Typing tool
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Typing tool
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Complete norovirus genomes
| MK752933 | GII.4 Sydney | |
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| GII.P16 |
ORF1: 1..5010
ORF2: 4991..6613
ORF3: 6613..7414
LOCUS MK752933 7414 bp RNA linear VRL 11-APR-2019
DEFINITION Norovirus GII isolate Hu/US/2018/GII.P16-GII.4 Sydney/Grant0016
nonstructural polyprotein (ORF1) gene, partial cds; VP1 (ORF2)
gene, complete cds; and VP2 (ORF3) gene, partial cds.
ACCESSION MK752933
VERSION MK752933.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7414)
AUTHORS Barclay,L., Cannon,J.L., Wikswo,M.E., Phillips,A., Browne,H.,
Montmayeur,A.M., Tatusov,R.L., Burke,R.M., Hall,A.J. and Vinje,J.
TITLE Emergence and characterization of multiple viruses associated with
a novel GII.P16 polymerase in the United States, 2015-2018
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7414)
AUTHORS Barclay,L., Cannon,J.L., Davis,T., Montmayeur,A.M., Tatusov,R.L.
and Vinje,J.
TITLE Direct Submission
JOURNAL Submitted (04-APR-2019) Division of Viral Diseases, Centers for
Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA
30329, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: Geneious v. R10; SPAdes v. 3.6
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7414
/organism="Norovirus GII"
/mol_type="genomic RNA"
/strain="Grant0016"
/isolate="Hu/US/2018/GII.P16-GII.4 Sydney/Grant0016"
/isolation_source="stool"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="USA"
/collection_date="04-Jan-2018"
/note="genotype: GII.P16-GII.4 Sydney"
gene <1..5010
/gene="ORF1"
CDS <1..5010
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="QBS47630.1"
/translation="NMSSTLKKALGARPKQPAPRDEPQKPPRPPTPELVKRIPPPPPN
GEEEEEPVIRYEVKSGISGLPELTTVPQPDVANTAFSVPPLSLRENREAKEPLTGAIL
EMWDGEIYHYGLYVEKGLVLGVHKPPAAISMARVELTPLSLYWRVVYTPQYLISPETL
RRLNGEAFPYTAFDNNCYAFCCWVLDLNDSWLSRRMVQRTTGFFRPYQEWNRKPLPTM
DDSKIKKVANIFLCSLSTLFTRPIKDLIGKIKPLNILNILATCDWTFAGIVESLILLA
ELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVVMGGIGLVLGFTKEKIGKML
SSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANELAMVRAIEDAVLDLEAIENNH
MTTLLKDKDSLATYMKTLDMEEEKARRLSTKSASPDIVGTINALLARIAAARSLVHRA
KEELSSRIRPVVVMISGKPGIGKTHLAREVARKVASTLTGDQRVGLIPRNGVDHWDAY
KGERVVLWDDYGMSNPIHDALRIQELADTCPLTLNCDRIENKGKVFDSEVIIITTNLA
NPAPLDYVNFEACSRRIDFLVYADAPEVEKAKRDFPGQPDMWKDAFKSDFSHIKLQLA
PQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERMDEFELQGPTITTFNFDRNRI
TAFRQLAAENKYGLVDTMKVGNQLKGVKTMEELKQAIRNVTIKRCRIIYGGSTYDLES
DGKGKVLVEKVKNTSVQTNNELTGALHHLKHARIRYYVKCVQEAVYSIIQIAGAAFVT
TRIARRMNIQELWSKPQLDQNESETKEETPKSEDDEFIISSKDIKEEGKKGKNKTGRG
KKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDRDRYYEELAIAKATEEDFCE
EEEIKIRQRIFRPTRKQRKEERATLGLVTGSEIRKRNPDDFKPKGKLWADDNRSVDYN
EKLDFEAPPSIWSRIVSFGSGWGFWVSPSLFITSTHVIPAGITEAFGVPIKQIQIHKS
GEFCRFRFPKPIRPDVTGMILEEGAPEGTVATVLIKRPTGELMPLAARMGTHATMKIQ
GRMVGGQMGMLLTGSNAKGMDLGTTPGDCGCPYIYKRGNDYIVIGVHTAAARGGNTVI
CATQGSEGEATLEGGDDKGTYCGAPILGPGGAPKLSTKTKFWRSSNTPLPPGTYEPAY
LGGRDPRVKGGPSLQQVMRDQLKPFTEPRGKPPRPSVLEAAKQTIINVLEQTLDPPQK
WSYAQACASLDKTTSSGHPHHVRKNESWNGETFTGKLADQASKANLMFEEGKHMTPVY
TAALKDELVKTEKIYGKIKKRLLWGSDLSTMIRCARSFGGLMDEMKAHCITLPVRVGM
NMNEDGPIIFEKHSRYKYHYDADYSRWDSTQQRAVLAAALEIMVRFSAEPQLAQIVAE
DLLAPSVVDVGDFKITINEGLPSGVPCTSQWNSIAHWLLTLCALSEVTKLSPDIIQAN
SMFSFYGDDEIVSTDIKLDPEQLTAKLKEYGLKPTRPDKTEGPLIISEDLNGLTFLRR
TVTRDPAGWFGKLDQSSILRQMYWTRGPNHEDPNETMIPHSQRPIQLMALLGEASLHG
PSFYSKISKLVITELKEGGMDFYVPRQEPMFRWMRFSDLSTWEGDRNLAPNFVNEDGV
E"
mat_peptide <1..906
/gene="ORF1"
/product="p48"
mat_peptide 907..2004
/gene="ORF1"
/product="NTPase"
mat_peptide 2005..2535
/gene="ORF1"
/product="p22"
mat_peptide 2536..2934
/gene="ORF1"
/product="VPg"
mat_peptide 2935..3477
/gene="ORF1"
/product="Pro"
mat_peptide 3478..5007
/gene="ORF1"
/product="RdRp"
gene 4991..6613
/gene="ORF2"
CDS 4991..6613
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QBS47631.1"
/translation="MKMASSDANPSDGSAANLVPEVNNEVMALEPVVGAAIAAPVAGQ
QNVIDPWIRNNFVQAPGGEFTVSPRNAPGEILWSAPLGPDLNPYLSHLARMYNGYAGG
FEVQVILAGNAFTAGKIIFAAVPPNFPTEGLSPSQVTMFPHIIVDVRQLEPVLIPLPD
VRNNFYHYNQSNDSTIKLIAMLYTPLRANNAGDDVFTVSCRVLTRPSPDFDFIFLVPP
TVESRTKPFSVPVLTVEEMTNSRFPIPLEKLFTGPSSAFVVQPQNGRCTTDGVLLGTT
QLSPVNICTFRGDVTHTTGSHNYTMNLASQNWNNYDPTEEIPAPLGTPDFVGKIQGML
TQTTRTDGSTRGHKATVYTGSADFAPKLGRVQFETDTNHDFEVNQNTKFTPVGVIQDG
GTTHRNEPQQWVLPSYSGRNTHNVHLAPAVAPTFPGEQLLFFRSTMPGCSGYPNMDLD
CLLPQEWVQYFYQEAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYVTVAHTGQHDLV
IPPNGYFRFDSWVNQFYTLAPMGNGTGRRRVV"
gene 6613..>7414
/gene="ORF3"
CDS 6613..>7414
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QBS47632.1"
/translation="MAGTFFAGLASDVLGSGLGSLINAGAGAINQKVEFENNRKLQQA
SFQFSSNLQQASFQHDKEMLQAQIEATKKLQQEMMKVKQAMLLEGGFSETDAARGAIN
APMTKALDWSGTRYWAPDARTTTYNAGRFSTPQPSGALPGRANLRDAVPARGPSNKSS
NSSTATSVYSNQTISTRLGSTAGSGTSFSNLPSTARTRSWVEDQSRNLSPFMRGAHNI
SFVTPPSSRSSSQGTVSTVPKEILDSWTGAFNTRRQPLFAHIPKRGESR"
ORIGIN
1 aatatgtctt ccaccttaaa gaaagccctc ggggctaggc ccaaacagcc tgccccgaga
61 gacgaaccac aaaagccccc aagaccacca actcccgagt tggtcaagag gataccccct
121 cctccaccta atggcgaaga agaagaagaa ccagtcatta ggtatgaggt taagagtgga
181 atctctggcc tgcccgagct cacaacagtc ccccaaccgg acgtggccaa cacagcattc
241 agtgttccac cactgagctt gagagaaaac agggaggcca aggaaccgct aacgggggca
301 atattagaga tgtgggatgg agagatatac cactacggcc tgtacgtgga gaaaggctta
361 gtgttgggtg tgcacaaacc acctgcagcc ataagcatgg caagagtgga gctgacaccg
421 ctgtcattgt actggcgtgt ggtgtacact ccccaatacc tcatctcccc tgaaactctc
481 aggaggctca acggagaggc attcccttac accgccttcg acaacaactg ctatgccttt
541 tgctgctggg tgttggacct caatgactca tggcttagta ggaggatggt gcaaagaaca
601 acgggcttct tcagacctta ccaagagtgg aacagaaaac ccctgcctac catggatgac
661 tccaaaatta agaaggtagc aaatatattc ctatgttcat tgtccacatt attcaccaga
721 cccataaaag acctcatagg aaaaattaaa ccattaaaca tattgaacat cctggcaacg
781 tgtgactgga cgtttgccgg aatagtggag tctctgatat tacttgctga actcttcgga
841 gttttctgga cacccccaga tgtgtctgct atgatcgctc ccttactcgg ggactacgag
901 ttgcaagggc cagaagacct cgccgttgaa ctcgtacctg tggtaatggg agggattggt
961 ttggtgttgg gattcaccaa agagaaaatt ggcaaaatgt tgtcctcagc agcatcaaca
1021 ctcagggctt gcaaagatct tggtgcctat ggcttagaga tactcaaatt ggtcatgaag
1081 tggttcttcc caaagaaaga ggaggctaat gagctagcca tggtgagggc catagaggat
1141 gccgtactag atcttgaggc aatagaaaat aaccacatga caaccctgtt gaaagacaaa
1201 gacagcttag caacatacat gaaaacactg gacatggagg aggagaaagc cagaaggtta
1261 tccacaaaat ctgcatcccc cgacatagtt gggacaatca acgctctgct ggctcgaata
1321 gcagcggcca ggtcattagt ccacagggcc aaggaagagc tatctagcag gataagacca
1381 gtagttgtta tgatatctgg taaaccagga ataggcaaaa ctcatctggc cagggaggtg
1441 gcaagaaagg tggcatccac tctcacaggt gatcaaagag tcggactcat accgagaaac
1501 ggtgtggacc attgggatgc atacaaaggt gagagagtcg tgctgtggga cgactatggc
1561 atgagtaacc ccatccatga cgctcttcgc atacaagaat tggctgacac gtgtcccctt
1621 accttaaatt gtgacagaat tgaaaataag ggaaaagttt ttgacagtga agtcataata
1681 atcacaacaa accttgccaa cccagcccca cttgattatg tcaactttga ggcctgttcc
1741 aggagaattg atttcctggt gtacgctgat gcaccagaag tggaaaaggc aaaacgggac
1801 tttcctggtc agccagatat gtggaaggac gccttcaagt cggacttttc acacatcaag
1861 ctgcagcttg cacctcaggg cggctttgac aagaatggca acaccccaca tgggaaagga
1921 gtgatgaaga ccctcactac cggttctctg attgcccgtg catcaggcct actgcatgag
1981 aggatggatg aatttgaact ccaaggtccc acaatcacca ccttcaattt cgaccggaat
2041 agaatcacag cattcagaca attggctgca gaaaacaagt atggattggt ggataccatg
2101 aaagttggca atcaactaaa aggagtgaaa accatggaag aactcaaaca agcaatcagg
2161 aatgtgacca tcaagaggtg ccggatcatc tacggtggct ccacgtatga ccttgaatct
2221 gatggcaagg gcaaggtttt ggtggaaaag gtcaagaaca cctctgtgca gaccaacaac
2281 gagttgactg gggccctgca ccatctcaaa cacgcacgaa tcaggtacta tgtcaaatgt
2341 gtgcaagaag cagtctattc catcatacaa attgccggcg ctgcgtttgt caccacgcgc
2401 attgcacgcc gcatgaacat acaagaactc tggtcgaagc cacaattaga ccaaaacgaa
2461 tcagagacta aggaagagac ccctaagtca gaagatgacg agttcatcat atcttctaag
2521 gacatcaagg aggaaggaaa gaagggcaaa aacaaaactg gccgtggcaa gaagcatact
2581 gcattctcca gcaagggctt gagcgatgag gagtatgacg agtacaagag gataagagaa
2641 gagagaaatg ggaagtactc tatagaggag tatcttcaag acagagacag gtactatgag
2701 gagctcgcca ttgccaaggc cacggaagaa gacttctgtg aagaggagga gatcaaaatc
2761 cgtcagagaa ttttccgtcc caccaggaaa caaaggaagg aagagagggc cacattaggg
2821 ctagtgacag gttcagaaat cagaaaaaga aaccctgatg acttcaaacc caaagggaag
2881 ctgtgggccg atgacaacag aagtgttgat tacaatgaga aactggactt tgaggccccc
2941 ccaagcatat ggtctaggat tgtgagcttt ggttctggct ggggcttctg ggtgtcacca
3001 agcctgttca taacatcaac tcatgtaatt cccgctggca taacagaagc atttggagtc
3061 cccatcaaac aaattcagat ccacaaatca ggtgaatttt gccgattcag attcccaaaa
3121 ccaattagac cagatgtgac aggaatgatc ttggaagaag gtgcgcctga aggcaccgtg
3181 gcaactgtgc tcatcaaacg ccccaccgga gagctcatgc ctcttgcagc cagaatggga
3241 acacacgcaa ccatgaaaat tcaaggccgc atggttggcg gacagatggg tatgttgctc
3301 actggatcaa atgctaaagg aatggatttg ggaacaactc ctggtgactg tggctgtcct
3361 tacatctata aaaggggcaa tgactatata gtcattgggg tgcacactgc agcagcccgt
3421 ggtggaaaca ccgttatctg tgccacacag ggaagtgagg gtgaggcaac tcttgagggt
3481 ggagatgaca agggaacata ctgtggggca cccattctag gccctggggg tgcaccaaag
3541 ttgagcacca aaaccaaatt ttggaggtca tcgaacacgc cccttccacc agggacatat
3601 gagcctgcct acctcggtgg ccgtgacccg cgtgttaagg gtgggccctc cttgcagcag
3661 gtaatgagag accagttgaa accattcact gaacccaggg gcaaacctcc aagaccaagt
3721 gtattggaag cagccaaaca aaccattatt aatgtcctcg aacaaaccct ggaccctcca
3781 caaaaatggt catacgcaca ggcgtgtgcc tcacttgaca aaaccacctc cagcgggcac
3841 ccccatcacg tccgaaagaa tgaatcctgg aatggtgaga ccttcactgg taaattggca
3901 gaccaagcat caaaagcaaa cctaatgttt gaggaaggga aacatatgac accagtgtat
3961 acagcagcac tcaaggacga gctggtcaag actgagaaaa tctatggaaa aatcaagaag
4021 agactgctct ggggctctga cttgtccacc atgatccggt gcgctaggtc atttggtggg
4081 ctcatggacg agatgaaggc acactgcata acactcccag tacgagttgg catgaatatg
4141 aatgaagatg gcccaataat atttgagaaa cattccagat acaaatatca ctatgatgca
4201 gactactctc gttgggattc aacacaacag agggcagtac tagcagcagc cctggaaatc
4261 atggtcagat tctctgcaga accacaattg gcacaaatag tcgctgagga cctgctggcc
4321 cctagtgtag tagatgtggg agactttaaa atcacaataa atgaagggct cccatctggt
4381 gtgccatgca cttcccaatg gaactctatc gcacactggc tgctaactct ctgtgcctta
4441 tctgaagtca ccaaactgtc ccctgacatt atacaagcaa attccatgtt ctcattttac
4501 ggtgatgacg agattgtcag caccgacata aaattggacc ctgaacagtt aaccgccaaa
4561 ttgaaggagt acggcctgaa accaactcgc ccagacaaga ctgagggacc cctgatcatc
4621 agtgaagatt tgaacggact cactttcctc cgaaggacgg tgactcgtga cccagctggc
4681 tggtttggaa aactggacca aagctcaatt ttgaggcaga tgtactggac tagaggacca
4741 aatcatgaag atcccaatga gacaatgata ccccattctc aaagacccat acagctcatg
4801 gcactgcttg gtgaagcctc tctccacgga ccctctttct acagtaaaat cagcaaattg
4861 gtcataactg aactcaaaga aggtgggatg gacttttacg tgccaaggca ggaacccatg
4921 ttcaggtgga tgaggttttc tgacttgagc acgtgggagg gcgatcgcaa tctggctccc
4981 aattttgtga atgaagatgg cgtcgagtga cgccaaccca tctgatgggt ccgcagccaa
5041 cctcgtacca gaggtcaaca atgaggttat ggctttggag cccgttgttg gtgccgctat
5101 tgcggcacct gtggcgggtc aacaaaatgt aattgacccc tggatcagaa ataattttgt
5161 acaagcccct ggtggggaat ttacagtgtc ccctagaaac gctccaggtg aaatactgtg
5221 gagcgcgccc ctaggccctg acctaaatcc ctacctatcc catttggcca gaatgtacaa
5281 tggttatgca ggtggttttg aagtgcaggt aattctcgcg gggaacgcgt tcaccgccgg
5341 gaagattata tttgcagcag tcccaccaaa ttttccaact gaaggcttaa gccctagcca
5401 ggtcactatg ttcccccata taatagtaga tgttagacaa ttagaacctg tgctgattcc
5461 cttacccgat gtcaggaata atttctatca ttataatcag tcaaatgact ccactattaa
5521 gttgattgca atgttgtata caccacttag ggctaataat gctggggatg atgttttcac
5581 agtttcgtgc cgagttctca cgagaccatc ccctgatttt gattttatat ttttagtgcc
5641 acccacagtt gaatcaagaa ctaaaccatt ctctgtccca gttttaactg ttgaggagat
5701 gaccaattca agattcccca ttcctttgga aaagttgttc acgggcccca gcagtgcctt
5761 tgttgttcaa ccacaaaacg gcaggtgcac aactgatggc gtgctcctag gcaccaccca
5821 actgtctcct gtcaacatct gcaccttcag aggggatgtc acccacacca caggtagtca
5881 caactacaca atgaacttgg cttctcaaaa ttggaataac tatgacccaa cagaagaaat
5941 cccagcccct ctaggaactc cagattttgt ggggaagatt caaggcatgc tcacccaaac
6001 cacaaggaca gatggttcaa cacgcggcca caaagctaca gtgtacactg ggagtgccga
6061 ttttgctcca aaactgggta gagttcaatt tgaaactgac acaaaccatg attttgaagt
6121 taatcaaaac acaaagttca ccccagtcgg tgtcatccaa gatggtggca ccacccaccg
6181 aaacgaaccc caacagtggg tgctcccaag ttactcaggc agaaatactc acaatgtaca
6241 tctggccccc gctgtagccc ccacctttcc aggtgagcaa cttctcttct tcagatccac
6301 tatgcccgga tgcagcgggt accccaacat ggatttggac tgtctgctcc cccaggaatg
6361 ggtgcagtac ttctatcaag aggcagcccc agcacaatct gatgtggctc tgctaagatt
6421 tgtgaatcca gacactggta gggttttgtt tgagtgcaag cttcacaaat caggctatgt
6481 tacagtggct cacactggcc aacatgattt ggttattccc cccaatggtt actttaggtt
6541 tgattcctgg gtcaaccagt tctacacgct tgcccccatg ggaaatggaa cggggcgtag
6601 acgtgtagta taatggctgg aactttcttt gctggattgg catctgatgt ccttggctct
6661 ggacttggtt cccttatcaa tgctggggct ggggccatca accaaaaagt tgagtttgaa
6721 aataacagaa aattgcaaca agcatccttc caatttagca gcaatctgca acaggcttcc
6781 tttcaacatg ataaagagat gctccaagca caaattgagg ccaccaaaaa gctacaacag
6841 gaaatgatga aagttaaaca ggcaatgctc ctagagggtg ggttctctga gacagatgca
6901 gcccgcgggg caattaacgc tcccatgaca aaagctttgg actggagcgg gacaaggtac
6961 tgggctcccg atgctaggac tacaacatac aatgcaggcc gcttttccac ccctcaacca
7021 tcgggggcac tgccaggaag agctaacctt agggatgctg tccctgctcg gggaccctcc
7081 aacaaatctt ctaactcttc cactgccacc tctgtgtact caaatcaaac catttcaacg
7141 agacttggtt ctacagctgg ttctggaacc agtttctcga acctcccgtc aactgcaagg
7201 actaggagct gggttgagga tcaaagtagg aatttgtcac ctttcatgag gggggcccac
7261 aacatatcat ttgtcacccc accatctagc agatcctcta gccaaggcac agtctcaacc
7321 gtgcctaaag agattttgga ctcctggact ggcgctttca acacgcgcag gcagcctctc
7381 ttcgctcaca ttcctaagcg aggggagtca cggg
//