Typing tool
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Typing tool
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Complete norovirus genomes
| MK733205 | GII.27 | |
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| GII.PNA9 |
ORF1: 1..4891
ORF2: 4872..6503
ORF3: 6503..7267
LOCUS MK733205 7308 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GII isolate Hu/AR/2018/GII.27[PNA9]/Arg15813
nonstructural polyprotein (ORF1) gene, partial cds; and VP1 (ORF2)
and VP2 (ORF3) genes, complete cds.
ACCESSION MK733205
VERSION MK733205.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7308)
AUTHORS Tohma,K., Lepore,C.J., Degiuseppe,J.I., Stupka,J.A., Saito,M.,
Mayta,H., Zimic,M., Ford-Siltz,L.A., Gilman,R.H. and Parra,G.I.
TITLE Recombinant Nontypeable Genotype II Human Noroviruses in the
Americas
JOURNAL Emerging Infect. Dis. 26 (1), 157-159 (2020)
PUBMED 31855537
REFERENCE 2 (bases 1 to 7308)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 7308)
AUTHORS Tohma,K., Lepore,C.J., Degiuseppe,J.I., Stupka,J.A., Saito,M.,
Mayta,H., Zimic,M., Ford-Siltz,L.A., Gilman,R.H. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (01-APR-2019) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2.3.1
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7308
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Hu/AR/2018/GII.27[PNA9]/Arg15813"
/isolation_source="feces of an immunocompromised patient"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Argentina"
/collection_date="09-Jan-2018"
/note="genotype: GII.27 [PNA9]"
gene <1..4891
/gene="ORF1"
CDS <1..4891
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QBR98804.1"
/translation="PPIPPPPPNGEDIVVTYTKQDDKISGVPTVSTVENSPLHDTAYS
VPPLDQREKVDAKEPLTGSILEMWDGEIYHYGLYVERGLILGVHKPPSALSMARIELT
PLSLYWRVVYTPPYLVAPDTLRKLHGESFPYTAFDNNCYMFCCWVLDLNDSWLNRKFV
SRTTGFYRPYQDWNRKPLPTMDEGKLKKVANVLLCGLSSLFTRPIKDLISRLKPLNIL
NIVSNCDWTFPGVVEALILLAELFGIFWTPPDISAFVASLLGDYEMQGPEDIATEIVP
VVLGGIGMVLGFTKEKIGRLLSSAASSLRACREIGNYGIEVVKLIMKWFFPTKNEVNE
MEMVRAIEDAVLDFEAIENNHMTALLKDKNSLATFLRALDMEEEKARKLSTKSASPDI
VGTINAILARIAAARSLVHRAKEEMSSRMRPVVIMISGRPGIGKTHLARDLAKRMAST
LSGDQRVGLVPRNGVDHWDAYKGERIVLWDDYGMSNPVADALRLQELADTCPLTLNCD
RIENKGKVFDSDTIIITTNLSNPAPLDYVNFEACSRRIDFLVYADSPSVDKAKKDFPG
QPDMWKDAFKPDFSHIKLQLAPQGGFDKNGNTPHGKGVMKTLTTHSLIARATGLLHER
LDEFDLQGTELPMYNFDQNKVAAFRRLAADNKYGLMETLKAGNKLKEVKTLEHFKEAV
KDIRIKPCRIIYNSTAYELESSGTGRVIVKKVGDQKVQANNELYSALNNLRRARIRYY
IKCFQEMIYTLLQIAGAAFVTSRMTQRMNIGRLWAKPEKQMETSVEPPPPPIEDWTIS
PTDTVQEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERQGKYSIEEYLQDRD
RYYEELAIAQATEENFCEEEEIKIRQRIFRPTRKQRREERANLGLVTGSEIRKRNPDD
FKPRGKLWADDDRSVNYNEKIDFEAPPSLWSRIVNFGSGWGFWVSSNLFITSTHVVPP
NITEAFGVPISQIQVHRSGEFCKMRFPKAIRPDVSGMILEEGAPEGTVVTILIKRTTG
ELMPLASRMGTHATMKIQGRMIGGQMGMLLTGSNAKNMDLGTIPGDCGCPYVYKRGNE
WVVIGVHTAAARGGNTVICATQGPEGEATLEGGDNHGTYCGAPILGPGNAPKLSTKTK
FWRSSNAPLPPGTYEPAYLGGRDPRVKGGPSLQQVMREQLKPFTAPRGKPPRPAILEA
AKETICNVLEQTIEPPQKWSYAQACASLDKTTSSGYPHHKKKNDNWNGESFTGVLADQ
ASKANLMFEQGKHMQPVYTAALKDELVKTSKIYDKIKKRLLWGSDLGTMIRCARSFGG
LMDEMKANCVRLPIRVGMNMNEDGPIIFEKHSRYRYHYDADYSRWDSTQQRHVLGLAL
EIMVRFSAEPELAQIVAEDLLSPSVVDVGDFKITINEGLPSGVPCTSQWNSIAHWLLT
LCAMSEVSGLSPDVVQSNSCFSFYGDDEIVSTDIKLDPQKLTDKLKEYGLIPTRPDKT
EGPLIIKESLEGLTFLRRNICRDPVGWYGQLDQSSIMRQLYWTKGPNHEDPNETMIPH
SQRPVQLMSLLGEASLHGPAFYKKVSKLVITELREGGMDFYVPRQEPMFRWMRFSDLS
TWEGDRNLAPEGVNEDGVE"
mat_peptide <1..796
/gene="ORF1"
/product="p48"
mat_peptide 797..1894
/gene="ORF1"
/product="NTPase"
mat_peptide 1895..2419
/gene="ORF1"
/product="p22"
mat_peptide 2420..2815
/gene="ORF1"
/product="VPg"
mat_peptide 2816..3358
/gene="ORF1"
/product="Pro"
mat_peptide 3359..4888
/gene="ORF1"
/product="RdRp"
gene 4872..6503
/gene="ORF2"
CDS 4872..6503
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QBR98802.1"
/translation="MKMASNDAAPSNDGAAGLVPEINNETMALEPVAGGAIAAPLTGQ
TNFIDPWIRNNYVQAPNGEFTVSPRNSPGEILLNLELGPELNPFLAHLSRMYNGFAGG
IEVQVIMAGNAFTAGKIIFAAVPPNFPTENLSPPQITMFPHVIIDVRTLEPVNIPLPD
VRNNFFHYSQNNEPRMRLLAMLYTPLRSNGSAEDVFTVSCRVLTKPSPDFEFNYLVPP
TVESRTKPFTIPILTIGEMTNSRFPVAIDFLHTSPTENIVVQPQNGRCTLDGELLGTT
QLVTSNICAFRGSISGHENTGDNHQWHFNITNPNGTPFDPTEDVPAPLGTPDFTGQLY
GVISQRNREGTSGENNQKANRSHEGVISTLAPRFTPKLGSVMIGTWTTDDIENQPSRF
APIGLNDDDNYNQWQLPNYSGALTLNMGLASSVFPTYPGEQLLFFRSYIPMKGGYGSP
FIDCLIPQEWVSHFYQESAPSQTDVALIRYVNPDTGRVLFEAKLHRQGYITVAKTGDS
PINVPANGYFRFDSWVNQFYSLAPMGTGNGRRRIQ"
gene 6503..7267
/gene="ORF3"
CDS 6503..7267
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QBR98803.1"
/translation="MAGAFIAGLAGDMLTNTVGSLVNAGANAINQKVDFENNKYLQNA
SFAHDKEMLQAQVEATKKLQAEMIAIKQGVLTAGGFSPSDAARGAINAPMTKVLDWNG
TRYWAPNATSTTSMSGGFTGQTVHRPTPNFKTNQAPKSMPSSGSSVRSNTTQLSSLSS
HSSGSSRSSGSTTVSSLPSSSRTRDWVNQQNLNLAPHMPGSLRTAFVTPPSSRASSSG
TVSTVPKGVLDSWTSAFNTRRQPLFAHLRRRGESNV"
ORIGIN
1 ccccccaata cctcccccac cacctaatgg ggaggacatt gtcgtcacgt acacaaaaca
61 agatgacaaa atcagtggag ttcccaccgt ctccaccgtt gaaaactctc ccttgcatga
121 caccgcatac agtgttccac ccttggacca aagggaaaag gttgatgcaa aggagcccct
181 gacgggttca atactcgaaa tgtgggatgg tgagatttac cactatgggc tttatgtgga
241 aaggggtctg attctcggcg tgcacaagcc accatctgct ctgagcatgg cacgcattga
301 gttgaccccc ctttccctct attggagggt ggtgtatacc ccgccctacc ttgttgcccc
361 agacaccctc aggaaactcc atggggaatc cttcccctac acagcatttg acaataactg
421 ttacatgttc tgctgttggg tcctggatct taacgattcg tggctcaaca ggaagttcgt
481 gtcaaggact acaggattct acagacccta ccaggactgg aacaggaagc ccctgcccac
541 catggatgaa ggcaaactca agaaggtagc caatgtacta ctgtgtggtc tatccagcct
601 cttcaccagg cccattaaag acctcataag taggctgaaa ccactaaaca ttctcaacat
661 tgtatccaat tgtgattgga cattccccgg tgttgtagag gcccttatcc tgcttgcaga
721 actctttggt atcttctgga ccccaccaga catatctgct ttcgtcgctt ccctgttggg
781 agactacgaa atgcagggtc ctgaggacat tgcaaccgag atcgtgccag tcgtccttgg
841 tggcattggt atggtccttg gtttcaccaa ggagaagatt ggccgactac tcagctcggc
901 tgcgtcatca ctacgggcgt gtagggagat tggcaactac gggatagagg tggtcaaatt
961 aataatgaaa tggttcttcc ccaccaaaaa tgaagtgaac gagatggaaa tggtcagggc
1021 gatagaggat gcagtgcttg actttgaggc aatagaaaac aatcacatga cagctctact
1081 caaggacaag aatagtttgg ccacctttct tagagcccta gacatggagg aggagaaggc
1141 gcgaaaactg tcaaccaaat ccgcatctcc agacatagtc ggcaccataa atgccattct
1201 agccaggata gctgctgcta ggtccctagt ccacagagcc aaggaagaaa tgtcatctag
1261 gatgcgtcct gttgtcatca tgatttcggg ccgacctgga atagggaaga cacatctagc
1321 ccgggactta gccaagagga tggcgtccac actctcggga gaccagagag tgggccttgt
1381 accaagaaac ggcgtcgacc actgggatgc ctacaaaggt gagagaatcg tcctttggga
1441 tgattatggc atgagtaacc ccgtggcgga cgctctgcgc ctccaggagc ttgccgacac
1501 ctgccctttg acactcaact gtgataggat agagaacaag gggaaggtgt ttgacagtga
1561 taccataatc ataaccacca acttgtcaaa ccccgcccca cttgactatg tgaactttga
1621 ggcctgttca cgccgcattg acttccttgt ttatgcggac tctccttcag ttgacaaggc
1681 aaagaaagac ttccccggcc aaccagacat gtggaaagat gcattcaaac ctgacttctc
1741 gcacataaaa ttacaattgg caccgcaggg aggattcgac aagaacggga acaccccaca
1801 tggcaaggga gtgatgaaga ccctgactac gcattccctc atagccaggg ccaccggctt
1861 gctgcatgaa agattggatg aattcgattt acaggggaca gagctaccaa tgtacaactt
1921 tgaccaaaac aaagtggccg cattcaggag gctagcggcc gacaacaagt acggcctaat
1981 ggaaacctta aaggcgggca acaagttgaa ggaggtcaag accctagaac acttcaagga
2041 ggctgtcaag gacatccgca taaaaccatg caggataatc tacaattcca ccgcttacga
2101 attggagtca agcggtactg ggagagtcat cgtcaagaaa gtgggtgacc agaaggtgca
2161 ggccaataat gaactctact ctgccctcaa caatctgcgc agagctagga tcaggtacta
2221 catcaagtgt ttccaggaga tgatctacac actcctccaa atcgctggtg cggcttttgt
2281 aacatcaaga atgacacaga ggatgaacat tggaagactg tgggccaaac cggaaaagca
2341 aatggaaacc tctgtggagc cccccccccc tcctattgaa gactggacca taagcccaac
2401 tgacacagtc caggaaggca agaagggcaa aaacaagagc ggtagaggca agaaacatac
2461 tgccttctct agtaaaggtc tcagtgatga agagtacgac gagtacaaaa ggatcagaga
2521 ggagcgccag gggaaatact ctatagagga gtatctccag gacagagacc ggtactatga
2581 agaattggcc atagcccaag caacagaaga aaatttctgt gaggaggaag agatcaaaat
2641 aagacaaagg attttcaggc caaccaggaa acaacgcaga gaagagaggg ccaatctggg
2701 cctggtcaca gggagtgaaa ttaggaagag gaaccctgac gacttcaagc caagaggaaa
2761 gctgtgggcc gatgatgacc gcagtgtcaa ctacaatgag aaaatagact ttgaggcccc
2821 tcccagtctg tggtccagaa tagtcaactt tggctcgggg tggggtttct gggtctcgtc
2881 caacctattc atcacatcaa cgcatgttgt gccaccaaac atcacggaag cttttggggt
2941 cccaataagc caaatccaag tccacaggag cggagagttc tgcaaaatga ggttccccaa
3001 ggccatcagg cctgatgttt ctgggatgat tcttgaagaa ggtgcgccag aggggacggt
3061 tgtaaccata ctgatcaaaa ggacaaccgg tgagctcatg ccattagcat cccgcatggg
3121 cacccatgcc accatgaaaa tacagggaag aatgattggt ggccaaatgg gaatgctcct
3181 cacagggtcc aacgccaaaa acatggacct tggcaccatc ccaggggact gtggctgccc
3241 ctatgtctac aagaggggca atgagtgggt tgtgatcggg gtacacaccg ctgcggccag
3301 agggggcaac acggtgatat gtgcaacaca agggcccgaa ggtgaggcca cacttgaagg
3361 aggagataac catggaacct actgtggtgc accaatcttg ggaccaggaa atgcaccaaa
3421 actcagcacc aaaaccaaat tttggagatc ctccaatgcc ccacttcccc ctggcacata
3481 tgagcctgcc tacctcggtg ggagggatcc tagagtcaag ggtggcccat cactacagca
3541 agtcatgaga gaacaactca agccattcac tgccccgcgc gggaagccac ctaggccggc
3601 aatcttggaa gctgcaaagg agaccatctg caacgtgctc gagcaaacca tcgaaccacc
3661 tcaaaaatgg tcttacgcgc aagcctgcgc ctccctggac aagaccacgt caagtggcta
3721 cccccatcat aagaaaaaga atgacaactg gaatggtgaa tcttttactg gtgttttggc
3781 cgatcaggca tcaaaagcaa acctcatgtt tgaacaggga aaacacatgc aacccgtgta
3841 cacagctgca ctcaaggatg agcttgtaaa gactagtaag atatatgata agatcaagaa
3901 gaggctcttg tggggctctg acctgggcac gatgattcgc tgcgcaaggt cgtttggggg
3961 cctgatggat gagatgaaag ctaactgtgt gagattgcct atcagagttg ggatgaacat
4021 gaatgaggat ggacccataa tctttgagaa acattcaaga tacaggtacc attatgatgc
4081 tgactactcc aggtgggact cgacccagca aaggcacgtg ttgggtcttg cacttgaaat
4141 catggttagg ttttcagccg aacctgaatt ggcacaaata gtggctgagg accttttgtc
4201 acccagtgtc gtggacgttg gtgacttcaa aattacaata aacgagggat tgccctctgg
4261 tgttccatgc acatcacaat ggaactcaat tgcccactgg ctgttaacat tgtgtgccat
4321 gtcggaggtc tcaggactct cgccagatgt ggtgcagtca aattcgtgct tctcctttta
4381 tggagacgac gagatagtca gcacagacat aaaattggac ccacaaaaac tgacagacaa
4441 gctgaaagaa tatggactga tcccaacccg gcccgacaag acagaggggc cactcataat
4501 caaagagagc ttagaaggcc tgacatttct aagaaggaac atttgcaggg acccggttgg
4561 atggtatggt caacttgacc agtcatcaat catgaggcag ttgtattgga caaaaggacc
4621 caaccatgaa gaccccaacg aaacaatgat cccacactcc caaagaccag tgcagttaat
4681 gtctctcctt ggtgaagctt ccctacacgg ccctgctttt tacaagaaag ttagcaaatt
4741 ggtcatcact gaattgaggg aaggggggat ggatttctat gtgcccagac aagaaccaat
4801 gttcagatgg atgagattct ctgacctgag cacgtgggag ggcgatcgca atcttgctcc
4861 tgaaggtgtg aatgaagatg gcgtcgaatg acgccgctcc atctaatgat ggtgcagccg
4921 gtctcgtacc agagatcaac aacgagacaa tggctttgga accagtagct ggaggagcaa
4981 ttgctgcccc tctaactgga caaacaaatt tcattgatcc ctggattaga aataattatg
5041 tgcaggcacc taatggtgaa tttacagttt ctcccagaaa ttcccctggt gaaattttgc
5101 tcaatttgga attgggtccc gagctcaacc ctttcttggc ccatttgtct aggatgtata
5161 atggttttgc tggtggcatt gaggttcagg tcatcatggc gggcaacgcc ttcaccgctg
5221 gtaagatcat ctttgcagca gtgcctccca attttcccac agaaaatctt agccctccac
5281 aaatcaccat gtttccccac gtcataatag atgtgagaac cctcgagcct gtcaacattc
5341 ccttgcctga tgttagaaac aacttcttcc attatagcca aaataatgag ccccgcatga
5401 gattgttagc aatgttgtat accccactca gatcaaatgg ttctgcagaa gatgttttta
5461 ctgtgtcgtg tagggtcctc accaaaccct caccagattt tgaattcaac tacttggtcc
5521 ccccaactgt cgagtctagg acaaagccct tcaccatacc aatactcaca attggagaga
5581 tgacaaattc aagattccct gtggccattg atttcctgca caccagcccc accgagaaca
5641 tcgttgttca gccgcaaaac ggcaggtgca cgctggatgg tgaactgctg ggcaccactc
5701 aattggtcac ttctaacatc tgtgccttca gagggtccat ctcaggacat gagaacacag
5761 gagataacca ccaatggcat tttaatatca ccaaccccaa tggcactccg tttgacccca
5821 cagaggatgt gcctgctcca cttggaaccc cagatttcac aggccagctc tatggagtca
5881 tttctcaacg gaacagggag gggacttctg gtgaaaacaa ccagaaggcc aacaggtccc
5941 atgagggagt gatctcaaca ctcgcaccaa gatttacacc aaagctgggg tcggtcatga
6001 ttggcacatg gaccaccgat gacattgaaa accaaccctc cagattcgct ccaattggct
6061 taaatgatga tgacaattat aaccagtggc aattgccaaa ctactccggg gcactcactc
6121 tcaacatggg gttggcctcg tctgttttcc ctacttaccc tggtgaacag cttcttttct
6181 tccgctcata catcccaatg aaggggggat atggtagccc attcatcgac tgccttatac
6241 cccaagagtg ggtctcccat ttctatcaag aatcagcacc ctcacagaca gatgtggctc
6301 tgatcaggta tgtcaacccc gacacaggac gcgtcctgtt cgaggccaaa ttacacagac
6361 aaggatacat caccgtcgcc aagaccggtg acagccccat caatgtacct gctaatggtt
6421 atttcagatt tgattcttgg gttaatcagt tttactctct cgcccccatg ggaactggga
6481 atgggcgcag aaggattcaa taatggcagg agcttttata gcaggattgg ctggtgacat
6541 gttaacaaac actgtagggt ctttagttaa tgcaggggct aatgctatta atcagaaagt
6601 tgattttgag aataataaat atttgcaaaa tgcatcattt gcccatgata aggaaatgtt
6661 acaagcacaa gttgaggcca caaagaaact gcaggccgaa atgattgcca tcaaacaagg
6721 ggttttgacc gcaggcggct tttccccttc tgatgcggcc cgtggggcaa ttaacgcccc
6781 tatgacaaaa gtcttagatt ggaatgggac aagatactgg gcccccaacg ccacctctac
6841 aacctccatg tcaggtggct tcacgggtca aaccgtgcac aggcccacac caaatttcaa
6901 aacgaaccag gcacccaaat ctatgcccag tagtggatcc tcagtaaggt caaacacgac
6961 ccaactttct agtctgagtt cacattcctc tgggtcttcc cgatccagcg ggtccacaac
7021 tgtcagctcc ctaccatcat ccagtaggac tagggactgg gttaatcagc aaaatctcaa
7081 tttggcacca catatgcctg gatccctcag aacagctttt gtcactccac catctagcag
7141 ggcctccagt tcaggcacag tctcaaccgt gcccaaaggt gttttggact cctggacatc
7201 tgcgtttaat acacgcagac agccgctgtt tgcacacctt cggagaaggg gggagtcaaa
7261 tgtttagtga aaagattagt ttaagtttga tttaatttgg atttaaaa
//