Typing tool
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Typing tool
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Complete norovirus genomes
| MK773582 | GII.2 | |
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| GII.P16 |
ORF1: 1..4968
ORF2: 4949..6577
ORF3: 6577..7346
LOCUS MK773582 7346 bp RNA linear VRL 14-APR-2019
DEFINITION Norovirus GII isolate Hu/US/2016/GII.P16-GII.2/Mecklenburg0362
nonstructural polyprotein (ORF1) gene, partial cds; VP1 (ORF2)
gene, complete cds; and VP2 (ORF3) gene, partial cds.
ACCESSION MK773582
VERSION MK773582.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7346)
AUTHORS Barclay,L., Cannon,J.L., Wikswo,M.E., Phillips,A., Browne,H.,
Montmayeur,A.M., Tatusov,R.L., Burke,R.M., Hall,A.J. and Vinje,J.
TITLE Emergence and characterization of multiple viruses associated with
a novel GII.P16 polymerase in the United States, 2015-2018
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7346)
AUTHORS Barclay,L., Cannon,J.L., Rath,S., Montmayeur,A.M., Tatusov,R.L.,
Chhabra,P. and Vinje,J.
TITLE Direct Submission
JOURNAL Submitted (09-APR-2019) Division of Viral Diseases, Centers for
Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA
30329, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: Geneious v. R10; SPAdes v. 3.6
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7346
/organism="Norovirus GII"
/mol_type="genomic RNA"
/strain="Mecklenburg0362"
/isolate="Hu/US/2016/GII.P16-GII.2/Mecklenburg0362"
/isolation_source="stool"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="USA"
/collection_date="01-Dec-2016"
/note="genotype: GII.P16-GII.2"
gene <1..4968
/gene="ORF1"
CDS <1..4968
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="QBY34783.1"
/translation="KQPAPRNKPQEPPRPPTPELVKRIPPPPPNGEEEEEPVIRYEVK
SGISGLPELTTVPQPDVANTAFSVPPLSLRENREAKEPLTGAILEMWDGEIYHYGLYV
EKGLVLGVHKPPAAISMARVELTPLSLYWRVVYTPQYLISPDTLRRLNGEAFPYTAFD
NNCYAFCCWVLDLNDSWLSRRMVQRTTGFFRPYQEWNRKPLPTMDDSKIKKVANIFLC
SLSTLFTRPIKDLIGKIKPLNILNILATCDWTFAGIVESLILLAELFGVFWTPPDVSA
MIAPLLGDYELQGPEDLAVELVPVVMGGIGLVLGFTKEKIGKMLSSAASTLRACKDLG
AYGLEILKLVMKWFFPKKEEANELAMVRAIEDAVLDLEAIENNHMTTLLKDKDSLATY
MKTLDMEEEKARRLSTKSASPDIVGTINALLARIAAARSLVHRAKEELSSRIRPVVVM
ISGKPGIGKTHLAREVARKVASTLTGDQRVGLIPRNGVDHWDAYKGERVVLWDDYGMS
NPIHDALRIQELADTCPLTLNCDRIENKGKVFDSEVIIITTNLANPAPLDYVNFEACS
RRIDFLVYAEAPDVEKAKRDFPGQPDMWKDAFKPDFSHIKLQLAPQGGFDKNGNTPHG
KGVMKTLTTGSLIARASGLLHERMDEFELQGPTTTTFNFDRNRITAFRQLAAENKYGL
VDTMKVGNQLKGVKTMEELKQAIRNVTIKRCQIIYGGSTYDLESDGKGKVLVEKVKNT
SVQTNNELAGALHHLKHARIRYYVKCVQEAVYSIIQIAGAAFVTTRIARRMNIQELWS
KPQLDQNESETKEEAPKSEDDEFIISSKDIKEEGKKGKNKTGRGKKHTAFSSKGLSDE
EYDEYKRIREERNGKYSIEEYLQDRDRYYEELAIAKATEEDFCEEEEIKIRQRIFRPT
RKQRKEERATLGLVTGSEIRKRNPDDFKPKGKLWADDNRSVDYNEKLDFEAPPSIWSR
IVSFGSGWGFWVSPSLFITSTHVIPAGITEAFGVPIKQIQIHKSGEFCRFRFPKPIRP
DVTGMILEEGAPEGTVATVLIKRPTGELMPLAARMGTHATMKIQGRMVGGQMGMLLTG
SNAKGMDLGTTPGDCGCPYIYKRGNDYIVIGVHTAAARGGNTVICATQGSEGEATLEG
GDDKGTYCGAPILGPGGAPKLSTKTKFWRSSNTPLPPGTYEPAYLGGRDPRVKGGPSL
QQVMRDQLKPFTEPRGKPPRPSVLEAAKQTIINVLEQTLDPPQKWTYAQACASLDKTT
SSGHPHHVRKNEFWNGETFTGKLADQASKANLMFEEGKHMTPVYTAALKDELVKTEKI
YGKIKKRLLWGSDLSTMIRCARSFGGLMDEMKTHCISLPVRVGMNMNEDGPIIFEKHS
RYKYHYDADYSRWDSTQQRAVLAAALEIMVRFSAEPQLAQIVAEDLLAPSVVDVGDFK
ITINEGLPSGVPCTSQWNSIAHWLLTLCALSEVTKLSPDIIQANSMFSFYGDDEIVST
DIKLDPEQLTVKLKEYGLKPTRPDKTEGPLIISEDLNGLTFLRRTVTRDPAGWFGKLD
QSSILRQMYWTRGPNHEDPNETMIPHSQRPIQLMALLGEASLHGPSFYSKISKLVITE
LKEGGMDFYVPRQEPMFRWMRFSDLSTWEGDRNLAPNFVNEDGVE"
mat_peptide <1..864
/gene="ORF1"
/product="p48"
mat_peptide 865..1962
/gene="ORF1"
/product="NTPase"
mat_peptide 1963..2493
/gene="ORF1"
/product="p22"
mat_peptide 2494..2892
/gene="ORF1"
/product="VPg"
mat_peptide 2893..3435
/gene="ORF1"
/product="Pro"
mat_peptide 3436..4965
/gene="ORF1"
/product="RdRp"
gene 4949..6577
/gene="ORF2"
CDS 4949..6577
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QBY34784.1"
/translation="MKMASNDAAPSTDGAAGLVPESNNEVMALEPVAGAALAAPVTGQ
TNIIDPWIRANFVQAPNGEFTVSPRNAPGEVLLNLELGPELNPYLAHLARMYNGYAGG
MEVQVMLAGNAFTAGKLVFAAVPPHFPVENLSPQQITMFPHVIIDVRTLEPVLLPLPD
VRNNFFHYNQKDDPKMRIVAMLYTPLRSNGSGDDVFTVSCRVLTRPSPDFDFTYLVPP
TVESKTKPFTLPILTLGELSNSRFPVSIDQMYTSPNEVISVQCQNGRCTLDGELQGTT
QLQVSGICAFKGEVTAHLHDNDHLYNVTITNLNGSPFDPSEDIPAPLGVPDFQGRVFG
IISQRDKHNSPGHNEPANRGHDAVVPTYTAQYTPKLGQIQIGTWQTDDLTVNQPVKFT
PVGLNDTEHFNQWVVPRYAGALNLNTNLAPSVAPVFPGERLLFFRSYIPLKGGYGNPA
IDCLLPQEWVQHFYQEAAPSMSEVALVRYINPDTGRALFEAKLHRAGFMTVSSNTSAP
VVVPANGYFRFDSWVNQFYSLAPMGTGNGRRRVQ"
gene 6577..>7346
/gene="ORF3"
CDS 6577..>7346
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QBY34785.1"
/translation="MAGAFVAGLAGDVLSNGLSSLINAGANAINQRAEFDFNQKLQQN
SFNHDKEMLQAQIQATKQLQADMMAIKQGVLTAGGFSPADAARGAVNAPMTQALDWNG
TRYWAPNSMRTTSYSGKFTSTAPVRQADFQHTQNRPSSGSSVSSFATQSSRPTLTTTT
GSSHGTASSNSTRSTSLSQSTVSRATSRTGEWVRDQNRNLEPYMHGALQTAFVTPPSS
RASDGTVSTVPKGVLDSWTPAFNTRRQPLFAHLRKRGES"
ORIGIN
1 aaacagcctg ccccgagaaa caaaccacaa gagcccccaa gaccaccaac tcccgagttg
61 gtcaagagga taccccctcc tccacctaat ggcgaagaag aagaagaacc agtcattagg
121 tatgaggtta agagtgggat ctctggcctg cccgagctca caacagtccc ccaaccggac
181 gtggccaaca cagcatttag tgttccacca ctgagcttga gagaaaacag ggaggccaag
241 gaaccgctaa cgggggcaat attagagatg tgggatggag agatatacca ctatggcctg
301 tacgtggaga aaggcttagt gttgggtgtg cacaaaccac ctgcagccat aagcatggca
361 agagtggagc tgacgccgct gtcattgtac tggcgtgtgg tgtacactcc ccaatacctc
421 atctcccctg atactctcag gaggctcaac ggagaggcat tcccttacac cgcctttgac
481 aacaactgct acgccttttg ctgctgggtg ttagacctta atgactcatg gcttagcagg
541 aggatggtac aaagaacaac gggcttcttc agaccttacc aagagtggaa cagaaaaccc
601 ctgcctacca tggatgactc caaaattaag aaggtagcaa atatattcct atgttcattg
661 tccacattat tcaccagacc cataaaagac ctcataggaa aaattaaacc attaaacata
721 ttgaatatcc tggcaacgtg tgactggact tttgccggaa tagtggagtc tctgatatta
781 cttgctgaac tcttcggagt tttctggaca cccccagatg tgtctgctat gatcgctccc
841 ttactcgggg actacgagtt gcaagggcca gaagacctcg ccgttgaact cgtacctgtg
901 gtgatggggg ggattggttt ggtgttggga ttcaccaaag agaaaattgg caaaatgttg
961 tcctcagcag catcaacact cagggcttgc aaagatcttg gtgcctatgg cttagagata
1021 ctcaaattgg tcatgaagtg gttcttccca aagaaagagg aggccaatga gctagccatg
1081 gtgagggcca tagaggatgc tgtactagat cttgaggcaa tagaaaataa ccacatgaca
1141 accctgttga aagacaaaga cagcttagca acatacatga aaacattgga catggaggag
1201 gagaaggcca ggaggttgtc cacaaaatct gcatcccctg acatagttgg gacaatcaac
1261 gccctgctgg ctcgaatagc agcggccagg tcgttagtcc acagggccaa ggaagagcta
1321 tctagcagga taagaccagt agttgttatg atatctggca agccaggaat aggtaaaact
1381 catctggcca gggaggtggc aagaaaggtg gcatccactc tcacagggga tcaaagagtc
1441 ggactcatac cacgaaacgg tgtggaccat tgggatgcat acaaaggtga gagagtcgtg
1501 ctgtgggacg actatggcat gagtaacccc attcatgatg ctcttcgcat acaagaattg
1561 gctgatacgt gtccccttac cttaaattgt gacagaattg aaaataaggg aaaagttttt
1621 gacagtgaag tcataataat tacaacaaac cttgccaatc cagccccact tgattatgtc
1681 aactttgagg cctgttccag gagaattgat ttcctggtat acgctgaggc accagatgta
1741 gaaaaggcaa aacgggactt tcctggtcag ccagacatgt ggaaggacgc cttcaagccg
1801 gacttttcac acatcaagct acagcttgca ccccagggcg gctttgacaa gaatggcaac
1861 accccacatg ggaaaggagt gatgaagacc ctcactaccg gttctctgat tgcccgtgca
1921 tcaggcctac tgcatgagag gatggatgaa tttgaactcc aaggtcccac aaccaccacc
1981 ttcaatttcg accggaacag aatcacagca ttcagacaat tggctgcaga aaacaagtat
2041 ggattggtgg ataccatgaa agttggcaat caattaaaag gagtgaaaac catggaagaa
2101 ctcaaacaag caatcaggaa tgtgaccatc aagaggtgcc agatcatcta cggtggttcc
2161 acgtatgacc ttgaatctga tggcaagggc aaagttttgg tggaaaaggt caagaacacc
2221 tctgtacaga ccaacaacga gttggctggg gccctgcacc atctcaaaca tgcccgaatc
2281 agatactatg tcaaatgtgt gcaagaagca gtctattcca tcatacaaat tgccggcgct
2341 gcgtttgtca ccacgcgcat tgcacgccgc atgaacatac aagaactctg gtcgaagcca
2401 caattagatc aaaatgaatc agagactaag gaagaggccc ccaagtcaga agatgacgag
2461 ttcatcatat cttctaagga catcaaggag gaaggaaaga agggcaaaaa caaaactggc
2521 cgtggcaaga aacacactgc attctccagc aagggcttga gcgatgagga gtatgacgag
2581 tacaagagga taagagaaga gagaaatggg aagtactcta tagaggagta tcttcaagac
2641 agagacaggt actatgagga gctcgccatt gccaaggcca cggaagaaga cttctgtgaa
2701 gaggaggaga tcaaaatccg tcagagaatt ttccgtccca ccaggaaaca aagaaaggaa
2761 gagagggcca cattagggct agtaacaggt tcagaaatca gaaaaagaaa ccctgatgac
2821 ttcaaaccca aagggaagct gtgggccgat gacaacagga gtgttgacta caatgagaaa
2881 ctggactttg aggccccccc aagcatatgg tctaggattg tgagctttgg ttctggctgg
2941 ggcttctggg tgtcaccaag ccttttcata acatcaactc atgtaatccc cgcaggcata
3001 acagaggcat ttggagtccc catcaaacaa attcagatcc acaaatcagg tgaattttgc
3061 cgattcagat tcccaaaacc aattagacca gatgtgacag gaatgatttt ggaagaaggt
3121 gcgcctgagg gcaccgtggc aactgtgctc atcaaacgcc ccaccggaga gctcatgcct
3181 cttgcagcca gaatgggaac acacgcaacc atgaaaattc aaggccgcat ggttggcgga
3241 cagatgggta tgttgctcac tggatcaaat gctaaaggaa tggatttggg aacaacccct
3301 ggtgactgtg gctgtcctta catctataaa aggggcaatg actatatagt cattggggtg
3361 cacactgcag cagcccgtgg tggaaacacc gtcatctgtg ccacacaggg aagtgagggt
3421 gaggcaactc ttgagggtgg agatgacaaa ggaacatact gtggggcacc cattctaggc
3481 cctggaggtg caccaaaatt gagcaccaaa accaaatttt ggagatcatc gaacacgccc
3541 cttccaccag ggacatatga gcctgcctac ctcggtggcc gtgatccgcg tgttaagggt
3601 gggccttccc tgcagcaggt aatgagagac cagttgaagc cattcactga acccaggggc
3661 aaacctccaa gaccaagtgt attggaagca gccaaacaaa ccatcatcaa tgtcctcgag
3721 caaaccctgg accctccaca aaaatggaca tacgcacagg cgtgtgcctc acttgacaaa
3781 accacctcca gcgggcatcc ccatcacgtc cgaaagaatg aattctggaa tggtgagacc
3841 ttcactggta aactggcaga ccaagcatca aaagcaaacc taatgtttga ggaagggaaa
3901 cacatgacac cagtgtacac agcagcactc aaggacgagc tagtcaagac tgagaaaatc
3961 tatggaaaga tcaagaagag actgctctgg ggctctgact tgtccaccat gatccggtgc
4021 gctaggtcat ttggtgggct catggacgag atgaagacac actgcatatc actcccagtc
4081 cgagttggca tgaatatgaa tgaagatggc ccaataatat ttgagaaaca ttccagatac
4141 aaatatcact atgatgcaga ctactctcgt tgggattcaa cacaacagag ggcagtacta
4201 gcagcagcct tggaaatcat ggtcagattc tctgcagaac cacaattggc acaaatagtc
4261 gctgaggatc tgctggcccc tagtgtagta gatgtaggag actttaaaat tacaataaat
4321 gaagggctcc cttctggtgt gccatgcact tctcaatgga actccatcgc acactggctg
4381 ctaactctct gtgccttgtc tgaagtcacc aaactgtccc ctgacattat acaggcaaat
4441 tccatgttct cattttacgg tgatgacgag attgtcagca ccgacataaa attggaccct
4501 gaacaattaa ccgtcaaatt gaaggagtac ggcctgaaac caacccgccc agacaaaacc
4561 gagggacccc tgattatcag tgaagatttg aacggtctca ctttcctccg aaggacggtg
4621 actcgtgacc cagctggctg gtttggaaaa ctggaccaaa gctcaatttt gaggcagatg
4681 tactggacta gaggaccaaa tcatgaagac cccaatgaga caatgatacc ccattctcaa
4741 agacccatac agctcatggc actgcttggt gaagcctctc ttcacggacc ctctttctac
4801 agtaaaatca gtaaattggt cataactgaa ctcaaagaag gtgggatgga cttttacgtg
4861 ccaaggcagg aacccatgtt caggtggatg aggttttctg acttgagcac gtgggagggc
4921 gatcgcaatc tggctcccaa ttttgtgaat gaagatggcg tcgaatgacg ccgctccatc
4981 tactgatggt gcagccggcc tcgtgccaga aagtaacaat gaggtcatgg ctcttgaacc
5041 cgtggctggt gccgccttgg cagccccggt caccggtcaa acaaatatta tagacccttg
5101 gattagagca aattttgtcc aggcccccaa tggtgaattt acagtctctc cccgaaatgc
5161 ccctggtgaa gtgctattga atctagagtt gggtccagaa ttaaatcctt atctggcaca
5221 tttagcaaga atgtacaatg ggtatgccgg tgggatggag gtgcaggtca tgttggctgg
5281 gaacgcgttc acagccggca agttggtctt cgccgccgtg cctcctcact tcccggttga
5341 aaaccttagc ccacagcaaa tcaccatgtt ccctcatgtg atcatagatg tgagaacctt
5401 ggaacctgtt ttattaccac tccctgatgt taggaataat ttcttccatt ataatcagaa
5461 agatgatccc aagatgagga ttgtggctat gctttatacc cccctcaggt ctaatggttc
5521 aggtgatgac gtgtttacag tctcctgtag agtgttgact agaccttccc ctgactttga
5581 cttcacatac ctggtgccac caacagtgga gtctaaaaca aagccattca ccctcccaat
5641 cctcacactt ggggaactat ccaattctag gttcccagtg tccatagacc agatgtacac
5701 cagccctaat gaagttatat cagtgcagtg tcaaaatggc aggtgcacac tggacgggga
5761 gctccaaggg acaacacaac tccaagtcag tggcatttgt gctttcaaag gtgaagtgac
5821 cgcccacttg catgacaatg atcacctata taatgttacc atcacaaact tgaatgggtc
5881 cccttttgat ccctccgagg acatccctgc ccctctgggt gtgcctgact tccagggaag
5941 ggtttttggt atcatctccc aaagagacaa acacaatagt cctgggcata atgaaccagc
6001 aaacagggga cacgacgctg tggtccctac ttacacagca cagtacactc caaaactggg
6061 acaaattcaa attggcacat ggcagactga cgaccttaca gtcaaccaac cagtcaaatt
6121 caccccagtt ggactcaatg acactgaaca ttttaatcaa tgggtggtcc ctaggtatgc
6181 tggtgcccta aacctcaata caaatcttgc cccttctgtt gctccagtat ttccaggaga
6241 gcgcctgctc ttcttcagat catacattcc cctcaagggc ggttatggaa acccagccat
6301 tgattgccta ctaccacaag agtgggtgca acacttctat caggaagcag ccccttcaat
6361 gagtgaggtg gccctcgtca gatacatcaa cccggacact ggtcgggcac tgtttgaggc
6421 caagctccac agagctggtt tcatgacagt ctcgagcaac accagtgccc cggtggttgt
6481 gcctgccaac ggatacttca gatttgattc ttgggtgaac caattctatt ctctcgcccc
6541 catgggaact gggaatgggc gtagaagggt tcaataatgg ctggagcttt tgtagctggt
6601 cttgcagggg acgtgctcag caatgggctt agttcattaa ttaatgcagg tgctaatgca
6661 ataaatcaga gggcagaatt tgattttaat caaaaattgc agcaaaattc ttttaatcat
6721 gataaggaga tgttgcaggc tcagattcag gcaactaagc agctgcaggc agacatgatg
6781 gctataaaac aaggggtctt gaccgctggc ggcttttccc ctgctgatgc agccagaggt
6841 gctgtgaacg cgcccatgac acaggcgctg gattggaatg gcacaaggta ttgggcacca
6901 aactccatga gaaccacatc ttattctgga aaattcacat caaccgcccc agtgaggcag
6961 gctgacttcc agcacaccca aaaccggcct tcgagtggct cctctgtgtc ttccttcgcc
7021 actcagtctt caaggccaac tctgaccaca accactggtt cctcacatgg cacagcctca
7081 tcaaattcaa ctcgcagcac aagcctctcc caatcaacgg tctccagagc tacatctagg
7141 actggtgagt gggttagaga tcaaaataga aatttggaac cctacatgca tggtgcctta
7201 cagacagcct ttgtcacccc accttccagc agggcatctg acgggacagt ctcaaccgtc
7261 ccgaaaggtg ttttggactc ctggacacct gcgtttaaca cccgcaggca gccgcttttt
7321 gcacacctcc gtaagagggg ggagtc
//