Typing tool
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Typing tool
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Complete norovirus genomes
| MK754445 | GII.12 | |
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| GII.P16 |
ORF1: 1..5100
ORF2: 5081..6688
ORF3: 6688..7467
LOCUS MK754445 7513 bp RNA linear VRL 11-APR-2019
DEFINITION Norovirus GII isolate Hu/US/2017/GII.P16-GII.12/Somerset0204
nonstructural polyprotein (ORF1), VP1 (ORF2), and VP2 (ORF3) genes,
complete cds.
ACCESSION MK754445
VERSION MK754445.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7513)
AUTHORS Barclay,L., Cannon,J.L., Wikswo,M.E., Phillips,A., Browne,H.,
Montmayeur,A.M., Tatusov,R.L., Burke,R.M., Hall,A.J. and Vinje,J.
TITLE Emergence and characterization of multiple viruses associated with
a novel GII.P16 polymerase in the United States, 2015-2018
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7513)
AUTHORS Barclay,L., Cannon,J.L., Johnston,J., Montmayeur,A.M.,
Tatusov,R.L., Chhabra,P. and Vinje,J.
TITLE Direct Submission
JOURNAL Submitted (05-APR-2019) Division of Viral Diseases, Centers for
Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA
30329, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: Geneious v. R10; SPAdes v. 3.6
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7513
/organism="Norovirus GII"
/mol_type="genomic RNA"
/strain="Somerset0204"
/isolate="Hu/US/2017/GII.P16-GII.12/Somerset0204"
/isolation_source="stool"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="USA"
/collection_date="11-Dec-2017"
/note="genotype: GII.P16-GII.12"
gene 1..5100
/gene="ORF1"
CDS 1..5100
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="QBW96036.1"
/translation="MKMASNDATVAVACNNNNDKEKSSGEGLFTNMSSTLKKALGARP
KQPAPRDKPQKPPRPLTPELVKRIPPPPPNGEEEEEPVIRYEVKSGISGLPELTTVPQ
PDVANTAFSVPPLSLRENREAKEPLTGAILEMWDGEIYHYGLYVEKGLVLGVHKPPAA
ISMAKVELTPLSLYWRVVYTPQYLISPETLRRLNGEAFPYTAFDNNCYAFCCWVLDLN
DSWLSRRMVQRTTGFFRPYQEWNRKPLPTMDDSKIKKVANIFLCSLSTLFTRPIKDLV
GKIKPLNILNILATCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGP
EDLAVELVPVVMGGIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWF
FPKKEEANELAMVRAIEDAVLDLEAIENNHMTTLLKDKDSLATYMKTLDMEEEKARRL
STKSASPDIVGTINALLARIAAARSLVHRAKEELSSRMRPVVVMISGKPGIGKTHLAR
EVARKVASTLTGDQRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRIQELAD
TCPLTLNCDRIENKGKVFDSEVIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPDV
EKAKRDFPGQPDMWKDAFKTDFSHIKLQLAPQGGFDKNGNTPHGKGVMKTLTTGSLIA
RASGLLHERMDEFELQGPTITTFNFDRNRITAFRQLAAENKYGLVDTMKVGNQLKGVK
TMEELKQAIRNVTIKRCRIIYGGSTYDLESDGKGKVLVEKVNNASVQTNNELAGALHH
LKHARIRYYVKCVQEAVYSIIQIAGAAFVTTRIARRMNIQELWSKPQLDQNESETKEE
APKPEDDEFVISSKDIKEEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNG
KYSIEEYLQDRDRYYEELAIAKATEEDFCEEEEIKIRQRIFRPTRKQRKEERATLGLV
TGSEIRKRNPDDFKPKGKLWADDNRSVDYNEKLDFEAPPSIWSRIVSFGSGWGFWVSP
SLFITSTHVIPTGITEAFGVPIKQVQIHKSGEFCRFRFPKPIRQDVTGMILEEGAPEG
TVATVLIKRPTGELMPLAARMGTHATMKIQGRMVGGQMGMLLTGSNAKGMDLGTTPGD
CGCPYIYKRGNDYIVIGVHTAAARGGNTVICATQGSEGEATLEGGDDKGTYCGAPILG
PGGAPKLSTKTKFWRSSNTPLPPGTYEPAYLGGRDPRVKGGPSLQQVMRDQLKPFTEP
RGKPPRPSVLEAAKQTIINVLDQTLDPPQKWTYAQACASLDKTTSSGHPYHVRKNEFW
NGETFTGKLADQASKANLMFEEGKHMTPVYTAALKDELVKTEKIYGKIKKRLLWGSDL
STMIRCARSFGGLMDEMKAHCISLPVRVGMNMNEDGPIIFEKHSRYKYHYDADYSRWD
STQQRAVLAAALEIMVRFSAEPQLAQIVAEDLLAPSVVDVGDFKITINEGLPSGVPCT
SQWNSIAHWLLTLCALSEVTKLSPDIIQANSMFSFYGDDEIVSTDIKLDPEQLTAKLK
EYGLKPTRPDKTEGPLIISEDLNGLTFLRRTVTRDPAGWFGKLDQSSILRQMYWTRGP
NHEDPDETMIPHSQRPIQLMALLGEASLHGPSFYSKISKLVITELKEGGMDFYVPRQE
PMFRWMRFSDLSTWEGDRNLAPNFVNEDGVE"
mat_peptide 1..996
/gene="ORF1"
/product="p48"
mat_peptide 997..2094
/gene="ORF1"
/product="NTPase"
mat_peptide 2095..2625
/gene="ORF1"
/product="p22"
mat_peptide 2626..3024
/gene="ORF1"
/product="VPg"
mat_peptide 3025..3567
/gene="ORF1"
/product="Pro"
mat_peptide 3568..5097
/gene="ORF1"
/product="RdRp"
gene 5081..6688
/gene="ORF2"
CDS 5081..6688
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QBW96037.1"
/translation="MKMASNDAAPSNDGAAGLVPEVNNETMALEPVAGASIAAPLTGQ
NNVIDPWIRLNFVQAPNGEFTVSPRNSPGEVLLNLELGPELNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKLVLAAVPPHFPLENISPGQITMFPHVIIDVRTLEPVLLPLPD
VRNNFFHYNQQNEPRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPSPDFDFNYLVPP
TVESKTKPFTLPVLTIGELTNSRFPVPIDELYTSPNESLVVQPQNGRCALDGELQGTT
QLLPTAICSFRGRINQKVSGENHVWNMQVTNINGTPFDPTEDVPAPLGTPDFSGKLFG
VLSQRDHDNACRSHDAVIATDSTKFTPKLGAVQIGTWEQDDVHINQPTKFTPVGLFEN
EGFNQWTLPNYSGALTLNMGLAPPVAPTFPGEQILFFRSHIPLKGGVADPVIDCLLPQ
EWIQHLYQESAPSQTDVALIRFTNPDTGRVLFEAKLHRSGYITVANTGSRPIVVPANG
YFRFDSWVNQFYSLAPMGTGNGRRRMQ"
gene 6688..7467
/gene="ORF3"
CDS 6688..7467
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QBW96038.1"
/translation="MAGAFIAGLAGDIVTNSIGSLVNAGANAINQKVDFENNKQLQQA
SFNHDKEMLQVQIQATKQLQADMIAIRQGVLTAGGFSPTDAARGAVNAPMTQVLDWNG
TRHWAPGATKTTAFSGGFTSASHARTVDLTKKTSATPAPMPVSRPSSIASTVSTRSTL
ISGSSNSPSSARSSSSVSSQPTSSSSRTSEWVRSQNRALEPYMNGALRTAYVTPPSSR
ASSNGTVSTVPKEVLDSWSSAFNTHRQPLFAHLRRRGESQA"
ORIGIN
1 atgaagatgg cgtctaacga cgctaccgtt gccgttgctt gcaacaacaa caacgacaag
61 gaaaaatctt caggtgaagg cttattcaca aatatgtctt ccaccttaaa gaaagccctc
121 ggggctaggc ccaaacagcc tgccccgaga gacaaaccac aaaagccccc aagaccacta
181 actcccgagt tggtcaaaag gataccccct cctccaccta atggcgaaga agaagaagaa
241 ccagtcatta ggtatgaggt taagagtggg atctctggcc tgcccgagct cacaacagtc
301 ccccaaccgg acgtggccaa cacagcattc agtgttccac cactgagctt gagagaaaac
361 agggaagcca aggaaccgct aacaggggca atattagaga tgtgggatgg agagatatac
421 cactacggcc tgtacgtgga gaaaggctta gtgttgggtg tacacaaacc acctgcagcc
481 ataagcatgg caaaagtgga gctgacgccg ctgtcattgt attggcgtgt ggtgtacact
541 ccccaatacc tcatctcccc tgaaactctc aggaggctca acggagaggc attcccttac
601 accgcctttg acaacaactg ctatgccttt tgctgctggg tattagacct caatgactca
661 tggcttagca ggaggatggt gcaaagaaca acgggcttct tcagacctta ccaagagtgg
721 aacagaaaac ccctgcctac catggatgac tccaaaatta agaaggtagc aaatatattc
781 ctatgttcat tgtccacatt gttcactaga cccataaaag acctcgtagg aaaaattaaa
841 ccattaaata tattgaatat cctggcaacg tgtgactgga cgtttgccgg aatagtggag
901 tctctaatat tacttgctga actcttcgga gttttctgga cacccccaga tgtgtctgct
961 atgatcgctc ccttacttgg ggattacgag ttgcaagggc cagaagacct cgccgttgaa
1021 ctcgtacctg tggtgatggg agggattggt ttggtgttgg gattcaccaa agagaaaatt
1081 ggcaaaatgt tgtcctcagc agcatcaaca ctcagggctt gcaaagacct tggtgcctat
1141 ggcttagaga tactcaaatt ggtcatgaag tggttcttcc caaagaaaga ggaggccaat
1201 gagctagcca tggtgagggc catagaggac gctgtactag atcttgaggc aatagaaaac
1261 aaccacatga caaccctgtt gaaagacaaa gacagcttag caacatacat gaaaacactg
1321 gacatggagg aggagaaagc cagaaggttg tccacaaaat ctgcatcccc tgacatagtt
1381 gggacaatca acgccctgct ggctcgaata gcagcggcca ggtcattagt ccacagggcc
1441 aaggaagagc tatctagcag gatgagacca gtagttgtta tgatatctgg caaaccagga
1501 ataggcaaaa cccatctggc cagggaagtg gcaagaaagg tggcatccac tctcacaggg
1561 gatcaaagag tcggactcat accaagaaac ggtgtggacc attgggatgc atacaaaggt
1621 gagagagtcg tgctgtggga cgactatggc atgagcaacc ccattcatga tgctcttcgc
1681 atacaagaat tggctgatac gtgtcccctc accttaaatt gtgacagaat tgaaaataaa
1741 ggaaaagttt ttgacagtga agtcataata atcacaacaa accttgccaa tccagccccg
1801 cttgattatg tcaactttga ggcctgttcc aggagaattg atttcctggt gtacgctgag
1861 gcaccagatg tagaaaaggc aaaacgggac tttcctggtc agccagatat gtggaaggac
1921 gccttcaaaa cggacttttc acacatcaag ctacagcttg caccccaggg cggctttgac
1981 aaaaacggca acaccccaca tgggaaaggg gtgatgaaga ccctcactac cggttctctg
2041 attgcccgcg catcaggcct actgcatgag aggatggatg aatttgaact ccaaggtcct
2101 acaatcacca ccttcaattt cgaccggaat agaatcacag cattcagaca attggctgca
2161 gaaaacaagt atggactggt ggacaccatg aaagtcggca atcaattaaa aggagtgaaa
2221 accatggaag agctcaaaca agcaatcagg aatgtgacca tcaagaggtg ccggatcatc
2281 tacggtggtt ccacatatga ccttgaatct gatggcaagg gcaaagtttt ggtggaaaag
2341 gtcaataacg cctctgtaca gaccaacaac gagttggccg gggccctgca ccatctcaaa
2401 cacgcccgaa tcaggtacta tgtcaagtgt gtgcaagaag cagtctattc tatcatacaa
2461 attgccggcg ctgcgtttgt caccacgcgc attgcacgcc gcatgaacat acaagaactc
2521 tggtcgaagc cacaattgga tcaaaatgaa tcagagacta aggaagaggc ccccaagcca
2581 gaagatgacg agttcgtcat atcttctaag gacatcaagg aggaaggaaa gaagggcaaa
2641 aataaaactg gccgtggcaa gaaacacact gcattctcca gcaagggctt gagcgatgag
2701 gagtatgacg agtacaagag gataagagaa gagagaaatg ggaagtactc tatagaggaa
2761 tatcttcaag acagagacag gtactatgaa gaactcgcca ttgccaaggc cacggaagaa
2821 gacttctgtg aagaggagga gataaaaatc cgtcagagaa ttttccgtcc taccaggaaa
2881 caaaggaagg aagagagggc cacattaggg ctagtaacag gttcagaaat cagaaagaga
2941 aaccctgatg acttcaaacc caaagggaag ctgtgggccg atgacaacag aagtgttgac
3001 tacaatgaga aactggattt tgaggccccc ccaagcatat ggtctaggat tgtgagcttt
3061 ggttctggct ggggcttctg ggtatcacca agcctgttta taacatcaac tcatgtaatc
3121 cccacaggca taacagaagc atttggagtc cccatcaaac aagtccaaat ccacaaatca
3181 ggtgaatttt gccgattcag attcccaaaa ccaattagac aagatgtgac aggaatgatc
3241 ttggaagaag gtgcgcctga gggcaccgtg gcaactgtgc tcatcaaacg ccccaccgga
3301 gagctcatgc ctcttgcagc cagaatggga acacacgcaa ccatgaaaat tcaaggccgc
3361 atggttggcg gacagatggg catgttgctc actggatcaa atgctaaagg aatggatttg
3421 ggaacaactc ctggagactg tggctgtcct tacatctata aaaggggcaa tgactatata
3481 gtcattgggg tgcacactgc agcagcccgt ggtggaaaca ccgtcatctg tgccacacag
3541 ggaagtgagg gtgaggcaac tcttgagggt ggagatgaca aaggaacata ctgtggggca
3601 cccatcctag gccctggggg tgcaccaaaa ttgagcacca aaaccaaatt ttggaggtca
3661 tcgaacacgc cccttccacc agggacatat gagcctgcct acctcggcgg ccgtgacccg
3721 cgtgttaagg gtgggccctc cttgcagcag gtaatgagag accagttgaa gccattcact
3781 gaacccaggg gcaaacctcc aagaccaagt gtattggaag cagccaaaca aaccatcatc
3841 aatgtcctcg atcaaaccct ggaccctcca caaaaatgga cctacgcaca ggcgtgtgcc
3901 tcacttgaca aaaccacctc cagcggtcac ccctatcacg ttcgaaagaa tgaattctgg
3961 aatggtgaaa ccttcactgg taaattggca gaccaagcat caaaagcaaa cctaatgttt
4021 gaggaaggga aacacatgac accagtgtat acagcagcac tcaaggacga gctagtcaag
4081 actgagaaaa tctatggaaa gatcaagaag agactgctct ggggctctga tttgtccacc
4141 atgatccggt gcgctaggtc atttggtggg ctcatggacg agatgaaggc acactgcata
4201 tcactcccag tccgagttgg catgaatatg aatgaagatg gcccaataat atttgagaaa
4261 cattccagat acaaatatca ctatgatgca gactactctc gttgggattc aacacaacag
4321 agggcagtac tggcagcagc cttggaaatc atggtcagat tctctgcaga accacaattg
4381 gcacaaatag tcgctgagga cctactggcc cctagtgtag tagatgtagg agactttaaa
4441 atcacaataa atgaggggct cccctctggt gtgccatgca cttctcaatg gaactccatc
4501 gcacactggc tgctaactct ctgtgccttg tctgaagtca ctaagctgtc acctgacatt
4561 atacaggcaa attccatgtt ctcattttac ggtgatgacg agattgtcag caccgacata
4621 aaattggacc ccgaacagtt aaccgccaag ttgaaggagt acggcctaaa accaacccgc
4681 ccagacaaaa ccgagggacc cctgatcatc agtgaagatt tgaacggact cactttcctc
4741 cgaaggacgg tgactcgtga cccagctggc tggtttggaa aactggacca aagctcaatt
4801 ttgaggcaga tgtactggac tagaggacca aatcatgaag accccgatga gacaatgata
4861 ccccattctc aaaggcccat acagctcatg gcactgcttg gtgaagcctc tcttcacgga
4921 ccctctttct acagtaaaat cagtaaattg gtcataactg aactcaaaga aggtgggatg
4981 gacttttacg tgccaaggca ggaacccatg ttcaggtgga tgaggttttc tgacttgagc
5041 acgtgggagg gcgatcgcaa tctggctccc aattttgtga atgaagatgg cgtcgaatga
5101 cgccgctcca tctaatgatg gtgcagccgg tctcgtacca gaggtcaaca atgagaccat
5161 ggcacttgaa ccggtggctg gggcttcgat agccgcccca ctcaccggcc aaaataatgt
5221 tatagacccc tggattagat taaattttgt gcaggcccct aatggagagt ttacagtctc
5281 accccgcaac tcgcctgggg aagtcctact caatttggaa ttaggtcccg aattgaatcc
5341 atatttggca cacctttcta gaatgtataa tggttatgca ggtggagttg aggtacaagt
5401 gctactggcc gggaacgcgt tcacggctgg aaaattggta cttgctgcag ttccccctca
5461 ttttccatta gagaatataa gccctggtca aataaccatg ttccctcatg taattattga
5521 tgttaggact ttggaaccag ttttattgcc tctaccagat gtcagaaata acttcttcca
5581 ttacaatcag caaaatgagc cgaggatgag gcttgttgca atgctttata cccctcttag
5641 atctaatggt tctggtgatg atgtgttcac cgtctcctgt agggtgctca ctcgaccctc
5701 tcctgatttt gattttaatt atttggtgcc cccaacagtc gaatctaaaa caaaaccatt
5761 cacactccct gtcttgacca ttggggagtt aaccaattcc aggttccctg tgcccataga
5821 tgaactctac actagcccca atgagagttt ggtggtacaa ccccagaacg ggaggtgcgc
5881 gctggatggg gagttgcagg gcaccaccca gctccttccc acggcgattt gctcgttcag
5941 gggtcggatc aatcagaaag tgagtggaga gaatcatgtt tggaacatgc aagtcaccaa
6001 cattaacgga accccttttg atccaacaga ggatgttcca gcccctctgg gcacgccaga
6061 cttttctggc aagctctttg gtgtcctaag ccagagggac catgataatg cctgcaggag
6121 tcatgatgca gtgattgcaa ctgattctac caaatttacc ccaaaattgg gtgctgtaca
6181 aattggcaca tgggaacaag atgatgtaca catcaaccaa cccaccaagt ttactccagt
6241 tggattgttt gagaatgaag gttttaatca atggacactt cctaattatt ctggagcttt
6301 aacactcaat atggggttgg ccccccctgt ggcccccaca ttccctggtg agcaaattct
6361 cttcttcagg tcccacattc cccttaaagg aggtgttgca gacccagtta ttgattgtct
6421 tctaccccaa gagtggatcc aacaccttta tcaggagtca gccccttcac aaacagatgt
6481 ggcactgatt agattcacaa atccagacac agggcgtgtc ctatttgaag caaaattgca
6541 caggagtggc tacatcacag tggccaacac tggtagcaga ccaattgtgg tgccagctaa
6601 tggttatttc aggtttgact cttgggttaa tcagttttac tctcttgccc ccatgggaac
6661 tgggaatggg cgcagaagga tgcagtaatg gctggagctt tcatagcagg gcttgccggt
6721 gacatagtca ccaatagcat tggctcactc gtgaacgctg gggccaatgc aataaaccag
6781 aaagtagact ttgaaaacaa caagcaacta caacaagcat ctttcaacca tgacaaagag
6841 atgttgcaag ttcaaattca ggccaccaaa cagctacagg ctgatatgat tgcaatcaga
6901 caaggggtgt tgaccgcagg cggcttctcc cctactgatg cagcaagagg tgcagtcaac
6961 gcgcccatga ctcaagtctt ggattggaat gggaccagac attgggcccc cggagccacg
7021 aaaacaactg ctttctccgg tgggtttacc agtgcctctc atgccaggac cgttgacctg
7081 accaagaaga catcagccac accagcccct atgcctgttt ctaggcccag ttctattgct
7141 tccactgttt ctactcgctc tactttgatt agtgggtctt ctaattctcc ttcttcagct
7201 aggagctctt ctagtgtttc ttcccaaccc acttcctcat cctcccgaac tagtgagtgg
7261 gtacgcagtc aaaatagggc gctggagcct tatatgaatg gggcgctgcg tacagcctac
7321 gtgacgcctc catccagtag ggcttctagc aatggcacag tctcaaccgt gccaaaagag
7381 gttttggact cctggtcgtc tgcgttcaat acacacagac agccgctgtt tgctcatctc
7441 cgtcggagag gggagtcaca agcttagtga aaagatggtc ttttctttct ttcctttgaa
7501 aatccctgtc gac
//