Typing tool
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Typing tool
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Complete norovirus genomes
| MK762627 | GII.12 | |
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| GII.P16 |
ORF1: 4..5103
ORF2: 5084..6691
ORF3: 6691..7470
LOCUS MK762627 7504 bp RNA linear VRL 13-APR-2019
DEFINITION Norovirus GII isolate Hu/US/2017/GII.P16-GII.12/Douglas0168
nonstructural polyprotein (ORF1), VP1 (ORF2), and VP2 (ORF3) genes,
complete cds.
ACCESSION MK762627
VERSION MK762627.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7504)
AUTHORS Barclay,L., Cannon,J.L., Wikswo,M.E., Phillips,A., Browne,H.,
Montmayeur,A.M., Tatusov,R.L., Burke,R.M., Hall,A.J. and Vinje,J.
TITLE Emergence and characterization of multiple viruses associated with
a novel GII.P16 polymerase in the United States, 2015-2018
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7504)
AUTHORS Barclay,L., Cannon,J.L., Getz,K., Montmayeur,A.M., Tatusov,R.L.,
Chhabra,P. and Vinje,J.
TITLE Direct Submission
JOURNAL Submitted (05-APR-2019) Division of Viral Diseases, Centers for
Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA
30329, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: Geneious v. R10; SPAdes v. 3.6
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7504
/organism="Norovirus GII"
/mol_type="genomic RNA"
/strain="Douglas0168"
/isolate="Hu/US/2017/GII.P16-GII.12/Douglas0168"
/isolation_source="stool"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="USA"
/collection_date="26-Sep-2017"
/note="genotype: GII.P16-GII.12"
gene 4..5103
/gene="ORF1"
CDS 4..5103
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="QBX91108.1"
/translation="MKMASNDATVAVACNNNNDKEKSSGEGLFTNMSSTLKKALGARP
KQPAPRDKPQKPPRPLTPELVKRIPPPPPNGEEEEEPVIRYEVKSGISGLPELTTVPQ
PDVANTAFSVPPLSLRENREAKEPLTGAILEMWDGEIYHYGLYVEKGLVLGVHKPPAA
ISMAKVELTPLSLYWRVVYTPQYLISPETLRRLNGEAFPYTAFDNNCYAFCCWVLDLN
DSWLSRRMVQRTTGFFRPYQEWNRKPLPTIDDSKIKKVANIFLCSLSTLFTRPIKDLI
GKIKPLNILNILATCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGP
EDLAVELVPVVMGGIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWF
FPKKEEANELAMVRAIEDAVLDLEAIENNHMTTLLKDKDSLATYMKTLDMEEEKARRL
STKSASPDIVGTINALLARIAAARSLVHRAKEELSSRMRPVVVMISGKPGIGKTHLAR
EVARKVASTLTGDQRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRIQELAD
TCPLTLNCDRIENKGKVFDSEVIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPDV
EKAKRDFPGQPDMWKDAFKSDFSHIKLQLAPQGGFDKNGNTPHGKGVMKTLTTGSLIA
RASGLLHERMDEFELQGPTITTFNFDRNRITAFRQLAAENKYGLVDTMKVGNQLKGVK
TMEELKQAIRNVTIKRCRIIYGGSTYDLESDGKGKVLVEKVKNASVQTNNELAGALHH
LKHARIRYYVKCVQEAVYSIIQIAGAAFVTTRIARRMNIQELWSKPQLDQNESETKEE
ALKPEDDEFVISSKDIKEEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNG
KYSIEEYLQDRDRYYEELAIAKATEEDFCEEEEIKIRQRIFRPTRKQRKEERATLGLV
TGSEIRKRNPDDFKPKGKLWADDNRSVDYNEKLDFEAPPSIWSRIVSFGSGWGFWVSP
SLFITSTHVIPTGITEAFGVPIKQVQIHKSGEFCRFRFPKPIRPDVTGMILEEGAPEG
TVATVLIKRPTGELMPLAARMGTHATMKIQGRMVGGQMGMLLTGSNAKGMDLGTTPGD
CGCPYIYKRGNDYIVIGVHTAAARGGNTVICATQGSEGEATLEGGDDKGTYCGAPILG
PGGAPKLSTKTKFWRSSNTPLPPGTYEPAYLGGRDPRVKGGPSLQQVMRDQLKPFTEP
RGKPPRPSVLEAAKQTIINVLEQTLDPPQKWTYAQACASLDKTTSSGHPYHVRKNEFW
NGETFTGKLADQASKANLMFEEGKHMTPVYTAALKDELVKTEKIYGKIKKRLLWGSDL
STMIRCARSFGGLMDEMKAHCISLPVRVGMNMNEDGPIIFEKHSRYKYHYDADYSRWD
STQQRAVLAAALEIMVRFSAEPQLAQIVAEDLLAPSVVDVGDFKITINEGLPSGVPCT
SQWNSIAHWLLTLCALSEVTKLSPDIIQANSMFSFYGDDEIVSTDIKLDPEQLTAKLK
EYGLKPTRPDKTEGPLIISEDLNGLTFLRRTVTRDPAGWFGKLDQSSILRQMYWTRGP
NHEDPNETMIPHSQRPIQLMALLGEASLHGPSFYSKISKLVITELKEGGMDFYVPRQE
PMFRWMRFSDLSTWEGDRNLAPNFVNEDGVE"
mat_peptide 4..999
/gene="ORF1"
/product="p48"
mat_peptide 1000..2097
/gene="ORF1"
/product="NTPase"
mat_peptide 2098..2628
/gene="ORF1"
/product="p22"
mat_peptide 2629..3027
/gene="ORF1"
/product="VPg"
mat_peptide 3028..3570
/gene="ORF1"
/product="Pro"
mat_peptide 3571..5100
/gene="ORF1"
/product="RdRp"
gene 5084..6691
/gene="ORF2"
CDS 5084..6691
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QBX91109.1"
/translation="MKMASNDAVPSNDGAAGLVPEVNNETMALEPVAGASIAAPLTGQ
NNVIDPWIRLNFVQAPNGEFTVSPRNSPGEVLLNLELGPELNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKLVFAAVPPHFPLENISPGQITMFPHVIIDVRTLEPVLLPLPD
VRNNFFHYNQQNEPRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPSPDFDFNYLVPP
TVESKTKPFTLPVLTIGELTNSRFPVPIDELYTSPNESLVVQPQNGRCALDGELQGTT
QLLPTAICSFRGRINQKVSGENHVWNMQVTNINGTPFDPTEDVPAPLGTPDFSGKLFG
VLSQRDHDNACRSHDAVIATDSTKFTPKLGAVQIGTWEQDDVHINQPTKFTPVGLFEN
EGFNQWTLPNYSGALTLNMGLAPPVAPTFPGEQILFFRSHIPLKGGVADPVIDCLLPQ
EWIQHLYQESAPSQTDVALIRFTNPDTGRVLFEAKLHRSGYITVANTGSRPIVVPANG
YFRFDSWVNQFYSLAPMGTGNGRRRMQ"
gene 6691..7470
/gene="ORF3"
CDS 6691..7470
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QBX91110.1"
/translation="MAGAFIAGLAGDIVTNSIGSLVNAGANAINQKVDFENNKQLQQA
SFNHDKEMLQAQIQATKQLQADMIAIRQGVLTAGGFSPTDAARGAVNAPMTQVLDWNG
TRHWAPGATKTTAFSGGFTSASHARTVDLTKKTSATPAPMPVSRPSSITSTVSTRSTL
ISGSSNSPSSARSSSSVSSQPTSSSSRTSEWVRSQNRALEPYMNGALRTAYVTPPSSR
ASSNGTVSTVPKEVLDSWSSAFNTHRQPLFAHLRRRGESQA"
ORIGIN
1 tgaatgaaga tggcgtctaa cgacgctacc gttgccgttg cttgcaacaa caacaacgac
61 aaggaaaaat cttcaggtga aggcttattc acaaatatgt cttccacctt aaagaaagcc
121 ctcggggcca ggcccaaaca gcctgccccg agagacaaac cacaaaagcc cccaagacca
181 ctaactcccg agttggtcaa gaggataccc cctcctccac ctaatggcga agaagaagaa
241 gaaccagtca ttaggtatga ggttaagagt gggatctctg gcctgcccga gctcacaaca
301 gtcccccaac cggacgtggc caacacagca ttcagtgttc caccactgag cttgagggaa
361 aacagggaag ccaaggaacc gctaacaggg gcaatattag agatgtggga tggagagata
421 taccactacg gcctgtacgt ggagaaaggt ttagtgttgg gtgtacacaa accacctgca
481 gccataagca tggcaaaagt ggagctgacg ccgctgtcat tgtattggcg tgtggtgtac
541 actccccaat acctcatctc ccctgaaact ctcaggaggc tcaacggaga ggcattccct
601 tacaccgcct ttgacaacaa ctgctatgcc ttttgctgct gggtgttaga cctcaatgac
661 tcatggctta gcaggaggat ggtgcaaaga acaacgggct tcttcagacc ttaccaagag
721 tggaacagaa aacccctgcc taccatagat gactccaaaa ttaagaaggt agcaaatata
781 ttcctatgtt cattgtccac attgttcact agacccataa aagacctcat aggaaaaatt
841 aaaccattaa acatattgaa tatccttgca acgtgtgact ggacgtttgc cggaatagtg
901 gagtctctaa tattacttgc tgaactcttc ggagttttct ggacaccccc agatgtgtct
961 gctatgatcg ctcccttact tggggattac gagttgcaag ggccagaaga cctcgccgtt
1021 gaactcgtac ctgtggtgat gggagggatt ggtttggtgt tgggattcac caaagagaaa
1081 attggcaaaa tgttgtcctc agcagcatca acactcaggg cttgcaaaga ccttggtgcc
1141 tatggcttag agatactcaa attggtcatg aagtggttct tcccaaagaa agaggaggcc
1201 aatgagctag ccatggtgag ggccatagag gacgctgtac tagatcttga ggcaatagaa
1261 aataaccaca tgacaaccct gttgaaagac aaagacagct tagcaacata catgaaaaca
1321 ctggacatgg aggaggagaa agccagaagg ttgtccacaa aatctgcatc ccctgacata
1381 gttgggacaa tcaacgccct gctggctcga atagcagcgg ccaggtcatt agtccacagg
1441 gccaaggaag agctatctag caggatgaga ccagtagttg ttatgatatc tggcaaacca
1501 ggaataggca aaactcatct ggccagggaa gtggcaagaa aggtggcatc cactctcaca
1561 ggggatcaaa gagtcggact cataccaaga aacggtgtgg accattggga tgcatacaaa
1621 ggtgagagag tcgtgctgtg ggacgactat ggcatgagta accccattca tgatgctctt
1681 cgcatacaag aattggctga tacgtgtccc ctcaccttaa attgtgacag aattgaaaat
1741 aaaggaaaag tttttgacag tgaagtcata ataatcacaa caaaccttgc caatccagcc
1801 ccacttgatt atgtcaactt tgaggcctgt tccaggagaa ttgatttcct ggtgtacgct
1861 gaggcaccag atgtggaaaa ggcaaaacgg gactttcctg gtcagccaga tatgtggaag
1921 gacgccttca aatcggactt ttcacacatc aagctacagc tcgcacctca gggcggcttt
1981 gacaaaaacg gcaacacccc acatgggaaa ggggtgatga agaccctcac taccggttct
2041 ctgattgccc gcgcatcagg cctactgcat gagaggatgg atgaatttga actccaaggt
2101 cctacaatca ccaccttcaa tttcgaccgg aacagaatca cagcatttag acaattggct
2161 gcagaaaaca agtatggact ggtggacacc atgaaagtcg gcaatcaatt aaaaggagtg
2221 aaaaccatgg aagagctcaa acaagcaatc aggaatgtga ccatcaagag gtgccggatc
2281 atctacggtg gatccacata tgatcttgaa tctgatggca agggcaaagt tttggtggaa
2341 aaggtcaaga acgcctctgt acagaccaac aacgagttgg ccggggccct gcaccatctc
2401 aaacacgccc gaatcaggta ctatgtcaag tgtgtgcaag aagcagtcta ttctatcata
2461 caaattgccg gcgctgcgtt tgtcaccacg cgcattgcac gccgcatgaa catacaagaa
2521 ctctggtcga agccacaatt ggatcaaaat gaatcagaga ctaaggaaga ggccctcaag
2581 ccagaagatg acgagttcgt catatcttct aaggacatca aggaggaagg aaagaagggc
2641 aaaaataaaa ctggccgtgg caagaaacac actgcattct ccagcaaggg cttgagcgat
2701 gaggagtatg acgagtacaa gaggataaga gaagagagaa atgggaagta ctctatagag
2761 gaatatcttc aagacagaga caggtactat gaagaactcg ccattgccaa ggccacggaa
2821 gaagacttct gtgaagagga ggagataaaa atccgtcaga gaattttccg tcctaccagg
2881 aaacaaagga aggaagagag ggccacatta gggctagtaa caggttcaga aatcagaaaa
2941 agaaaccctg atgacttcaa acccaaaggg aagctgtggg ccgatgacaa cagaagtgtt
3001 gactacaatg agaaactgga ttttgaggcc cccccaagca tatggtctag gattgtgagc
3061 tttggttctg gctggggctt ctgggtatca ccaagcctgt tcataacatc aactcatgta
3121 atccccacag gcataacaga agcatttgga gtccccatca aacaagttca aatccacaaa
3181 tcaggtgaat tttgccgatt cagattccca aaaccaatta gaccagatgt gacaggaatg
3241 atcttggaag aaggtgcgcc tgagggcacc gtggcaactg tgctcatcaa acgccccacc
3301 ggagagctca tgcctcttgc agccagaatg ggaacacacg caaccatgaa aattcaaggc
3361 cgcatggttg gcggacagat gggcatgttg ctcactggat caaatgctaa aggaatggat
3421 ttgggaacaa ctcctggaga ctgtggctgt ccttacatct ataaaagggg caatgactat
3481 atagtcattg gggtgcacac tgcagcagcc cgtggtggaa acaccgtcat ctgtgccaca
3541 cagggaagtg agggtgaggc aactcttgag ggtggagatg acaaaggaac atactgtggg
3601 gcacccatcc taggccctgg gggtgcacca aaattgagca ccaaaaccaa attttggagg
3661 tcatcgaaca cgccccttcc accagggaca tatgagcctg cctacctcgg cggccgtgac
3721 ccgcgtgtta agggtgggcc ctccttgcag caggtaatga gagaccagtt gaagccattc
3781 actgaaccca ggggcaaacc tccaagacca agtgtattgg aagcagccaa acaaaccatc
3841 atcaatgtcc tcgagcaaac cctggaccct ccacaaaaat ggacatacgc acaggcgtgt
3901 gcctcacttg acaaaaccac ctccagcggt cacccctatc acgttcgaaa gaatgaattc
3961 tggaatggtg agaccttcac tggtaaattg gcagaccaag cgtcaaaagc aaacctaatg
4021 tttgaggaag ggaaacacat gacaccagtg tacacagcag cactcaagga cgagctagtc
4081 aagactgaga aaatctatgg aaagatcaag aagagactgc tctggggctc tgatttgtcc
4141 accatgatcc ggtgcgctag gtcatttggt gggctcatgg acgagatgaa ggcacactgt
4201 atatcactcc cagtccgagt tggcatgaat atgaatgaag atggcccaat aatatttgag
4261 aaacattcca gatacaaata tcactatgat gcagactact ctcgttggga ttcaacacaa
4321 cagagggcag tactggcagc agccttggaa atcatggtca gattctctgc agaaccacaa
4381 ttggcacaaa tagtcgctga ggacctactg gcccctagtg tagtagatgt aggagacttt
4441 aaaatcacaa taaatgaggg gctcccctct ggtgtgccat gcacttctca atggaactcc
4501 atcgcacact ggctgctaac tctctgtgcc ttgtctgaag tcactaagct gtcacctgac
4561 attatacagg caaattccat gttctcattt tacggtgatg acgagattgt cagcaccgac
4621 ataaagttgg accccgaaca gttaaccgcc aaattgaagg agtacggcct aaaaccaacc
4681 cgcccagaca aaaccgaggg acccctgatc atcagtgaag atttgaacgg actcactttc
4741 ctccgaagga cggtgactcg tgacccagct ggctggtttg gaaaactgga ccaaagctca
4801 attttgaggc agatgtactg gactagagga ccaaatcatg aagaccccaa tgagacaatg
4861 ataccccatt ctcaaaggcc catacagctc atggcactgc ttggtgaagc ctctcttcac
4921 ggaccctctt tctacagtaa aatcagtaaa ttggtcataa ctgaactcaa agaaggtggg
4981 atggactttt acgtgccaag gcaggaaccc atgttcaggt ggatgaggtt ttctgacttg
5041 agcacgtggg agggcgatcg caatctggct cccaattttg tgaatgaaga tggcgtcgaa
5101 tgacgccgtt ccatctaatg atggtgcagc cggtctcgta ccagaggtca acaatgagac
5161 catggcactt gaaccggtgg ctggggcttc gatagccgcc ccactcaccg gtcaaaataa
5221 tgttatagac ccctggatta gattaaattt tgtgcaggcc cctaatggag agtttacagt
5281 ctcaccccgc aactcgcctg gggaagtcct actcaatttg gaattaggtc ctgaattgaa
5341 tccatatttg gcacaccttt ctagaatgta taatggttat gcaggtggag ttgaggtaca
5401 agtgctactg gctgggaacg cgttcacggc tggaaaattg gtatttgctg cagttccccc
5461 ccattttcca ttagagaata taagccctgg tcaaataacc atgttccctc atgtaattat
5521 tgatgttagg actttggaac cagttttatt gcctctacca gatgtcagaa ataacttctt
5581 ccattacaat cagcaaaatg agccgaggat gaggcttgtt gcaatgcttt atacccctct
5641 tagatctaat ggttctggtg atgatgtgtt caccgtctcc tgtagggtgc tcactcgacc
5701 ctctcctgat tttgatttta attatttggt gcccccaaca gttgaatcta aaacaaaacc
5761 attcacactc cctgtcttga ccattgggga gttaaccaat tccaggttcc ctgtgcccat
5821 agatgaactc tacactagcc ccaatgagag tttggtggtt caaccccaga acgggaggtg
5881 cgcgctggat ggggagttgc agggcaccac ccagctcctt cccacggcga tttgctcgtt
5941 caggggtcgg atcaatcaga aagtgagtgg agagaatcat gtttggaaca tgcaagtcac
6001 caacattaac ggaacccctt ttgacccaac agaggatgtt ccagcccctc tgggcacgcc
6061 agatttttct ggcaagctct ttggtgtcct aagccagagg gaccatgata atgcctgcag
6121 gagtcatgat gcagtgattg caactgattc taccaaattt accccaaaat tgggtgctgt
6181 acaaattggc acatgggaac aagatgatgt acacatcaac caacccacca agtttactcc
6241 agttggattg tttgagaatg aaggttttaa tcaatggaca cttcctaatt attctggagc
6301 tttaacactc aatatggggt tggccccccc tgtggccccc acattccctg gtgagcaaat
6361 tctcttcttc aggtcccaca ttccccttaa aggaggtgtt gcagacccag ttattgattg
6421 tcttctaccc caagagtgga tccaacacct ttatcaggag tcagccccct cacaaacaga
6481 tgtggcactg attagattca caaatccaga cacagggcgt gtcctatttg aagcaaaatt
6541 gcacaggagt ggctacatca cagtggccaa cactggtagc agaccaattg tggtgccagc
6601 taatggttat ttcaggtttg actcttgggt taatcagttt tactctcttg cccccatggg
6661 aactgggaat gggcgcagaa ggatgcagta atggctggag ctttcatagc agggcttgcc
6721 ggtgacatag tcaccaatag cattggctca ctcgtgaacg ctggggccaa tgcaataaac
6781 cagaaagtag actttgaaaa caacaagcaa ctacaacagg catcttttaa ccatgacaaa
6841 gagatgttgc aagctcaaat tcaggccacc aaacagctac aggctgatat gattgcaatc
6901 agacaagggg tgttgaccgc aggcggcttc tcccctactg atgcagcaag aggtgcagtc
6961 aacgcgccca tgactcaagt cttggattgg aatgggacca gacattgggc cccaggagcc
7021 acgaaaacaa ctgctttctc cggtgggttt accagtgcct ctcatgccag gaccgttgac
7081 ctgaccaaga agacatcagc cacaccagcc cctatgcctg tttctaggcc cagttctatt
7141 acttccactg tttctactcg ctctactttg attagtgggt cctctaattc tccttcttca
7201 gctaggagct cttctagtgt ttcttcccaa cctacttcct catcctcccg aactagtgag
7261 tgggtacgca gtcaaaatag ggcgctggag ccttatatga atggggcgct gcgcacagcc
7321 tacgtgacgc ctccatccag tagggcttct agcaatggca cagtctcaac cgtgccaaaa
7381 gaggttttgg actcctggtc gtctgcattc aatacacaca gacagccgct gtttgctcat
7441 ctccgtcgga gaggggagtc acaagcttag tgaaaagatg gtcttttctt tctttccttt
7501 gaaa
//