Typing tool
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Typing tool
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Complete norovirus genomes
| MK762637 | GII.4 Sydney | |
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| GII.P16 |
ORF1: 3..5102
ORF2: 5083..6705
ORF3: 6705..7511
LOCUS MK762637 7557 bp RNA linear VRL 13-APR-2019
DEFINITION Norovirus GII isolate Hu/US/2015/GII.P16-GII.4 Sydney/LaPorte0381
nonstructural polyprotein (ORF1), VP1 (ORF2), and VP2 (ORF3) genes,
complete cds.
ACCESSION MK762637
VERSION MK762637.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7557)
AUTHORS Barclay,L., Cannon,J.L., Wikswo,M.E., Phillips,A., Browne,H.,
Montmayeur,A.M., Tatusov,R.L., Burke,R.M., Hall,A.J. and Vinje,J.
TITLE Emergence and characterization of multiple viruses associated with
a novel GII.P16 polymerase in the United States, 2015-2018
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7557)
AUTHORS Barclay,L., Cannon,J.L., Hindenlang,M., Montmayeur,A.M.,
Tatusov,R.L., Chhabra,P. and Vinje,J.
TITLE Direct Submission
JOURNAL Submitted (05-APR-2019) Division of Viral Diseases, Centers for
Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA
30329, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: Geneious v. R10; SPAdes v. 3.6
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7557
/organism="Norovirus GII"
/mol_type="genomic RNA"
/strain="LaPorte0381"
/isolate="Hu/US/2015/GII.P16-GII.4 Sydney/LaPorte0381"
/isolation_source="stool"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="USA"
/collection_date="05-Dec-2015"
/note="genotype: GII.P16-GII.4 Sydney"
gene 3..5102
/gene="ORF1"
CDS 3..5102
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="QBX91138.1"
/translation="MKMASNDATVAVACNNNNDKEKSSGEGLFTNMSSTLKKALGARP
KQPAPRDEPQKPPRPPTPELVKRIPPPPPNGEEEEEPVIRYEVKSGISGLPELTTVPQ
PDVANTAFSVPPLSLRENREAKEPLTGAILEMWDGEIYHYGLYVEKGLVLGVHKPPAA
ISMARVELTPLSLYWRVVYTPQYLISPETLRRLNGEAFPYTAFDNNCYAFCCWVLDLN
DSWLSRRMVQRTTGFFRPYQEWNRKPLPTMDDSKIKKVANIFLCSLSTLFTRPIKDLI
GKIKPLNILNVLATCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGP
EDLAVELVPVVMGGIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWF
FPKKEEANELAMVRAIEDAVLDLEAIENNHMTTLLKDKDSLATYMKTLDMEEEKARRL
STKSASPDIVGTINALLARIAAARSLVHRAKEELSSRIRPVVVMISGKPGIGKTHLAR
EVARKVASTLTGDQRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRIQELAD
TCPLTLNCDRIENKGKVFDSEVIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPEV
EKAKRDFPGQPDMWKDAFKPDFSHIKLQLAPQGGFDKNGNTPHGKGVMKTLTTGSLIA
RASGLLHERMDEFELQGPTITTFNFDRNRITAFRQLAAENKYGLVDTMKVGNQLKGVK
TMEELKQAIRNVTIKRCRIIYGGSTYDLESDGKGKVLVEKVKNTSVQTNNELAGALHH
LKHARIRYYVKCAQEAVYSIIQIAGAAFVTTRIARRMNIQELWSKPQLDQNESETKEE
APKSEDDEFIISSKDIKEEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNG
KYSIEEYLQDRDRYYEELAIAKATEEDFCEEEEIKIRQRIFRPTRKQRKEERATLGLV
TGSEIRKRNPDDFKPKGKLWADDNRSVDYNEKLDFEAPPSIWSRIVSFGSGWGFWVSP
SLFITSTHVIPAGITEAFGVPIKQIQIHKSGEFCRFRFPKPIRPDVTGMILEEGAPEG
TVATVLIKRPTGELMPLAARMGTHATMKIQGRMVGGQMGMLLTGSNAKGMDLGTTPGD
CGCPYIYKRGNDYIVIGVHTAAARGGNTVICATQGSEGEATLEGGDDKGTYCGAPILG
PGGAPKLSTKTKFWRSSNTPLPPGTYEPAYLGGRDPRVKGGPSLQQVMRDQLKPFTEP
RGKPPRPSVLEAAKQTIINVLEQTLDPPQKWTYAQACASLDKTTSSGHPHHVRKNEFW
NGETFTGKLADQASKANLMFEEGKHMTPVYTAALKDELVKTEKIYGKIKKRLLWGSDL
STMIRCARSFGGLMDEMKAHCISLPVRVGMNMNEDGPIIFEKHSRYKYHYDADYSRWD
STQQRAVLAAALEIMVRFSAEPQLTQIVAEDLLAPSVVDVGDFKITINEGLPSGVPCT
SQWNSIAHWLLTLCALSEVTKLSPDIIQANSMFSFYGDDEIVSTDIKLDPEQLTAKLK
EYGLKPTRPDKTEGPLIISEDLNGLTFLRRTVTRDPAGWFGKLDQSSILRQMYWTRGP
NHEDPNETMIPHSQRPIQLMALLGEASLHGPSFYSKISKLVITELKEGGMDFYVPRQE
PMFRWMRFSDLSTWEGDRNLAPNFVNEDGVE"
mat_peptide 3..998
/gene="ORF1"
/product="p48"
mat_peptide 999..2096
/gene="ORF1"
/product="NTPase"
mat_peptide 2097..2627
/gene="ORF1"
/product="p22"
mat_peptide 2628..3026
/gene="ORF1"
/product="VPg"
mat_peptide 3027..3569
/gene="ORF1"
/product="Pro"
mat_peptide 3570..5099
/gene="ORF1"
/product="RdRp"
gene 5083..6705
/gene="ORF2"
CDS 5083..6705
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QBX91139.1"
/translation="MKMASSDANPSDGSAANLVPEVNNEVMALEPVVGAAIAAPVAGQ
QNVIDPWIRNNFVQAPGGEFTVSPRNAPGEILWSAPLGPDLNPYLSHLARMYNGYAGG
FEVQVILAGNAFTAGKIIFAAVPPNFPTEGLSPSQVTMFPHIIVDVRQLEPVLIPLPD
VRNNFYHYNQSNDSTIKLIAMLYTPLRANNAGDDVFTVSCRVLTRPSPDFDFIFLVPP
TVESRTKPFSVPVLTVEEMTNSRFPIPLEKLFTGPSSAFVVQPQNGRCTTDGVLLGTT
QLSPVNICTFRGDVTHITGSRNYTMNLASQNWNNYDPTEEIPAPLGTPDFVGKIQGML
TQTTRTDGSTRGHKATVYTGSADFAPKLGRVQFETDTDHDFEANQNTKFTPVGVIQDG
STTHRNEPQQWVLPSYSGRNTHNVHLAPAVAPTFPGEQLLFFRSTMPGCSGYPNMDLD
CLLPQEWVQYFYQEAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYVTVAHTGQHDLV
IPPNGYFRFDSWVNQFYTLAPMGNGTGRRRVV"
gene 6705..7511
/gene="ORF3"
CDS 6705..7511
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QBX91140.1"
/translation="MAGAFFAGLASDVLGSGLGSLINAGAGAINQKVEFENNRKLQQA
SFQFSSNLQQASFQHDKEMLQAQIEATKKLQQEMMKVKQAMLLEGGFSETDAARGAIN
APMTKALDWSGTRYWAPDARTTTYNAGRFSTPQPSGALPGRANLRDAVPARGPSNKSS
NSSTATSVYSNQTVSTRLGSTAGSGTSVSSLPSTARTRSWVEDQSRNLSPFMRGAHNI
SFVTPPSSRSSSQGTVSTVPKEILDSWTGAFNTRRQPLFAHIRKRGESRV"
ORIGIN
1 gaatgaagat ggcgtctaac gacgctaccg ttgccgttgc ttgcaacaac aacaacgaca
61 aggaaaaatc ttcaggtgaa ggcttattca caaatatgtc ttccacctta aagaaagccc
121 tcggggctag gcccaaacag cctgccccga gagacgaacc acaaaagccc ccaagaccac
181 caactcccga gttggtcaag aggatacccc ctcctccacc taatggcgaa gaagaagaag
241 aaccagtcat taggtatgag gttaagagtg ggatctctgg cctgcccgag ctcacaacag
301 tcccccaacc ggacgtggcc aacacagcat tcagtgttcc accattgagc ctgagagaaa
361 acagggaggc caaggaaccg ctaacagggg caatattaga gatgtgggat ggagagatat
421 accactatgg cctgtacgtg gagaaaggct tagtgttggg tgtgcacaaa ccacctgcag
481 ccataagcat ggcaagagtg gaactgacgc cgctgtcatt gtactggcgt gtggtgtaca
541 ctccccaata cctcatctcc cctgaaactc tcaggaggct caacggagag gcgttccctt
601 acactgcctt tgacaacaat tgctatgctt tttgctgctg ggtgttggac ctcaatgact
661 catggcttag caggaggatg gtgcaaagaa caacgggctt cttcagacct taccaagagt
721 ggaacagaaa acccctgcct accatggatg actccaaaat taagaaggta gcaaatatat
781 tcctatgttc attgtccaca ttattcacca gacccataaa agacctcata ggaaaaatta
841 aaccattaaa catattgaat gtcctggcaa cgtgtgactg gacgtttgcc ggaatagtgg
901 agtctctgat attacttgct gaactcttcg gagttttctg gacaccccca gatgtgtctg
961 ctatgatcgc tcccttactc ggggactacg agttgcaagg gccagaagac ctcgccgttg
1021 aactcgtacc tgtggtaatg ggagggattg gtttggtgtt gggattcacc aaagagaaaa
1081 ttggaaaaat gttgtcctca gcagcatcaa cactcagggc ttgcaaagat cttggtgcct
1141 atggcttaga gatactcaaa ttggtcatga agtggttctt cccaaagaaa gaggaggcca
1201 atgagctagc catggtgagg gccatagagg atgccgtact agatcttgag gcaatagaaa
1261 ataatcacat gacaaccctg ttgaaagaca aagacagctt agcaacatac atgaaaacac
1321 tggacatgga ggaggagaaa gccagaaggt tgtccacaaa atctgcatcc cctgacatag
1381 ttgggacaat caacgccctg ctggctcgaa tagcagcggc caggtcatta gtccataggg
1441 ccaaggaaga gctatctagc aggataagac cagtagtcgt tatgatatct ggcaaaccag
1501 gaataggcaa aacccatctg gccagggagg tggcaagaaa ggtggcatcc actctcacag
1561 gggatcaaag agtcggactc ataccaagaa acggtgtgga ccattgggat gcatacaaag
1621 gtgagagagt cgtgctgtgg gacgactatg gcatgagtaa ccccattcat gatgctcttc
1681 gcatacaaga attggctgat acgtgtcccc ttaccttaaa ttgtgacaga attgaaaata
1741 agggaaaagt ctttgacagt gaagtcataa taattacaac aaaccttgcc aacccagccc
1801 cacttgatta tgtcaacttt gaggcctgtt ccaggagaat tgacttcctg gtgtacgctg
1861 aggcaccaga agtagaaaag gcaaaacggg actttcctgg tcagccagat atgtggaagg
1921 acgccttcaa accggacttt tcacacatca agctacagct tgcacctcag ggcggctttg
1981 acaagaatgg caacacccca catgggaaag gagtgatgaa gaccctcact accggctctc
2041 tgattgcccg tgcatcaggc ctactgcatg agaggatgga tgaatttgaa ctccaaggtc
2101 ccacaatcac caccttcaat ttcgaccgga acagaatcac agcattcaga caattggctg
2161 cagaaaacaa gtatggattg gtggatacca tgaaagttgg caatcaacta aaaggagtga
2221 aaaccatgga agaactcaaa caagcaatca ggaatgtgac catcaagagg tgccggatca
2281 tctacggtgg ctccacgtat gaccttgaat ctgatggcaa gggcaaagtt ttggtggaaa
2341 aggtcaagaa cacctctgta cagaccaaca acgagttggc cggggccctg caccatctca
2401 aacacgcccg aatcaggtac tatgtcaaat gtgcgcaaga agcagtctat tccattatac
2461 aaattgccgg cgctgcgttt gtcaccacgc gcattgcacg ccgcatgaac atacaagaac
2521 tctggtcgaa gccacaatta gatcaaaatg agtcagagac taaggaagag gcccccaagt
2581 cagaagatga cgagttcatc atatcttcta aggacatcaa ggaggaagga aagaagggca
2641 aaaacaagac tggccgtggc aagaaacaca ctgcattctc cagcaagggc ttgagcgatg
2701 aggagtatga cgagtacaag aggataagag aagagagaaa tgggaagtac tctatagagg
2761 agtatcttca agacagagac aggtactatg aggagctcgc cattgccaag gccacggaag
2821 aagacttctg tgaagaggag gagatcaaaa tccgtcagag aatttttcgt cccaccagga
2881 aacaaagaaa ggaagagagg gccacattag ggctagtaac aggttcagaa atcagaaaaa
2941 gaaaccctga tgacttcaaa cccaaaggga agctgtgggc cgatgacaac agaagtgttg
3001 actacaatga gaaactggac tttgaggccc ccccaagcat atggtctagg attgtgagct
3061 ttggttctgg ctggggcttc tgggtatcac caagcctgtt cattacatca actcatgtaa
3121 tccccgcagg cataacagaa gcatttgggg tccccatcaa acaaattcag atccacaaat
3181 caggtgaatt ttgccgattc agattcccaa aaccaattag accagatgtg acaggaatga
3241 tcttggaaga aggtgcgcct gaaggcaccg tggcaactgt gctcatcaaa cgccccaccg
3301 gagagctcat gcctcttgca gccagaatgg gaacacatgc aaccatgaaa attcaaggcc
3361 gcatggttgg cggacagatg ggtatgttgc tcactggatc aaatgctaaa ggaatggatt
3421 tgggaacaac tcctggtgac tgtggctgtc cttacatcta taaaaggggc aatgactata
3481 tagtcattgg ggtgcacact gcagcagccc gtggtgggaa caccgtcatc tgtgccacac
3541 agggaagtga gggtgaggca actcttgagg gtggagatga caaaggaaca tactgtgggg
3601 cacccattct aggccctggg ggtgcaccaa aattgagcac caaaaccaaa ttttggaggt
3661 catcgaacac gccccttcca ccagggacat atgagcctgc ctacctcggt ggccgcgatc
3721 cgcgtgttaa gggtgggccc tccttgcagc aggtaatgag agaccagttg aagccattca
3781 ctgaacccag gggcaaacct ccaagaccaa gtgtattgga agcagccaaa caaaccatta
3841 tcaatgtcct cgaacaaacc ctggaccctc cacaaaaatg gacatacgca caggcgtgtg
3901 cctcacttga caaaaccacc tccagcgggc atccccatca cgtccgaaag aatgaattct
3961 ggaatggtga gaccttcact ggtaaattgg cagaccaagc atcaaaagca aacctaatgt
4021 ttgaggaagg gaaacacatg acaccagtgt atacagcagc actcaaggac gagctagtca
4081 agactgagaa aatctatgga aagatcaaga agagactgct ctggggctct gacttgtcca
4141 ccatgatccg gtgcgctagg tcatttggtg ggctcatgga cgagatgaag gcacactgca
4201 tatcactccc agtacgagtt ggcatgaata tgaatgaaga tggcccaata atatttgaaa
4261 aacattccag atacaaatac cactatgatg cagactactc tcgttgggat tcaacacaac
4321 agagggcagt actagcagca gccttggaaa tcatggtcag attctctgca gaaccacaat
4381 tgacacaaat agtcgctgag gatctgctgg cccctagtgt agtagatgta ggagacttta
4441 aaatcacaat aaatgaaggg ctcccatctg gtgtgccatg cacttctcaa tggaactcca
4501 tcgcacactg gctgctaact ctctgtgcct tgtctgaagt caccaaactg tcccctgaca
4561 ttatacaagc aaattccatg ttctcatttt acggtgatga cgagattgtc agcaccgaca
4621 taaaattgga ccctgaacag ttaaccgcca aattgaagga gtacggcctg aaaccaaccc
4681 gcccagacaa gaccgaggga cccctgatca tcagtgaaga tttgaacgga ctcactttcc
4741 tccgaaggac ggtgactcgt gacccagctg gctggtttgg aaaactggac caaagctcaa
4801 ttttgaggca gatgtactgg actagaggac caaatcatga agaccccaat gagacaatga
4861 taccccattc tcaaagacct atacagctca tggcactgct tggtgaagcc tctcttcacg
4921 gaccctcttt ctatagtaaa atcagtaaat tggtcataac tgaactcaaa gaaggtggga
4981 tggactttta cgtgccaagg caggaaccca tgttcaggtg gatgaggttt tctgacttga
5041 gcacgtggga gggcgatcgc aatctggctc ccaattttgt gaatgaagat ggcgtcgagt
5101 gacgccaacc catctgatgg gtccgcagcc aacctcgtac cagaggtcaa caatgaggtt
5161 atggctttgg agcccgttgt tggtgccgct attgcggcac ctgtagcggg ccaacaaaat
5221 gtaattgacc cctggattag aaataatttt gtacaagccc ctggtgggga gtttacagta
5281 tcccctagaa acgctccagg tgaaatacta tggagcgcgc ccctaggccc tgacctaaat
5341 ccctacctat cccatttggc cagaatgtac aatggttatg caggtggttt tgaagtgcag
5401 gtaattctcg cggggaacgc gttcaccgcc gggaagatca tatttgcagc agtcccacca
5461 aattttccaa ctgaaggctt aagtcctagc caggtcacta tgttccccca tataatagta
5521 gatgttagac aattagaacc tgtgctgatt cccttacccg atgtcaggaa taatttctat
5581 cattataatc agtcaaatga ttccactatt aagttgatag caatgttgta tacaccactt
5641 agggctaata atgctgggga tgatgttttc acagtttcgt gccgagttct cacgaggcca
5701 tcccccgatt ttgatttcat atttttagtg ccacccacag ttgagtcaag aactaaacca
5761 ttctctgtcc cagttttaac tgttgaggag atgaccaatt caagattccc cattcctttg
5821 gaaaagttgt tcacgggccc cagcagtgcc tttgttgttc aaccacaaaa cggcaggtgc
5881 acaactgatg gcgtgctcct aggcaccacc caactgtctc ctgtcaacat ctgcaccttc
5941 agaggggatg tcacccacat cacaggtagt cgcaactaca caatgaattt ggcttctcaa
6001 aattggaaca actatgaccc aacagaagaa atcccagccc ctctaggaac tccagatttt
6061 gtggggaaga ttcaaggcat gctcacccaa accacaagga cagatggttc aacacgcggc
6121 cacaaagcta cagtgtacac tgggagcgcc gactttgctc caaaactggg tagagttcaa
6181 tttgaaactg acacagacca tgattttgaa gctaatcaaa acacaaagtt caccccagtc
6241 ggtgtcatcc aagatggtag caccacccac cgaaacgaac cccaacagtg ggtgctccca
6301 agttactcag gcagaaatac tcacaatgta catctggccc ccgctgtagc ccccaccttc
6361 ccgggtgagc aacttctctt cttcagatcc accatgcccg gatgcagcgg gtaccccaac
6421 atggatttgg actgtctgct cccccaggaa tgggtacagt acttctacca agaggcagcc
6481 ccagcacaat ctgatgtggc tctgctaaga tttgtgaatc cagacacagg tagggttttg
6541 tttgagtgca agcttcacaa atcaggctat gttacagtgg ctcacactgg ccaacatgat
6601 ttggttatcc cccccaatgg ttactttagg tttgactcct gggtcaacca gttctacacg
6661 cttgccccta tgggaaatgg aacggggcgt agacgtgtag tataatggct ggagctttct
6721 ttgctggatt ggcatctgat gtccttggct ctggacttgg ttcccttatc aatgctgggg
6781 ctggggccat caaccaaaaa gttgagtttg aaaataacag aaaattgcaa caagcatcct
6841 tccaatttag cagcaatctg caacaggctt cctttcaaca tgataaagag atgctccaag
6901 cacaaattga ggccaccaaa aagctacaac aggaaatgat gaaagttaag caggcaatgc
6961 tcctagaggg tgggttctct gagacagatg cagcccgcgg ggcaattaac gcccccatga
7021 caaaagcttt ggactggagc gggacaaggt actgggctcc cgatgctagg actacaacat
7081 acaatgcagg ccgcttttcc acccctcaac catcgggggc actgccagga agagctaatc
7141 ttagggatgc tgtccctgct cggggaccct ccaacaaatc ttctaactct tctactgcca
7201 cctctgtgta ttcaaatcaa actgtttcaa cgagacttgg ttctacagct ggttctggaa
7261 ccagtgtctc gagcctcccg tcaactgcaa ggactaggag ctgggttgag gatcaaagta
7321 ggaatttgtc acctttcatg aggggggccc acaacatatc atttgtcacc ccaccatcta
7381 gcagatcctc tagccaaggc acagtctcaa ccgtgcctaa agagattttg gactcctgga
7441 ctggcgcttt taacacgcgc aggcagcctc tcttcgctca cattcgtaag cgaggggagt
7501 cacgggtgta atgtgaaaag acaaaactga ttatctttct ttttttttct gtagtgt
//