Typing tool
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Typing tool
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Complete norovirus genomes
| MK773581 | GII.2 | |
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| GII.P16 |
ORF1: 1..5008
ORF2: 4989..6617
ORF3: 6617..7386
LOCUS MK773581 7386 bp RNA linear VRL 14-APR-2019
DEFINITION Norovirus GII isolate Hu/US/2016/GII.P16-GII.2/Mecklenburg0360
nonstructural polyprotein (ORF1) gene, partial cds; VP1 (ORF2)
gene, complete cds; and VP2 (ORF3) gene, partial cds.
ACCESSION MK773581
VERSION MK773581.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7386)
AUTHORS Barclay,L., Cannon,J.L., Wikswo,M.E., Phillips,A., Browne,H.,
Montmayeur,A.M., Tatusov,R.L., Burke,R.M., Hall,A.J. and Vinje,J.
TITLE Emergence and characterization of multiple viruses associated with
a novel GII.P16 polymerase in the United States, 2015-2018
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7386)
AUTHORS Barclay,L., Cannon,J.L., Rath,S., Montmayeur,A.M., Tatusov,R.L.,
Chhabra,P. and Vinje,J.
TITLE Direct Submission
JOURNAL Submitted (09-APR-2019) Division of Viral Diseases, Centers for
Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA
30329, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: Geneious v. R10; SPAdes v. 3.6
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7386
/organism="Norovirus GII"
/mol_type="genomic RNA"
/strain="Mecklenburg0360"
/isolate="Hu/US/2016/GII.P16-GII.2/Mecklenburg0360"
/isolation_source="stool"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="USA"
/collection_date="01-Oct-2016"
/note="genotype: GII.P16-GII.2"
gene <1..5008
/gene="ORF1"
CDS <1..5008
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QBY34780.1"
/translation="MSSTLKKALGARPKQPAPRDKPQKPPRPPTPELVKRIPPPPPNG
EEEEEPVIRYEVKSGISGLPELTTVPQPDVANTAFSVPPLSLRENREAKEPLTGAILE
MWDGEIYHYGLYVEKGLVLGVHKPPAAVSMARVELTPLSLYWRVVYTPQYLISPEALR
RLNGEAFPYTAFDNNCYAFCCWVLDLNDSWLSRRMVQRTTGFFRPYQEWNRKPLPTMD
DSKIKKVANIFLCSLSTLFTRPIKDLIGKIKPLNILNILATCDWTFAGIVESLILLAE
LFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVVMGGIGLVLGFTKEKIGKMLS
SAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANELAMVRAIEDAVLDLEAIENNHM
TTLLKDKDSLATYMKTLDMEEEKARRLSTKSASPDIVGTINALLARIAAARSLVHRAK
EELSSRMRPVVVMISGKPGIGKTHLAREVARKVASTLTGDQRVGLIPRNGVDHWDAYK
GERVVLWDDYGMSNPIHDALRIQELADTCPLTLNCDRIENKGKVFDSEVIIITTNLAN
PAPLDYVNFEACSRRIDFLVYAEAPEVEKAKRDFPGQPDMWKDAFKSDFSHIKLQLAP
QGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERMDEFELQGPTITTFNFDRNRIT
AFRQLAAENKYGLVDTMKVGNQLKGVKTMEELKQAIRNVTIKRCRIIYGGSTYDLESD
GKGKVLVEKVKNTSVQTNNELAGALHHLKHARIRYYVKCVQEAVYSIMQIAGAAFVTT
RIARRMNIQELWSKPQLDQNESETKEEAPKSEDDEFIISSKDIKEEGKKGKNKTGRGK
KHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDRDRYYEELAIAKATEEDFCEE
EEIKIRQRIFRPTRKQRKEERATLGLVTGSEIRKRNPDDFKPKGKLWADDNRSVDYNE
KLDFEAPPSIWSRIVSFGSGWGFWVSPSLFITSTHVIPAGITEAFGVSIKQIQIHKSG
EFCRFRFPKPIRPDVTGMILEEGAPEGTVATVLIKRPTGELMPLAARMGTHATMKIQG
RMVGGQMGMLLTGSNAKGMDLGTTPGDCGCPYIYKRGNDYIVIGVHTAAARGGNTVIC
ATQGSEGEATLEGGDDKGTYCGAPILGPGGAPKLSTKTKFWRSSNTPLPPGTYEPAYL
GGRDPRVKSGPSLQQVMRDQLKPFTEPRGKPPRPSVLEAAKQTIINVLEQTLDPPQKW
TYAQACASLDKTTSSGHPYHVRKNEFWNGETFTGKLADQASKANLMFEEGKHMTPVYT
AALKDELVKTEKIYGRIKKRLLWGSDLSTMIRCARSFGGLMDEMKAHCISLPVRVGMN
MNEDGPIIFEKHSRYKYHYDADYSRWDSTQQRAVLAAALEIMVRFSAEPQLAQVVAED
LLAPSVVDVGDFKITINEGLPSGVPCTSQWNSIAHWLLTLCALSEVTKLSPDIIQANS
MFSFYGDDEIVSTDIKLDPEQLTAKLKEYGLKPTRPDKTEGPLIISEDLNGLTFLRRT
VTRDPAGWFGKLDQSSILRQMYWTRGPNHEDPNETMIPHSQRPIQLMALLGEASLHGP
SFYSKISKLVITELKEGGMDFYVPRQEPMFRWMRFSDLSTWEGDRNLAPNFVNEDGVE
"
mat_peptide <1..904
/gene="ORF1"
/product="p48"
mat_peptide 905..2002
/gene="ORF1"
/product="NTPase"
mat_peptide 2003..2533
/gene="ORF1"
/product="p22"
mat_peptide 2534..2932
/gene="ORF1"
/product="VPg"
mat_peptide 2933..3475
/gene="ORF1"
/product="Pro"
mat_peptide 3476..5005
/gene="ORF1"
/product="RdRp"
gene 4989..6617
/gene="ORF2"
CDS 4989..6617
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QBY34781.1"
/translation="MKMASNDAAPSTDGAAGLVPESNNEVMALEPVAGAALAAPVTGQ
TNIIDPWIRANFVQAPNGEFTVSPRNAPGEVLLNLELGPELNPYLAHLARMYNGYAGG
MEVQVMLAGNAFTAGKLVFAAVPPHFPVENLSPQQITMFPHVIIDVRTLEPVLLPLPD
VRNNFFHYNQKDDPKMRIVAMLYTPLRSNGSGDDVFTVSCRVLTRPSPDFDFTYLVPP
TVESKTKPFTLPILTLGELSNSRFPVSIDQMYTSPNEVISVQCQNGRCTLDGELQGTT
QLQVSGICAFKGEVTAHLHDNDHLYNVTITNLNGSPFDPSEDVPAPLGAPDFQGRVFG
IISQRDKHNSPGHNEPANRGHDAVVPTYTAQYTPKLGQIQIGTWQTDDLTVNQPVKFT
PVGLNDTEHFNQWVVPRYAGALNLNTNLAPSVAPVFPGERLLFFRSYIPLKGGYGNPA
IDCLLPQEWVQHFYQEAAPSMSEVALVRYINPDTGRALFEAKLHRAGFMTVSSNTSAP
VIVPANGYFRFDSWVNQFYSLAPMGTGNGRRRVQ"
gene 6617..>7386
/gene="ORF3"
CDS 6617..>7386
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QBY34782.1"
/translation="MAGAFVAGLAGDVLSNGLSSLINAGANAINQRAEFDFNQKLQQN
SFNHDKEMLQAQIQATKQLQADMMAIKQGVLIAGGFSPADAARGAVNAPMTQALDWNG
TRYWAPNSMRTTSYSGKFTSTAPVRQADFQHTQSRPSSGSSVSSFATQSSRPTLTTTT
GSSHGTVSSNSTRSTSLSQSTVSRATSRTGEWVRDQNRNLEPYMHGALQTAFVTPPSS
RASDGTVSTVPKGVLDSWTPAFNTRRQPLFAHLRKRGES"
ORIGIN
1 tatgtcttcc accttaaaga aagccctcgg ggctaggccc aaacagcctg ccccgagaga
61 caaaccacaa aagcccccaa gaccaccaac tcccgagttg gtcaagagga taccccctcc
121 tccacctaat ggcgaagaag aagaagaacc agtcattagg tatgaggtta agagtgggat
181 ctctggcctg cccgagctca caacagtccc ccaaccggac gtggccaaca cagcattcag
241 tgttccacca ctgagcttga gagaaaacag ggaggccaag gaaccgctaa caggggcaat
301 attagagatg tgggatggag agatatacca ctatggcctg tacgtggaga aaggcttagt
361 gttgggtgtg cacaaaccac ctgcagccgt aagcatggca agagtggagc tgacgccgct
421 gtcattgtac tggcgtgtgg tgtacactcc ccaatacctc atctcccctg aagctctcag
481 gagactcaac ggagaggcat tcccttacac cgcctttgac aataactgct atgccttttg
541 ctgctgggtg ttagacctca atgactcatg gcttagcagg aggatggtgc aaagaacaac
601 gggcttcttc agaccttacc aagagtggaa cagaaaaccc ctgcccacca tggatgactc
661 caaaattaag aaggtagcaa atatattcct atgttcattg tccacattat tcaccagacc
721 cataaaagac ctcataggaa aaattaaacc attaaacata ttgaatatcc tggcaacgtg
781 tgactggact tttgccggaa tagtggagtc tctgatatta cttgctgaac tcttcggagt
841 tttctggaca cccccagatg tgtctgctat gatcgctccc ttactcgggg actacgagtt
901 gcaggggcca gaagacctcg ccgttgaact cgtacctgtg gtaatggggg ggattggttt
961 ggtgttggga ttcaccaaag agaaaattgg caaaatgttg tcctcagcag cctcaacact
1021 cagggcttgc aaagatcttg gtgcctatgg cttagagata ctcaaattgg tcatgaagtg
1081 gttcttccca aagaaagagg aggccaatga gttagccatg gtgagggcca tagaggatgc
1141 tgtactagat cttgaagcaa tagaaaataa ccacatgaca accctgttga aagacaaaga
1201 cagcttagca acatacatga aaacactgga catggaggag gagaaagcca ggaggttgtc
1261 cacaaaatct gcatcccctg acatagttgg gacaatcaac gccctgctgg ctcgaatagc
1321 agcggccagg tcattagtcc acagggccaa ggaagagcta tctagcagga tgagaccagt
1381 agttgttatg atatctggca aaccaggaat aggcaaaact catctggcca gggaggtggc
1441 aagaaaggtg gcatccactc tcacagggga tcaaagagtc ggactcatac caagaaacgg
1501 tgtggaccat tgggatgcat acaaaggtga gagagtcgtg ctgtgggatg actatggcat
1561 gagtaacccc attcatgatg ctctccgcat acaagaattg gctgatacgt gtcccctcac
1621 cttaaattgt gacagaattg aaaataaggg aaaagttttt gacagtgagg tcataataat
1681 cacaacaaac cttgccaatc cagccccact tgattatgtt aactttgagg cctgttccag
1741 gagaattgat ttcctggtgt acgctgaggc accagaagta gaaaaggcaa aacgggactt
1801 tcctggtcag ccagatatgt ggaaggacgc cttcaagtcg gacttttcac acatcaagct
1861 acagcttgca ccccagggcg gctttgacaa gaatggcaac accccacatg ggaaaggagt
1921 gatgaagacc ctcactaccg gttctctgat tgcccgtgca tcaggcctac tgcatgagag
1981 gatggatgaa tttgaactcc aaggtcccac aatcaccacc ttcaatttcg accggaacag
2041 aatcacagca ttcagacaat tggctgcaga gaacaagtat ggattggtgg acaccatgaa
2101 agttggcaat caactaaaag gagtgaaaac catggaggaa cttaaacaag caatcaggaa
2161 tgtgaccatc aagaggtgcc ggatcatcta cggtggctcc acgtatgacc ttgaatctga
2221 tggcaagggc aaagttttgg tggaaaaggt caagaacacc tctgtacaga ccaacaacga
2281 gttggctggg gccctgcacc atcttaaaca cgcccgaatc aggtactatg tcaaatgtgt
2341 gcaagaagcg gtctattcca tcatgcaaat tgccggcgct gcgtttgtca ccacgcgcat
2401 tgcacgccgc atgaacatac aagaactctg gtcgaagcca caattagatc aaaatgaatc
2461 agagactaag gaagaggccc ccaagtcaga agatgacgag ttcatcatat cttctaagga
2521 catcaaggag gaaggaaaga agggcaaaaa caaaactggc cgtggcaaga aacacactgc
2581 attctccagc aagggcttga gcgacgagga gtatgacgag tacaagagga taagagaaga
2641 gagaaatggg aagtactcca tagaggagta tcttcaagac agagacaggt actatgagga
2701 gctcgccatt gccaaggcca cggaagaaga tttctgtgaa gaggaggaga tcaaaatccg
2761 tcagagaatt ttccgtccca ccaggaaaca aagaaaggaa gagagggcca cattagggct
2821 agtaacaggt tcagaaatca gaaaaagaaa ccctgatgac ttcaaaccca aagggaagct
2881 gtgggccgat gacaacagga gtgttgacta caatgagaaa ctggactttg aggccccccc
2941 aagcatatgg tctaggattg tgagctttgg ttctggctgg ggcttctggg tgtcaccaag
3001 ccttttcata acatcaactc atgtaatccc cgcaggcata acagaagcat ttggagtctc
3061 catcaaacaa attcagatcc acaaatcagg tgaattttgc cgattcagat tcccaaaacc
3121 aattagacca gatgtgacag ggatgatctt ggaagaaggt gcgcctgagg gcaccgtggc
3181 aactgtgctc atcaaacgcc ccaccggaga gctcatgcct cttgcagcca gaatgggaac
3241 gcacgcaacc atgaaaattc aaggccgcat ggttggcgga cagatgggta tgttgctcac
3301 tggatcaaat gctaaaggaa tggatttggg aacaactcct ggtgactgtg gctgtcctta
3361 catctataaa aggggcaatg actatatagt cattggggtg cacactgcag cagcccgtgg
3421 tggaaacacc gtcatctgtg ccacacaggg aagtgagggt gaggcaactc ttgagggtgg
3481 agatgacaaa ggaacatact gtggggcacc cattctaggc cctgggggtg caccaaagtt
3541 gagcaccaaa accaaatttt ggaggtcatc gaacacgccc cttccaccag ggacatatga
3601 gcctgcctac ctcggtggcc gtgatccgcg tgttaagagt gggccctccc tgcagcaggt
3661 aatgagagac cagttgaagc cattcactga acccaggggc aaacctccaa gaccaagtgt
3721 attggaagca gccaaacaaa ccatcatcaa tgtcctcgaa caaaccctgg accctccaca
3781 aaaatggaca tacgcacagg cgtgtgcctc acttgacaaa accacctcca gcgggcatcc
3841 ctatcacgtc cgaaagaatg aattctggaa tggtgagacc ttcactggta aattggcaga
3901 ccaagcatcg aaagcaaacc taatgtttga ggaagggaaa cacatgacac cagtgtacac
3961 agcagcactc aaggacgagc tagtcaagac tgagaaaatc tatggaagga tcaagaagag
4021 actgctctgg ggctctgact tgtccaccat gatccggtgc gctaggtcat ttggtgggct
4081 catggacgag atgaaggcac actgtatatc actcccagtc cgagttggca tgaatatgaa
4141 tgaagatggc ccaataatat ttgagaaaca ttccagatac aaatatcact atgatgcaga
4201 ctactctcgt tgggactcaa cacaacagag ggcagtacta gcagcagcct tggaaattat
4261 ggtcagattc tctgcagaac cacaattggc acaagtggtc gctgaggatc tgctggcccc
4321 tagtgtagta gatgtaggag actttaaaat tacaataaat gaagggctcc cctctggtgt
4381 gccatgcact tctcaatgga actccatcgc acactggctg ctaactctct gtgccttgtc
4441 tgaagtcacc aagctgtccc ctgacattat acaggcaaat tccatgttct cattttacgg
4501 tgatgacgag attgtcagca ccgacataaa attggaccct gaacagttaa ccgccaaatt
4561 gaaggagtac ggcctgaaac caacccgccc agacaaaacc gagggacccc tgattatcag
4621 tgaagatttg aacgggctca ctttcctccg aaggacagtg actcgtgacc cagctggctg
4681 gtttggaaaa ctggaccaaa gttcaatttt gaggcagatg tactggacta gaggaccaaa
4741 tcatgaagac cccaatgaga caatgatacc ccattctcaa agacccatac agctcatggc
4801 actactcggc gaagcctctc ttcacggacc ctctttctac agtaaaatta gtaaattggt
4861 cataactgag ctcaaagaag gtgggatgga cttttacgtg ccaaggcagg aacccatgtt
4921 caggtggatg aggttttctg acttgagcac gtgggagggc gatcgcaatc tggctcccaa
4981 ttttgtgaat gaagatggcg tcgaatgacg ccgctccatc tactgatggt gcagccggcc
5041 tcgtgccaga aagtaacaat gaggtcatgg ctcttgaacc cgtggctggt gccgccttgg
5101 cagccccggt cactggtcaa acaaatatta tagacccttg gattagagca aattttgtcc
5161 aggcccccaa tggtgaattt acagtctctc cccgtaatgc ccctggtgaa gtgctactga
5221 atctagagtt gggtccagaa ttaaatcctt atctggcaca tttagcaaga atgtacaatg
5281 ggtatgccgg tgggatggag gtgcaggtca tgttggctgg gaacgcgttc acagccggca
5341 agttggtctt cgccgccgtg ccgcctcact tcccggttga aaaccttagc ccacagcaaa
5401 tcaccatgtt ccctcatgtg atcatagatg tgagaacctt ggaacctgtt ttattaccac
5461 tccctgatgt taggaataat ttcttccatt ataatcagaa agatgatccc aagatgagaa
5521 ttgtggctat gctttatacc cccctcaggt ctaatggttc aggtgatgat gtgtttacag
5581 tctcctgcag agtgttgact agaccttccc ctgactttga cttcacatac ctggtgccac
5641 caacagtgga gtctaaaaca aaaccattca ccctcccaat cctcacactt ggggaacttt
5701 ctaattccag gttcccagtg tccatagacc agatgtatac cagccctaat gaagttatat
5761 cagtgcagtg tcaaaatggt aggtgcacac tggacgggga gctccagggg acaacgcaac
5821 tccaagtcag tggcatctgt gctttcaaag gtgaagtgac cgcccacttg catgacaatg
5881 atcacctata taatgttacc atcacaaact tgaatgggtc cccttttgat ccctccgagg
5941 atgtccctgc ccctctgggt gcgcctgact tccagggaag ggtttttggt atcatctccc
6001 aaagagacaa acacaatagt cctgggcata atgaaccagc aaacagggga cacgacgctg
6061 tggtccccac ttacacagca cagtacactc caaaactggg acaaattcaa attggcacat
6121 ggcagactga cgaccttaca gtcaatcaac cagtcaaatt cactccagtt ggactcaatg
6181 atactgaaca ttttaaccaa tgggtggtcc ctaggtatgc tggtgcccta aacctcaata
6241 caaaccttgc cccttctgtt gctccagtat ttccaggaga gcgcctgctc ttcttcagat
6301 catacatccc cctcaagggc ggttatggaa acccagccat tgattgccta ctaccacaag
6361 agtgggtgca acacttctat caggaagcag ccccctcaat gagtgaggtg gccctcgtca
6421 gatacatcaa cccggacact ggtcgggcac tgtttgaggc caagctccac agagctggtt
6481 tcatgacagt ctcgagcaac accagtgccc cggtgattgt gcctgccaac gggtatttca
6541 gatttgattc ttgggtgaac caattttatt ctctcgcccc catgggaact gggaatgggc
6601 gcagaagggt tcaataatgg ctggagcttt tgtagctggt cttgcagggg acgtgctcag
6661 caatgggctt agttcattaa tcaatgcagg tgccaatgca ataaatcaga gggcagaatt
6721 tgattttaat cagaaattgc agcaaaattc ttttaatcat gataaggaga tgttgcaggc
6781 tcagattcag gcaactaagc agctgcaggc agacatgatg gctataaagc aaggggtctt
6841 gatcgctggc ggcttttccc ctgctgatgc agccagaggt gctgtgaacg cgcccatgac
6901 acaagcgctg gattggaatg gtacaaggta ttgggcacca aactccatga ggaccacgtc
6961 ttattctgga aaattcacat caaccgcccc agtgaggcag gccgacttcc agcacaccca
7021 gagccggcct tcgagtggct cctctgtgtc ttcctttgcc actcagtctt caaggccaac
7081 tctgaccaca accactggtt cctcacatgg cacagtctca tcaaattcaa ctcgcagcac
7141 aagcctctcc caatcaacgg tctccagagc tacatctagg actggtgagt gggttagaga
7201 tcaaaataga aatttggaac cctacatgca tggtgcctta cagacagcct ttgtcacccc
7261 accttccagc agggcatctg acgggacagt ctcaaccgtc ccgaaaggtg ttttggactc
7321 ctggacacct gcgtttaaca cccgcaggca gccgcttttt gcacacctcc gtaagagggg
7381 ggagtc
//