tatgaagccc acaaccctca ataggctatt
2221 gatccaggcc acagcattag ccatggagcg gcaagatgag tttcagcttc aaggggccac
2281 ctacaatttt gacgaggata gggtggccgc tttcaccaac ttagcacgcg ccaatggcct
2341 ggggctcata agcatggcaa cattgggtaa gaaattgagg ggtgtcaaat caatggaggg
2401 gctgcgcaat gcactattgg gctataaaat agaagaatgt gacatagtct ggaacaccag
2461 aatgtactct attaagagtg acgggaatac cgtcacaatt aaagagaagc aggcaccaac
2521 ctcgccccaa caccaggcta tctgcacggc caccctcgcg ctctcccggt tgcgggctgc
2581 tagggccctt gcatatgctt cttgcttaca gagtgctgtg ctgtcaatac ttcaggtggc
2641 tggatccgct gtggtggtaa gcagggccgt taagcgtatg tttggtacgc gcaccgaaca
2701 gcctatgcta gaaggtaagc acaaggaaca taattgcaga gtgcaccgag ctgaggcagc
2761 cggccatggc cccattggcc acgatggggt cattgaacgc tatggcctgt gtgagagtga
2821 acaagaggag gaaagcgtcc agacagtaga actacccact gccagtgagg agggcaagaa
2881 caaaggtaag accaagaagg gtcgtgggcg aaagtctaat ttcaatgcct tctccagacg
2941 cggccttagt gatgaggagt atgaagagta caagaaaatc agggaggaga aaagtggcaa
3001 ctacagtata caagagtacc ttgaagaccg acaacgctac gaggaagagc ttgctgaagt
3061 acaggcgggc ggagatggcg gaataggtga aactgaggca gaaatccgcc atcgggtctt
3121 ctataaatca aaatctggta tgaggaaaca acgccaagaa gaacggcgcc agctagggct
3181 cgtgagcggc accgagatca gaaagcgcaa acccatagac tggacccccc ccaagaacga
3241 ttggtcagag gacactagaa cagtcaatta tgacgaacat atcagttttg aagcaccacc
3301 ctcaatctgg agtagagtgg taaaatttgg tagtggttgg ggtttctggg ttagctcaac
3361 agtgttcatc accacgaccc atgtcatacc acctggggcc aaggaagttt ttggtgaaag
3421 catcagtaat gtggctatcc atagagtcgg tgagttcacc cagtttcgct tccctaaaaa
3481 gatgagacct gatctctctg gtatggtgct agaggaaggt tgtccagaag gcacagtatg
3541 caccataatg ataaagagag actctggtga gctgttacca cttgctgttc gcatgggtgc
3601 agtggcctca atgaaaatcc aaggaaagct catgcatgga caatcaggaa tgttgctcac
3661 tggcgccaat gccaaaggca tggacctcgg gaccataccc ggtgactgtg gggcgcctta
3721 cgtccacaaa aggggtaacg attgggttgt ttgcggagtc catgcagctg ccacaaaatc
3781 aggtaacact gtagtttgtg ctatacaagg tggtgagggt gaagccacgc tagagggtgg
3841 cgaccgcaat aagggccatt atgcaggaca cccaatattg agatacggga atggcccttc
3901 actctcaact aaaacaaaat tttggaagtc aaccccacaa cccctacctc caggtactta
3961 tgaaccagct tatctcggag gtagagaccc cagggtcgaa gggggcccat cactacaaca
4021 agttctaagg gaccagctga aaccatttgc tgaacctcga ggcagattac ctgaggcggg
4081 attgctagaa gccgcagttg agacagtcac caatgcactt gaacaggtca tggacacacc
4141 agtggcatgg agtttcagtg atgcttgcat gtctttggat aaaacaacta gctctggcta
4201 tccccaccat aagaggaaga atgatgattg gaatgggagt tcattcgtgc gagagctggg
4261 agaccaagca gcacacgcca ataacatgta tgaacttggc aaacccatga agcccgtgta
4321 cacagcagcc ctcaaggacg agcttgttaa accagataag gtttacaata aaatcaagaa
4381 gagactgctt tggggagctg accttggtac tgtcatacgt gctgctaggg cctttggacc
4441 attctgtgag gccataaagc cacatgtgat taagttgcct atcaaagtgg gcatgaatgc
4501 catagaagat ggccctctga tatatgcaga acattccaaa tataagtacc attatgatgc
4561 tgattacact gcttgggact caacgcaaaa cagagagatt atgatggagt ccttcaacat
4621 catgtgcaag ctcacagcca atccctcctt ggctgcggtg gtggctcagg acctactctc
4681 cccatctgag atggatgttg gtgattatgt aatcagtgtc aaagatggtc tgccatctgg
4741 ctttccatgc acctcacaag tcaacagcat taaccactgg atcatgaccc tatgtgcact
4801 atcagaggtc actggcttat cccctgatgt aatacaatca caatcctact tctccttcta
4861 cggtgatgat gagatagtct caacagacat tgaatttgac ccagctaaat tgacacaaat
4921 attaaaagag tatggcctga aacccacaag gcccgataaa actgatggcc ccattatagt
4981 caggcaacag gtggatggtc tggtcttcct tcgtcgcaca atttcgaagg acgctattgg
5041 gtaccaaggt cgacttgacc gcaactccat tgaaagacaa ctctggtgga cccgcggacc
5101 caaccatgaa gacccgtttg agaccctggt gccacactca caaagaaaag ttcaattgat
5161 atccctactg ggtgaggccg ccctgcatgg tgaaaaattc tacaggaaga tagccagtag
5221 ggtcatccaa gaagttaagg aagggggtct ggagatctat atccctgggt ggcaggctat
5281 gttccgctgg atgcgattcc atgacttaag tttgtggaca ggagatcgcg atctcttgcc
5341 cgattatgta aatgatgatg gcgtctaagg acgccccaac aaacatggat ggcaccagtg
5401 gtgccggtca gctggtacca gaggcaaata cagctgaacc tttaccaata aaaccagtgg
5461 ccggggctgc gactgcggtt gcaaccgccg gtcaggtaaa tatgattgac ccctggataa
5521 tgaataattt tgtacaggct ccccaagggg agtttaccat ttccccaaac aatacacctg
5581 gtgatatttt atttgatttg caattaggac cacatcttaa tcctttcttg gctcatttgt
5641 ctagaatgta taatggttgg gttgggaata tgcaggtccg tataatgctt gctggtaatg
5701 ccttttcagc tggaaagatt attgtgtgct gcataccgcc gggtttttct tctcaatcta
5761 tttctattgc tcaagctaca atgttcccac atgtcatagc tgatgttaga gtgttagaac
5821 ctattgatgt acccttagat gatgttagaa atgtcctttt tcataataat gataaccccc
5881 aaacgatgag attgctttgc atgttgtata caccccttcg gtctggtggt acatcttcag
5941 gtacagatcc ttttgtcatt gctggtcgtg tcttgacctg ccccacacct gattttagtt
6001 tcttgttcct tgtccctcct gatatcgagc aaagaactaa gccattcagt gtacccaata
6061 tccctatgaa cctgatgtcc aactcccgtg tttcaatgtt gattgatggt atgatggttt
6121 caaatgatca gaatcaagtc ccccagtttc agaatggtcg agtcacttta gatggacagc
6181 tgcagggtac caccacagtt tcagctgcgt gtgtagcaag gatgagggga cgcattttta
6241 ataataatgg caattatggt gtgaacctga ctgaactgga tggcaaccct tatcatgcct
6301 ttgatagccc ggctccctta ggctttcctg actttggaaa ttgtgatttg cacatgacct
6361 ttgttaaaat taatcccaat gagttgtcct ctggagaccc ttctggcaaa gtggtcattc
6421 attcctacga tgccactttt gccccccatc ttggtactgt caaactggag aatgatgatg
6481 agctagctcg gtttgtgggt aaggaggtag tactggagct gacgtgggtt tccaacagag
6541 agggtgccac ccttaaccta tgggctgttc caaattatgg ttccaatttg acacaggcgt
6601 cacagcttgc cccaccaatt tacccccctg ggtttggtga ggctattgtg tatttcacct
6661 ctacttttcc aacagtcagc aacccaaaag tcccatgtac acttcctcaa gaatttgttt
6721 cacattttgt caatgaacag gcccccacac gcggcgatgc cgctcttctt cattatgttg
6781 atcctgacac acaccgtaat cttggagagt ttaagatgta ccctgagggc tacatgacat
6841 gtgtccctaa tgctggtggt gggccacaaa ccttaccaat caatggtgta tttgtcttca
6901 tttcttgggt ttctagatat taccagttaa agcctgtggg aactgccggt gcggctagga
6961 ggcttggtct taggagatca taatggccca ggctgtcttg ggagccattg ctgcgactgc
7021 agcagggagt gctgtgggag caggtattga agctggcaca caggccgccc tgcaacatca
7081 aaggtatcaa caggatttaa atatgcagtc cctatccttt caacatgata aagaaatgtt
7141 aggcttacaa gtagatgctt ctaatgcttt attgcaaaga aatttggcca caagatataa
7201 tttgctgagt gcagcaggct tgtcgtctgc agatgctgct aggatgatag caggtgctcc
7261 accaactaaa gtagtggatt ggaatggagt cagaatatct gcccccacat caagtgcaat
7321 aaccctaaaa tctggcagtt ttatgtcagt gccagtcatg aattacaaaa ccaacaagaa
7381 tgtgacaggc atagacaacc caaattatgc acccagtggc tcatcaatgg ttagtcgcac
7441 cagccaatgg gtggaatctc aaaattcatt gcgctcgctt gatcctttcc ataggagcgc
7501 gttgcagaca acgtgggtta ctcctccagg atccacatct gtgtcaacag tgtcaagcac
7561 ttcaacaata cctaggtatt ttaatactga aagacttccg ctattcgcaa atctgcggaa
7621 gtaagttttt gtaatataaa gtgggcatta tattcagatt ggcttttgat tataattaat
7681 ttggctgatt agaaatttaa tgt
//