Typing tool
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Typing tool
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Complete norovirus genomes
| MK752934 | GII.4 Sydney | |
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| GII.P16 |
ORF1: 1..5100
ORF2: 5081..6703
ORF3: 6703..7509
LOCUS MK752934 7511 bp RNA linear VRL 11-APR-2019
DEFINITION Norovirus GII isolate Hu/US/2018/GII.P16-GII.4 Sydney/Grant0015
nonstructural polyprotein (ORF1), VP1 (ORF2), and VP2 (ORF3) genes,
complete cds.
ACCESSION MK752934
VERSION MK752934.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7511)
AUTHORS Barclay,L., Cannon,J.L., Wikswo,M.E., Phillips,A., Browne,H.,
Montmayeur,A.M., Tatusov,R.L., Burke,R.M., Hall,A.J. and Vinje,J.
TITLE Emergence and characterization of multiple viruses associated with
a novel GII.P16 polymerase in the United States, 2015-2018
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7511)
AUTHORS Barclay,L., Cannon,J.L., Davis,T., Montmayeur,A.M., Tatusov,R.L.
and Vinje,J.
TITLE Direct Submission
JOURNAL Submitted (04-APR-2019) Division of Viral Diseases, Centers for
Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA
30329, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: Geneious v. R10; SPAdes v. 3.6
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7511
/organism="Norovirus GII"
/mol_type="genomic RNA"
/strain="Grant0015"
/isolate="Hu/US/2018/GII.P16-GII.4 Sydney/Grant0015"
/isolation_source="stool"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="USA"
/collection_date="04-Jan-2018"
/note="genotype: GII.P16-GII.4 Sydney"
gene 1..5100
/gene="ORF1"
CDS 1..5100
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="QBS47633.1"
/translation="MKMASNDATVAVACNNNNDKEKSSGEGLFTNMSSTLKKALGARP
KQPAPRDEPQKPPRPPTPELVKRIPPPPPNGEEEEEPVIRYEVKSGISGLPELTTVPQ
PDVANTAFSVPPLSLRENREAKEPLTGAILEMWDGEIYHYGLYVEKGLVLGVHKPPAA
ISMARVELTPLSLYWRVVYTPQYLISPETLRRLNGEAFPYTAFDNNCYAFCCWVLDLN
DSWLSRRMVQRTTGFFRPYQEWNRKPLPTMDDSKIKKVANIFLCSLSTLFTRPIKDLI
GKIKPLNILNILATCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGP
EDLAVELVPVVMGGIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWF
FPKKEEANELAMVRAIEDAVLDLEAIENNHMTTLLKDKDSLATYMKTLDMEEEKARRL
STKSASPDIVGTINALLARIAAARSLVHRAKEELSSRIRPVVVMISGKPGIGKTHLAR
EVARKVASTLTGDQRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRIQELAD
TCPLTLNCDRIENKGKVFDSEVIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPEV
EKAKRDFPGQPDMWKDAFKSDFSHIKLQLAPQGGFDKNGNTPHGKGVMKTLTTGSLIA
RASGLLHERMDEFELQGPTITTFNFDRNRITAFRQLAAENKYGLVDTMKVGNQLKGVK
TMEELKQAIRNVTIKRCRIIYGGSTYDLESDGKGKVLVEKVKNTSVQTNNELTGALHH
LKHARIRYYVKCVQEAVYSIIQIAGAAFVTTRIARRMNIQELWSKPQLDQNESETKEE
TPKSEDDEFIISSKDIKEEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNG
KYSIEEYLQDRDRYYEELAIAKATEEDFCEEEEIKIRQRIFRPTRKQRKEERATLGLV
TGSEIRKRNPDDFKPKGKLWADDNRSVDYNEKLDFEAPPSIWSRIVSFGSGWGFWVSP
SLFITSTHVIPAGITEAFGVPIKQIQIHKSGEFCRFRFPKPIRPDVTGMILEEGAPEG
TVATVLIKRPTGELMPLAARMGTHATMKIQGRMVGGQMGMLLTGSNAKGMDLGTTPGD
CGCPYIYKRGNDYIVIGVHTAAARGGNTVICATQGSEGEATLEGGDDKGTYCGAPILG
PGGAPKLSTKTKFWRSSNTPLPPGTYEPAYLGGRDPRVKGGPSLQQVMRDQLKPFTEP
RGKPPRPSVLEAAKQTIINVLEQTLDPPQKWSYAQACASLDKTTSSGHPHHVRKNESW
NGETFTGKLADQASKANLMFEEGKHMTPVYTAALKDELVKTEKIYGKIKKRLLWGSDL
STMIRCARSFGGLMDEMKAHCITLPVRVGMNMNEDGPIIFEKHSRYKYHYDADYSRWD
STQQRAVLAAALEIMVRFSAEPQLAQIVAEDLLAPSVVDVGDFKITINEGLPSGVPCT
SQWNSIAHWLLTLCALSEVTKLSPDIIQANSMFSFYGDDEIVSTDIKLDPEQLTAKLK
EYGLKPTRPDKTEGPLIISEDLNGLTFLRRTVTRDPAGWFGKLDQSSILRQMYWTRGP
NHEDPNETMIPHSQRPIQLMALLGEASLHGPSFYSKISKLVITELKEGGMDFYVPRQE
PMFRWMRFSDLSTWEGDRNLAPNFVNEDGVE"
mat_peptide 1..996
/gene="ORF1"
/product="p48"
mat_peptide 997..2094
/gene="ORF1"
/product="NTPase"
mat_peptide 2095..2625
/gene="ORF1"
/product="p22"
mat_peptide 2626..3024
/gene="ORF1"
/product="VPg"
mat_peptide 3025..3567
/gene="ORF1"
/product="Pro"
mat_peptide 3568..5097
/gene="ORF1"
/product="RdRp"
gene 5081..6703
/gene="ORF2"
CDS 5081..6703
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QBS47634.1"
/translation="MKMASSDANPSDGSAANLVPEVNNEVMALEPVVGAAIAAPVAGQ
QNVIDPWIRNNFVQAPGGEFTVSPRNAPGEILWSAPLGPDLNPYLSHLARMYNGYAGG
FEVQVILAGNAFTAGKIIFAAVPPNFPTEGLSPSQVTMFPHIIVDVRQLEPVLIPLPD
VRNNFYHYNQSNDSTIKLIAMLYTPLRANNAGDDVFTVSCRVLTRPSPDFDFIFLVPP
TVESRTKPFSVPVLTVEEMTNSRFPIPLEKLFTGPSSAFVVQPQNGRCTTDGVLLGTT
QLSPVNICTFRGDVTHTTGSHNYTMNLASQNWNNYDPTEEIPAPLGTPDFVGKIQGML
TQTTRTDGSTRGHKATVYTGSADFAPKLGRVQFETDTNHDFEVNQNTKFTPVGVIQDG
GTTHRNEPQQWVLPSYSGRNTHNVHLAPAVAPTFPGEQLLFFRSTMPGCSGYPNMDLD
CLLPQEWVQYFYQEAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYVTVAHTGQHDLV
IPPNGYFRFDSWVNQFYTLAPMGNGTGRRRVV"
gene 6703..7509
/gene="ORF3"
CDS 6703..7509
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QBS47635.1"
/translation="MAGTFFAGLASDVLGSGLGSLINAGAGAINQKVEFENNRKLQQA
SFQFSSNLQQASFQHDKEMLQAQIEATKKLQQEMMKVKQAMLLEGGFSETDAARGAIN
APMTKALDWSGTRYWAPDARTTTYNAGRFSTPQPSGALPGRANLRDAVPARGPSNKSS
NSSTATSVYSNQTISTRLGSTAGSGTSFSNLPSTARTRSWVEDQSRNLSPFMRGAHNI
SFVTPPSSRSSSQGTVSTVPKEILDSWTGAFNTRRQPLFAHIPKRGESRV"
ORIGIN
1 atgaagatgg cgtctaacga cgctaccgtt gccgttgctt gcaacaacaa caacgacaag
61 gaaaaatctt caggtgaagg cttattcaca aatatgtctt ccaccttaaa gaaagccctc
121 ggggctaggc ccaaacagcc tgccccgaga gacgaaccac aaaagccccc aagaccacca
181 actcccgagt tggtcaagag gataccccct cctccaccta atggcgaaga agaagaagaa
241 ccagtcatta ggtatgaggt taagagtgga atctctggcc tgcccgagct cacaacagtc
301 ccccaaccgg acgtggccaa cacagcattc agtgttccac cactgagctt gagagaaaac
361 agggaggcca aggaaccgct aacgggggca atattagaga tgtgggatgg agagatatac
421 cactacggcc tgtacgtgga gaaaggctta gtgttgggtg tgcacaaacc acctgcagcc
481 ataagcatgg caagagtgga gctgacaccg ctgtcattgt actggcgtgt ggtgtacact
541 ccccaatacc tcatctcccc tgaaactctc aggaggctca acggagaggc attcccttac
601 accgccttcg acaacaactg ctatgccttt tgctgctggg tgttggacct caatgactca
661 tggcttagta ggaggatggt gcaaagaaca acgggcttct tcagacctta ccaagagtgg
721 aacagaaaac ccctgcctac catggatgac tccaaaatta agaaggtagc aaatatattc
781 ctatgttcat tgtccacatt attcaccaga cccataaaag acctcatagg aaaaattaaa
841 ccattaaaca tattgaacat cctggcaacg tgtgactgga cgtttgccgg aatagtggag
901 tctctgatat tacttgctga actcttcgga gttttctgga cacccccaga tgtgtctgct
961 atgatcgctc ccttactcgg ggactacgag ttgcaagggc cagaagacct cgccgttgaa
1021 ctcgtacctg tggtaatggg agggattggt ttggtgttgg gattcaccaa agagaaaatt
1081 ggcaaaatgt tgtcctcagc agcatcaaca ctcagggctt gcaaagatct tggtgcctat
1141 ggcttagaga tactcaaatt ggtcatgaag tggttcttcc caaagaaaga ggaggctaat
1201 gagctagcca tggtgagggc catagaggat gccgtactag atcttgaggc aatagaaaat
1261 aaccacatga caaccctgtt gaaagacaaa gacagcttag caacatacat gaaaacactg
1321 gacatggagg aggagaaagc cagaaggtta tccacaaaat ctgcatcccc cgacatagtt
1381 gggacaatca acgctctgct ggctcgaata gcagcggcca ggtcattagt ccacagggcc
1441 aaggaagagc tatctagcag gataagacca gtagttgtta tgatatctgg taaaccagga
1501 ataggcaaaa ctcatctggc cagggaggtg gcaagaaagg tggcatccac tctcacaggt
1561 gatcaaagag tcggactcat accgagaaac ggtgtggacc attgggatgc atacaaaggt
1621 gagagagtcg tgctgtggga cgactatggc atgagtaacc ccatccatga cgctcttcgc
1681 atacaagaat tggctgacac gtgtcccctt accttaaatt gtgacagaat tgaaaataag
1741 ggaaaagttt ttgacagtga agtcataata atcacaacaa accttgccaa cccagcccca
1801 cttgattatg tcaactttga ggcctgttcc aggagaattg atttcctggt gtacgctgat
1861 gcaccagaag tggaaaaggc aaaacgggac tttcctggtc agccagatat gtggaaggac
1921 gccttcaagt cggacttttc acacatcaag ctgcagcttg cacctcaggg cggctttgac
1981 aagaatggca acaccccaca tgggaaagga gtgatgaaga ccctcactac cggttctctg
2041 attgcccgtg catcaggcct actgcatgag aggatggatg aatttgaact ccaaggtccc
2101 acaatcacca ccttcaattt cgaccggaat agaatcacag cattcagaca attggctgca
2161 gaaaacaagt atggattggt ggataccatg aaagttggca atcaactaaa aggagtgaaa
2221 accatggaag aactcaaaca agcaatcagg aatgtgacca tcaagaggtg ccggatcatc
2281 tacggtggct ccacgtatga ccttgaatct gatggcaagg gcaaggtttt ggtggaaaag
2341 gtcaagaaca cctctgtgca gaccaacaac gagttgactg gggccctgca ccatctcaaa
2401 cacgcacgaa tcaggtacta tgtcaaatgt gtgcaagaag cagtctattc catcatacaa
2461 attgccggcg ctgcgtttgt caccacgcgc attgcacgcc gcatgaacat acaagaactc
2521 tggtcgaagc cacaattaga ccaaaacgaa tcagagacta aggaagagac ccctaagtca
2581 gaagatgacg agttcatcat atcttctaag gacatcaagg aggaaggaaa gaagggcaaa
2641 aacaaaactg gccgtggcaa gaagcatact gcattctcca gcaagggctt gagcgatgag
2701 gagtatgacg agtacaagag gataagagaa gagagaaatg ggaagtactc tatagaggag
2761 tatcttcaag acagagacag gtactatgag gagctcgcca ttgccaaggc cacggaagaa
2821 gacttctgtg aagaggagga gatcaaaatc cgtcagagaa ttttccgtcc caccaggaaa
2881 caaaggaagg aagagagggc cacattaggg ctagtgacag gttcagaaat cagaaaaaga
2941 aaccctgatg acttcaaacc caaagggaag ctgtgggccg atgacaacag aagtgttgat
3001 tacaatgaga aactggactt tgaggccccc ccaagcatat ggtctaggat tgtgagcttt
3061 ggttctggct ggggcttctg ggtgtcacca agcctgttca taacatcaac tcatgtaatt
3121 cccgctggca taacagaagc atttggagtc cccatcaaac aaattcagat ccacaaatca
3181 ggtgaatttt gccgattcag attcccaaaa ccaattagac cagatgtgac aggaatgatc
3241 ttggaagaag gtgcgcctga aggcaccgtg gcaactgtgc tcatcaaacg ccccaccgga
3301 gagctcatgc ctcttgcagc cagaatggga acacacgcaa ccatgaaaat tcaaggccgc
3361 atggttggcg gacagatggg tatgttgctc actggatcaa atgctaaagg aatggatttg
3421 ggaacaactc ctggtgactg tggctgtcct tacatctata aaaggggcaa tgactatata
3481 gtcattgggg tgcacactgc agcagcccgt ggtggaaaca ccgttatctg tgccacacag
3541 ggaagtgagg gtgaggcaac tcttgagggt ggagatgaca agggaacata ctgtggggca
3601 cccattctag gccctggggg tgcaccaaag ttgagcacca aaaccaaatt ttggaggtca
3661 tcgaacacgc cccttccacc agggacatat gagcctgcct acctcggtgg ccgtgacccg
3721 cgtgttaagg gtgggccctc cttgcagcag gtaatgagag accagttgaa accattcact
3781 gaacccaggg gcaaacctcc aagaccaagt gtattggaag cagccaaaca aaccattatt
3841 aatgtcctcg aacaaaccct ggaccctcca caaaaatggt catacgcaca ggcgtgtgcc
3901 tcacttgaca aaaccacctc cagcgggcac ccccatcacg tccgaaagaa tgaatcctgg
3961 aatggtgaga ccttcactgg taaattggca gaccaagcat caaaagcaaa cctaatgttt
4021 gaggaaggga aacatatgac accagtgtat acagcagcac tcaaggacga gctggtcaag
4081 actgagaaaa tctatggaaa aatcaagaag agactgctct ggggctctga cttgtccacc
4141 atgatccggt gcgctaggtc atttggtggg ctcatggacg agatgaaggc acactgcata
4201 acactcccag tacgagttgg catgaatatg aatgaagatg gcccaataat atttgagaaa
4261 cattccagat acaaatatca ctatgatgca gactactctc gttgggattc aacacaacag
4321 agggcagtac tagcagcagc cctggaaatc atggtcagat tctctgcaga accacaattg
4381 gcacaaatag tcgctgagga cctgctggcc cctagtgtag tagatgtggg agactttaaa
4441 atcacaataa atgaagggct cccatctggt gtgccatgca cttcccaatg gaactctatc
4501 gcacactggc tgctaactct ctgtgcctta tctgaagtca ccaaactgtc ccctgacatt
4561 atacaagcaa attccatgtt ctcattttac ggtgatgacg agattgtcag caccgacata
4621 aaattggacc ctgaacagtt aaccgccaaa ttgaaggagt acggcctgaa accaactcgc
4681 ccagacaaga ctgagggacc cctgatcatc agtgaagatt tgaacggact cactttcctc
4741 cgaaggacgg tgactcgtga cccagctggc tggtttggaa aactggacca aagctcaatt
4801 ttgaggcaga tgtactggac tagaggacca aatcatgaag atcccaatga gacaatgata
4861 ccccattctc aaagacccat acagctcatg gcactgcttg gtgaagcctc tctccacgga
4921 ccctctttct acagtaaaat cagcaaattg gtcataactg aactcaaaga aggtgggatg
4981 gacttttacg tgccaaggca ggaacccatg ttcaggtgga tgaggttttc tgacttgagc
5041 acgtgggagg gcgatcgcaa tctggctccc aattttgtga atgaagatgg cgtcgagtga
5101 cgccaaccca tctgatgggt ccgcagccaa cctcgtacca gaggtcaaca atgaggttat
5161 ggctttggag cccgttgttg gtgccgctat tgcggcacct gtggcgggtc aacaaaatgt
5221 aattgacccc tggatcagaa ataattttgt acaagcccct ggtggggaat ttacagtgtc
5281 ccctagaaac gctccaggtg aaatactgtg gagcgcgccc ctaggccctg acctaaatcc
5341 ctacctatcc catttggcca gaatgtacaa tggttatgca ggtggttttg aagtgcaggt
5401 aattctcgcg gggaacgcgt tcaccgccgg gaagattata tttgcagcag tcccaccaaa
5461 ttttccaact gaaggcttaa gccctagcca ggtcactatg ttcccccata taatagtaga
5521 tgttagacaa ttagaacctg tgctgattcc cttacccgat gtcaggaata atttctatca
5581 ttataatcag tcaaatgact ccactattaa gttgattgca atgttgtata caccacttag
5641 ggctaataat gctggggatg atgttttcac agtttcgtgc cgagttctca cgagaccatc
5701 ccctgatttt gattttatat ttttagtgcc acccacagtt gaatcaagaa ctaaaccatt
5761 ctctgtccca gttttaactg ttgaggagat gaccaattca agattcccca ttcctttgga
5821 aaagttgttc acgggcccca gcagtgcctt tgttgttcaa ccacaaaacg gcaggtgcac
5881 aactgatggc gtgctcctag gcaccaccca actgtctcct gtcaacatct gcaccttcag
5941 aggggatgtc acccacacca caggtagtca caactacaca atgaacttgg cttctcaaaa
6001 ttggaataac tatgacccaa cagaagaaat cccagcccct ctaggaactc cagattttgt
6061 ggggaagatt caaggcatgc tcacccaaac cacaaggaca gatggttcaa cacgcggcca
6121 caaagctaca gtgtacactg ggagtgccga ttttgctcca aaactgggta gagttcaatt
6181 tgaaactgac acaaaccatg attttgaagt taatcaaaac acaaagttca ccccagtcgg
6241 tgtcatccaa gatggtggca ccacccaccg aaacgaaccc caacagtggg tgctcccaag
6301 ttactcaggc agaaatactc acaatgtaca tctggccccc gctgtagccc ccacctttcc
6361 aggtgagcaa cttctcttct tcagatccac tatgcccgga tgcagcgggt accccaacat
6421 ggatttggac tgtctgctcc cccaggaatg ggtgcagtac ttctatcaag aggcagcccc
6481 agcacaatct gatgtggctc tgctaagatt tgtgaatcca gacactggta gggttttgtt
6541 tgagtgcaag cttcacaaat caggctatgt tacagtggct cacactggcc aacatgattt
6601 ggttattccc cccaatggtt actttaggtt tgattcctgg gtcaaccagt tctacacgct
6661 tgcccccatg ggaaatggaa cggggcgtag acgtgtagta taatggctgg aactttcttt
6721 gctggattgg catctgatgt ccttggctct ggacttggtt cccttatcaa tgctggggct
6781 ggggccatca accaaaaagt tgagtttgaa aataacagaa aattgcaaca agcatccttc
6841 caatttagca gcaatctgca acaggcttcc tttcaacatg ataaagagat gctccaagca
6901 caaattgagg ccaccaaaaa gctacaacag gaaatgatga aagttaaaca ggcaatgctc
6961 ctagagggtg ggttctctga gacagatgca gcccgcgggg caattaacgc tcccatgaca
7021 aaagctttgg actggagcgg gacaaggtac tgggctcccg atgctaggac tacaacatac
7081 aatgcaggcc gcttttccac ccctcaacca tcgggggcac tgccaggaag agctaacctt
7141 agggatgctg tccctgctcg gggaccctcc aacaaatctt ctaactcttc cactgccacc
7201 tctgtgtact caaatcaaac catttcaacg agacttggtt ctacagctgg ttctggaacc
7261 agtttctcga acctcccgtc aactgcaagg actaggagct gggttgagga tcaaagtagg
7321 aatttgtcac ctttcatgag gggggcccac aacatatcat ttgtcacccc accatctagc
7381 agatcctcta gccaaggcac agtctcaacc gtgcctaaag agattttgga ctcctggact
7441 ggcgctttca acacgcgcag gcagcctctc ttcgctcaca ttcctaagcg aggggagtca
7501 cgggtgtaat g
//