Typing tool
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Typing tool
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Complete norovirus genomes
| MK754446 | GII.4 Sydney | |
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| GII.P16 |
ORF1: 1..5083
ORF2: 5064..6686
ORF3: 6686..7488
LOCUS MK754446 7488 bp RNA linear VRL 11-APR-2019
DEFINITION Norovirus GII isolate Hu/US/2018/GII.P16-GII.4
Sydney/Washington0207 nonstructural polyprotein (ORF1) gene,
partial cds; VP1 (ORF2) gene, complete cds; and VP2 (ORF3) gene,
partial cds.
ACCESSION MK754446
VERSION MK754446.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7488)
AUTHORS Barclay,L., Cannon,J.L., Wikswo,M.E., Phillips,A., Browne,H.,
Montmayeur,A.M., Tatusov,R.L., Burke,R.M., Hall,A.J. and Vinje,J.
TITLE Emergence and characterization of multiple viruses associated with
a novel GII.P16 polymerase in the United States, 2015-2018
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7488)
AUTHORS Barclay,L., Cannon,J.L., Johnston,J., Montmayeur,A.M.,
Tatusov,R.L., Chhabra,P. and Vinje,J.
TITLE Direct Submission
JOURNAL Submitted (05-APR-2019) Division of Viral Diseases, Centers for
Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA
30329, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: Geneious v. R10; SPAdes v. 3.6
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7488
/organism="Norovirus GII"
/mol_type="genomic RNA"
/strain="Washington0207"
/isolate="Hu/US/2018/GII.P16-GII.4 Sydney/Washington0207"
/isolation_source="stool"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="USA"
/collection_date="10-Jan-2018"
/note="genotype: GII.P16-GII.4 Sydney"
gene <1..5083
/gene="ORF1"
CDS <1..5083
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QBW96039.1"
/translation="DATVAVACNNNNDKEKSSGEGLFTNMSSTLKKALGARPKQPAPR
GEPQKPPRPPTPELVKRIPPPPPNGEEEGEPVIRYEVKSGISGLPELTTVPQPDVANT
AFSVPPLSLRENREAKEPLTGAILEMWDGEIYHYGLYVEKGLVLGVHKPPAAISMARV
ELTPLSLYWRVVYTPQYLISPETLRRLNGEAFPYTAFDNNCYAFCCWVLDLNDSWLSR
RMVQRTTGFFRPYQEWNRKPLPTMDDSKIKKVANIFLCSLSTLFTRPIKDLIGKIKPL
NILNILATCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVE
LVPVVMGGVGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEE
ANELAMVRAIEDAVLDLEAIENNHMTTLLKDKDSLATYMKTLDMEEEKARRLSTKSAS
PDIVGTINALLARIAAARSLVHRAKEELSSRIRPVVVMISGKPGIGKTHLAREVARKV
ASTLTGDQRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRIQELADTCPLTL
NCDRIENKGKVFDSEVIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPEVEKAKRD
FPGQPDMWKDAFKSDFSHIKLQLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLL
HERMDEFELQGPTTTTFNFDRNRITAFRQLAAENKYGLVDTMKVGNQLKGVKTMEELK
QAIRNVTIKRCRIIYGGSTYDLESDGKGKVLVEKVKNTSVQTNNELAGALHHLKHARI
RYYVKCVQEAVYSIIQIAGAAFVTTRIARRMNIQELWSKPQLDQNESETKEETPKSGD
DEFIISSKDIKEEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEE
YLQDRDRYYEELAIAKATEEDFCEEEEIKIRQRIFRPTRKQRKEERATLGLVTGSEIR
KRNPDDFKPKGKLWADDNRSVDYNEKLDFEAPPSIWSRIVSFGSGWGFWVSPSLFITS
THVIPAGITEAFGVPIKQIQIHKSGEFCRFRFPKPIRPDVTGMILEEGAPEGTVATVL
IKRPTGELMPLAARMGTHATMKIQGRMVGGQMGMLLTGSNAKGMDLGTTPGDCGCPYI
YKRGNDYIVIGVHTAAARGGNTVICATQGSEGEATLEGGDDKGTYCGAPILGPGGAPK
LSTKTKFWRSSNTPLPPGTYEPAYLGGRDPRVKGGPSLQQVMRDQLKPFTEPRGKPPR
PSVLEAAKQTIINVLEQTLDPPQKWSYAQACASLDKTTSSGHPHHVRKNEFWNGETFT
GKLADQASKANLMFEEGKHMTPVYTAALKDELVKTEKIYGKVKKRLLWGSDLSTMIRC
ARSFGGLMDEMKAHCISLPVRVGMNMNEDGPIIFEKHSRYKYHYDADYSRWDSTQQRA
VLAAALEIMVRFSAEPQLAQIVAEDLLAPSVVDVGDFKITINEGLPSGVPCTSQWNSI
AHWLLTLCALSEVTRLSPDIIQANSMFSFYGDDEIVSTDIKLDPEQLTAKLKEYGLKP
TRPDKTEGPLIISEDLNGLTFLRRTVTRDPAGWFGKLDQSSILRQMYWTRGPNHEDPN
ETMIPHSQRPIQLMALLGEASLHGPSFYSKISKLVITELKEGGMDFYVPRQEPMFRWM
RFSDLSTWEGDRNLAPNFVNEDGVE"
mat_peptide <1..979
/gene="ORF1"
/product="p48"
mat_peptide 980..2077
/gene="ORF1"
/product="NTPase"
mat_peptide 2078..2608
/gene="ORF1"
/product="p22"
mat_peptide 2609..3007
/gene="ORF1"
/product="VPg"
mat_peptide 3008..3550
/gene="ORF1"
/product="Pro"
mat_peptide 3551..5080
/gene="ORF1"
/product="RdRp"
gene 5064..6686
/gene="ORF2"
CDS 5064..6686
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QBW96040.1"
/translation="MKMASSDANPSDGSAANLVPEVNNEVMALEPVVGAAIAAPVAGQ
QNVIDPWIRNNFVQAPGGEFTVSPRNAPGEILWSAPLGPDLNPYLSHLARMYNGYAGG
FEVQVILAGNAFTAGKIIFAAVPPNFPTEGLSPSQVTMFPHIIVDVRQLEPVLIPLPD
VRNNFYHYNQSNDSTIKLIAMLYTPLRANNAGDDVFTVSCRVLTRPSPDFDFIFLVPP
TVESRTKPFSVPVLTVEEMTNSRFPIPLEKLFTGPSSAFVVQPQNGRCTTDGVLLGTT
QLSPVNICTFRGDVTHITGSRNYTMNLASQNWNNYDPTEEIPAPLGTPDFVGKIQGML
TQTTRTDGSTRGHKATVYTGSADFAPKLGRVQFETDTDHDFEANQNTKFTPVGVIQDG
STTHRNEPQQWVLPSYSGRNTHNVHLAPAVAPTFPGEQLLFFRSTMPGCSGYPNMDLD
CLLPQEWVQYFYQEAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYVTVAHTGQHDLV
IPPNGYFRFDSWVNQFYTLAPMGNGTGRRRVV"
gene 6686..>7488
/gene="ORF3"
CDS 6686..>7488
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QBW96041.1"
/translation="MAGAFFAGLASDVLGSGLGSLINAGAGAINQKVEFENNRKLQQA
SFQFSSNLQQASFQHDKEMLQAQIEATKKLQQEMMKVKQAMLLEGGFSETDAARGAIN
APMTKALDWSGTRYWAPDARTTTYNAGRFSTPQPSGTLPGRANLRDAVPARGPSNKSS
NSSTATSVYSNQTISTRLGSTAGSGTSVSSLPSTARTRSWVEDQSRNLSPFMRGAHNI
SFVTPPSSRSSSQGTVSTVPKEILDSWTGAFNTRRQPLFAHIRKRGESRV"
ORIGIN
1 cgacgctacc gtcgccgttg cttgcaacaa caacaacgac aaggaaaaat cttcaggtga
61 aggcttattc acaaatatgt cttccacctt aaagaaagcc ctcggggcta ggcccaaaca
121 gcctgccccg agaggcgaac cacaaaagcc cccaagacca ccaactcccg agttggtcaa
181 gaggataccc cctcctccac ctaatggcga agaagaagga gaaccagtca ttaggtatga
241 ggttaagagt gggatctctg gcctgcccga gctcacaaca gtccctcaac cggacgtggc
301 caacacagca ttcagtgttc caccactgag tttgagagaa aatagggagg ccaaggaacc
361 gctaacaggg gcaatattag agatgtggga tggagagata taccactacg gcctgtacgt
421 ggagaaaggc ttagtgttgg gtgtgcacaa accgcctgca gccataagca tggcaagagt
481 ggagctgacg ccgctgtcat tgtactggcg tgtggtgtac accccccaat acctcatctc
541 ccctgaaact cttaggaggc tcaacggaga ggcattccct tacaccgcct tcgacaacaa
601 ttgctatgcc ttttgctgct gggtgttaga cctcaatgac tcatggctta gtaggaggat
661 ggtgcaaaga acaacgggct tctttagacc ttaccaagag tggaacagaa aacccctgcc
721 taccatggat gactccaaaa ttaagaaggt agcaaatata ttcctatgtt cattgtccac
781 attattcacc agacccataa aagacctcat aggaaaaatt aaaccattaa acatattgaa
841 catcctggca acgtgtgact ggacgtttgc cggaatagtg gagtccctga tattacttgc
901 tgagctcttc ggagttttct ggacaccccc agatgtgtct gctatgatcg ctcccttact
961 cggggactac gagttgcaag ggccagaaga cctcgccgtt gaactcgtac ctgtggtaat
1021 gggaggggtt ggtttggtgt tgggattcac caaagagaaa attggcaaga tgttgtcctc
1081 agcagcatca acactcaggg cttgcaaaga tcttggtgcc tatggcttag agatactcaa
1141 attggtcatg aagtggttct tcccaaagaa agaggaggcc aatgagctag ccatggtgag
1201 ggccatagag gatgccgtac tagatcttga ggcaatagaa aataaccaca tgacaaccct
1261 gttgaaagac aaagacagct tagcaacata catgaaaaca ctggacatgg aggaggagaa
1321 agccagaagg ttgtccacaa aatctgcatc ccctgacata gttgggacaa tcaacgctct
1381 gctggctcga atagcagcgg ccaggtcatt agtccacagg gccaaggaag agttatctag
1441 caggataaga ccagtagttg ttatgatatc tggcaaacca ggaataggca aaactcatct
1501 ggccagggag gtggcaagaa aggtggcatc cactctcaca ggggatcaaa gagtcggact
1561 cataccaaga aacggtgtgg accattggga tgcatacaaa ggtgagagag tcgtgctgtg
1621 ggacgactat ggcatgagta accccattca tgatgctctt cgcatacaag aactggctga
1681 tacgtgtccc cttaccttaa attgtgacag aattgagaat aagggaaaag tttttgacag
1741 tgaagtcata ataattacaa caaaccttgc caacccagcc ccacttgatt atgtcaactt
1801 tgaggcctgt tccaggagga ttgatttcct ggtgtacgct gaggcaccag aagtggaaaa
1861 ggcaaaacgg gactttcctg gtcagccaga tatgtggaag gacgccttca agtcggactt
1921 ttcacacatc aagctacagc ttgcacctca gggcggcttt gacaagaatg gcaacacccc
1981 acatgggaaa ggagtgatga agaccctcac taccggttct ctgattgccc gcgcatcagg
2041 cctactgcat gagaggatgg atgaatttga actccaaggt cccacaacca ccaccttcaa
2101 tttcgaccgg aacagaatca cagcattcag acaattggct gcagaaaaca agtatggatt
2161 ggtggatacc atgaaagttg gcaatcaact aaaaggagta aaaaccatgg aagaactcaa
2221 acaagcaatc aggaatgtga ccatcaagag gtgccggatc atctacggtg gctccacgta
2281 tgaccttgaa tctgatggca agggcaaagt tttggtggaa aaggtcaaga acacctctgt
2341 acagaccaac aacgagttgg ccggggccct gcaccatctc aaacacgccc gaatcaggta
2401 ctatgtcaaa tgtgtgcaag aagcagtcta ttccatcata caaattgccg gcgctgcgtt
2461 tgtcaccacg cgcattgcac gccgcatgaa catacaagaa ctctggtcga agccacaatt
2521 agatcaaaat gaatcagaga ctaaggaaga gacccccaag tcaggagatg acgagttcat
2581 catatcttct aaggacatca aggaggaggg aaagaagggc aaaaacaaaa ctggccgtgg
2641 caagaaacac actgcattct ccagcaaggg cttgagcgat gaggagtatg acgagtacaa
2701 gaggataaga gaagagagaa atgggaagta ctctatagag gagtatcttc aagacagaga
2761 caggtactat gaggagctcg ccattgccaa ggccacggaa gaagacttct gtgaagagga
2821 ggagatcaaa atccgtcaga gaattttccg tcccaccagg aaacaaagga aggaagagag
2881 ggccacatta gggctggtga caggttcaga aatcagaaaa agaaaccctg atgacttcaa
2941 acccaaaggg aagctgtggg ccgacgacaa cagaagtgtt gactacaatg agaaactgga
3001 ctttgaggcc cccccaagca tatggtctag gattgtgagc tttggttctg gctggggctt
3061 ctgggtatca ccaagcctgt tcataacatc aactcatgta atccccgctg gcataacaga
3121 agcatttgga gtccccatca aacaaattca gatccacaaa tcaggtgaat tttgccgatt
3181 cagattccca aaaccaatta gaccagatgt gacaggaatg atcttggaag aaggtgcgcc
3241 tgaaggcacc gtggcaactg tgctcatcaa acgccccacc ggagagctca tgcctcttgc
3301 agccagaatg ggaacacacg caaccatgaa aattcaaggc cgcatggttg gcggacagat
3361 gggtatgttg ctcactggat caaatgctaa aggaatggat ttgggaacaa ctcctggtga
3421 ctgtggctgc ccttacatct ataaaagggg caatgactat atagtcattg gggtgcacac
3481 agcagcagcc cgtggtggaa acaccgtcat ctgtgccaca cagggaagtg agggtgaggc
3541 gactcttgag ggtggagatg acaaaggaac atactgtggg gcacccattc taggccctgg
3601 gggtgcacca aaattgagca ctaaaaccaa attctggagg tcatcgaaca cgccccttcc
3661 accagggaca tatgagcctg cctacctcgg tggccgtgat ccgcgtgtta agggtgggcc
3721 ctccttgcag caggtaatga gagaccagtt gaagccattc actgaaccca ggggcaaacc
3781 tccaagacca agtgtattgg aagcagccaa acaaaccatt atcaatgtcc tcgaacaaac
3841 cctggaccct ccacaaaaat ggtcatacgc acaggcgtgt gcctcacttg acaaaaccac
3901 ctccagcgga catccccatc acgtccgaaa gaatgaattc tggaatggtg agaccttcac
3961 tggtaaattg gcagaccaag catcaaaagc aaacctaatg tttgaggaag ggaaacacat
4021 gacaccagtg tatacagcag cactcaagga cgagctagtc aagactgaga aaatctatgg
4081 aaaggtcaag aagagactgc tctggggttc tgacttgtcc accatgatcc ggtgcgctag
4141 gtcgtttggt gggctcatgg acgagatgaa ggcacactgc atatcactcc cagtacgagt
4201 tggcatgaat atgaatgaag atggcccaat aatatttgag aaacattcca gatacaaata
4261 tcattatgat gcagactact ctcgttggga ttcaacacaa cagagggcag tactagcagc
4321 agccttggaa atcatggtca gattctctgc agaaccacaa ttggcacaaa tagtcgctga
4381 ggatctgctg gcccccagtg tagtagatgt aggagacttt aaaatcacaa taaatgaagg
4441 gctcccatct ggtgtgccat gcacctccca atggaactcc atcgcacact ggctgctaac
4501 tctctgtgcc ttgtctgaag tcaccagact gtcccctgac attatacaag caaattccat
4561 gttctcgttt tacggtgatg acgagattgt cagcaccgac ataaaattgg accctgaaca
4621 gttaaccgcc aaattgaagg agtacggcct gaaaccaacc cgcccagaca agaccgaggg
4681 acccctgatc atcagtgaag atttgaacgg actcactttc ctccgaagga cggtgactcg
4741 tgacccagct ggctggtttg gaaaactgga ccaaagctca attttaaggc agatgtactg
4801 gactagagga ccaaatcatg aagaccccaa tgagacaatg ataccccatt ctcaaagacc
4861 catacagctc atggcactgc ttggtgaagc ctctctccac ggaccctctt tctacagtaa
4921 aatcagtaaa ttggtcataa ctgaactcaa agaaggtggg atggactttt acgtgccaag
4981 gcaggaaccc atgttcaggt ggatgaggtt ttctgacttg agcacgtggg agggcgatcg
5041 caatctggct cccaattttg tgaatgaaga tggcgtcgag tgacgccaac ccatctgatg
5101 ggtccgcagc caacctcgta ccagaggtca ataatgaggt tatggctttg gagcccgttg
5161 ttggtgccgc tattgcggca cctgtagcgg gccaacaaaa tgtaattgac ccctggatta
5221 gaaataattt tgtacaagcc cctggtggag agtttacagt atcccctaga aacgctccag
5281 gtgaaatact atggagcgcg cccctaggcc ctgacctaaa cccctatcta tcccatttgg
5341 ccagaatgta caatggttat gcaggtggtt ttgaagtgca ggtaattctc gcggggaacg
5401 cgttcaccgc cgggaagatc atatttgcag cagtcccacc aaattttcca actgaaggct
5461 taagccctag ccaggtcact atgttccccc atataatagt agatgttaga caattagaac
5521 ctgtgctgat tcccttaccc gatgtcagga ataatttcta tcattataat caatcaaatg
5581 attccactat taagttgata gcaatgttgt atacaccact tagggctaat aatgctgggg
5641 atgatgtttt cacagtttcg tgccgagttc tcacgagacc atcccccgat tttgatttta
5701 tatttttagt gccacccaca gttgaatcaa gaactaaacc attctctgtc ccagttttaa
5761 ctgttgagga gatgaccaat tcaagattcc ccattccttt ggaaaagttg ttcacgggcc
5821 ccagcagtgc ctttgttgtt caaccacaaa acggcaggtg cacaactgat ggcgtgctcc
5881 taggcaccac ccaactgtct cctgtcaaca tctgcacctt cagaggggat gtcacccaca
5941 tcacaggtag tcgcaactac acaatgaatt tggcttccca aaattggaat aactatgacc
6001 caacagaaga aatcccagcc cctctgggaa ctccagattt tgtggggaag attcaaggca
6061 tgctcactca aaccacaagg acagatggtt caacacgcgg ccacaaagct acagtgtaca
6121 ctgggagcgc cgactttgct ccaaaactgg gtagagttca atttgaaact gacacagacc
6181 atgattttga agctaaccaa aacacaaagt tcaccccagt cggtgtcatc caagatggta
6241 gcaccaccca ccgaaacgaa ccccaacagt gggtgctccc aagttactca ggcagaaata
6301 ctcacaatgt acatctggcc cccgctgtag cccccacctt tccaggtgag caacttctct
6361 tcttcagatc caccatgccc ggatgcagcg ggtaccccaa catggatttg gactgtctgc
6421 tcccccagga atgggtgcag tacttctatc aagaggcagc cccagcacaa tctgatgtgg
6481 ctctgctaag atttgtgaat ccagacacag gtagggtttt gtttgagtgc aagcttcata
6541 aatcaggcta tgttacagtg gctcacactg gccaacatga tttggttatc ccccccaatg
6601 gttactttag gtttgattcc tgggtcaacc aattctacac gcttgccccc atgggaaatg
6661 gaacggggcg tagacgtgta gtataatggc tggagctttc tttgctggat tggcatctga
6721 tgtccttggc tctggacttg gttcccttat caatgctggg gctggggcca tcaaccaaaa
6781 agttgagttt gaaaataaca gaaaattgca acaagcatcc ttccaattta gcagcaatct
6841 gcaacaggct tcctttcaac atgataaaga gatgctccaa gcacaaattg aggccaccaa
6901 aaagctacaa caggaaatga tgaaagttaa gcaggcaatg ctcctagagg gtgggttctc
6961 tgagacagat gcagcccgcg gggcaatcaa cgctcccatg acaaaagctt tggactggag
7021 cgggacaagg tactgggctc ccgatgctag gactacaaca tacaatgcag gccgcttctc
7081 cacccctcaa ccatcgggga cactgccagg aagagctaac cttagggatg ctgtccctgc
7141 tcggggaccc tccaacaaat cttctaactc ttctactgcc acctctgtgt actcaaatca
7201 aactatttca acgagacttg gttctacagc tggttctgga accagtgtct cgagcctccc
7261 gtcaactgca aggactagga gctgggttga ggatcaaagt aggaatttgt cacctttcat
7321 gaggggggcc cacaacatat catttgtcac cccaccatct agcagatcct ctagccaagg
7381 cacagtctca accgtgccta aagagatttt ggactcctgg actggcgctt tcaacacgcg
7441 caggcagcct ctcttcgctc acattcgtaa gcgaggggag tcacgggt
//