Typing tool
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Typing tool
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Complete norovirus genomes
| MK752944 | GII.2 | |
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| GII.P2 |
ORF1: 1..5052
ORF2: 5033..6661
ORF3: 6661..7434
LOCUS MK752944 7434 bp RNA linear VRL 11-APR-2019
DEFINITION Norovirus GII isolate Hu/US/2015/GII.P2-GII.2/Ozaukee0713
nonstructural polyprotein (ORF1) gene, partial cds; VP1 (ORF2)
gene, complete cds; and VP2 (ORF3) gene, partial cds.
ACCESSION MK752944
VERSION MK752944.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7434)
AUTHORS Barclay,L., Cannon,J.L., Wikswo,M.E., Phillips,A., Browne,H.,
Montmayeur,A.M., Tatusov,R.L., Burke,R.M., Hall,A.J. and Vinje,J.
TITLE Emergence and characterization of multiple viruses associated with
a novel GII.P16 polymerase in the United States, 2015-2018
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7434)
AUTHORS Barclay,L., Cannon,J.L., Davis,T., Montmayeur,A.M., Tatusov,R.L.
and Vinje,J.
TITLE Direct Submission
JOURNAL Submitted (04-APR-2019) Division of Viral Diseases, Centers for
Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA
30329, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: Geneious v. R10; SPAdes v. 3.6
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7434
/organism="Norovirus GII"
/mol_type="genomic RNA"
/strain="Ozaukee0713"
/isolate="Hu/US/2015/GII.P2-GII.2/Ozaukee0713"
/isolation_source="stool"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="USA"
/collection_date="05-Nov-2015"
/note="genotype: GII.P2-GII.2"
gene <1..5052
/gene="ORF1"
CDS <1..5052
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="QBS47663.1"
/translation="NNDNTKSSSDGMLNNMAVTLKRALGARPKQPAPREKPPRPPRPP
TPELIKRIPPPPPNDGDEPTVMFSTAGGVSGLPELTTVGQPPESNTAFSVPPLSQREN
RDAKEPLTGAILEMWDGEIYHYGLYVEKGLVLGVHKPPAAISIAKVELTPLSLYWRPV
YTPQYLISPDTLRKLHGELFPYTAFENNCYAFCCWVLDLNDSWLSRRMISRTTGFFRP
YQEWNRKPLPTMDDSKLKKVANIVLCALSSLFTRPIKDIIGKLKPLNILNILASCDWT
FAGIVESLILLAELFDVFWTPPDVSAMIAPLLGDYELQGPEDIAVELVPVVMGGIGLV
LGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKDEANELAVVRAIED
AVLDLEAIENNHMTTLLKDKNSLAAYMKTLDMEEEKARKLSTKSASPDIVGTINALLA
RIAAARSLVHRAKEELSSRPRPVVLMISGKPGIGKTHLARELAKKIASTLTGDQRVGL
IPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIENKGKVF
DSDAIIITTNLVNPAPLDYVNFEACSRRIDFLVYADAPEVEKAKRDFPGQPDMWKDAY
RSDFSHIKLQLAPQGGFDKNGNTPHGKGVMKTLTASSLVARASGLLHERLDEYELQGP
PLSTFNFDRNKIAAFRQLAAENKYGLVDTMRVGNQLRNVTTMDELKKAIKNIKIRKCQ
IVYGGNTYTLESDGKGKVVVERVQSTSVQINNEIAGAVHHLRCARIRYYVKCVQEAIY
SLLQIAGTVFVTSRIVSRMNIQNLWSRPLSEDADEATIKEGCPKPRDEEEFIVSSDDI
KPEGKKGKNKSGRGKKHTAFSSKGLSDEEYEEYKRIREERNGKYSIEEYLQDRDKYYE
EVAIARATEEDFCEEEEVKIRQRIFRPTRKQRKEERANLGLVTGSEIRKRNPDDFKPK
GKLWADDDRSVDYNERISFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIPQGITE
AFGVPIRQVQIHKSGEFCRLRFPKPIRTDVSGMILEEGAPEGTVATILIKRTTGELMP
LAARMGTHATMRIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGNDYIVI
GVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPILGPGSAPKLSTKTKFWRS
STTPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPKPSVLEAAKKT
IINVLEQTIDPPQKWTYAQACASLDKTTSSGYPHHVRKNEHWNGESFTGKLADQASKA
NLMFEEGKHMTPVYTAALKDELVKTEKVYGKIKKRLLWGSDLATMVRCARSFGGLMDE
LKAHCVTLPIRVGMNMNEDGPIVFEKHSRYRYHYDADYSRWDSTQQRAVLAAAMEIMV
KFSAEPQLAQIVAEDLLSPSVVDVGDFRVSINEGLPSGVPCTSQWNSIAHWLLTLCAL
SEVTDLSPDIVQANSLFSFYGDDEIVSTDIKLDPEKLTGKLREYGLKPTRPDKTEGPL
IISEDLNGLTFLRRTVTRDPAGWFGKLDQSSILRQLYWTKGPNHEDPFESMIPHSQRP
IQLMSLLGEAALHEPSFYSKISKLVISELKEGGMDFYVPRQEPMFRWMRFSDLSTWEG
DRNLAPSLVNEDGVE"
mat_peptide <1..942
/gene="ORF1"
/product="p48"
mat_peptide 943..2040
/gene="ORF1"
/product="NTPase"
mat_peptide 2041..2577
/gene="ORF1"
/product="p22"
mat_peptide 2578..2976
/gene="ORF1"
/product="VPg"
mat_peptide 2977..3519
/gene="ORF1"
/product="Pro"
mat_peptide 3520..5049
/gene="ORF1"
/product="RdRp"
gene 5033..6661
/gene="ORF2"
CDS 5033..6661
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QBS47664.1"
/translation="MKMASNDAAPSTDGAAGLVPESNNEVMALEPVAGAALAAPVTGQ
TNIIDPWIRANFVQAPNGEFTVSPRNAPGEVLLNLELGPELNPYLAHLARMYNGYAGG
MEVQVMLAGNAFTAGKLVFAAVPPHFPVENLSPQQITMFPHVIIDVRTLEPVLLPLPD
VRNNFFHYNQKDDPKMRIVAMLYTPLRSNGSGDDVFTVSCRVLTRPSPDFDFTYLVPP
TVESKTKPFTLPILTLGELSNSRFPVSIDQMYTSPNEVISVQCQNGRCTLDGELQGTT
QLQVSGICAFKGEVTAHLHDNDHLYNVTITNLNGSPFDPSEDIPAPLGVPDFQGKVFG
IISQRDKHNSPGHNEPANRGHDAVVPTYTAQYTPKLGQIQIGTWQTDDLTVNQPVKFT
PVGLNDTEHFNQWVVPRYAGALNLNTNLAPSVAPVFPGERLLFFRSYIPLKGGYGNPA
IDCLLPQEWVQHFYQEAAPSMSEVALVRYINPDTGRALFEAKLHRAGFMTVSSNTSAP
VVVPANGYFRFDSWVNQFYSLAPMGTGNGRRRVQ"
gene 6661..>7434
/gene="ORF3"
CDS 6661..>7434
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QBS47665.1"
/translation="MAGAFVAGLAGDVLSNGLSSLINAGANAINQRAEFDFNQKLQQN
SFNHDKEMLQAQIQATKQLQADMMAIKQGVLTAGGFSPADAARGAVNAPMTQALDWNG
TRYWAPSSMRTTSYSGKFTSTAPVRQADFQHTQSRPSSGSSVSSFATQSSRPTLTTTT
GSSHGTASSNSTRSTSLSQSTVSRATSRTGEWVRDQNRNLEPYMHGALQTAFVTPPSS
RASDGTVSTVPKGVLDSWTPAFNTRRQPLFAHLRKRGESQ"
ORIGIN
1 aacaacgaca acacaaaatc ttcaagtgac ggaatgctta ataacatggc cgtcaccctt
61 aaacgagccc ttggggcccg gcccaaacag ccagccccga gggaaaaacc cccaagaccc
121 cctagaccac caacaccaga attaatcaaa agaatccccc ccccaccacc taatgatggg
181 gacgaaccaa ccgtgatgtt tagcactgca ggtggtgtgt ctggcctacc tgagctcaca
241 acagtcggcc aaccacctga atctaacact gcctttagtg tgccccccct tagccaaagg
301 gaaaacaggg acgctaagga accgttaact ggggctattc tggaaatgtg ggatggggag
361 atttatcatt atggactgta tgtggaaaaa gggcttgtgc taggcgtgca caagccgccg
421 gctgccatta gcatagccaa agtggaattg acacccctct cgctgtattg gaggcctgtg
481 tacacgcctc agtacctcat atctcctgac accttgagga aactccacgg tgagttattt
541 ccctatacag cctttgaaaa caactgttat gccttctgct gttgggtttt ggacctcaac
601 gattcatggc taagcagaag gatgattagt aggactactg gcttcttcag gccctaccaa
661 gagtggaaca ggaagcctct cccaactatg gatgactcaa aattgaagaa ggtcgcaaac
721 atcgttctgt gtgcattgtc atcattgttc actaggccca ttaaggatat aattggcaaa
781 cttaaacccc ttaacatcct aaatattctg gcctcatgcg attggacctt cgctggcata
841 gtagaatcac taatcctctt ggctgaactc tttgatgtgt tctggacacc cccagatgtg
901 tctgcaatga tcgcacccct cctcggcgac tatgagctac aaggtcccga agacatcgct
961 gtggagctcg tgcccgttgt gatgggtggg ataggtctgg tgttgggatt caccaaagag
1021 aaaataggca agatgctctc ctctgcagcg tcaactctga gggcgtgcaa agatcttgga
1081 gcctatggat tggagatact aaaactagtc atgaaatggt ttttcccaaa gaaggatgag
1141 gccaacgaac tggctgtggt tagagccatt gaagacgctg tattagacct ggaggctatt
1201 gagaacaacc atatgaccac tctactgaaa gacaagaaca gccttgcagc atacatgaag
1261 accctggaca tggaagagga aaaagctagg aagctatcca ccaaatcagc ctcccctgac
1321 attgtgggca ctataaacgc cctgctggct aggatcgctg ccgcgcgttc cctagttcat
1381 agggccaagg aggagctctc cagcaggcca agaccggtcg ttttgatgat ctctggcaag
1441 ccagggatag gaaagaccca cttggccaga gaactggcaa agaaaattgc ctcgacactc
1501 acaggagacc aaagggttgg tcttatccca cggaatggag tcgaccattg ggacgcctac
1561 aaaggtgaga gagtagtgct ctgggatgac tatggaatga gcaaccccat ccacgatgcg
1621 ctgaggctgc aggaattggc agacacatgt ccattaactc taaattgtga caggattgaa
1681 aacaagggaa aagtcttcga cagcgacgcg atcataatca ccaccaattt ggtcaacccc
1741 gcgccgctgg attatgtcaa ctttgaggcc tgctccagac gtatagactt ccttgtgtat
1801 gctgatgccc cagaagtcga gaaagcaaaa cgggactttc ccggtcaacc ggacatgtgg
1861 aaagacgcct accgctctga cttctcacac attaaactac aacttgcacc acaaggtggg
1921 tttgacaaaa atggtaacac cccacatggt aaaggagtga tgaagactct cactgccagc
1981 tcactggtcg cgcgtgcctc tggtctcttg cacgagagat tagatgagta cgagttgcaa
2041 ggtccgcccc tctcaacctt caactttgac cgtaacaaaa tcgcagcgtt cagacaactc
2101 gccgctgaaa acaagtacgg tctggtagac acgatgaggg tgggcaacca gctcagaaat
2161 gtcacgacca tggatgaact caagaaggct atcaagaaca tcaaaatcag aaagtgccag
2221 atagtctatg gtggcaacac ttacacgctt gagtctgacg gcaagggcaa ggttgtagtt
2281 gagagggtgc agagcaccag cgtgcaaatc aacaatgaga tcgctggtgc agtacaccat
2341 cttagatgtg ccagaataag gtattatgtc aagtgtgtcc aagaggccat atactcactc
2401 ctccagattg ccggcacggt gtttgtcact tcacgcatcg taagccgcat gaacatccaa
2461 aatttgtggt ctaggccact atctgaagat gcagatgaag ccaccataaa agaggggtgc
2521 cctaaaccta gggatgaaga agaattcatc gtctcctcag atgatattaa gccagagggc
2581 aagaaaggca aaaacaagag tggccggggc aagaaacaca cggcattctc aagcaaaggg
2641 ctcagtgatg aggagtacga agagtacaaa agaatcagag aggagagaaa tggcaagtac
2701 tccatagagg aatacctaca ggacagagac aagtactatg aagaggtggc catcgccagg
2761 gcaactgaag aagacttctg tgaagaagaa gaggttaaga ttcgtcagag gatcttcagg
2821 ccaacaagaa agcaacgcaa ggaagaaaga gccaaccttg gcctcgtcac cgggtctgag
2881 atcaggaaga gaaacccaga tgacttcaaa ccaaaaggaa agctgtgggc cgacgatgac
2941 aggagcgtcg actacaatga aagaatcagc tttgaggccc caccaagcat ttggtctaga
3001 attgtcaact ttggttctgg atgggggttc tgggtgtcac ctagcctctt cataacatca
3061 acacacgtca tacctcaagg cataactgag gcctttggtg tacccataag gcaggtgcaa
3121 atacacaaat cgggcgagtt ctgtcgcttg agattcccaa aacccatcag aacagatgtg
3181 tcaggcatga tactggagga gggagcgccc gaaggtactg ttgccaccat actcatcaaa
3241 agaaccactg gagagctgat gcctctggca gcaagaatgg gaacccacgc gaccatgagg
3301 atacaagggc gcacagtggg cggccagatg ggaatgttgc tcactgggtc caatgcaaag
3361 agcatggatc ttggcaccac gcccggtgat tgtgggtgtc cctacattta caaaaggggc
3421 aatgattaca tagtcattgg agttcacaca gcagccgctc gtggcggaaa cactgtcatc
3481 tgcgccacac aaggtagtga gggtgaggct actctcgagg gtggtgacaa taaaggaaca
3541 tattgtgggg caccaatctt gggccccgga agtgccccaa aactaagcac taaaaccaag
3601 ttctggaggt cctctacaac accactccca cccggcacgt acgagccggc atatctggga
3661 ggaaaagacc cccgagtcaa aggtgggccg tctctgcaac aagtcatgcg agaccaactg
3721 aagccattca ccgaaccccg tggcaagcca ccaaaaccaa gtgtccttga agctgctaaa
3781 aagacaatta tcaatgtgtt agaacaaaca atagaccccc cacagaagtg gacgtacgcg
3841 caagcgtgcg cgtctcttga caaaaccaca tctagtgggt acccccacca cgtgcgcaaa
3901 aacgagcact ggaatgggga atctttcaca ggaaaattgg ctgatcaggc atcgaaggca
3961 aacctaatgt ttgaagaggg gaaacacatg accccagttt atacagctgc ccttaaggat
4021 gagttggtca aaactgagaa agtgtatggg aagataaaga agaggttgct ttggggctct
4081 gacttggcca ccatggtgag gtgtgcgcgc tcctttggcg gtttgatgga cgaactcaag
4141 gcccactgtg tgacactccc gataagggtt ggcatgaata tgaatgaaga tggaccaata
4201 gtctttgaga aacattccag atacaggtat cactatgatg cagactactc caggtgggat
4261 tcaacacagc agagagccgt tctggccgcg gccatggaga ttatggttaa attctcagca
4321 gaaccacaat tagcccaaat agttgcagag gatctgttgt cgcccagtgt tgttgacgtg
4381 ggcgacttca gagtttccat caatgaagga ttaccatcgg gtgtcccttg cacctctcag
4441 tggaactcca tcgcacactg gctcctcacc ttgtgtgccc tttctgaagt tacagacctc
4501 tctcctgaca ttgtgcaagc caactccctc ttctccttct atggtgatga tgaaattgtg
4561 agtacagaca tcaaattaga cccagagaag ttgacgggga agttgagaga atatggtctc
4621 aaacccaccc gtcctgacaa aactgagggc cccttgatta ttagcgagga tctgaatggc
4681 ctgaccttcc tgaggagaac cgtcacccgc gaccctgcag gatggtttgg caaactggac
4741 caaagctcca tacttaggca attgtattgg accaaaggcc ctaatcatga agaccccttt
4801 gagtcaatga ttccacattc ccagaggccc atacaactca tgtcactctt gggtgaagca
4861 gcactgcatg aaccatcatt ttacagcaag atcagcaagc ttgtgatatc tgagttgaaa
4921 gaaggtggaa tggattttta cgtgcccagg caagaaccta tgtttaggtg gatgagattc
4981 tcggatttga gcacgtggga gggcgatcgc aatcttgctc ccagtcttgt gaatgaagat
5041 ggcgtcgaat gacgccgctc catctactga tggtgcagcc ggcctcgtgc cagaaagtaa
5101 caatgaggtc atggctcttg aacccgtggc tggtgccgcc ttggcagccc cggtcaccgg
5161 tcaaacaaat attatagacc cttggattag agcaaatttt gtccaggccc ccaatggtga
5221 atttacagtc tctccccgaa atgcccctgg tgaagtgcta ctgaatctag agctgggtcc
5281 agaattaaat ccttatctgg cacatttagc aagaatgtac aatgggtatg ccggtgggat
5341 ggaggtgcag gtcatgctgg ctgggaacgc gttcacagcc ggcaagttgg tcttcgccgc
5401 cgtgccacct cacttcccgg ttgaaaacct tagcccacag caaatcacca tgttccctca
5461 tgtgatcata gatgtgagaa ccttggaacc tgttttatta ccactccctg atgttaggaa
5521 taatttcttc cattataatc agaaagatga tcccaagatg agaattgtgg ctatgcttta
5581 tacccccctc aggtctaatg gttcaggtga tgatgtgttt acagtctcct gcagagtgtt
5641 gactagacct tcccctgatt ttgattttac atacctggtg ccaccaacag tggagtctaa
5701 aacaaaacca ttcaccctcc caatcctcac acttggggaa ctttccaatt ctaggttccc
5761 agtgtccata gaccagatgt acaccagccc taatgaggtt atatcagtgc agtgtcaaaa
5821 tggtaggtgc acattggacg gggagctcca agggacaaca caactccaag tcagtggcat
5881 ttgtgctttc aaaggtgaag tgaccgccca cttgcatgac aatgatcacc tatataatgt
5941 caccatcaca aacttgaacg ggtccccttt tgatccctcc gaggatatcc ccgcccctct
6001 gggtgtgcct gatttccagg gaaaggtctt tggtatcatc tcccaaagag acaaacacaa
6061 tagtcccggg cataatgaac cagcaaacag gggacacgac gctgtggtcc ctacttacac
6121 agcacagtac actccaaaac tgggacaaat tcaaattggc acatggcaga ctgacgacct
6181 tacagtcaac caaccagtca aattcacccc agttggactc aatgacactg aacatttcaa
6241 ccaatgggtg gtccctaggt atgctggtgc cctaaatctc aacacaaacc ttgccccttc
6301 tgttgctcca gtatttccag gagagcgcct gctcttcttc agatcataca ttccccttaa
6361 gggtggttat ggaaacccag ccattgattg cctactacca caagagtggg tgcaacactt
6421 ctatcaggaa gcagcccctt caatgagtga ggtggccctt gtcagataca tcaacccgga
6481 tactggtcgg gcactgtttg aggccaagct tcacagagct ggtttcatga cagtctcgag
6541 caacaccagt gccccggtgg ttgtgcctgc caacggatac ttcagatttg attcttgggt
6601 gaatcaattc tattctctcg cccccatggg aactgggaat gggcgtagaa gggttcaata
6661 atggctggag cttttgtagc tggtcttgca ggggacgtgc tcagcaatgg gctcagttca
6721 ttaatcaatg caggtgctaa tgcaataaat cagagggcag aatttgattt taaccagaaa
6781 ttgcagcaaa attcttttaa tcatgacaag gagatgttgc aggctcagat tcaggcaact
6841 aagcagctgc aggcagacat gatggccatt aaacaggggg tcttgaccgc tggcggtttt
6901 tcccctgctg atgcagccag aggtgctgtg aacgcgccca tgacacaggc gctggattgg
6961 aatggcacaa gatattgggc accaagctcc atgaggacca catcttattc tggaaaattc
7021 acatcaaccg ccccagtgag gcaggccgac tttcagcaca cccaaagccg gccttcgagt
7081 ggttcttctg tgtcttcctt tgccactcag tcttcaaggc caactctgac cacaaccact
7141 ggttcctcac atggtacagc ctcatcaaat tcaactcgca gcacaagcct ctcccaatca
7201 acggtctcca gagctacatc taggactggt gagtgggtta gggatcaaaa tagaaatttg
7261 gaaccctaca tgcatggtgc cttacagaca gcctttgtca ccccaccttc cagcagggcg
7321 tctgacggga cagtctcaac cgtcccgaaa ggtgttttgg actcctggac acctgcgttt
7381 aacacccgca ggcagccgct ttttgcacac ctccgtaaga ggggggagtc acaa
//