Typing tool
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Typing tool
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Complete norovirus genomes
| MK752949 | GII.2 | |
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| GII.P16 |
ORF1: 1..5004
ORF2: 4985..6613
ORF3: 6613..7373
LOCUS MK752949 7373 bp RNA linear VRL 11-APR-2019
DEFINITION Norovirus GII isolate Hu/US/2013/GII.P16-GII.2/Rock0558
nonstructural polyprotein (ORF1) gene, partial cds; VP1 (ORF2)
gene, complete cds; and VP2 (ORF3) gene, partial cds.
ACCESSION MK752949
VERSION MK752949.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7373)
AUTHORS Barclay,L., Cannon,J.L., Wikswo,M.E., Phillips,A., Browne,H.,
Montmayeur,A.M., Tatusov,R.L., Burke,R.M., Hall,A.J. and Vinje,J.
TITLE Emergence and characterization of multiple viruses associated with
a novel GII.P16 polymerase in the United States, 2015-2018
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7373)
AUTHORS Barclay,L., Cannon,J.L., Davis,T., Montmayeur,A.M., Tatusov,R.L.
and Vinje,J.
TITLE Direct Submission
JOURNAL Submitted (04-APR-2019) Division of Viral Diseases, Centers for
Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA
30329, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: Geneious v. R10; SPAdes v. 3.6
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7373
/organism="Norovirus GII"
/mol_type="genomic RNA"
/strain="Rock0558"
/isolate="Hu/US/2013/GII.P16-GII.2/Rock0558"
/isolation_source="stool"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="USA"
/collection_date="14-Dec-2013"
/note="genotype: GII.P16-GII.2"
gene <1..5004
/gene="ORF1"
CDS <1..5004
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="QBS47678.1"
/translation="NMSSTLKKALGARPKQPAPRDNPQKPPRPPTPELVKRIPPPPPN
GEEEPVIRFEVKSGISGLPDLTTVPQPDATNTAFSVPPLSLRENREAKEPLTGAIIEM
WDGEIYHYGLYVEKGLVLGVHKPPAAISMAKVELAPLSLYWRVVYTPQYLISPDTLKR
LNGEAFPYTAFDNNCYAFCCWVLDLNDSWLSRRMVQRTTGFFRPYQEWNRKPLPTMDD
SKIKKVANIFLCSLSTLFTRPIKDIIGKIKPLNILNILATCDWTFAGIVESLILFAEL
FGVYWTPPDVSAMIAPLLGEYELQGPEDIAVELVPVVMGGIGLVLGFTKEKIGKMLSS
AASTLRACKDLGAYGLEILKLVMKWFFPKKEEANELAMVRAIEDAVLDLEAIENNHMT
ALLKDKDSLATYMKTLDLEEEKARKLSTKSASPDIVGTINALLARIAAARSLVHRAKE
ELSSRIRPVVVMISGKPGIGKTHLAREVAKKVASTLTGDQRVGLIPRNGVDHWDAYKG
ERVVLWDDYGMSNPIHDALRIQELADTCPLTLNCDRIENKGKVFDSDVIIITTNLANP
APLDYVNFEACSRRIDFLVYAEAPEVEKAKRDFPGQPDMWKDAFKADFSHIKLQLAPQ
GGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERMDEFELQGPTITTFNFDRNRVTA
FRQLAAENKYGLVDTMRIGNQLKGVKTMEELKQAIKNVSIKRCQIIYHGSTFDLESDG
KGKVTVEKVKNTTVQTNNELAGALHHLRSARIRYYVKCVQEAIYSILQIAGAAFVTTR
IARRMNIQELWSKPPLDQSEPEVKEETPKLEDDEFIISSKDIKEEGKKGKNKTGRGKK
HTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDRDRYYEELAIAKATEEDFCEEE
EIKIRQRIFRPTRKQRKEERATLGLVTGSEIRKRNPDDFKPKGKLWADDNRSVDYNEK
LDFEAPPSIWSRIVSFGSGWGFWVSPSLFITSTHVIPSGITEAFGVPIKQIQVHKSGE
FCRFRFPKPIRPDVTGMILEEGAPEGTVATVLIKRPTGELMPLAARMGTHATMKIQGR
MVGGQMGMLLTGSNAKGMDLGTTPGDCGCPYIYKRGNDYIVIGVHTAAARGGNTVICA
TQGSEGEATLEGGDDKGTYCGAPILGPGGAPKLSTKTKFWRSSNTPLPPGTYEPAYLG
GRDPRVKGGPSLQQVMRDQLKPFTEPRGKPPRPSVLEAAKQTIINVLEQTLDPPQKWT
YAQACASLDKTTSSGHPHHARKNEFWNGETFTGKLADQASKANLMFEEGKHMTPVYTA
ALKDELVKTDKIYGKIKKRLLWGSDLSTMVRCARAFGGLMDEMKAHCISLPVRVGMNM
NEDGPIIFEKHSRYKYHYDADYSRWDSTQQRAVLAAALEIMVRFSAEPQLAQTVAEDL
LAPSVVDVGDFKISINEGLPSGVPCTSQWNSISHWLLTLCALSEVTNLSPDIVQANSM
FSFYGDDEIVSTDIKLDPEKLTTKLREYGLKPTRPDKTEGPLIISEDLDGLTFLRRTV
SRDPAGWFGKLDQSSILRQMYWTRGPNHEDPNETMIPHSQRPIQLMALLGEASLHGPS
FYSKISKLVITELKEGGMDFYVPRQEPMFRWMRFSDLSTWEGDRNLAPSFVNEDGVE"
mat_peptide <1..900
/gene="ORF1"
/product="p48"
mat_peptide 901..1998
/gene="ORF1"
/product="NTPase"
mat_peptide 1999..2529
/gene="ORF1"
/product="p22"
mat_peptide 2530..2928
/gene="ORF1"
/product="VPg"
mat_peptide 2929..3471
/gene="ORF1"
/product="Pro"
mat_peptide 3472..5001
/gene="ORF1"
/product="RdRp"
gene 4985..6613
/gene="ORF2"
CDS 4985..6613
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QBS47679.1"
/translation="MKMASNDAAPPTDGAAGLVPESNNEVMALEPVAGAALAAPVTGQ
TNIIDPWIRANFVQAPNGEFTVSPRNSPGEVLLNLELGPELNPYLAHLARMYNGYAGG
MEVQVMLAGNAFTAGKLVFAAVPPHFPVENLSPQQITMFPHVIIDVRTLEPVLLPLPD
VRNNFFHYNQKDDPKMRIVAMLYTPLRSNGSGDDVFTVSCRVLTRPSPDFDFTYLVPP
TVESKTKPFTLPILTLGELSNSRFPVSIDQMYTSPNEVISVQCQNGRCTLDGELQGTT
QLQISGICAFKGEVTAHLHDNDHLYNVTITNLNGSPFDPSEDIPAPLGVPDFQGRVFG
VISQRDKHNTPGHNEPANRAHDAVVPTYTAQYTPKLGQIQIGTWQTDDLTVNQPVKFT
PVGLNDTDHFNQWVVPRYAGALNLNTNLAPSVAPVFPGERLLFFRSYIPLKGGYGTPA
IDCLLPQEWVQHFYQEAAPSMSEVALVRYINPDTGRALFEAKLHRAGFMTVSSNTSAP
VVVPANGYFRFDSWVNQFYSLAPMGTGNGRRRIQ"
gene 6613..>7373
/gene="ORF3"
CDS 6613..>7373
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QBS47680.1"
/translation="MAGAFVAGLAGDVLSNGLSSLINAGANAINQRAEFDFNQRLQQN
SFNHDKEMLQAQVQATKQLQADMMAIKQGVLAAGGFSPADAARGAVNAPMTQALDWNG
TRYWAPGSMRTTAYSGRFTSTAPVRQADFQHTQSRPSSGSSVSSFATQSSRPTLTTTT
GSSYGTASSNSTRSTNLSQSTVSRATSRTGEWIRDQNRNLEPYMHGALQTAFVTPPSS
RASNGTVSTVPKGVLDSWTPAFNTRRQPLFAHLRK"
ORIGIN
1 aatatgtctt ccaccctaaa gaaagccctc ggggctcggc ctaaacagcc tgccccgagg
61 gacaacccac aaaaaccccc aagaccacca acgcccgagt tggttaaaag gataccccct
121 cccccaccta atggcgaaga agagccagtc attaggtttg aggtcaagag tggaatttct
181 ggcctgcccg atctcacgac agttcctcaa ccagatgcga ccaatacggc attcagtgtt
241 ccaccgttga gcttaagaga aaacagggag gccaaggaac cgctaactgg ggcaataata
301 gagatgtggg atggagagat ataccactat ggtttgtatg tggagaaagg cctagtcttg
361 ggtgtgcaca aaccacccgc agctataagc atggcaaaag tggaattagc accgctgtcg
421 ttatactggc gtgtggtgta cactccccaa tacctcatct cccctgacac tctcaagagg
481 ctcaacggag aggcattccc ctacaccgcc tttgataata actgttatgc cttttgctgc
541 tgggtgttag accttaatga ttcatggctc agcagaagaa tggtgcagag gacgacaggc
601 ttcttcagac cctaccaaga gtggaacaga aagcccctac ccaccatgga tgattccaaa
661 attaagaagg tggcaaacat attcctatgt tcattgtcta cactgttcac caggcctata
721 aaggacatca taggaaaaat caaaccactg aacatcttaa acattctggc aacatgtgat
781 tggacgttcg ccggaatcgt agagtctcta atattatttg ctgaactctt tggagtttac
841 tggacacccc cagatgtgtc tgctatgatc gctcccttac ttggcgaata cgagttgcag
901 ggaccagaag acatcgccgt tgagctcgta cctgtagtga tgggggggat tggtttggtg
961 ctaggattca ccaaagagaa aattggcaaa atgctgtcct cagcagcgtc aacgctcagg
1021 gcttgcaaag acttaggtgc ctatggttta gagatactca aattagtcat gaaatggttt
1081 ttcccaaaga aagaagaagc caatgaacta gccatggtga gagcaataga ggatgctgtt
1141 ctggatcttg aggcgataga aaacaatcac atgacagccc tgctgaaaga taaagacagc
1201 cttgcaacct acatgaaaac actggaccta gaggaggaga aagccagaaa actttccacg
1261 aaatctgcat ctcctgacat agttgggaca atcaacgccc tgctggctcg aatagcggcg
1321 gctagatcac tagtccacag ggccaaggag gagctatcta gcagaatcag accagttgtc
1381 gttatgatat ctggcaagcc agggataggc aagacccact tggccaggga ggtggcaaaa
1441 aaggtggcgt ccactctcac aggagatcaa agagttggac tcataccgag aaacggtgtg
1501 gaccattggg atgcatacaa aggtgaaagg gtcgtgttgt gggatgacta tggcatgagc
1561 aaccctattc atgatgcgct gcgcatacag gaattggccg acacatgccc cctcaccttg
1621 aattgtgaca gaatcgaaaa taagggaaaa gtttttgata gtgatgttat aataattaca
1681 acaaaccttg ccaacccagc tcctcttgat tatgtcaact ttgaggcctg ttccaggagg
1741 attgacttcc tggtgtacgc cgaagcgcca gaagtggaaa aggcaaaacg ggatttccct
1801 ggtcaaccag atatgtggaa ggacgccttc aaagcggact tctcgcacat caagttgcaa
1861 cttgcgcctc agggcggctt tgacaagaac ggcaacaccc cacatgggaa aggagtgatg
1921 aagaccctta ccaccggttc tctgatcgcc cgtgcgtcag gtttgctaca tgagaggatg
1981 gatgaatttg aacttcaggg ccccacaatt accactttca actttgaccg gaacagggtc
2041 accgctttca gacaactggc tgctgagaac aaatatgggc tggtggacac catgaggatt
2101 ggcaatcaat tgaaaggggt gaaaaccatg gaagaactca agcaagctat caagaatgtg
2161 tccatcaaga ggtgccagat tatctaccat ggatccacgt ttgaccttga gtctgatggc
2221 aagggtaaag ttacagtgga aaaggtcaaa aacaccactg ttcagaccaa caacgaactg
2281 gccggagccc tgcaccacct cagaagtgct cgaatcaggt attatgtcaa atgtgtgcaa
2341 gaggcaatct attccatcct acaaattgcc ggcgccgcgt tcgtcaccac acgcattgca
2401 cgccgcatga atatacaaga gctttggtca aagccaccat tagaccaaag cgagccagag
2461 gttaaggagg agacccccaa gttagaggat gatgaattca tcatctcctc caaggacatt
2521 aaggaggaag ggaagaaggg caaaaacaaa actggccgtg gcaagaaaca cactgcattc
2581 tctagcaagg gcttgagcga tgaggagtat gacgagtaca agaggataag agaagagaga
2641 aatgggaagt actctataga ggagtatctt caagacaggg acaggtacta tgaagaactc
2701 gccatcgcca aggccacgga agaagacttt tgtgaggagg aagaaataaa aatccgccag
2761 cggatctttc gtcccactag aaaacaaagg aaggaagaaa gggccacgtt agggctagtg
2821 actggttcgg aaatcagaaa aagaaaccct gatgacttca aacctaaagg gaaattatgg
2881 gccgacgaca acagaagtgt tgactacaat gaaaaactgg actttgaggc ccccccaagc
2941 atatggtcta ggatcgtaag ctttggttca ggttggggct tctgggtgtc accaagcctg
3001 tttataacat caactcatgt gatcccttcg ggtataacag aggcatttgg agtccctatc
3061 aaacagattc aagtccacaa atcgggcgag ttttgtcggt tcagattccc aaaaccaatt
3121 agaccagatg taacaggaat gatcctggaa gaaggtgcgc cagagggcac cgtagcaacc
3181 gtgctcatca agcgccccac tggagaactc atgcccctcg cagctagaat gggaacacac
3241 gcaaccatga aaattcaggg ccgcatggtt ggtgggcaga tgggcatgtt gctcactggt
3301 tcaaatgcta agggtatgga tctggggaca actcccggtg actgtggctg cccgtatatt
3361 tacaaaaggg gcaatgacta catagtcatt ggagtgcaca cagcagcagc ccgaggtggt
3421 aacactgtca tctgtgccac acagggaagt gagggtgagg cgaccctcga gggtggagac
3481 gacaaaggaa catactgtgg ggcacccatc ctgggccctg gaggggcgcc aaagttaagc
3541 acaaaaacca aattttggag gtcatcaaac acgccccttc caccagggac atatgagcct
3601 gcctaccttg gcggtcgtga tccgcgtgta aagggtgggc cttccctaca acaagtcatg
3661 agagatcagt taaagccctt caccgagccc aggggtaaac ccccgagacc tagtgtgctg
3721 gaggcagcca aacagaccat catcaacgtt ctcgagcaaa ctttggatcc tccacaaaaa
3781 tggacgtacg cacaggcgtg cgcttcactt gataaaacca cctctagtgg gcacccccat
3841 cacgctcgaa agaatgaatt ctggaacggt gagaccttta ccggtaagtt ggcagaccaa
3901 gcatcaaaag caaacttaat gtttgaggaa gggaaacata tgacaccagt gtacacagca
3961 gcccttaagg atgagttggt taaaaccgac aaaatctatg ggaagatcaa gaaacgcctg
4021 ctttggggct ctgatttatc caccatggtc cgatgtgcta gggcctttgg tggactcatg
4081 gacgagatga aggcgcactg catatcgctc ccagtccgag ttggcatgaa tatgaatgag
4141 gatggcccaa taatatttga gaagcactcc agatataaat atcactatga tgcagattac
4201 tctcgctggg actcaacaca acagagggct gttctagcag cggccttgga aataatggtc
4261 agattctctg cagaaccgca actggcccaa acagttgctg aggatctgct ggcccccagt
4321 gtagtagatg tcggagactt caaaatttca ataaatgagg gactcccttc tggtgtacca
4381 tgcacttccc agtggaactc catctcacac tggttactaa ctctctgtgc tttgtctgaa
4441 gtcaccaatc tgtctcctga catcgtgcag gcaaattcta tgttctcatt ttacggtgat
4501 gacgagatcg tcagcaccga tataaaattg gaccctgaaa agttaaccac caaattgagg
4561 gagtatggtc taaaaccaac tcgcccagac aaaaccgagg ggcccttgat catcagtgag
4621 gatttggacg gtctcacctt cctccggagg acggtttctc gtgacccagc tggttggttt
4681 ggaaagttag atcaaagctc aatactaagg cagatgtatt ggaccagagg accaaaccat
4741 gaagacccca atgagacaat gataccccac tctcaaagac ccatacagct catggcacta
4801 cttggtgagg cctcccttca cggaccctct ttctacagca agattagtaa attggtcata
4861 actgaactca aagaaggtgg gatggacttt tacgtgccaa gacaggaacc catgttcaga
4921 tggatgaggt tttctgactt gagcacgtgg gagggcgatc gcaatctggc tcccagtttt
4981 gtgaatgaag atggcgtcga atgacgccgc tccacctact gatggtgcag ccggcctcgt
5041 gccagaaagt aataatgagg tcatggctct tgaacccgtg gctggtgccg ccttggcagc
5101 cccagtcacc ggtcaaacaa atataataga cccttggatt agagcaaatt ttgtccaggc
5161 ccccaatggt gaatttacag tctctccccg taactcccct ggtgaagtgc tattgaatct
5221 agagttgggt ccagaattaa atccttatct ggcacattta gcaagaatgt acaatgggta
5281 tgccggtggg atggaggtgc aggtcatgtt ggctgggaat gcgttcacag ccggcaagtt
5341 agtcttcgcc gctgtgccac cccacttccc ggtcgaaaac cttagcccac agcaaattac
5401 catgttccct catgtgatta tagatgtcag gactttggaa cctgttttat taccactccc
5461 tgatgttagg aataacttct tccattacaa tcagaaagat gatcccaaga tgagaattgt
5521 ggctatgctt tacacccccc ttaggtctaa tggttcaggc gatgatgtgt ttacagtctc
5581 ctgcagggtg ttgactagac cctcccctga ttttgatttc acatatctgg tgccaccaac
5641 agtggaatct aaaacaaaac cattcactct cccaatcctc acgcttgggg aactttccaa
5701 ttctagattc ccagtgtcca tagaccagat gtacaccagc cccaacgaag tcatatcagt
5761 gcagtgtcaa aatggcaggt gcacactgga tggggaactc caaggaacaa cacaactcca
5821 aatcagtggc atttgtgctt tcaagggaga agtgactgcc cacttgcatg acaatgatca
5881 cctgtacaat gtcaccatca caaacttgaa tgggtcccct tttgacccct ccgaggacat
5941 ccccgcccct ctgggcgtac ctgactttca gggaagggtc tttggtgtca tctcccaaag
6001 agacaaacac aacacccctg gacataatga accagcaaac agggcacacg atgccgtggt
6061 ccctacttat acagcacagt ataccccaaa attgggtcag attcaaattg gcacatggca
6121 gactgacgat ctcacagtca accaaccagt caaattcacc ccagttggac ttaatgacac
6181 tgaccatttt aaccaatggg tggtccccag gtatgctggt gccctaaacc ttaacacaaa
6241 ccttgcccct tctgttgctc cagtatttcc aggggagcgt ctgctctttt tcagatcata
6301 catccccctc aagggcggtt atggaactcc agccatcgat tgcctactac cacaagagtg
6361 ggtgcaacat ttctatcagg aagcagcccc ttcgatgagt gaggtggccc ttgtcagata
6421 catcaacccg gatactggtc gggcactgtt tgaggccaaa ctccacagag ctggtttcat
6481 gacagtctca agcaacacca gtgccccggt ggttgtgcct gccaacggat acttcaggtt
6541 tgattcttgg gtgaaccaat tctattctct cgcccccatg ggaactggaa atgggcgcag
6601 aaggatccaa taatggctgg agcttttgta gctggtcttg caggggacgt gctcagcaat
6661 gggcttagtt cattaattaa tgcaggtgct aatgcaataa atcagagggc agaatttgat
6721 ttcaatcaga gattacagca aaattctttc aatcatgata aggagatgtt gcaggcccag
6781 gtccaggcaa ctaagcagct gcaggcagac atgatggcca taaaacaggg ggtcctggcc
6841 gctggcggct tttcccctgc tgatgcagcc agaggtgctg tgaacgcgcc catgacacag
6901 gcgctggatt ggaacggcac aaggtattgg gcaccaggct ccatgaggac tacagcctac
6961 tctgggagat tcacatcaac cgccccagtg aggcaggctg atttccagca cacccaaagc
7021 cggccttcga gtggttcttc tgtgtcctcc tttgctactc agtcttcaag gccgaccctg
7081 actacaacca ctgggtcctc gtatggcaca gcctcatcaa attcgactcg cagcacaaac
7141 ctctcccaat caacggtctc cagggctaca tctaggactg gtgaatggat tagagaccaa
7201 aacagaaatt tggaacctta catgcatggt gccttacaga cggcctttgt caccccacct
7261 tccagcaggg cgtctaatgg gacggtctca accgttccaa aaggtgtttt ggactcctgg
7321 acacctgcgt ttaacacccg caggcagccg cttttcgcac acctccgtaa gag
//