Typing tool
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Typing tool
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Complete norovirus genomes
| MK762628 | GII.2 | |
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| GII.P2 |
ORF1: 1..5098
ORF2: 5079..6707
ORF3: 6707..7482
LOCUS MK762628 7482 bp RNA linear VRL 13-APR-2019
DEFINITION Norovirus GII isolate Hu/US/2018/GII.P2-GII.2/Ada0178 nonstructural
polyprotein (ORF1) gene, partial cds; VP1 (ORF2) gene, complete
cds; and VP2 (ORF3) gene, partial cds.
ACCESSION MK762628
VERSION MK762628.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7482)
AUTHORS Barclay,L., Cannon,J.L., Wikswo,M.E., Phillips,A., Browne,H.,
Montmayeur,A.M., Tatusov,R.L., Burke,R.M., Hall,A.J. and Vinje,J.
TITLE Emergence and characterization of multiple viruses associated with
a novel GII.P16 polymerase in the United States, 2015-2018
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7482)
AUTHORS Barclay,L., Cannon,J.L., Getz,K., Montmayeur,A.M., Tatusov,R.L.,
Chhabra,P. and Vinje,J.
TITLE Direct Submission
JOURNAL Submitted (05-APR-2019) Division of Viral Diseases, Centers for
Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA
30329, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: Geneious v. R10; SPAdes v. 3.6
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7482
/organism="Norovirus GII"
/mol_type="genomic RNA"
/strain="Ada0178"
/isolate="Hu/US/2018/GII.P2-GII.2/Ada0178"
/isolation_source="stool"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="USA"
/collection_date="06-Mar-2018"
/note="genotype: GII.P2-GII.2"
gene <1..5098
/gene="ORF1"
CDS <1..5098
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QBX91111.1"
/translation="KMASNDASAAAAVNSNNDNTKSSSDGMLNNMAVTLKRALGARPK
QPAPREKPPRPPRPPTPELIKRIPPPPPNDGDEPTVMFSTAGGVSGLPELTTVGQPPE
ANTAFSVPPLSQRENRDAKEPLTGAILEMWDGEIYHYGLYVEKGLVLGVHKPPAAISI
AKVELTPLSLYWRPVYTPQYLISPDTLRKLHGELFPYTAFENNCYAFCCWVLDLNDSW
LSRRMISRTTGFFRPYQEWNRKPLPTMDDSKLKKVANIVLCALSSLFTRPIKDIIGKL
KPLNILNILASCDWTFAGIVESLILLAELFDVFWTPPDVSAMIAPLLGDYELQGPEDI
AVELVPVVMGGIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPK
KDEANELAMVRAIEDAVLDLEAIENNHMTTLLKDKNSLAAYMKTLDMEEEKARKLSTK
SASPDIVGTINALLARIAAARSLVHRAKEELSSRPRPVVLMISGKPGIGKTHLARELA
KKIASTLTGDQRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCP
LTLNCDRIENKGKVFDSDAIIITTNLVNPAPLDYVNFEACSRRIDFLVYADAPEVEKA
KRDFPGQPDMWKDAYRPDFSHIKLQLAPQGGFDKNGNTPHGKGVMKTLTASSLVARAS
GLLHERLDEYELQGPPLSTFNFDRNKIAAFRQLAAENKYGLVDTMRVGNQLRNVTTMD
ELKKAIKNITIRKCQIVYGGNTYTLESDGKGKVVVERVQSASVQINNEIAGAVHHLRC
ARIRYYVKCAQEAIYSLLQIAGTVFVTSRIVSRMNIQNLWSRPLSEDADEATIKEGCP
KPRDEEEFIVSSDDIKPEGKKGKNKSGRGRKHTAFSSKGLSDEEYEEYKRIREERNGK
YSIEEYLQDRDKYYEEVAIARATEEDFCEEEEVKIRQRIFRPTRKQRKEERANLGLVT
GSEIRKRNPDDFKPKGKLWADDDRSVDYNERISFEAPPSIWSRIVNFGSGWGFWVSPS
LFITSTHVIPQGITEAFGVPIRQVQIHKSGEFCRLRFPKPIRTDVSGMILEEGAPEGT
VATILIKRTTGELMPLAARMGTHATMRIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDC
GCPYIYKRGNDYIVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPILGP
GNAPKLSTKTKFWRSSTTPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPR
GKPPKPSVLEAAKKTIINVLEQTIDPPQKWTYAQACASLDKTTSSGYPHHVRKNEHWN
GESFTGKLADQASKANLMFEEGKHMTPVYTAALKDELVKTEKVYGKIKKRLLWGSDLA
TMVRCARSFGGLMDELKAHCVTLPIRVGMNMNEDGPIVFEKHSRYRYHYDADYSRWDS
TQQRAVLAAAMEIMVKFSAEPQLAQIVAEDLLSPSVVDVGDFKVSINEGLPSGVPCTS
QWNSIAHWLLTLCALSEVTDLSPDIVQANSLFSFYGDDEIVSTDIKLDPEKLTGKLRE
YGLKPTRPDKTEGPLIISEDLNGLTFLRRTVTRDPAGWFGKLDQSSILRQLYWTKGPN
HEDPFESMIPHSQRPIQLMSLLGEAALHEPSFYSKISKLVISELKEGGMDFYVPRQEP
MFRWMRFSDLSTWEGDRNLAPSLVNEDGVE"
mat_peptide <1..988
/gene="ORF1"
/product="p48"
mat_peptide 989..2086
/gene="ORF1"
/product="NTPase"
mat_peptide 2087..2623
/gene="ORF1"
/product="p22"
mat_peptide 2624..3022
/gene="ORF1"
/product="VPg"
mat_peptide 3023..3565
/gene="ORF1"
/product="Pro"
mat_peptide 3566..5095
/gene="ORF1"
/product="RdRp"
gene 5079..6707
/gene="ORF2"
CDS 5079..6707
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QBX91112.1"
/translation="MKMASNDAAPSTDGAAGLVPESNNEVMALEPVAGAALAAPVTGQ
TNIIDPWIRANFVQAPNGEFTVSPRNAPGEVLLSLELGPELNPYLAHLARMYNGYAGG
MEVQVMLAGNAFTAGKLVFAAVPPHFPVENLSPQQITMFPHVIIDVRTLEPVLLPLPD
VRNNFFHYSQKDDPKMRIVAMLYTPLRSNGSGDDVFTVSCRVLTRPSPDFDFTYLVPP
TVESKTKPFTLPILTLGELSNSRFPVSIDQMYTSPNEVISVQCQNGRCTLDGELQGST
QLQVSGICAFKGEVTAHLHDNDHLYNVTITNLNGSPFDPSEDIPAPLGVPDFQGRVFG
IISQRDKHNSPGHNEPANRGHDAVVPTYTAQYTPKLGQIQIGTWQTDDLTVNQPVKFT
PVGLNDTEHFNQWVVPRYAGALNLNTNLAPSVAPVFPGERLLFFRSYIPLKGGYGSPA
IDCLLPQEWVQHFYQEAAPSMSEVALVRYINPDTGRAMFEAKLHRAGFMTVSSNTSAP
VVVPANGYFRFDSWVNQFYSLAPMGTGNGRRRVQ"
gene 6707..>7482
/gene="ORF3"
CDS 6707..>7482
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QBX91113.1"
/translation="MAGAFVAGLAGDVLSNGLSSLINAGANAINQRAEFDFNQKLQQN
SFNHDKEMLQAQIQATKQLQADMMAIKQGVLTAGGFSPADAARGAVNAPMTQALDWNG
TRYWAPSSMRTTSYSGKFTSTAPVRQADFQHTQSRPSSGSSVSSFATQSSRPTLTTTT
GFSHGTASSNSTRSTSLSQSTVSRATSRTGEWVRDQNRNLEPYMHGALQTAFVTPPSS
RASDGTVSTVPKGVLDSWTPAFNTRRQPLFAYLRKRGESQA"
ORIGIN
1 gaagatggcg tctaacgacg cttctgctgc cgctgctgtc aacagcaaca acgacaacac
61 aaaatcttca agtgacggaa tgcttaataa catggccgtc acccttaaac gagcccttgg
121 ggcccggccc aaacagccag ccccgaggga aaaaccccca agacccccta gaccaccaac
181 accagaatta atcaaaagaa tccccccccc accacctaat gatggggacg aaccaaccgt
241 gatgtttagc actgcaggtg gtgtgtctgg cctacctgag ctcacaacag tcggtcaacc
301 acctgaagct aacactgcct ttagtgtgcc cccccttagc caaagggaaa acagggacgc
361 taaggaaccg ttaactgggg ctattctgga aatgtgggat ggggagattt atcattatgg
421 actgtatgtg gaaaaagggc ttgtgctagg cgtgcacaag ccgccggctg ccatcagcat
481 agccaaagtg gaattaacac ccctctcact gtattggagg cctgtgtaca cgcctcagta
541 cctcatatct cctgacacct tgaggaaact ccacggtgag ttgtttccct atacagcctt
601 tgaaaacaac tgttatgcct tctgttgttg ggttttggac ctcaacgatt catggctaag
661 caggaggatg attagtagga ctactggctt cttcaggccc taccaagagt ggaacaggaa
721 gcctctccca actatggatg actcaaaatt gaagaaggtc gcaaacatcg ttctgtgtgc
781 attgtcatca ttgttcacta ggcccattaa ggatataatt ggcaaactta aaccccttaa
841 catcctaaat attctggcct catgcgattg gaccttcgct ggcatagtag aatcactaat
901 cctcttggct gaactctttg atgtgttctg gacaccccca gatgtgtctg caatgatcgc
961 acccctcctc ggcgactatg agctacaagg tcccgaagac atcgctgtgg agctcgtgcc
1021 cgttgtgatg ggtgggatag gtctggtgtt gggattcacc aaagagaaaa taggcaagat
1081 gctctcctct gcagcgtcaa ccctgagggc gtgcaaagat cttggagcct atggattgga
1141 gatactgaaa ctagtcatga aatggttttt cccaaagaag gatgaggcca acgaactggc
1201 tatggttaga gccattgaag acgctgtatt agacctggag gctattgaga acaaccatat
1261 gaccactcta ttgaaagaca agaacagcct tgcagcatac atgaagaccc tggacatgga
1321 agaggaaaaa gctaggaagc tatccaccaa atcagcctcc cctgacattg tgggcactat
1381 aaacgccctg ctggctagga tcgctgccgc gcgttcccta gttcataggg ccaaggagga
1441 gctctccagc aggccaagac cggtcgtttt gatgatctct ggcaagccag ggataggaaa
1501 gacccacttg gccagagaac tggcaaagaa aattgcctcg acactcacag gagaccaaag
1561 ggttggtctt atcccacgga atggagttga ccattgggac gcctacaaag gtgagagagt
1621 ggtgctctgg gatgactatg gaatgagcaa ccccatccac gatgcgctga ggctgcagga
1681 attggcagac acatgtccat taactctaaa ttgtgacagg attgaaaaca aggggaaagt
1741 cttcgacagc gacgcgatca taatcaccac caatttggtc aaccccgcgc cgctggatta
1801 tgtcaacttt gaggcctgct ccagacgtat agacttcctt gtgtatgctg atgccccaga
1861 agtcgagaaa gcaaagcggg actttcccgg tcaaccggac atgtggaaag acgcctatcg
1921 ccctgacttc tcacacatta aactacaact tgcaccacaa ggtgggtttg acaaaaatgg
1981 taacacccca catggtaaag gagtgatgaa gactctcact gccagctcac tggtcgcacg
2041 tgcctctggt ctcttgcacg agagattaga tgagtacgag ttgcaaggtc cgcccctctc
2101 aaccttcaac tttgaccgta acaaaatcgc agcgttcaga caactcgccg ctgaaaacaa
2161 gtacggtctg gtagacacga tgagggtggg caaccagctc agaaatgtca cgaccatgga
2221 tgaactcaag aaggctatca agaacatcac aatcagaaag tgccagatag tctatggtgg
2281 caacacttac acgcttgagt ctgacggcaa gggcaaggtt gtagttgaga gggtgcagag
2341 cgccagcgtg caaatcaaca atgagatcgc tggtgcagta caccatctta gatgtgccag
2401 aataaggtat tatgtcaagt gtgcccaaga ggccatatac tcactcctcc agattgccgg
2461 cacggtgttt gtcacttcac gcatcgtaag ccgcatgaac atccaaaatc tgtggtctag
2521 gccactatct gaagatgcag atgaagccac cataaaagag gggtgcccta aacctaggga
2581 tgaagaagaa ttcatcgttt cctcagatga tattaagcca gagggcaaga aaggcaaaaa
2641 caagagtggc cggggcagga aacacacggc attctcaagc aaagggctca gtgatgagga
2701 gtacgaagag tacaaaagaa tcagagagga gagaaatggc aagtactcca tagaggaata
2761 cctacaggac agagacaagt actatgaaga ggtggccatt gccagggcaa ctgaagaaga
2821 cttctgtgaa gaagaagagg ttaagattcg tcagaggatc ttcaggccaa caagaaagca
2881 acgcaaggaa gaaagagcca accttggcct cgttaccggg tctgagatca ggaagagaaa
2941 cccagatgac ttcaaaccaa aaggaaagct gtgggccgac gatgacagga gcgtcgacta
3001 caatgaaaga atcagctttg aggctccacc aagcatttgg tctagaattg tcaactttgg
3061 ttctggatgg gggttctggg tgtcacctag cctcttcata acatcaacac acgtcatacc
3121 tcaaggcata actgaggcct ttggtgtacc cataaggcag gtgcaaatac acaaatcggg
3181 cgagttctgt cgcttgagat tcccaaaacc catcagaaca gatgtgtcag gcatgatact
3241 ggaggaggga gcgcccgaag gtactgttgc caccatactc atcaaaagaa ccactggaga
3301 gctgatgcct ctagcagcaa gaatgggaac ccacgcgacc atgaggatac aagggcgcac
3361 agtgggcggc cagatgggaa tgttgctcac tgggtccaat gcaaagagca tggatcttgg
3421 caccacgccc ggtgactgtg ggtgtcccta catttacaaa aggggtaatg attacatagt
3481 cattggagtt cacacagcag ccgctcgtgg cggaaacact gtcatctgcg ccacacaagg
3541 tagtgagggt gaggctactc ttgagggtgg tgacaataaa ggaacatatt gtggggcacc
3601 aatcttgggc cccggaaatg ccccaaaact gagcactaaa accaagttct ggaggtcctc
3661 tacaacacca ctcccacccg gcacgtacga gccggcatat ctgggaggaa aagacccccg
3721 agtcaaaggt gggccatctc tgcaacaagt catgcgagac caattgaagc cattcaccga
3781 accccgtggc aagccaccaa aaccaagtgt acttgaagct gccaaaaaga cgattatcaa
3841 tgtgttagag caaacaatag accccccaca gaagtggaca tacgcgcaag cgtgcgcgtc
3901 tcttgacaaa accacatcca gtgggtaccc ccaccacgtg cgcaaaaacg agcactggaa
3961 tggggaatct ttcacaggaa aattggctga tcaggcatcg aaggcaaacc taatgtttga
4021 ggaggggaaa cacatgaccc cagtttatac agctgccctt aaggatgagt tggttaaaac
4081 tgagaaagtg tatgggaaga taaagaagag gttactttgg ggctctgact tggccaccat
4141 ggtgaggtgt gcgcgctcct ttggcggttt gatggacgaa ctcaaggccc actgtgtgac
4201 actcccgata agggttggca tgaatatgaa tgaagatggg ccaatagtct ttgagaaaca
4261 ttccagatac aggtatcact atgatgcaga ctactccagg tgggattcaa cacagcagag
4321 agccgttctg gccgcggcta tggagattat ggttaaattc tcagcagaac cacaattagc
4381 ccaaatagtt gcagaggatc tgctgtcgcc cagtgttgtt gacgtgggcg acttcaaagt
4441 ttccatcaat gaaggattac catcgggtgt cccttgcacc tctcaatgga actccatcgc
4501 acactggctc ctcaccttgt gtgccctttc tgaagttaca gacctctctc ctgacattgt
4561 gcaagccaac tccctcttct ccttctatgg tgatgatgaa attgtgagta cagatatcaa
4621 attagaccca gaaaagttga cggggaagtt gagagaatat ggtctcaaac ccacccgtcc
4681 tgacaaaact gagggcccct tgattattag cgaggatctg aatggcctga ccttcctgag
4741 gagaaccgtc acccgcgacc ctgcaggatg gtttggcaaa ctggaccaaa gctccatact
4801 taggcaattg tattggacca aaggccctaa tcatgaagac ccctttgagt caatgattcc
4861 acattcccag aggcccatac aactcatgtc acttttgggt gaagcagcac tgcatgaacc
4921 atcattttac agcaagatca gcaagcttgt gatatctgag ttaaaagaag gtggaatgga
4981 tttttacgtg cccaggcaag aacctatgtt taggtggatg agattctcgg atttgagcac
5041 gtgggagggc gatcgcaatc ttgctcccag tcttgtgaat gaagatggcg tcgaatgacg
5101 ccgctccatc tactgatggt gcagccggcc tcgtgccaga aagtaacaat gaggtcatgg
5161 ctcttgaacc cgtggctggt gccgccttgg cagccccggt caccggtcaa acaaatatta
5221 tagacccttg gattagagca aattttgtcc aggcccccaa tggtgaattt acagtctctc
5281 cccgaaatgc ccctggtgaa gtgctactga gtctagagtt gggtccagaa ttaaatcctt
5341 atctggcaca tttagcaaga atgtacaatg ggtatgccgg tgggatggag gtgcaggtca
5401 tgttggctgg gaacgcgttc acagccggca agttggtctt cgccgccgtg ccacctcact
5461 tcccggttga aaaccttagc ccacaacaaa tcaccatgtt ccctcatgtg atcatagatg
5521 tgagaacctt ggaacctgtt ttattaccac tccctgatgt taggaataat ttcttccatt
5581 atagtcagaa agatgatccc aagatgagaa ttgtggctat gctttatacc cccctcaggt
5641 ctaatggttc aggtgatgat gtgtttacag tctcctgcag agtgttgact agaccttccc
5701 ctgattttga ctttacatac ctggtgccac caacagtgga gtctaaaaca aaaccattca
5761 ccctcccaat cctcacactt ggggaacttt ccaattctag gttcccagtg tccatagacc
5821 agatgtacac cagccctaat gaagttatat cagtgcagtg tcaaaatggt aggtgcacat
5881 tggatgggga gctccaaggg tcaacacaac tccaagtcag tggcatttgt gctttcaaag
5941 gtgaagtaac cgcccacttg catgacaatg atcacctata taatgttacc atcacaaact
6001 tgaatgggtc cccttttgat ccctccgagg atattcccgc ccctctgggt gtacctgatt
6061 tccagggaag ggtctttggt atcatctccc aaagggacaa acataatagt cccgggcata
6121 atgaaccagc aaacagggga cacgacgctg tggtccctac ttacacagca cagtacactc
6181 caaaactggg acaaattcaa attggcacat ggcagactga cgaccttaca gtcaaccaac
6241 cagtcaaatt caccccagtt ggactcaatg acactgaaca ttttaaccaa tgggtggtcc
6301 ctaggtatgc tggtgcccta aatctcaaca caaaccttgc cccttctgtt gctccagtat
6361 ttccaggaga gcgcctgctc ttcttcagat catacattcc cctcaagggt ggttatggaa
6421 gcccagccat tgactgccta ctaccacaag agtgggtgca acacttctat caggaagcag
6481 ccccttcaat gagtgaggtg gcccttgtca gatacatcaa cccggatact ggtcgggcaa
6541 tgtttgaggc caagcttcac agagctggtt tcatgacagt ctcgagcaac accagtgccc
6601 cggtggttgt gcctgccaac ggatacttca gatttgattc ttgggtgaat caattctatt
6661 ctctcgcccc catgggaact gggaatgggc gtagaagggt tcaataatgg ctggagcttt
6721 tgtagctggt cttgcagggg acgtgctcag caatgggctc agttcattaa tcaacgcagg
6781 tgctaatgca ataaatcaga gggcagaatt tgattttaac cagaaattgc agcaaaattc
6841 ttttaatcat gacaaggaga tgttgcaggc tcagattcag gcaactaagc agctgcaggc
6901 agacatgatg gctattaaac aaggggtctt gaccgctggc ggtttttccc ctgctgatgc
6961 agccagaggt gctgtgaacg cgcccatgac acaggcgctg gattggaatg gcacaagata
7021 ttgggcacca agctccatga ggaccacatc ttattctgga aaattcacat caaccgcccc
7081 agtgaggcag gccgactttc agcacaccca aagccggcct tcgagtggtt cttctgtgtc
7141 ttcctttgcc actcagtctt caaggccaac tctgaccaca accactggtt tctcacatgg
7201 tacagcctca tcaaattcaa ctcgcagcac aagcctctcc caatcaacgg tctccagagc
7261 tacatctagg actggtgagt gggttaggga tcaaaatagg aatttggaac cctacatgca
7321 tggtgcctta cagacagcct ttgtcacccc accctccagc agggcgtctg acgggacagt
7381 ctcaaccgtc ccgaaaggtg ttttggactc ctggacacct gcgtttaaca cccgcaggca
7441 gccgcttttt gcatacctcc gtaagagggg ggagtcacaa gc
//