Typing tool
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Typing tool
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Complete norovirus genomes
| MK733207 | GII.27 | |
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| GII.P22 |
ORF1: 1..5060
ORF2: 5041..6672
ORF3: 6672..7436
LOCUS MK733207 7444 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GII isolate PNV027026 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MK733207
VERSION MK733207.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7444)
AUTHORS Tohma,K., Lepore,C.J., Degiuseppe,J.I., Stupka,J.A., Saito,M.,
Mayta,H., Zimic,M., Ford-Siltz,L.A., Gilman,R.H. and Parra,G.I.
TITLE Recombinant Nontypeable Genotype II Human Noroviruses in the
Americas
JOURNAL Emerging Infect. Dis. 26 (1), 157-159 (2020)
PUBMED 31855537
REFERENCE 2 (bases 1 to 7444)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 7444)
AUTHORS Tohma,K., Lepore,C.J., Degiuseppe,J.I., Stupka,J.A., Saito,M.,
Mayta,H., Zimic,M., Ford-Siltz,L.A., Gilman,R.H. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (01-APR-2019) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2.3.1
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7444
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="PNV027026"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Peru"
/collection_date="11-Jun-2010"
/note="genotype: GII"
gene <1..5060
/gene="ORF1"
CDS <1..5060
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QBR98810.1"
/translation="TAGKTSSNSEIHNNDATPASNIFANMTVGLKKALGARPKQPTPR
APSPPKEKKRTLPPIPPPPPNGEDIVIKYTKQGDLVEGVPTVSTVEIPPTLDTAYSVP
PLDQREKLDAKEPLTGSIIEMWDGEIYHYGIYVERGLILGVHKPPAAISFARIELTPL
SLYWRTVYTPPYLVDPQNLKKLHGESFPYTAFDNNCYSFCCWVLDLNDSWLNRKHVSR
TTGFYRPYQEWNRKPMPTVDEGKLKKVANVFLCAISGLFTRPIKDIIGKLKPLNILNI
VSNCDWTFPGVVESLILLAELFGIFWTPPDISAFVASLLGDYEMQGPEDIATEIVPVI
LGGIGMVLGFTREKIGRILSSAASSLRACREIGNYGIEVVKLVMKWFFPSKNEASEMD
MVRAIEDAVLDFEAIENNHMTSLLKDKNSLATFLRALDMEEEKARKLSTKSASPDIVG
TINALLARIAAARSLVHRAKEEMSSRMRPVVIMISGRPGIGKTHLARDLAKKMAATLA
GDQRVGLVPRNGVDHWDAYKGERIVLWDDYGMSNPISDALRLQELADTCPLTLNCDRI
ENKGKVFDSDTIIITTNLANPAPLDYVNFEACSRRIDFLVYADSPAVDKAKRDFPGQP
DMWKDAFKQDFSHIKLQLAPQGGFDKNGNTPHGKGVMKSLTTHSLIARATGLLHERLD
EFDLQGPELPVYNFDQNKVASFRRLAADNKYGLMETIKAGNKLKEVKTLEQFKEAVKN
IRINPCRIIYNSIAYDLDSNGAGKVNVKKVGDTKIQTSNELSSALTNLRGARIRYYVK
CFQEMIYSLLQIAGAAFVTTRMAKRININNIWSKPEEKPIVSPEPPAPPEEHWTIAPS
DAIQEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERQGKYSIEEYLQDRDRY
YEELAIAKATEEDFCEEEEVKIRQRIFRPTRKQRKEERATLGLVTGSEIRKRNPDDFR
PRGKLWADDDRSVNYNEKIDFEAPPSLWSRIVNFGSGWGFWVSSNLFITSTHVIPPNI
SEAFGVPINQIQVHRCGEFCKMRFPKAIRPDVSGMILEEGAPEGTVVTILIKRTTGEL
MPLAARMGTHATMKIQGRMIGGQMGMLLTGSNAKNMDLGTVPGDCGCPYVYKRGNDWV
VIGVHTAAARGGNTVICATQGPDGEATLEGGDNHGTYCGAPILGPGSAPKLSTKTKFW
RSSNAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMREQLKPFTAPRGKPPKPAVLEAAK
ETICGVLEQTIDPPQQWSYAQACSSLDKTTSSGHPHHKKKNDNWNGESFTGVLADQAS
RANLMYEQGKHMQPVYTAALKDELVKTSKIYDKVKKRLLWGSDLGTMIRCARSFGGLM
DEMKANCVNLPIRVGMNMNEDGPIIFEKHSKYKYHYDADYSRWDSTQQRHVLGVALEI
MVRFSAEPELAQIVAEDLLSPSVVDVGDFKITINEGLPSGVPCTSQWNSITHWLLTLC
AMSEVSGLSPDVVQANSCFSFYGDDEIVSTDIKLDAFKLTEKLKEYGLIPTRPDKTEG
PLVIKEKLEGLTFLRRDVCRDPAGWYGKLDQSSIIRQLYWTKGPNHEDPNETMIPHSQ
RPIQLMSLLGEAALHGPPFYKKVSKLVITELKEGGMDFYVPRQEPMFRWMRFSDLSTW
EGDRNLAPEGVNEDGVE"
mat_peptide <1..965
/gene="ORF1"
/product="p48"
mat_peptide 966..2063
/gene="ORF1"
/product="NTPase"
mat_peptide 2064..2588
/gene="ORF1"
/product="p22"
mat_peptide 2589..2984
/gene="ORF1"
/product="VPg"
mat_peptide 2985..3527
/gene="ORF1"
/product="Pro"
mat_peptide 3528..5057
/gene="ORF1"
/product="RdRp"
gene 5041..6672
/gene="ORF2"
CDS 5041..6672
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QBR98808.1"
/translation="MKMASNDAAPSNDGAAGLVPEINNETMALEPVAGGAIAAPLTGQ
TNFIDPWIRNNYVQAPNGEFTVSPRNSPGEILLNLELGPELNPFLAHLSRMYNGFAGG
IEVQVVMAGNAFTAGKIIFAAVPPHFPVDNISPSQITMFPHIIIDVRTLEPVNIPLPD
VRNSFFHYSQNNEPRMRLLAMLYTPLRSNGSADDVFTVSCRVLTKPSPDFEFNYLVPP
TVESRTKPFTIPILTIGEMTNSRFPVAIDMLHTSPTENIVVQPQNGRCTLDGELLGTT
QLVTSNICAFRGSIHDHQTNGDEHQWHFNITNPNGTPFDPTEDVPAPLGTPDFKGQLY
GVISQRDREGTLGENNQKANRSHEGVISTIAPRFTPKLGSVMIGTWTTTDIRNQPSRF
TPVGLNDDDNYRQWELPNYSGALTLNMGLAPSVFPTYPGEQILFFRSYMPMKGGYGSP
YIDCLIPQEWISHFYQESAPSQTDVALIRYVNPDTGRVLFEAKLHRQGFITVAKTGDS
PINVPANGYFRFDSWVNQFYSLAPMGTGNGRRRVQ"
gene 6672..7436
/gene="ORF3"
CDS 6672..7436
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QBR98809.1"
/translation="MAGAFIAGLAGDMLTNTVGSLVNAGANAINQKFDFENNKYLQNA
SFAHDKEMLKAQIEATKQLQADMIAIKQGVLTAGGFSPTDAARGAINAPMTKVLDWNG
TRYWAPNATSTTSMSGGFTGQVVHRTTPNFKTNQAPKSIPSSGSSVRSNSTQLTSLSS
HSSGSSRSSGSTAVSSLPSSNRTREWVNQQNLNLEPHMPGSLKTAFVTPPSSTASSSG
TVSTVPKGVLDSWTSAFNTRRQPLFAYLHRRGESKV"
ORIGIN
1 cgaccgctgg caaaaccagc tcaaacagtg aaattcacaa caatgacgcc acaccagcgt
61 caaacatctt cgccaacatg actgttggct tgaagaaagc cctgggggca cggcctaaac
121 agcctacccc cagggcccct tctcctccta aggagaagaa gagaaccctc cctccaatac
181 cacccccacc acccaatggt gaggatattg tcatcaagta caccaaacag ggtgaccttg
241 tggagggggt ccccacggtt tccaccgtgg agatcccccc tacactggac accgcatata
301 gtgtcccccc cttagaccag agggagaaac ttgatgccaa agaaccgcta acaggctcaa
361 taattgaaat gtgggatgga gagatatacc attatgggat ttatgtggag cgaggtttga
421 ttctcggcgt gcacaagccg cctgcagcaa ttagcttcgc ccgcattgag ttgacccccc
481 tctctcttta ttggagaact gtctacacac caccctacct agtggaccca caaaacctga
541 agaaactcca tggtgagtcc ttcccttaca ccgcatttga caacaactgc tactccttct
601 gctgttgggt tttggacttg aatgattctt ggctcaacag aaaacatgtg tcaaggacta
661 cgggatttta cagaccctac caggagtgga atagaaaacc aatgcccacc gtggatgaag
721 gaaaacttaa gaaagtggcc aatgtgttct tgtgtgccat ctccggcctt ttcaccaggc
781 caatcaagga catcataggg aaactgaaac cattgaacat ccttaacata gtgtcaaact
841 gtgattggac attccctggt gtcgtggaat ccctcatatt gcttgctgaa ttatttggga
901 tcttctggac accgccagac atctccgctt tcgtggcatc cctcctgggt gattacgaaa
961 tgcaggggcc tgaggatata gccactgaga tcgtaccagt catcctcggt ggcattggaa
1021 tggtcctcgg cttcacaagg gaaaagatag ggcgtatact gagttctgcc gcctcatcac
1081 tcagagcatg cagggagatt ggcaactacg gtatagaggt ggtgaagctc gtgatgaagt
1141 ggttcttccc ttccaagaac gaggcgagcg agatggacat ggtcagagca atagaggatg
1201 cagtgcttga tttcgaagcc attgagaaca accacatgac atctctgcta aaagacaaga
1261 acagcctcgc gaccttcctc agggcactgg acatggaaga agagaaagca cggaaactgt
1321 ctaccaaatc tgcctctccg gacattgttg gaaccataaa tgcactccta gccagaattg
1381 cagctgccag atccctcgtc caccgcgcca aagaagagat gtcatccagg atgcgtcctg
1441 ttgtcatcat gatctctggg cggccaggga tagggaaaac acaccttgca cgcgacctgg
1501 ctaagaagat ggcagcaacc ctcgctggtg accaaagggt tggccttgtc ccgagaaacg
1561 gtgttgacca ctgggatgca tacaagggag agaggatagt tctgtgggat gactacggca
1621 tgagcaaccc aatatcagat gcactaagac tccaagaact tgctgacacc tgtcctctaa
1681 cactcaactg tgacagaata gagaacaagg ggaaagtatt tgacagtgac accataatca
1741 tcaccaccaa tctggccaac cctgcccctc ttgactatgt caatttcgag gcatgctctc
1801 gccgcattga ctttctcgtc tatgcggact cccccgctgt tgacaaggca aagagagact
1861 tcccggggca acctgacatg tggaaggatg cattcaagca ggacttctca cacataaaac
1921 tacaattggc accacaagga ggctttgaca agaatggcaa caccccacat ggcaagggcg
1981 tgatgaaatc cctaaccaca cattctctca ttgcccgcgc cacggggctc ctacatgaga
2041 ggctggatga atttgatcta caggggcctg aactcccagt ctataacttt gaccagaaca
2101 aagtggcgtc gttcaggcga ctcgccgccg acaacaagta tggtcttatg gaaaccatca
2161 aagctggtaa taaactaaaa gaggtcaaga cactggaaca gttcaaggag gctgtgaaaa
2221 acatacggat aaacccctgc agaataatct acaactccat agcttatgac ttggactcga
2281 atggagcagg caaagtcaat gtcaagaagg tgggcgacac caagatccag acgagcaatg
2341 agctcagctc cgcactcacc aacttacgcg gcgctagaat tagatactat gtgaaatgct
2401 tccaagaaat gatctattcg ctcctgcaga tcgctggcgc agcgtttgtg acgacgcgga
2461 tggccaaaag aataaacatc aacaatatct ggtccaagcc tgaggaaaag ccgattgtca
2521 gcccagaacc cccagcgcct ccagaagaac actggaccat cgccccaagc gacgcgattc
2581 aggagggcaa gaagggcaag aacaagagtg gcagaggcaa gaaacacact gctttctcca
2641 gtaagggtct cagtgatgag gagtatgatg aatacaagag aatcagggag gagagacaag
2701 gaaaatactc tattgaagaa tacctccaag acagagaccg atactatgag gaattggcaa
2761 tagcaaaagc aactgaagag gatttctgtg aggaggagga ggtcaaaatt aggcagagga
2821 tctttcgtcc taccagaaaa cagcgcaagg aggaaagggc caccctaggg ttagtgacag
2881 gcagtgaaat taggaagagg aacccagatg acttcagacc gagagggaag ttgtgggctg
2941 atgatgatcg tagtgtcaac tataatgaga agatagactt cgaggcccct cctagcctgt
3001 ggtcaagaat agtcaacttt ggatcaggct ggggtttctg ggtgtcatct aacctgttca
3061 taacctccac acacgtgatc cccccaaaca tatcagaagc atttggtgtc ccaattaatc
3121 agatacaggt tcacaggtgt ggcgagttct gcaagatgag gtttcccaag gccatcaggc
3181 ctgatgtctc tggcatgatt ctggaggaag gggcccccga agggacagtg gtgaccatac
3241 ttataaagag gacaactgga gagctcatgc cattggcagc tcgcatgggc acacacgcca
3301 ccatgaagat ccaagggaga atgattggag gtcaaatggg tatgctcctc acaggttcca
3361 atgctaagaa catggacctt ggcaccgtcc cgggtgattg tggatgcccg tatgtctaca
3421 agagaggaaa tgattgggtt gtgatcggag tccacactgc cgccgccaga ggaggcaaca
3481 cagtgatctg tgccacccag ggtccagatg gggaggctac actggaaggg ggtgataacc
3541 atggcaccta ctgtggggcg ccaatactgg gacccggtag cgctccaaaa ctcagcacca
3601 agacaaaatt ctggcggtcc tccaatgcac cactcccccc tggcacgtac gagcctgcct
3661 accttggtgg taaagatccc agggtcaaag ggggcccatc cctgcaacaa gtcatgagag
3721 aacagctgaa acccttcacc gccccacgcg gcaagccacc caagcccgca gtcctggagg
3781 cggccaagga gactatatgt ggtgtgcttg aacagaccat tgacccaccc caacagtggt
3841 cctacgcgca ggcctgctcc tcactagaca aaacaacatc aagtggccac ccccatcaca
3901 agaagaagaa tgacaattgg aatggagaat cattcactgg cgtgctagcc gatcaggctt
3961 ccagagcaaa cctcatgtat gagcagggga aacacatgca gcccgtgtac acagcagcac
4021 ttaaggatga gttggtgaag accagcaaga tatatgacaa agtcaaaaag aggctcttgt
4081 ggggatcaga cctgggaacc atgattcggt gtgcaagatc ttttggtggg cttatggatg
4141 aaatgaaggc aaactgtgta aatctaccaa taagagtggg tatgaacatg aatgaggatg
4201 gccccataat ctttgagaag cactccaagt acaaatatca ttatgatgct gactactcca
4261 ggtgggactc aacacaacaa aggcatgtcc ttggggttgc tcttgagatc atggtcagat
4321 tttcagcaga acctgagttg gcacagatag tggctgagga tctcctgtcg cccagtgtcg
4381 tagacgtggg tgacttcaaa atcacaataa acgagggcct cccatctgga gtcccatgca
4441 catcacagtg gaactcaata acccattggc tgctgactct gtgcgcaatg tcagaagttt
4501 ctggattgtc accagacgtt gtgcaagcaa actcatgctt ctcattctat ggggatgatg
4561 agatagtcag cacagacatt aaattggatg ccttcaaatt aacagaaaag ctcaaagagt
4621 atgggctgat cccaaccagg ccagacaaga cagaaggacc actagtgata aaagagaaac
4681 tagaggggtt gactttcctg aggagggatg tgtgtaggga cccagctgga tggtatggca
4741 agcttgatca gtcatcaatc ataaggcaac tgtattggac caaaggaccc aaccatgaag
4801 atcccaatga aacgatgatc ccacactctc aaagacccat ccaactgatg tcacttcttg
4861 gtgaggcggc tctccacgga ccgccctttt acaagaaggt gagcaagttg gttatcacag
4921 agctaaaaga gggtggaatg gacttttatg tgcccaggca ggaacccatg tttaggtgga
4981 tgagattctc tgacctaagc acgtgggagg gcgatcgcaa tctggctccc gaaggtgtga
5041 atgaagatgg cgtcgaatga cgccgctcca tctaatgatg gtgcagccgg tctcgtacca
5101 gagatcaaca acgagacaat ggctttggag ccagtagcag gaggggcaat tgctgctccc
5161 ctgactgggc aaacaaattt cattgatccc tggattagaa acaactatgt acaagcacct
5221 aatggtgagt tcacagtatc ccctagaaac tcccctggtg aaattttact caatttggaa
5281 ttaggccctg agctcaaccc tttcttggcc cacctgtcta ggatgtacaa cgggtttgct
5341 ggtggcattg aggttcaagt cgtcatggcg ggcaacgcct tcactgccgg aaagatcatc
5401 ttcgcggcag tgccacccca cttccccgtt gacaacatta gtccttctca aattactatg
5461 ttcccacaca ttataataga tgtaagaacc cttgaacctg taaatatccc attacccgat
5521 gtcaggaata gtttcttcca ttacagccaa aataatgaac cccgtatgag attattagct
5581 atgttgtata cccctcttag atcaaatggt tctgctgatg atgtcttcac agtttcttgt
5641 agggtcctta ccaagccttc ccctgatttt gagttcaatt atttggtccc cccaactgtt
5701 gagtctagga caaaaccctt cacaatacca atacttacga ttggagaaat gacaaactca
5761 aggttccccg tggccattga catgctacac accagcccta ctgagaacat tgttgtccaa
5821 ccgcaaaatg gcagatgcac tctggacggt gagttgctgg gcactacaca gctggtcact
5881 tccaacatct gtgcattcag ggggtccatc catgatcacc agaccaatgg agacgaacat
5941 cagtggcact tcaacatcac caaccccaat ggcactccgt ttgaccccac tgaggacgtg
6001 cccgctccac ttgggacccc ggacttcaag ggacaactct acggagtcat ctctcaaaga
6061 gaccgggagg gaacccttgg tgaaaacaac cagaaggcta acaggtccca tgaaggggtg
6121 atctcaacaa ttgcaccaag gttcacacca aagttagggt cagtcatgat cggcacttgg
6181 actaccactg atataagaaa tcaaccctcc agattcaccc cagttggttt gaatgatgat
6241 gacaattata gacagtggga attaccaaat tattctggag cgctcaccct taatatggga
6301 ttggcaccct ctgtcttccc cacctatcct ggggaacaaa ttcttttctt ccgctcctac
6361 atgccaatga agggaggata tggcagtccg tacatcgatt gccttatacc tcaagaatgg
6421 atttctcatt tctatcagga atcagcaccc tcccaaactg atgtggcttt gattaggtat
6481 gtgaaccccg acacaggacg agtcctgttc gaggccaaat tacacagaca aggattcatt
6541 accgttgcca agactggtga cagccccatc aatgtgcctg ctaatggtta ctttagattt
6601 gattcctggg ttaatcaatt ctactctctc gcccccatgg gaactgggaa tgggcgcaga
6661 agagttcagt aatggctgga gcttttatag caggattggc tggtgacatg ctcacaaaca
6721 ctgtagggtc tctagtaaat gcaggggcta atgcaattaa tcagaaattt gattttgaaa
6781 ataataaata tttacaaaat gcatcatttg ctcatgataa ggagatgttg aaggcacaaa
6841 ttgaggcaac aaaacaactg caggctgaca tgattgcaat caagcaaggg gttctgaccg
6901 ctggcggctt ttcccctact gatgctgcac gtggggccat aaatgccccc atgacaaaag
6961 ttttggattg gaatggaaca aggtactggg caccaaatgc cacctccaca acctcaatgt
7021 cgggtggctt cacaggacaa gttgtgcaca gaaccacgcc aaattttaaa acaaaccagg
7081 cccccaaatc aatacccagt agtgggtctt cagtcaggtc aaactcgacc cagcttacta
7141 gtctgagctc acactcctct ggatcatccc gttccagtgg atccacagct gtcagctctc
7201 taccatcctc caataggact agggaatggg tcaatcagca aaatctcaat ttggaaccac
7261 acatgcctgg atctctcaaa acagcttttg tcacaccacc atctagcaca gcctctagtt
7321 cgggcacagt ctcaaccgtg cccaaaggtg ttttggactc ctggacatct gcgtttaaca
7381 cacgcagaca gccgctcttc gcataccttc atagaagggg ggagtcaaaa gtttagtgaa
7441 aaga
//