Typing tool
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Typing tool
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Complete norovirus genomes
| MW305481 | GI.2 | |
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| GI.P2 |
ORF1: 1..5335
ORF2: 5319..6959
ORF3: 6959..7594
LOCUS MW305481 7671 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GI isolate PNV006003 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305481
VERSION MW305481.1
KEYWORDS .
SOURCE Norovirus GI
ORGANISM Norovirus GI
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7671)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REFERENCE 2 (bases 1 to 7671)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7671
/organism="Norovirus GI"
/mol_type="genomic RNA"
/isolate="PNV006003"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122928"
/geo_loc_name="Peru"
/collection_date="28-Apr-2008"
/note="genotype: GI.2[GI.P2]"
gene <1..5335
/gene="ORF1"
CDS <1..5335
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QPJ58779.1"
/translation="NVASNNNANNTSATSRFLSRFKGLGGGASPPSPIKIKSTEMALG
LIGKTTPEATGTAGPPPKQQRDRPPRTQEEVQYGMGWSDKPVDQNVKSWEELDTTVKE
EILDNHKEWFDAGGLGPCTMPPTYERVKDDNSPGEQVRWSARDGVNIGIERLTTVSGP
EWNLCPLPPIDLRNMEPASEPTIGDMIEFYEGHIYHYSIYIGQGKTVGVHSPQAAFSV
ARVTIQPIAAWWRVCYIPQPKHRLSYDQLKELENEPWPYAAITNNCFEFCCQVMNLED
TWLQRRLITSGRFHHPTQSWSQQTPEFQQDSKLELVRDAILAAVNGLVSQPFKNFLGK
LKPLNVLNILSNCDWTFMGVVEMVILLLELFGVFWNPPDVSNFIASLLPDFHLQGPED
LARDLVPVILGGMGLAIGFTRDKVTKVMKSAVDGLRAATQLGQYGLEIFSLLKKYFFG
GDQTERTLKGIEAAVIDMEVLSSTSVTQLVRDKQAAKAYMNILDNEEEKARRLSARNA
DPHVISSTNALISRISMARSALAKAQAEMTSRIRPVVIMMCGPPGIGKTKAAEHLAKR
LANEIRPGGKVGLVPREAVDHWDGYHGEEVMLWDDYGMTKIQDDCNKLQAIADSAPLT
LNCDRIENKGMQFVSDAIVITTNAPGPAPVDFVNLGPVCRRVDFLVYCSAPEVEQVRR
VSPGDTSALKDCFKPDFSHLKMELAPQGGFDNQGNTPFGRGTMKPTTINRLLIQAVAL
TMERQDEFQLQGKMYDFDDDRVSAFTSMARDNGLGILSMAGLGKKLRGVTTMEGLKNA
LKGYKISACTIKWQAKVYSLESDGSNVNIKEERNILTQQQQSVCTASVALTRLRAARA
AAYASCVQSAITSILQIAGSALVVNRAVKRMFGTRTATLSLEGPPREHKCRVHMAKAA
GKGPIGHDDVVEKYGLCETEEDEEVVHAEIPTATIEGKNKGKNKKGRGRRNNYNAFSR
RGLNDEEYEEYKKIREEKGGDYSIQEYLEDRQRYEEELAEVQAGGDGGIGETEMEIRH
RVFYKSKSRKHHQEERRQLGLVTGSDIRKRKPIDWTPPKSAWADDEREVDYNEKISFE
APPTLWSRVTKFGSGWGFWVSPTVFITTTHVIPTSAKEFFGEPLTSIAIHRAGEFTLF
RFSKKIRPDLTGMILEEGCPEGTVCSVLIKRDSGELLPLAVRMGAIASMRIQGRLVHG
QSGMLLTGANAKGMDLGTIPGDCGAPYVYKRANDWVVCGVHAAATKSGNTVVCAVQAS
EGETTLEGGDKGHYAGHEIIKHGCGPALSTKTKFWKSSPEPLPPGVYEPAYLGGRDPR
VTGGPSLQQVLRDQLKPFAEPRGRMPEPGLLEAAVETVTSSLEQVMDTPVPWSYSDAC
QSLDKTTSSGFPYHRRKNDDWNGTTFIRELGEQAAHANNMYEQAKSMKPMYTAALKDE
LVKPEKVYQKVKKRLLWGADLGTVVRAARAFGPFCDAIKSHTIKLPIKVGMNSIEDGP
LIYAEHSKYKYHFDADYTAWDSTQNRQIMTESFSIMCRLTASPELASVVAQDLLAPSE
MDVGDYVIRVKEGLPSGFPCTSQVNSINHWLITLCALSEVTGLSPDVIQSMSYFSFYG
DDEIVSTDIEFDPAKLTQVLREYGLRPTRPDKSEGPIIVRKSVDGLVFLRRTISRDAA
GFQGRLDRASIERQIYWTRGPNHSDPFETLVPHQQRKVQLISLLGEASLHGEKFYRKI
SSKVIQEIKTGGLEMYVPGWQAMFRWMRFHDLGLWTGDRNLLPEFVNDDGV"
mat_peptide <1..1165
/gene="ORF1"
/product="p48"
mat_peptide 1166..2254
/gene="ORF1"
/product="NTPase"
mat_peptide 2255..2851
/gene="ORF1"
/product="p22"
mat_peptide 2852..3265
/gene="ORF1"
/product="VPg"
mat_peptide 3266..3808
/gene="ORF1"
/product="Pro"
mat_peptide 3809..5332
/gene="ORF1"
/product="RdRp"
gene 5319..6959
/gene="ORF2"
CDS 5319..6959
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58780.1"
/translation="MMMASKDAPQSADGASGAGQLVPEVNTADPLPMEPVAGPTTAIA
TAGQVNMIDPWIINNFVQSPQGEFTISPNNTPGDILFDLQLGPHLNPFLSHLSQMYNG
WVGNMRVRILLAGNAFSAGKIIVCCVPPGFTSSSLTIAQATLFPHVIADVRTLEPIEM
PLEDVRNVLYHTNDNQPTMRLVCMLYTPLRTGGGSGSSDSFVVAGRVLTAPSSDFSFL
FLVPPTIEQKTRAFTVPNIPLQTLSNSRFPSLIQGMILSPDTSQVVQFQNGRCLIDGQ
LLGTTPATSGQLFKVRGKINQGGRTLNLTEVDGKPFMAFDSPAPVGFPDFGKCDWHMR
ISKTPNNTRAGDPMRSVSVQTNVQGFVPHLGSIQLDEEFNHPTGDYIGTIEWISQPST
PPGTDINLWEIPDYGSSLSQAANLAPPVFPPGFGEALVYFTSAFPGPNNRSVSNDVPC
LLPQEYITHFVSEQAPTMGDAALLHYVDPDTNRNLGEFKLYPGGYVTCVPNGVGAGPQ
QLPLNGVFLFVSWVSRFYQLKPVGTASTARGRLGVRRI"
gene 6959..7594
/gene="ORF3"
CDS 6959..7594
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58781.1"
/translation="MAQAIIGAIAASAAGSALGAGIQAGAEAALQSQRYQQDLALQRN
TFEHDKDMLSYQVQASNALLAKNLNTRYSMLVAGGLSSADASRAVAGAPVTQLIDWNG
IRVAAPRSSATTLRSGGFMAVPMPVQPKSKAPQSSGFSNPAYDMSTVSSRTSSWVQSQ
NSLRSVSPFHRQALQTVWVTPPGSTSSSSVSSSPYGVFNTDRMPLFANLRR"
ORIGIN
1 taatgttgca agcaataaca atgctaacaa cactagtgct acatctcgat ttttatcgag
61 atttaaaggc ttaggaggtg gcgcaagccc ccctagccct ataaaaataa agagtactga
121 aatggccctg gggttaattg gtaaaacgac cccagaggca acagggactg ctggcccccc
181 acctaagcaa cagagggacc gacctcccag gacccaagag gaggtccagt atggtatggg
241 gtggtctgac aagcccgttg atcaaaacgt caagtcttgg gaagagcttg ataccacggt
301 caaggaagaa atcctggata atcacaaaga atggtttgat gctggcggct tgggcccttg
361 cacaatgcct ccaacatatg aacgggtcaa ggatgataat tcacctggtg aacaagtcag
421 gtggtccgca cgtgatgggg tcaacattgg aatagaacgt ctcacaacag tgagtggacc
481 tgaatggaac ctctgccctc taccccccat tgacctgagg aacatggaac cagcaagtga
541 acccaccatt ggagacatga tagaattcta tgaaggccat atctatcatt attccatata
601 tattggacag ggcaagacag ttggcgttca ttccccacag gcagcgttct cagtggccag
661 ggtgactatc cagcccatag ccgcttggtg gagggtctgc tacatacccc aacccaagca
721 caggctaagt tacgatcaac tcaaggaatt agagaatgag ccatggccat atgcggccat
781 aaccaacaat tgttttgagt tctgctgcca agtcatgaac cttgaggaca catggctaca
841 gaggcggcta atcacatcgg gcaggtttca ccaccctacc caatcgtggt cacaacaaac
901 ccctgagttc cagcaagata gcaagttgga gttggtcagg gatgctatac ttgctgcagt
961 gaatggcctt gtctcacaac cttttaaaaa tttcttgggt aaactcaaac ccctcaatgt
1021 gctcaacatc ctatccaact gtgattggac ctttatggga gtggttgaaa tggttatact
1081 gttgcttgaa ctctttggtg tgttctggaa cccacctgat gtgtccaact tcatagcgtc
1141 ccttctccct gacttccatc ttcaggggcc cgaagactta gcacgagacc tagtcccagt
1201 gatccttggc ggtatggggt tagctattgg gttcaccagg gacaaggtca caaaggttat
1261 gaaaagtgct gtggatggcc ttcgagctgc tacacagctt ggacaatatg ggttagaaat
1321 attctcacta ttgaaaaagt acttctttgg gggggaccag actgaacgca ccctcaaagg
1381 cattgaggca gcagtcatag atatggaggt gttatcctct acatcagtaa cacaactagt
1441 gagggacaaa caggcagcta aagcttatat gaacatctta gacaatgaag aagaaaaggc
1501 taggaggctc tctgccagga acgctgaccc acatgtgatc tcttcaacaa atgccctgat
1561 atcgcgcata tccatggcac gatctgcatt ggctaaggcc caagctgaga tgaccagtcg
1621 gataagacca gttgtcatta tgatgtgtgg tccacctggg attggaaaga ccaaggctgc
1681 tgagcatttg gcaaagcgtc tagccaatga gatcagaccc ggtggcaagg tggggttagt
1741 accccgtgaa gctgtcgacc actgggacgg ttaccatggt gaggaagtca tgctatggga
1801 tgattatggc atgacaaaaa tacaagacga ctgcaacaaa ctccaggcca ttgctgattc
1861 ggccccactc accctaaatt gtgacaggat tgagaacaaa ggaatgcagt tcgtgtcaga
1921 tgcaatagtc attaccacca acgccccagg ccccgcccct gtagattttg ttaatctcgg
1981 cccagtgtgc aggcgggttg acttcctagt ttattgttcc gctcctgaag tggagcaagt
2041 aaggagagtc agccctggtg atacatcagc actgaaggac tgtttcaagc cagacttctc
2101 ccatctaaaa atggaactgg ccccacaagg ggggtttgac aaccaaggga acacaccatt
2161 tggtagaggc accatgaagc caacaaccat taaccggctc ctcatacaag ctgtggccct
2221 caccatggag agacaagatg agttccagtt gcagggaaag atgtatgatt ttgatgatga
2281 cagggtctca gcattcactt ccatggcacg tgacaacggc ctaggcatct tgagcatggc
2341 aggtcttggc aagaagctac gcggtgtcac gacaatggag ggcctgaaga acgcattgaa
2401 gggatacaaa attagtgcat gcacaataaa atggcaagcc aaagtgtact cactagagtc
2461 agatggcagc aatgtcaaca ttaaagaaga gaggaacatc ctgactcaac aacaacagtc
2521 agtgtgcact gcctccgtcg cgcttactcg ccttcgggct gcgcgcgcgg cggcatacgc
2581 ttcatgcgtc caatcggcca taacttccat actacaaatt gctggctcag ccctagtggt
2641 taatagggcg gtgaagagaa tgtttggcac gcgcactgcc accttgtccc tagagggccc
2701 ccccagagaa cacaaatgca gggtccatat ggccaaggcc gcaggaaagg gacctattgg
2761 ccatgatgat gtggtagaaa agtatggact ttgtgagact gaggaggatg aagaagtggt
2821 tcacgctgaa attccaactg ctaccataga gggcaagaat aaaggaaaga acaagaaagg
2881 acgtggccga aggaacaact acaatgcctt ttcccgtaga gggcttaatg atgaggagta
2941 cgaagagtac aagaagatac gtgaggagaa aggcggtgat tatagcatac aggagtacct
3001 agaagacaga caaaggtatg aagaagagct tgcagaggtt caggcaggcg gagatggagg
3061 aatcggggaa actgaaatgg aaatccgcca cagggtgttc tacaaatcta agagcaggaa
3121 gcaccaccag gaagaaaggc gtcagctggg gctggtgaca ggctccgata ttcgcaagag
3181 aaaaccaatc gactggaccc cacccaagtc agcatgggca gatgacgagc gtgaggtgga
3241 ttacaatgag aagatcagct ttgaggcgcc ccccacccta tggagtagag tgacaaagtt
3301 cgggtccgga tggggtttct gggtcagtcc cactgtcttc ataaccacaa cgcacgttat
3361 accaactagt gcgaaggaat tctttggtga gcccttaacc agcatagcta tccacagggc
3421 aggcgagttc actctcttca ggttttcaaa gaaaatcaga cctgacctca caggtatgat
3481 ccttgaggag ggttgtcctg agggcacggt gtgctcggtg ctaataaaga gagactctgg
3541 tgaactgttg ccgttggccg tgagaatggg cgcaatagca tcaatgcgca tacagggccg
3601 tcttgtccac ggacaatctg gcatgttact cactggagcc aacgccaagg gcatggatct
3661 tggaaccata ccaggagatt gtggggcccc ctatgtctat aaaagagcca atgactgggt
3721 ggtctgtggt gtgcacgccg ctgccaccaa atcaggcaac actgttgtgt gtgctgtcca
3781 ggccagtgaa ggagaaacca cgcttgaagg tggcgacaaa ggccattatg ctggacatga
3841 aataattaag catggttgcg gaccagccct gtcaactaaa accaaatttt ggaagtcatc
3901 ccctgaacca ttaccccctg gggtttatga acctgcatat cttggaggcc gagaccctag
3961 ggtgactggt ggtccctcac tccagcaagt gttacgggat cagttaaaac catttgctga
4021 accacgagga cgcatgccag agccaggcct cttggaagct gcagttgaga ctgtgacttc
4081 atcattagag caggttatgg acacccccgt cccttggagc tacagtgatg cgtgccagtc
4141 ccttgacaaa actactagtt ctggcttccc ctaccacagg aggaagaatg atgactggaa
4201 tggtaccacc tttattaggg agctagggga gcaagcagca catgccaaca atatgtatga
4261 acaagctaaa agcatgaagc ccatgtacac ggcagcgctt aaagatgaat tagtgaaacc
4321 agaaaaagtg taccagaaag tcaaaaagcg cttattgtgg ggggcagatt tgggcacggt
4381 agtccgtgct gcacgggctt tcggcccatt ctgtgatgcc ataaagtccc acacaatcaa
4441 attacctatc aaagttggga tgaattcgat tgaagatggg ccattaattt atgctgaaca
4501 ttcaaagtat aaatatcact ttgatgcaga ttatacagct tgggactcaa ctcaaaatag
4561 gcaaatcatg actgagtcat tttcaatcat gtgccgactc acagcatcac ccgagttggc
4621 ttcggtggtg gctcaagact tactcgcacc ctcagaaatg gacgttggcg actatgtcat
4681 aagagtcaaa gagggcctcc catctgggtt cccatgtaca tcacaagtca atagtataaa
4741 tcattggcta ataaccctgt gtgccctttc tgaagtaact ggtctatcgc cagacgttat
4801 ccagtccatg tcatacttct ctttctatgg tgatgatgag atagtatcaa ctgacataga
4861 atttgatcca gcaaaactga cacaagttct cagagagtat gggcttaggc ctactcgccc
4921 tgacaagagt gagggcccaa taattgtaag gaagagtgtg gacggcttgg tcttcttgcg
4981 tcgcaccatt tcccgtgacg ctgcgggatt tcaagggcga ctggaccgag catccattga
5041 aaggcagatc tactggacca ggggacctaa tcattcggac ccttttgaga ccctagtgcc
5101 acaccaacaa aggaaagtcc aattaatttc actactaggt gaagcctcat tacatggtga
5161 aaagttttat aggaagattt caagcaaagt catccaggag attaagacag ggggtcttga
5221 aatgtatgtg ccaggatggc aagccatgtt ccgttggatg cggttccatg atcttggctt
5281 gtggacagga gatcgcaatc tcctgcccga atttgtaaat gatgatggcg tctaaggacg
5341 cccctcaaag cgctgatggc gcaagcggcg caggtcaact ggtgccggag gttaacacag
5401 ctgacccctt acccatggaa cccgtggctg ggccaacaac agccatagcc actgctgggc
5461 aagttaatat gattgatccc tggattatta ataattttgt ccagtcacca caaggtgagt
5521 ttacaatttc ccctaataac acccccggtg atattttgtt tgatttacaa ttaggtccac
5581 atttaaatcc cttcttgtca catttgtccc agatgtataa tggctgggtt ggaaatatga
5641 gggttaggat tctccttgct gggaatgcat tctcagctgg aaagattata gtttgttgtg
5701 tcccccctgg ttttacttcc tcctctctta ctatagccca ggccacattg tttccccatg
5761 tgattgctga tgtgaggact cttgaaccaa tagaaatgcc tcttgaggat gtgcgtaacg
5821 tcctctacca caccaatgat aaccaaccaa cgatgcggct ggtgtgtatg ctgtacacgc
5881 ctctccgcac tggtggaggg tctggcagtt ctgactcttt cgtagttgct ggtagggtgc
5941 tcacggctcc tagcagcgac ttcagcttct tgttcctcgt tccacctact atagaacaga
6001 aaacccgggc tttcactgtg cctaacattc ccctgcaaac cttgtccaat tctaggttcc
6061 cttccctcat tcaaggaatg attctatccc ctgacacatc ccaagtggtc caattccaga
6121 atggacgttg cctcatagac ggtcaactcc taggcaccac acctgctaca tcaggacagc
6181 tattcaaagt aagaggaaag ataaatcagg gaggccgcac actcaacctt acagaggtgg
6241 atggcaaacc gttcatggca tttgattccc ctgcacccgt ggggttccct gattttggaa
6301 aatgtgattg gcatatgagg atcagcaaga ctccaaataa cacaagagca ggtgacccca
6361 tgcgtagtgt cagtgtgcaa accaacgtgc agggttttgt gcctcatctg ggaagcatac
6421 agcttgatga agaattcaac caccccacgg gtgactacat tggcaccatt gaatggattt
6481 cccagccatc tacacccccc ggaacagata ttaacttgtg ggagattccc gattatgggt
6541 catctctttc ccaagcagct aatttggccc ctccagtgtt cccccccgga tttggtgagg
6601 ctcttgtgta cttcacttct gcttttccag gtcccaataa tcgttcagtt tcaaatgatg
6661 tgccttgcct tcttccccaa gaatacataa cccactttgt tagtgagcag gccccaacta
6721 tgggtgacgc agctttgctg cattatgttg accctgatac caacaggaac cttggggagt
6781 tcaaactata ccctggaggt tatgtcacct gtgtgccaaa tggggtgggt gccgggcctc
6841 aacagcttcc tctcaatggt gtctttctct ttgtctcttg ggtatctcga ttttatcagc
6901 tcaagcctgt gggaacagcc agtacggcaa gaggtaggct tggagtgcgc cgcatataat
6961 ggcccaagcc attataggag caattgccgc gtcggctgct ggctcagcac tgggtgcagg
7021 catccaggct ggtgccgaag ctgcgcttca gagtcagaga taccaacagg acttagccct
7081 gcaaaggaat acatttgaac atgacaaaga tatgctctcc taccaagtcc aggcaagcaa
7141 cgcactccta gccaaaaatc tcaacacccg ctattctatg cttgttgcag gaggtctttc
7201 tagtgctgat gcttcaagag ctgttgctgg agctccagtg acacaattga ttgattggaa
7261 cggtattcgg gttgccgccc ccagatcaag tgcaacaacc ttgaggtctg gtggtttcat
7321 ggcagtccct atgcctgttc aacccaaatc taaggccccg caatcttctg ggttctctaa
7381 tcctgcttat gatatgtcta cagtttcttc tagaacttct tcttgggtgc aatcacaaaa
7441 ttccttacga agtgtgtcac cattccatag gcaagctcta cagaccgtgt gggttacccc
7501 acctgggtcc acttcctctt cttctgtctc ttcttcacct tatggtgttt ttaatacaga
7561 tagaatgccg ctattcgcaa atctgcggcg ctaatgttgt aatataatgc agcagtgggc
7621 actatattca atttggttta attggtaact aatttgatca ttgattagtg t
//