Typing tool
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Typing tool
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Complete norovirus genomes
| MK733204 | GII.27 | |
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| GII.PNA9 |
ORF1: 1..4897
ORF2: 4878..6509
ORF3: 6509..7273
LOCUS MK733204 7314 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GII isolate Arg15559 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MK733204
VERSION MK733204.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7314)
AUTHORS Tohma,K., Lepore,C.J., Degiuseppe,J.I., Stupka,J.A., Saito,M.,
Mayta,H., Zimic,M., Ford-Siltz,L.A., Gilman,R.H. and Parra,G.I.
TITLE Recombinant Nontypeable Genotype II Human Noroviruses in the
Americas
JOURNAL Emerging Infect. Dis. 26 (1), 157-159 (2020)
PUBMED 31855537
REFERENCE 2 (bases 1 to 7314)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 7314)
AUTHORS Tohma,K., Lepore,C.J., Degiuseppe,J.I., Stupka,J.A., Saito,M.,
Mayta,H., Zimic,M., Ford-Siltz,L.A., Gilman,R.H. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (01-APR-2019) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2.3.1
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7314
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Arg15559"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Argentina"
/collection_date="26-Sep-2017"
/note="genotype: GII"
gene <1..4897
/gene="ORF1"
CDS <1..4897
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QBR98801.1"
/translation="TIPPIPPPPPNGEDIVVTYTKQDDKISGVPTVSTVENSPLHDTA
YSVPPLDQREKVDAREPLTGSILEMWDGEIYHYGLYVERGLVLGVHKPPSALSMARIE
LTPLSLYWRVVYTPPYLVAPDTLRKLHGESFPYTAFDNNCYMFCCWVLDLNDSWLNRK
FVSRTTGFYRPYQDWNRKPLPTMDEGKLKKVANVLLCGLSSFFTRPIKDLISRLKPLN
ILNIVSNCDWTFPGVVEALILLAELFGIFWTPPDISAFVASLLGDYEMQGPEDIATEI
VPVVLGGIGMVLGFTKEKIGRLLSSAASSLRACREIGNYGIEVVKLIMKWFFPTKNEV
NEMEMVRAIEDAVLDFEAIENNHMTALLKDKNSLATFLRALDMEEEKARKLSTKSASP
DIVGTINAILARIAAARSLVHRAKEEMSSRMRPVVIMISGRPGIGKTHLARDLAKRMA
STLSGDQRVGLVPRNGVDHWDAYKGERIVLWDDYGMSNPVADALRLQELADTCPLTLN
CDRIENKGKVFDSDTIIITTNLSNPAPLDYVNFEACSRRIDFLVYADSPSVDKAKKDF
PGQPDMWKDAFKPDFSHIKLQLAPQGGFDKNGNTPHGKGVMKTLTTHSLIARATGLLH
ERLDEFDLQGTELPMYNFDQNKVAAFRRLAADNKYGLMETLKAGNKLKEVKTLEHFKE
AVKDIRIKPCRIIYNSTAYELESSGTGRVIVKKVGDQKVQANNELYSALNNLRRARIR
YYIKCFQEMIYTLLQIAGAAFVTSRMTQRMNIGRLWAKPEKQVEASVEPPPPPIEDWT
ISPTDTVQEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERQGKYSIEEYLQD
RDRYYEELAIAQATEENFCEEEEIKIRQRIFRPTRKQRREERANLGLVTGSEIRKRNP
DDFKPRGKLWADDDRSVNYNEKIDFEAPPSLWSRIVNFGSGWGFWVSSNLFITSTHVV
PPNITEAFGVPISQIQVHRSGEFCKMRFPKAIRPDVSGMILEEGAPEGTVVTILIKRT
TGELMPLASRMGTHATMKIQGRMIGGQMGMLLTGSNAKNMDLGTIPGDCGCPYVYKRG
NEWVVIGVHTAAARGGNTVICATQGPEGEATLEGGDNHGTYCGAPILGPGNAPKLSTK
TKFWRSSNAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMREQLKPFTAPRGKPPRPAIL
EAAKETICNVLEQTIEPPQKWSYAQACASLDKTTSSGYPHHKKKNDNWNGESFTGVLA
DQASKANLMFEQGKHMQPVYTAALKDELVKTSKIYDKIKKRLLWGSDLGTMIRCARSF
GGLMDEMKANCVRLPIRVGMNMNEDGPIIFEKHSRYSYHYDADYSRWDSTQQRHVLGL
ALEIMVRFSAEPELAQIVAEDLLSPSVVDVGDFKITINEGLPSGVPCTSQWNSIAHWL
LTLCAMSEVSGLSPDVVQSNSCFSFYGDDEIVSTDIKLDPQKLTDKLKEYGLIPTRPD
KTEGPLIIKESLEGLTFLRRNICRDPVGWYGQLDQSSIMRQLYWTKGPNHDDPNETMI
PHSQRPVQLMSLLGEASLHGPAFYKKVSKLVITELREGGMDFYVPRQEPMFRWMRFSD
LSTWEGDRNLAPEGVNEDGVE"
mat_peptide <1..802
/gene="ORF1"
/product="p48"
mat_peptide 803..1900
/gene="ORF1"
/product="NTPase"
mat_peptide 1901..2425
/gene="ORF1"
/product="p22"
mat_peptide 2426..2821
/gene="ORF1"
/product="VPg"
mat_peptide 2822..3364
/gene="ORF1"
/product="Pro"
mat_peptide 3365..4894
/gene="ORF1"
/product="RdRp"
gene 4878..6509
/gene="ORF2"
CDS 4878..6509
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QBR98799.1"
/translation="MKMASNDAAPSNDGAAGLVPEINNETMALEPVAGGAIAAPLTGQ
TNFIDPWIRNNYVQAPNGEFTVSPRNSPGEILLNLELGPELNPFLAHLSRMYNGFAGG
IEVQVIMAGNAFTAGKIIFAAVPPNFPTENLSPPQITMFPHVIIDVRTLEPVNIPLPD
VRNNFFHYSQNNEPRMRLLAMLYTPLRSNGSAEDVFTVSCRVLTKPSPDFEFNYLVPP
TVESRTKPFTIPILTIGEMTNSRFPVAIDFLHTSPTENIVVQPQNGRCTLDGELQGTT
QLVTSNICAFRGSISGHENAGDNHQWHFNITNPNGTPFDPTEDVPAPLGTPDFTGQLY
GVISQRNREGTPGENNQKANRSHEGVISTLAPRFTPKLGSVMIGTWTTNDIENQPSRF
APIGLNDDDNYNQWQLPNYSGALTLNMGLASSVFPTYPGEQLLFFRSYIPMKGGYGSP
FIDCLIPQEWVSHFYQESAPSQTDVALIRYVNPDTGRVLFEAKLHRQGYITVAKTGDS
PINVPANGYFRFDSWVNQFYSLAPMGTGNGRRRIQ"
gene 6509..7273
/gene="ORF3"
CDS 6509..7273
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QBR98800.1"
/translation="MAGAFIAGLAGDMLTNTVGSLVNAGANAINQKVDFENNKYLQNA
SFSHDKEMLQAQVEATRKLQAEMIAIKQGVLTAGGFSPSDAARGAINAPMTKVLDWNG
TRYWAPNATSTTSMSGGFTGQTVHRPTPNFKTNQAPKSIPSSGSSVRSNTTQLSSLSS
HSSGSSRSSGSTTVSSLPSSSRTRDWVDQQNLNLEPHMPGSLRTAFVTPPSSRASSPG
TVSTVPKGVLDSWTPAFNTRRQPLFAHLRRRGESNV"
ORIGIN
1 caccatcccc ccaatacctc ccccaccacc taatggggag gacattgtcg tcacgtacac
61 aaaacaagac gacaaaatca gtggagttcc caccgtctcc accgttgaaa actctccctt
121 gcatgacacc gcatacagtg ttccaccctt ggaccaaagg gaaaaggttg atgcaaggga
181 gcccctgacg ggttcaatac tcgaaatgtg ggatggtgag atttaccact atgggcttta
241 tgtggaaagg ggtctggtcc tcggcgtgca caagccacca tctgctctga gcatggcacg
301 cattgagttg accccccttt ccctctattg gagggtggtg tataccccgc cctaccttgt
361 tgccccagac accctcagga aactccatgg ggaatccttc ccctacacag catttgacaa
421 taactgttac atgttctgct gttgggtcct ggatcttaac gattcgtggc tcaacaggaa
481 gttcgtgtca aggactacag gattctacag accctaccag gactggaaca ggaagcccct
541 gcccaccatg gatgaaggca aacttaagaa ggtagccaat gtgctactgt gtggtctatc
601 cagcttcttc accaggccca ttaaagacct cataagtagg ctgaaaccac taaacattct
661 caacattgta tccaattgtg attggacatt ccccggtgtt gtagaggctc ttatcctgct
721 tgcagaactc tttggtatct tctggactcc accagacata tctgctttcg tcgcttccct
781 gttgggagac tacgaaatgc agggtcctga ggacattgca accgagatcg tgccagtcgt
841 ccttggtggc attggtatgg tccttggttt caccaaggag aagattggcc gactactcag
901 ctcggccgcg tcatcactcc gggcgtgtag ggagattggc aactacggga tagaggtggt
961 caaattaata atgaaatggt tcttccccac caaaaatgaa gtgaacgaga tggaaatggt
1021 cagggcgata gaggatgcag tgcttgactt tgaggcaata gaaaacaatc acatgacagc
1081 tctactcaag gacaagaata gtttggccac ctttcttaga gccctagaca tggaggagga
1141 gaaggcgcga aaactgtcaa ccaaatccgc atctccagac atagtcggca ccataaatgc
1201 cattctagcc aggatagctg ctgctaggtc cctagtccac agagccaagg aagaaatgtc
1261 atctaggatg cgtcctgttg tcatcatgat ttcgggccga cctggaatag ggaagacaca
1321 tctagcccgg gacttagcca agaggatggc gtccacactc tcgggagacc agagagtggg
1381 ccttgtacca agaaacggcg tcgaccactg ggatgcctac aaaggtgaga gaatcgtcct
1441 ttgggatgat tatggcatga gtaaccccgt ggcggacgcc ctgcgcctcc aggagcttgc
1501 cgacacctgc cctctaacgc tcaactgtga taggatagag aacaagggga aggtgtttga
1561 cagtgacacc ataatcataa ccaccaactt gtcaaacccc gccccacttg actatgtgaa
1621 ctttgaggcc tgttcacgcc gcattgactt ccttgtttat gcggactctc cttcagttga
1681 caaggcaaag aaagacttcc ccggccaacc agacatgtgg aaagatgcat tcaaacctga
1741 cttctcgcac ataaaattac aattggcacc gcagggagga ttcgacaaga acgggaacac
1801 cccacatggc aagggagtga tgaagaccct gaccacgcac tccctcatag ccagggccac
1861 cggcttgctg catgaaagat tggatgaatt cgatttacag gggacagagc taccaatgta
1921 caactttgac caaaacaaag tggccgcatt caggaggcta gcggccgaca acaagtacgg
1981 cctaatggaa accttaaagg cgggcaacaa gttgaaggag gtcaagaccc tagaacactt
2041 caaggaggct gtcaaggaca tccgcataaa accatgcagg ataatctaca attccaccgc
2101 ttacgaattg gagtcaagcg ggactgggag agtcatcgtc aagaaagtgg gtgaccagaa
2161 ggtgcaagcc aataatgaac tctactctgc cctcaacaat ctgcgcagag ctaggatcag
2221 gtactacatc aagtgtttcc aggagatgat ctacacactc ctccaaatcg ctggtgcggc
2281 ttttgtaaca tcaagaatga cacagaggat gaacattggc agactgtggg ccaaaccgga
2341 aaagcaagtg gaagcctctg tagagccccc cccccctcct attgaagact ggaccataag
2401 cccaactgac acagtccagg aaggcaagaa gggcaaaaac aagagcggta gaggcaagaa
2461 acataccgcc ttctctagta aaggtctcag tgatgaagag tacgacgagt acaaaaggat
2521 cagagaggag cgccagggga aatactctat agaggagtat ctccaggaca gagaccggta
2581 ctatgaagaa ttggccatag cccaagcaac agaagaaaat ttctgtgagg aggaagagat
2641 caaaataaga caaaggattt tcaggccaac caggaaacaa cgcagagaag agagggccaa
2701 tctgggcctg gtcacaggga gtgaaattag gaagaggaac cctgacgact tcaagccaag
2761 aggaaagctg tgggccgatg atgaccgcag tgtcaactac aatgagaaaa tagactttga
2821 ggcccctccc agtctgtggt ccagaatagt caactttggc tcggggtggg gtttctgggt
2881 ctcgtccaac ctgttcatca catcaacgca tgttgtgcca ccaaacatca cggaagcttt
2941 tggggtccca ataagccaaa tccaagtcca caggagcgga gagttctgca aaatgaggtt
3001 ccccaaggcc atcaggcctg atgtttctgg gatgattctt gaagaaggtg cgccagaggg
3061 gacggttgtg accatactga tcaaaaggac aaccggtgag ctcatgccat tagcatcccg
3121 tatgggcacc catgccacca tgaaaataca gggaagaatg attggtggcc aaatgggaat
3181 gctcctcaca gggtccaacg ccaaaaacat ggatcttggc accatcccag gggactgtgg
3241 ctgcccctat gtctacaaga ggggcaatga gtgggttgtg atcggggtac acaccgctgc
3301 ggccagaggg ggcaacacgg tgatatgtgc aacacaaggg cccgaaggtg aggccacact
3361 tgaaggagga gacaaccatg gaacctactg tggtgcacca atcttgggac caggaaatgc
3421 accaaaactc agcaccaaaa ccaaattttg gagatcctcc aatgccccac ttccccctgg
3481 cacgtatgag cctgcctacc tcggtgggaa ggatcctaga gtcaagggtg gcccatcact
3541 acagcaagtc atgagagaac aactcaagcc attcactgcc ccgcgcggga agccacctag
3601 gccggcaatc ttggaagctg caaaggagac catctgcaac gtgctcgagc aaaccatcga
3661 accacctcaa aaatggtctt acgcgcaagc ctgcgcttcc ctggacaaga ccacgtcaag
3721 tggctacccc catcataaga aaaagaatga caactggaat ggtgaatctt ttactggtgt
3781 tttggccgat caggcatcaa aagcaaacct catgtttgaa cagggaaaac acatgcaacc
3841 cgtgtacaca gctgcactca aggatgagct tgtaaagacc agtaagatat atgataagat
3901 caagaagagg ctcttgtggg gctctgacct gggcacgatg attcgttgcg caaggtcgtt
3961 tgggggcctg atggatgaga tgaaagctaa ctgtgtgaga ttgcctatca gagttgggat
4021 gaacatgaat gaggatggac ccataatctt tgagaaacat tcaagataca gttaccatta
4081 tgatgctgac tactccaggt gggactcgac ccagcaaagg cacgtgttgg gtcttgcact
4141 tgaaatcatg gttaggtttt cagccgaacc tgaattggca caaatagtgg ctgaggacct
4201 tttgtcaccc agtgtcgtgg acgttggtga cttcaaaatt acaataaacg agggattgcc
4261 ctctggtgtt ccatgcacat cacaatggaa ctcaatcgcc cactggctgt taacattgtg
4321 tgccatgtcg gaggtctcag gactctcgcc agatgtggtg cagtcaaatt cgtgcttctc
4381 cttctatgga gacgacgaga tagtcagcac agacataaaa ttggacccac aaaaactgac
4441 agacaagctg aaagaatatg gactgatccc aacccgaccc gacaagacag aggggccact
4501 cataatcaaa gagagcttag aaggcctgac atttctaaga agaaacatat gcagggaccc
4561 ggttggatgg tatggtcaac ttgaccagtc atcaatcatg aggcagttgt attggacaaa
4621 aggacccaac catgatgacc ccaacgaaac gatgatccca cactcacaaa gaccagtgca
4681 gttaatgtct ctccttggtg aagcttccct acacggccct gctttttaca agaaagttag
4741 caaattggtc atcactgaat tgagggaagg ggggatggat ttctatgtgc ccagacaaga
4801 accaatgttc agatggatga gattctctga cttgagcacg tgggagggtg atcgcaatct
4861 tgctcccgaa ggtgtgaatg aagatggcgt cgaatgacgc cgctccatct aatgatggtg
4921 cagccggtct cgtaccagag atcaacaacg agacaatggc tttggaacca gtagctggag
4981 gagcaatcgc tgcccctcta actggacaaa caaatttcat tgatccctgg attagaaata
5041 attatgtgca ggcacctaat ggtgaattta cagtttctcc cagaaattcc cctggtgaaa
5101 ttttgctcaa cttggaattg ggtcccgagc tcaacccttt cttggcccat ttgtctagga
5161 tgtataatgg ttttgctggc ggcattgagg ttcaggtcat catggcgggc aacgccttca
5221 ccgctggtaa gatcatcttt gcagcagtgc ctcccaattt tcccacagaa aatcttagcc
5281 ctccacaaat caccatgttt ccccacgtca taatagatgt gagaaccctc gagcctgtca
5341 acattccctt gcctgatgtt agaaataatt tcttccatta tagccaaaat aatgagcccc
5401 gcatgagatt gttagcaatg ttgtataccc cactcagatc aaatggttct gcagaagatg
5461 ttttcactgt gtcgtgtagg gtcctcacca aaccctcacc agattttgaa ttcaactact
5521 tggtcccccc aactgtcgag tctaggacaa agcccttcac cataccaata ctcacaattg
5581 gagagatgac aaattcaaga ttccctgtgg ccattgattt cctgcacacc agccccactg
5641 agaacatcgt tgttcagccg caaaacggca ggtgcacgct ggatggtgaa ctgcagggca
5701 ccactcaatt ggtcacttct aacatctgtg ccttcagagg gtccatctca ggacatgaga
5761 atgcaggaga taaccaccaa tggcatttta atatcaccaa ccccaatggc actccgtttg
5821 accccacaga ggatgtgcct gctccacttg gaaccccaga tttcacaggc cagctctatg
5881 gagtcatttc tcaacggaac agggagggga ctcctggtga aaacaaccag aaggccaaca
5941 ggtcccatga gggagtgatc tcaacactcg caccaagatt tacaccaaag ctggggtcgg
6001 tcatgattgg cacatggacc accaatgaca ttgaaaacca accctccaga ttcgctccaa
6061 ttggcttaaa tgatgatgac aattacaacc agtggcaatt gccaaactac tccggggcac
6121 tcactctcaa catggggttg gcctcgtctg ttttccctac ttaccctggt gaacagcttc
6181 ttttcttccg ctcatacatc ccaatgaagg ggggatatgg cagcccattc atcgactgcc
6241 ttatacccca agagtgggtc tcccatttct atcaagaatc agcaccctca cagacagatg
6301 tggctctgat caggtatgtc aaccccgaca caggacgcgt cctgttcgag gccaaattgc
6361 acagacaagg atacatcacc gtcgccaaga ccggtgacag ccccatcaat gtacctgcta
6421 atggttattt cagatttgat tcttgggtta atcagtttta ctctctcgcc cccatgggaa
6481 ctgggaatgg gcgcagaagg attcaataat ggcaggagct tttatagcag gattggctgg
6541 tgacatgtta acaaatactg tagggtcttt agttaatgca ggggctaatg ctattaatca
6601 gaaagttgat tttgagaata ataaatattt gcaaaatgca tcattttccc atgataagga
6661 gatgttacaa gcacaagttg aggccacaag aaaactgcag gccgaaatga ttgccatcaa
6721 acaaggggtt ttgaccgcag gcggcttttc cccttctgat gcggcccgtg gggcaattaa
6781 cgcccctatg acaaaagtct tagattggaa tgggacaaga tactgggccc ccaacgccac
6841 ctctacaacc tctatgtcag gtggcttcac gggtcaaacc gtgcacaggc ccacaccaaa
6901 tttcaaaaca aaccaggcgc ccaaatctat acccagtagt ggatcctcag taaggtcaaa
6961 cacgacccaa ctttctagtc tgagttcaca ttcctctggg tcttcccgat ccagcgggtc
7021 cacaactgtc agctccctac catcatccag taggactagg gactgggttg atcagcaaaa
7081 tctcaatttg gaaccacata tgcctggatc cctcagaaca gcttttgtca ctccaccatc
7141 tagcagggcc tccagtccag gcacagtctc aaccgtgccc aaaggtgttt tggactcctg
7201 gacacctgcg tttaacacac gcagacagcc gctgtttgca caccttcgga gaagggggga
7261 gtcaaatgtt tagtgaaaag attagtttaa atttgattta atttggattt aaag
//