Typing tool
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Typing tool
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Complete norovirus genomes
| MK733206 | GII.27 | |
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| GII.P22 |
ORF1: 1..5060
ORF2: 5041..6672
ORF3: 6672..7436
LOCUS MK733206 7444 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GII isolate PNV024019 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MK733206
VERSION MK733206.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7444)
AUTHORS Tohma,K., Lepore,C.J., Degiuseppe,J.I., Stupka,J.A., Saito,M.,
Mayta,H., Zimic,M., Ford-Siltz,L.A., Gilman,R.H. and Parra,G.I.
TITLE Recombinant Nontypeable Genotype II Human Noroviruses in the
Americas
JOURNAL Emerging Infect. Dis. 26 (1), 157-159 (2020)
PUBMED 31855537
REFERENCE 2 (bases 1 to 7444)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 7444)
AUTHORS Tohma,K., Lepore,C.J., Degiuseppe,J.I., Stupka,J.A., Saito,M.,
Mayta,H., Zimic,M., Ford-Siltz,L.A., Gilman,R.H. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (01-APR-2019) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2.3.1
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7444
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="PNV024019"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Peru"
/collection_date="12-Feb-2010"
/note="genotype: GII"
gene <1..5060
/gene="ORF1"
CDS <1..5060
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QBR98805.1"
/translation="TAGKTSSNSEIHNDDATPASNIFANMTVGLKKALGARPKQPTPR
APSPPKEKKRTLPPIPPPPPNGEDIVIKYTKQGDLVEGVPAVSTVEIPPTLDTAYSVP
PLDQREKLDAKEPLTGSIIEMWDGEIYHYGLYVERGLILGVHKPPAAISFARIELTPL
SLYWRAVYTPPYLVDPQNLKKLHGESFPYTAFDNNCYSFCCWVLDLNDSWFNRKHVSR
TTGFYRPYQEWNRKPMPTMDEGKLKKVANVFLCAISGLFTRPIKDIIGKLKPLNILNI
VSNCDWTFPGVVESLILLAELFGVFWTPPDISAFVASLLGDYEMQGPEDIATEIVPVI
LGGIGMVLGFTREKIGRILSSAASSLRACREIGNYGIEVVKLVMKWFFPSKNEASEMD
MVRAIEDAVLDFEAIENNHMTSLLKDKNSLATFLRALDMEEEKARKLSTKSASPDIVG
TINALLARIAAARSLVHRAKEEMSSRMRPVVIMISGRPGIGKTHLARDLAKKMAATLA
GDQRVGLVPRNGVDHWDAYKGERIVLWDDYGMSNPISDALRLQELADTCPLTLNCDRI
ENKGKVFDSDTIIITTNLANPAPLDYVNFEACSRRIDFLVYADSPAVDKAKRDFPGQP
DMWKDAFKQDFSHIKLQLAPQGGFDKNGNTPHGKGVMKSLTTHSLIARATGLLHERLD
EFDLQGPELPVYNFDQNKVASFRRLAADNKYGLMETIKAGNKLKEVKTLEQFKEAVKN
IRINPCRIIYNSIAYDLDSNGAGKVNVKKVGDTKIQTSNELISALTNLRGARIRYYVK
CFQEMIYSLLQIAGAAFVTTRMAKRININKIWSKPEEKPIVSPGPPAPPEEHWTIAPS
DTIQEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERQGKYSIEEYLQDRDRY
YEELAIAKATEEDFCEEEEVKIRQRIFRPTRKQRKEERATLGLVTGSEIRKRNPDDFR
PRGKLWADDDRSVNYNEKIDFEAPPSLWSRIVNFGSGWGFWVSSNLFITSTHVIPPNI
SEAFGVPINQIQVHRCGEFCKMRFPKAIRPDVSGMILEEGAPEGTVVTILIKRTTGEL
MPLAARMGTHATMKIQGRMIGGQMGMLLTGSNAKNMDLGTVPGDCGCPYVYKRGNDWV
VIGVHTAAARGGNTVICATQGPDGEATLEGGDNHGTYCGAPILGPGSAPKLSTKTKFW
RSSNAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMREQLKPFTAPRGKPPKPAVLEAAK
ETICGVLEQTIDPPQQWSYAQACSSLDKTTSSGHPHHKKKNDNWNGESFTGVLADQAS
RANLMYEQGKHMQPVYTAALKDELVKTSKIYDKVKKRLLWGSDLGTMIRCARSFGGLM
DEMKANCVNLPIRVGMNMNEDGPIIFERHSKYKYHYDADYSRWDSTQQRHVLGVALEI
MVRFSAEPELAQIVAEDLLSPSVVDVGDFKVTINEGLPSGVPCTSQWNSITHWLLTLC
AMSEVSGLSPDVVQANSCFSFYGDDEIVSTDIKLDAFKLTEKLKEYGLIPTRPDKTEG
PLVIKEKLEGLTFLRRDVCRDPAGWYGKLDQSSIIRQLYWTKGPNHEDPNETMIPHSQ
RPIQLMSLLGEAALHGPSFYKKVSKLVITELKEGGMDFYVPRQEPMFRWMRFSDLSTW
EGDRNLAPEGVNEDGVE"
mat_peptide <1..965
/gene="ORF1"
/product="p48"
mat_peptide 966..2063
/gene="ORF1"
/product="NTPase"
mat_peptide 2064..2585
/gene="ORF1"
/product="p22"
mat_peptide 2586..2984
/gene="ORF1"
/product="VPg"
mat_peptide 2985..3527
/gene="ORF1"
/product="Pro"
mat_peptide 3528..5057
/gene="ORF1"
/product="RdRp"
gene 5041..6672
/gene="ORF2"
CDS 5041..6672
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QBR98806.1"
/translation="MKMASNDAAPSSDGAASLVPEINNETMALEPVAGGAIAAPLTGQ
TNFIDPWIRNNYVQAPNGEFTVSPRNSPGEILLNLELGPELNPFLAHLSRMYNGFAGG
IEVQVIMAGNAFTAGKIIFAAVPPHFPVDNISPSQITMFPHIIIDVRTLEPVNIPLPD
VRNSFFHYSQNNEPRMRLLAMLYTPLRSNGSADDVFTVSCRVLTKPSPDFEFNYLVPP
TVESRTKPFTIPILTIGEMTNSRFPVAIDMLHTSPTENIVVQPQNGRCTLDGELQGTT
QLVTSNICAFRGSIHDHQTNGDEHQWHFNITNPNGTPFDPTEDVPAPLGTPDFKGQLY
GVISQRDREGTPGENNQKANRSHEGVISTVAPRFTPKLGSVMIGTWTTDDIRNQPSRF
TPVGLNDDDNYRQWELPNYSGALTLNMGLAPSVFPTYPGEQILFFRSYMPMKGGYGSP
YIDCLIPQEWISHFYQESAPSQTDVALIRYVNPDTGRVLFEAKLHRQGFITVAKTGDS
PINVPANGYFRFDSWVNQFYSLAPMGTGNGRRRVQ"
gene 6672..7436
/gene="ORF3"
CDS 6672..7436
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QBR98807.1"
/translation="MAGTFIAGLAGDMLTNTVGSLVNAGANAINQKVDFENNKYLQNA
SFAHDKEMLKAQIEATKQLQADMIAIKQGVLTAGGFSPTDAARGAINAPMTKVLDWNG
TRYWAPNATSTTSMSGGFTGQVVHRTTPNFKTSQAPKSTPSSGSSVRSNSTQLTSLSS
HSSGSSRSSGSTAVSSLPSSNRTREWVNQQNLNLEPHMPGSLKTAFVTPPSSTASSSG
TVSTVPKGVLDSWTSAFNTRRQPLFAYLHRRGESKV"
ORIGIN
1 cgaccgctgg caaaaccagc tcaaacagtg aaattcacaa cgatgacgcc acaccagcgt
61 caaacatctt cgccaacatg actgttggct tgaagaaagc cttgggggca cggcctaaac
121 agcctacccc cagggcccct tctcctccta aggagaagaa gagaaccctc cctccaatac
181 cacccccacc acccaatggt gaggatattg tcatcaagta caccaaacag ggtgaccttg
241 tggagggggt ccccgcggtt tccaccgtgg agatcccccc tacactggac accgcatata
301 gtgtcccccc cttagaccag agggagaagc ttgatgccaa agagccgcta acaggctcaa
361 taattgaaat gtgggatgga gagatttacc attatgggct ttatgtggag cgaggcttga
421 ttctcggcgt gcacaagcca cctgcagcaa ttagcttcgc ccgcattgag ttgacccctc
481 tctctcttta ttggagagct gtctacacac caccctacct agtggaccca caaaacctga
541 agaaactcca tggcgagtcc ttcccttaca ccgcatttga caacaactgc tactccttct
601 gctgttgggt tttggacttg aatgattcat ggttcaacag aaaacatgtg tcaaggacta
661 cggggtttta cagaccctat caggagtgga atagaaaacc aatgcccacc atggatgaag
721 gaaaacttaa gaaagtggcc aatgtgttct tgtgtgccat ctctggcctt ttcaccaggc
781 caatcaagga catcataggg aaactgaaac cattgaacat cctcaacata gtgtcaaact
841 gtgattggac attccctggt gtcgtggaat ccctcatatt gcttgctgaa ttatttgggg
901 tcttctggac accgccagac atctccgctt tcgtggcatc cctcttgggt gattacgaaa
961 tgcaggggcc tgaagatata gccactgaga tcgtgccagt catcctcggt ggcattggaa
1021 tggtcctcgg cttcacaagg gaaaagatag ggcgtatact gagttctgcc gcctcatcac
1081 tcagagcatg cagggagatt ggcaactacg gtatagaggt ggtgaagctc gtgatgaagt
1141 ggttcttccc ttccaagaac gaggcgagcg agatggacat ggtcagagca atagaggatg
1201 cagtgcttga tttcgaagcc attgaaaaca accacatgac atctctgcta aaagacaaga
1261 acagcctcgc gaccttcctc agggcactgg acatggaaga agagaaggca cggaaactgt
1321 ctaccaaatc tgcctctcca gacattgttg gaaccataaa tgcactccta gccagaattg
1381 cagctgccag atccctcgtc caccgcgcca aagaagagat gtcatccagg atgcgtcctg
1441 ttgtcatcat gatctctggg cggccaggga tagggaaaac acacttggca cgcgacctgg
1501 ctaagaagat ggcagcaacc ctcgctggtg atcaaagggt tggccttgtc ccgagaaatg
1561 gtgttgacca ctgggatgca tacaagggag agaggatagt tctgtgggat gactacggca
1621 tgagcaaccc aatatcagat gcactaagac tccaagaact tgctgacacc tgtcctctaa
1681 cactcaactg tgacagaata gagaacaagg ggaaagtatt tgacagtgac accataatca
1741 tcaccaccaa tctggccaac cctgcccctc ttgactatgt caatttcgag gcatgctctc
1801 gccgcattga cttcctcgtc tatgcggact cccccgctgt tgacaaggca aagagagact
1861 tcccggggca acctgatatg tggaaagatg cattcaagca ggacttctca cacataaaac
1921 tacaattggc accacaagga ggctttgaca aaaatggcaa caccccacac ggcaagggcg
1981 tgatgaaatc cctaaccaca cattctctca tcgcccgcgc cacggggctc ctacatgaga
2041 ggctggatga atttgatcta caggggcctg aactcccagt ctataacttt gaccagaaca
2101 aagtggcgtc gttcaggcga ctcgccgccg acaacaagta tggccttatg gaaaccatca
2161 aagctggcaa taaactaaaa gaggtcaaga cactggaaca gttcaaggag gctgtgaaaa
2221 acatacggat aaacccctgc agaataatct acaactccat agcttatgac ttggactcga
2281 atggagcagg caaagtcaac gtcaagaagg tgggcgacac caagatccag acgagcaatg
2341 agctcatctc cgcactcacc aacttacgcg gcgccagaat tagatactat gtgaagtgct
2401 tccaagaaat gatctactca cttctacaga tcgctggcgc agcgtttgtg acgacgcgga
2461 tggccaaaag aataaacatc aacaagatct ggtccaagcc tgaggaaaag ccgattgtca
2521 gcccaggacc cccagcgcct ccagaagaac actggaccat cgccccaagc gacacgattc
2581 aggagggcaa gaagggcaag aacaagagtg gcagaggcaa gaaacacact gctttctcca
2641 gtaagggtct cagtgatgag gagtatgatg aatacaagag aatcagggag gagagacaag
2701 gaaaatactc tattgaagaa tacctccaag acagagaccg atactatgag gaattggcaa
2761 tagcaaaagc aactgaagag gatttctgtg aggaggagga ggtcaaaatc aggcagagga
2821 tctttcgtcc taccagaaaa cagcgcaagg aggaaagggc caccctaggg ttagtgacag
2881 gcagtgaaat taggaagagg aacccagatg atttcagacc gagagggaag ttgtgggctg
2941 acgatgatcg tagtgtcaac tataatgaga agatagactt cgaggcccct cctagcctgt
3001 ggtcaagaat agtcaacttt ggatcaggct ggggtttctg ggtgtcatct aacctattta
3061 taacctccac acacgtgatc cccccaaaca tatcagaagc atttggtgtc ccaatcaatc
3121 agatacaggt tcacaggtgt ggcgagttct gcaagatgag gtttcccaag gccatcaggc
3181 ctgatgtctc tggcatgatt ctggaggaag gggcccccga agggacagtg gtgaccatac
3241 ttataaaaag gacaactgga gagctcatgc cattggcagc tcgcatgggc acacacgcca
3301 ccatgaagat tcaagggaga atgattggag gtcaaatggg tatgctcctt acaggttcca
3361 atgctaagaa catggacctt ggcaccgtcc cgggtgattg tggatgcccg tatgtttaca
3421 agagaggaaa tgattgggtt gtgatcggag tccacactgc cgccgccaga ggaggcaaca
3481 cagtaatctg tgccacccag ggtccagatg gggaggctac actggaaggg ggtgataacc
3541 atggcaccta ctgtggggcg ccaatactgg gacccggtag cgctccaaaa ctcagcacca
3601 agacaaaatt ctggcggtcc tccaatgcac cactcccccc tggcacgtac gagcctgcct
3661 accttggtgg gaaagatccc agggtcaaag ggggcccatc cctgcaacaa gtcatgagag
3721 aacaactgaa acccttcacc gccccacgcg gcaagccacc caagcccgca gtcctggagg
3781 cggccaagga gaccatatgt ggtgtgcttg aacagaccat tgacccaccc caacagtggt
3841 cctacgcgca ggcctgctcc tcactagaca aaacaacatc aagtggccac ccccatcaca
3901 agaagaagaa tgacaattgg aatggagaat cattcactgg cgtgctagcc gatcaggctt
3961 ccagagcgaa cctcatgtat gagcagggga aacacatgca gcccgtgtac acagcagcac
4021 ttaaggatga gttggtaaag accagcaaga tatatgacaa agtcaaaaag aggctcttgt
4081 ggggatcaga cttgggaacc atgattcggt gtgcaagatc ttttggtggg cttatggatg
4141 aaatgaaggc aaactgtgta aatctaccaa taagagtggg tatgaacatg aatgaggatg
4201 gccccataat ctttgagagg cactccaagt acaaatatca ttatgatgct gactactcca
4261 ggtgggactc aacacaacaa aggcatgtcc ttggggttgc tcttgagatc atggttagat
4321 tttcagcaga acctgagttg gcacagatag tggctgagga tctcctgtcg cccagtgtcg
4381 tagacgtggg tgacttcaaa gtcacaataa atgagggcct cccatctgga gtcccatgca
4441 cgtcacagtg gaactcaata acccattggc tgctgaccct gtgcgcaatg tcagaagtat
4501 ctggattgtc accagacgtt gtgcaagcaa attcatgctt ctcattctac ggggatgatg
4561 agatagtcag cacagacatt aaattggatg ccttcaaatt aacagaaaaa ctcaaagagt
4621 atgggctgat cccaaccagg ccagacaaga cagaaggacc actagtgata aaagagaaac
4681 tagaggggtt gactttcctg aggagggatg tgtgtaggga cccagctgga tggtatggca
4741 agcttgacca gtcatcaatc ataaggcaac tgtattggac caaaggaccc aaccatgaag
4801 atcccaatga aacgatgatc ccacactctc aaagacccat ccaactgatg tcacttcttg
4861 gtgaggcggc tctccacgga ccgtcctttt acaagaaggt gagcaaattg gttatcacag
4921 agctaaaaga gggtgggatg gacttttatg tgcccaggca agaacccatg ttcaggtgga
4981 tgagattctc tgacctaagc acgtgggagg gcgatcgcaa tctggctccc gaaggtgtga
5041 atgaagatgg cgtcgaatga cgccgctcca tctagtgatg gtgcagccag tctcgtacca
5101 gagatcaaca acgagacaat ggctttggag ccagtagcag gaggggcaat tgctgctccc
5161 ctgactgggc aaacaaattt cattgatccc tggattagaa acaactatgt acaagcacct
5221 aatggtgagt tcacagtgtc ccctagaaac tcccctggtg aaattttact caatttggaa
5281 ctaggccctg agctcaaccc tttcttggcc cacctgtcta ggatgtacaa cgggtttgct
5341 ggtggcattg aggttcaagt catcatggcg ggcaacgcct tcactgccgg aaagatcatc
5401 ttcgcggcag tgccacccca cttccccgtc gacaacatta gtccttctca aattactatg
5461 ttcccacaca ttataataga tgtaagaacc cttgaacctg taaatatccc actacccgat
5521 gtcaggaata gtttcttcca ttacagccaa aataatgagc cccgtatgag actattagct
5581 atgttgtata cccctctcag atcaaatggt tctgcagatg atgtcttcac agtttcttgt
5641 agggtcctta ccaagccttc ccctgatttt gagttcaatt atttggtccc cccaactgtt
5701 gagtctagga caaagccctt cacaatacca atacttacga ttggagaaat gacaaactca
5761 aggttccccg tggccattga catgctacac accagtccta ctgagaacat tgttgtccaa
5821 ccacaaaatg gcagatgcac tctggacggt gagttgcagg gcaccacaca gctggtcact
5881 tccaatatct gtgcattcag ggggtccatc catgatcacc agaccaatgg agacgaacat
5941 cagtggcatt tcaacatcac taaccccaat ggcactccgt ttgaccccac tgaggacgtg
6001 cccgctccac ttgggacccc ggacttcaag ggacaactct acggagtcat ctctcaaaga
6061 gaccgagagg gaactcctgg tgaaaacaac cagaaggcta acaggtccca tgaaggggtg
6121 atctcaacag ttgcgccaag gttcacacca aagttagggt cagtcatgat cggcacttgg
6181 actactgatg atataagaaa tcaaccctcc agattcaccc cagttggttt gaatgatgat
6241 gataattata ggcagtggga actaccaaat tattctggag cactcaccct taacatggga
6301 ttggcaccct ctgtcttccc cacctatcct ggagaacaaa ttcttttctt ccgctcctac
6361 atgccaatga agggaggata tggcagtcca tacatcgatt gccttatacc tcaagaatgg
6421 atttctcatt tctatcagga atcagcaccc tcccaaactg atgtggcttt gattaggtat
6481 gtgaaccccg acacaggacg agtcctgttc gaggccaaat tacacagaca aggattcatc
6541 accgttgcca agactggtga cagccccatc aatgtacctg ccaatggtta ctttagattt
6601 gattcctggg ttaaccaatt ctactctctc gcccccatgg gaactgggaa cgggcgcaga
6661 agagttcagt aatggctgga acttttatag caggattggc tggtgacatg ctcacaaaca
6721 ctgtagggtc tctagtaaat gcaggggcta atgcaattaa tcagaaagtt gattttgaaa
6781 acaataaata tttacaaaat gcatcatttg ctcatgataa ggagatgttg aaggcacaaa
6841 ttgaggcaac aaaacaactg caggctgaca tgattgcaat caagcaaggg gttctgaccg
6901 ctggcggctt ttcccccact gatgctgcac gtggggccat aaatgccccc atgacaaaag
6961 ttttggattg gaatggaaca aggtactggg caccaaatgc cacctccaca acctcaatgt
7021 cgggtggctt cacaggacaa gttgtgcaca gaaccacgcc aaattttaaa acgagccagg
7081 cccccaaatc aacacccagt agtgggtcct cagtcaggtc aaactctacc cagcttacta
7141 gtctgagctc acactcctct ggatcatctc gttccagtgg atccacagct gtcagctctc
7201 taccatcctc caataggact agggaatggg tcaatcagca aaacctcaac ttggaaccac
7261 acatgcctgg atctctcaaa acagcttttg tcacaccacc atctagcaca gcctctagtt
7321 cgggcacagt ctcaaccgtg cccaaaggtg ttttggactc ctggacatct gcgtttaaca
7381 cacgcagaca gccgctcttc gcataccttc atagaagggg ggagtcaaaa gtttagtgaa
7441 aaga
//