Typing tool
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Typing tool
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Complete norovirus genomes
| MK733203 | GII.27 | |
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| GII.PNA9 |
ORF1: 1..4896
ORF2: 4877..6508
ORF3: 6508..7272
LOCUS MK733203 7302 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GII isolate Arg15482 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MK733203
VERSION MK733203.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7302)
AUTHORS Tohma,K., Lepore,C.J., Degiuseppe,J.I., Stupka,J.A., Saito,M.,
Mayta,H., Zimic,M., Ford-Siltz,L.A., Gilman,R.H. and Parra,G.I.
TITLE Recombinant Nontypeable Genotype II Human Noroviruses in the
Americas
JOURNAL Emerging Infect. Dis. 26 (1), 157-159 (2020)
PUBMED 31855537
REFERENCE 2 (bases 1 to 7302)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 7302)
AUTHORS Tohma,K., Lepore,C.J., Degiuseppe,J.I., Stupka,J.A., Saito,M.,
Mayta,H., Zimic,M., Ford-Siltz,L.A., Gilman,R.H. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (01-APR-2019) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2.3.1
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7302
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Arg15482"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Argentina"
/collection_date="01-Aug-2017"
/note="genotype: GII"
gene <1..4896
/gene="ORF1"
CDS <1..4896
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="QBR98798.1"
/translation="TIPPIPPPPPNGEDIVVTYTKQDDKISGVPTVSTVENSPLHDTA
YSVPPLDQREKVDAKEPLTGSILEMWDGEIYHYGLYVERGLVLGVHKPPSALSMARIE
LTPLSLYWRVVYTPPYLVAPDTLRKLHGESFPYTAFDNNCYMFCCWVLDLNDSWLNRK
FVSRTTGFYRPYQDWNRKPLPTMDEGKLKKVANVLLCGLSSLFTRPIKDLISRLKPLN
ILNIVSNCDWTFPGVVEALILLVELFGIFWTPPDISAFVASLLGDYEMQGPEDIATEI
VPVVLGGIGMVLGFTKEKIGRLLSSAASSLRACREIGNYGIEVVKLIMKWFFPTKNEV
NEMEMVRAIEDAVLDFEAIENNHMTALLKDKNSLATFLRALDMEEEKARKLSTKSASP
DIVGTINAILARIAAARSLVHRAKEEMSSRMRPVVIMISGRPGIGKTHLARDLAKRMA
STLSGDQRVGLVPRNGVDHWDAYKGERIVLWDDYGMSNPVADALRLQELADTCPLTLN
CDRIENKGKVFDSDTIIITTNLSNPAPLDYVNFEACSRRIDFLVYADSPSVDKAKKDF
PGQPDMWKDAFKPDFSHIKLQLAPQGGFDKNGNTPHGKGVMKTLTTHSLIARATGLLH
ERLDEFDLQGTELPMYNFDQNKVAAFRRLAADNKYGLMETLKAGNKLKEVKTLEHFKE
AVKDIRIKPCRIIYNSTAYELESSGTGRVIVKKMGDQKVQANNELYSALNNLRRARIR
YYIKCFQEMIYTLLQIAGAAFVTSRMTQRMNIGRLWAKPEKQVETSVEPPPPPIEDWT
ISPTDTVQEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERQGKYSIEEYLQD
RDRYYEELAIAQATEENFCEEEEIKIRQRIFRPTRKQRREERANLGLVTGSEIRKRNP
DDFKPRGKLWADDDRSVNYNEKIDFEAPPSLWSRIVNFGSGWGFWVSSNLFITSTHVV
PPNITEAFGVSISQIQVHRSGEFCKMRFPKAIRPDVSGMILEEGAPEGTVVTILIKRT
TGELMPLASRMGTHATMKIQGRMIGGQMGMLLTGSNAKNMDLGTIPGDCGCPYVYKRG
NEWVVIGVHTAAARGGNTVICATQGPEGEATLEGGDNHGTYCGAPILGPGNAPKLSTK
TKFWRSSNAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMREQLKPFTAPRGKPPRPAIL
EAAKETICNVLEQTIEPPQKWSYAQACASLDKTTSSGYPHHKKKNDNWNGESFTGVLA
DQASKANLMFEQGKHMQPVYTAALKDELVKTSKIYDKIKKRLLWGSDLGTMIRCARSF
GGLMDEMKANCVRLPIRVGMNMNEDGPIIFEKHSRYRYHYDADYSRWDSTQQRHVLGL
ALEIMVRFSAEPELAQIVAEDLLSPSVVDVGDFKITINEGLPSGVPCTSQWNSIAHWL
LTLCAMSEVSGLSPDVVQSNSCFSFYGDDEIVSTDIKLDPQKLTDKLKEYGLIPTRPD
KTEGPLIIKESLEGLTFLRRNICRDPVGWYGQLDQSSIMRQLYWTKGPNHEDPNETMI
PHSQRPVQLMSLLGEASLHGPAFYKKVSKLVITELREGGMDFYVPRQEPMFRWMRFSD
LSTWEGDRNLAPEGVNEDGVE"
mat_peptide <1..801
/gene="ORF1"
/product="p48"
mat_peptide 802..1899
/gene="ORF1"
/product="NTPase"
mat_peptide 1900..2424
/gene="ORF1"
/product="p22"
mat_peptide 2425..2820
/gene="ORF1"
/product="VPg"
mat_peptide 2821..3363
/gene="ORF1"
/product="Pro"
mat_peptide 3364..4893
/gene="ORF1"
/product="RdRp"
gene 4877..6508
/gene="ORF2"
CDS 4877..6508
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QBR98796.1"
/translation="MKMASNDAAPSNDGAAGLVPEINNETMALEPVAGGAIAAPLTGQ
TNFIDPWIRNNYVQAPNGEFTVSPRNSPGEILLNLELGPELNPFLAHLSRMYNGFAGG
IEVQVIMAGNAFTAGKIIFAAVPPNFPTENLSPPQITMFPHVIIDVRTLEPVNIPLPD
VRNNFFHYNQNNEPRMRLLAMLYTPLRSNGSAEDVFTVSCRVLTKPSPDFEFNYLVPP
TVESRTKPFTIPILTIGEMTNSRFPVAIDFLHTSPTENIVVQPQNGRCTLDGELQGTT
QLVTSNICAFRGSISGHENTGDNHQWHFNVTNPNGTPFDPTEDVPAPLGTPDFTGQLY
GVISQRNREGNPGDNNQKANRSHEGVISTLAPRFTPKLGSVMIGTWTTNDIENQPSRF
APIGLNDDDNYNQWQLPNYSGALTLNMGLASSVFPTYPGEQLLFFRSYIPMKGGYGSP
FIDCLIPQEWVSHFYQESAPSQTDVALIRYVNPDTGRVLFEAKLHRQGYITVAKTGDS
PINVPANGYFRFDSWVNQFYSLAPMGTGNGRRRIQ"
gene 6508..7272
/gene="ORF3"
CDS 6508..7272
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QBR98797.1"
/translation="MAGAFIAGLAGDMLTNTVGSLVNAGANAINQKVDFENNKYLQNA
SFAHDKEMLQAQVEATKKLQAEMIAIKQGVLTAGGFSPSDAARGAINAPMTKVLDWNG
TRYWAPNATSTTSMSGGFTGQTVHRPTPNFKTNQAPKSIPSSGSSVRSNTTQLSSLSS
HSSGSSRSSGSTTVSSLPSSSRTRDWVNQQNLNLEPHMPGSLRTAFVTPPSSRASSSG
TVSTVPKGVLDSWTSAFNTRRQPLFAHLRRRGESNV"
ORIGIN
1 accatccccc caatacctcc cccaccacct aatggggagg acattgtcgt cacgtacaca
61 aaacaagacg acaaaatcag tggagttccc accgtctcca ccgttgaaaa ctctcccttg
121 catgacaccg catacagtgt tccacccttg gaccaaaggg aaaaagttga tgcaaaggag
181 cccctgacgg gttcaatact cgaaatgtgg gatggtgaga tttaccacta tgggctttat
241 gtggaaaggg gtctggtcct cggcgtgcac aagccaccat ctgctctgag catggcacgc
301 attgagttaa cccccctttc cctctattgg agggtggtgt ataccccgcc ctaccttgtt
361 gccccagaca ccctcaggaa actccatggg gaatccttcc cctacacagc atttgacaat
421 aactgttaca tgttctgctg ttgggtcctg gatcttaacg attcgtggct caacaggaag
481 ttcgtgtcaa ggactacagg attctacaga ccctaccagg actggaacag gaagcccctg
541 cccaccatgg atgaaggcaa actcaagaag gtagccaatg tgttactgtg tggtctatcc
601 agcctcttca ccaggcccat taaagacctc ataagtaggc tgaaaccact aaacattctc
661 aacattgtat ccaattgtga ttggacattc cccggtgttg tagaggccct tatcctgctt
721 gtagaactct ttggtatctt ctggactcca ccagacatat ctgctttcgt cgcttccctg
781 ttgggagact acgaaatgca gggtcctgag gacattgcaa ccgagatcgt gccagtcgtc
841 cttggtggca ttggtatggt ccttggtttc accaaggaga agattggccg actactcagc
901 tcggctgcgt catcactccg ggcgtgtagg gagattggca actacgggat agaggtggtc
961 aaattaataa tgaaatggtt cttccccacc aaaaatgaag tgaacgagat ggaaatggtc
1021 agggcgatag aggatgcagt gcttgacttt gaggcaatag aaaacaatca catgacagct
1081 ctactcaagg acaagaatag tttggccacc tttcttagag ccctagacat ggaggaggag
1141 aaggcgcgaa aactgtcaac caaatccgca tctccagaca tagtcggcac cataaatgcc
1201 attctagcca ggatagctgc tgctaggtcc ctagtccaca gagccaagga agaaatgtca
1261 tctaggatgc gtcctgttgt catcatgatt tcgggccgac ctggaatagg gaagacacat
1321 ctagcccggg acttagccaa gaggatggcg tccacactct cgggagacca gagagtgggc
1381 cttgtaccaa gaaacggcgt cgaccactgg gatgcctaca aaggtgagag aatcgtcctt
1441 tgggatgatt atggcatgag taaccccgtg gcggacgccc tgcgcctcca ggagcttgcc
1501 gacacctgcc ctctgacact caactgtgat aggatagaga acaaggggaa ggtgtttgac
1561 agtgacacca taattataac caccaacttg tcaaaccccg ccccacttga ctatgtgaac
1621 tttgaggcct gttcacgccg cattgacttc cttgtttatg cggactctcc ttcagttgac
1681 aaggcaaaga aagacttccc cggccaacca gacatgtgga aagatgcatt caaacctgac
1741 ttctcgcaca taaaattaca attggcaccg cagggaggat tcgacaagaa cgggaacacc
1801 ccacatggca agggagtgat gaagaccctg accacgcatt ccctcatagc cagggccacc
1861 ggcttgctgc atgaaagatt ggatgaattc gatttacagg ggacagagct accaatgtac
1921 aactttgacc aaaacaaagt ggccgcattc aggaggctag cggccgacaa caagtacggc
1981 ctaatggaaa ccttaaaggc gggcaacaag ttgaaggagg tcaagaccct agaacacttc
2041 aaggaggctg tcaaggacat ccgcataaaa ccatgcagga taatctacaa ttccaccgct
2101 tacgaattgg agtcaagcgg gactgggaga gtcatcgtca agaaaatggg tgaccagaag
2161 gtgcaggcca ataatgaact ctactctgcc ctcaacaatc tgcgcagagc taggatcagg
2221 tactacatca agtgtttcca ggagatgatc tacacactcc tccaaatcgc tggtgcggct
2281 tttgtaacat caagaatgac acagaggatg aacattggca gactgtgggc caaaccggaa
2341 aagcaagtgg aaacctctgt agagcccccc ccccctccta ttgaagactg gaccataagc
2401 ccaactgaca cagtccagga aggcaagaag ggcaaaaaca agagcggtag aggcaagaag
2461 catactgcct tctctagtaa aggtctcagt gatgaagagt acgacgagta caaaaggatc
2521 agagaggagc gccaggggaa atactctata gaggagtatc tccaggacag agaccggtac
2581 tatgaagaat tggccatagc ccaagcaaca gaagaaaatt tctgtgagga ggaagagatc
2641 aaaataagac aaaggatttt caggccaacc aggaaacaac gcagagaaga gagggccaat
2701 ctgggcctgg tcacagggag tgaaattagg aagaggaacc ctgacgactt caagccaaga
2761 ggaaagctgt gggccgatga tgaccgcagt gtcaactaca atgagaaaat agactttgag
2821 gcccctccca gtctgtggtc cagaatagtc aactttggct cggggtgggg tttctgggtc
2881 tcgtccaacc tgttcatcac atcaacgcat gttgtgccac caaacatcac ggaagctttt
2941 ggggtctcaa taagccaaat ccaagtccac aggagcggag agttctgcaa aatgaggttc
3001 cccaaggcca tcaggcctga tgtttctggg atgattcttg aagaaggtgc gccagagggg
3061 acggttgtaa ccatactgat caaaaggaca accggtgagc tcatgccatt agcatcccgc
3121 atgggcaccc atgccaccat gaaaatacag ggaagaatga ttggtggcca aatgggaatg
3181 ctcctcacag ggtccaacgc caaaaacatg gaccttggca ccatcccagg ggactgtggc
3241 tgcccctatg tctacaagag gggcaatgag tgggttgtga tcggggtaca caccgctgcg
3301 gccagagggg gcaacacggt gatatgtgca acacaagggc ccgaaggtga ggccacactt
3361 gaaggaggag acaaccatgg aacctactgt ggtgcaccaa tcttgggacc aggaaatgca
3421 ccaaaactca gcaccaaaac caaattttgg agatcctcca atgccccact tccccctggc
3481 acgtatgagc ctgcctacct cggtgggaag gatcctagag tcaagggtgg cccatcacta
3541 cagcaagtca tgagagaaca actcaagcca ttcactgccc cgcgcgggaa gccacctagg
3601 ccggcaatct tggaagctgc aaaggagact atctgcaacg tgctcgagca aaccatcgaa
3661 ccacctcaaa aatggtctta cgcgcaagcc tgcgcctccc tggacaagac cacgtcaagt
3721 ggctaccccc atcataagaa aaagaatgac aactggaatg gtgaatcttt tactggtgtt
3781 ttggccgatc aggcatcaaa agcaaacctc atgtttgaac agggaaaaca catgcaaccc
3841 gtgtacacag ctgcactcaa ggatgagctt gtaaagacta gtaagatata tgataagatc
3901 aagaagaggc tcttgtgggg ctctgacctg ggcacgatga ttcgctgcgc aaggtcgttt
3961 gggggcctga tggatgagat gaaagctaac tgtgtgagat tgcctatcag agttgggatg
4021 aacatgaatg aggatggacc cataatcttt gagaaacatt caagatacag gtaccattat
4081 gatgctgact actccaggtg ggactcgacc cagcaaaggc acgtgttggg tcttgcactt
4141 gaaatcatgg ttaggttttc agccgaacct gaattggcac aaatagtggc tgaggacctt
4201 ttgtcaccca gtgtcgtgga cgttggtgac ttcaaaatta caataaacga gggattgccc
4261 tctggtgttc catgcacatc acaatggaac tcaattgccc actggctgtt aacattgtgt
4321 gccatgtcgg aggtctcagg actctcgcca gatgtggtgc agtcaaattc gtgcttctcc
4381 ttctatggag acgacgagat agtcagcaca gacataaaat tggacccaca aaaactgaca
4441 gacaagctga aagaatatgg actgatccca acccggcccg acaagacaga ggggccactc
4501 ataatcaaag agagcttaga aggcctgaca tttctaagaa gaaacatatg cagggacccg
4561 gttggatggt atggccaact tgaccagtca tcaatcatga ggcagttgta ttggacaaaa
4621 ggacccaacc atgaagaccc caacgaaaca atgatcccac actcccaaag accagtgcag
4681 ttaatgtctc tccttggtga agcttcccta cacggccctg ctttttacaa gaaagttagc
4741 aaattggtca tcactgaatt gagggaaggg gggatggatt tctatgtgcc cagacaagaa
4801 ccaatgttca gatggatgag attctctgac ttgagcacgt gggagggcga tcgcaatctt
4861 gctcccgaag gtgtgaatga agatggcgtc gaatgacgcc gctccatcta atgatggtgc
4921 agccggtctc gtaccagaga tcaacaacga gacaatggct ttggaaccag tagctggagg
4981 agcaatcgct gcccctctaa ctggacaaac aaattttatt gatccctgga ttagaaataa
5041 ttatgtgcag gcacctaatg gtgaatttac agtttctccc agaaattccc ctggtgaaat
5101 tttgctcaac ttggaattgg gtcccgagct caaccctttc ttggcccatt tgtctaggat
5161 gtataatggt tttgctggcg gcattgaggt tcaggtcatc atggcgggca acgccttcac
5221 cgctggtaag atcatctttg cagcagtgcc tcccaatttt cccacagaaa atcttagccc
5281 tccacaaatc accatgtttc cccacgtcat aatagatgtg agaaccctcg agcctgtcaa
5341 cattcccttg cctgatgtta gaaacaattt cttccattat aaccaaaata atgagccccg
5401 catgagattg ttagcaatgt tgtatacccc actcagatca aatggttctg cagaagatgt
5461 tttcactgtg tcgtgtaggg tcctcaccaa accctcacca gattttgaat tcaactactt
5521 ggtcccccca actgtcgagt ctaggacaaa gcccttcacc ataccaatac tcacaattgg
5581 agagatgaca aattcaagat tccctgtggc cattgatttc ctgcacacca gccccactga
5641 gaacatcgtt gttcagccgc aaaacggcag gtgcacgctg gatggtgaac tgcagggcac
5701 cactcaattg gtcacttcta acatctgtgc cttcagaggg tccatctcag gacatgagaa
5761 tacaggagat aaccaccaat ggcattttaa tgtcaccaac cccaatggca ctccgtttga
5821 ccccacagag gatgtgcctg ctccacttgg aaccccagat ttcacaggcc agctctatgg
5881 agtcatttct caacggaaca gggaggggaa tcctggtgat aacaaccaga aggccaacag
5941 gtcccatgag ggagtgatct caacactcgc accaagattt acaccaaagc tggggtcggt
6001 catgattggc acatggacca ccaatgacat tgaaaaccaa ccctccagat tcgctccaat
6061 tggcttaaat gatgatgaca attataacca gtggcaattg ccaaactact ccggggcact
6121 cactctcaac atggggttgg cctcgtctgt tttccctact taccctggtg aacagcttct
6181 tttcttccgc tcatatatcc caatgaaggg gggatatggt agcccattca tcgactgcct
6241 tataccccaa gagtgggtct cccatttcta tcaagaatca gcaccctcac agacagatgt
6301 ggctctgatc aggtatgtca accccgacac aggacgcgtc ctgttcgagg ccaaattgca
6361 cagacaagga tacatcaccg tcgccaagac cggtgacagc cccatcaatg tacctgctaa
6421 tggttatttc agatttgatt cttgggttaa tcagttttac tctctcgccc ccatgggaac
6481 tgggaatggg cgcagaagga ttcaataatg gcaggagctt ttatagcagg attggctggt
6541 gatatgttaa caaacactgt agggtcttta gttaatgcag gggctaatgc tattaatcag
6601 aaagttgatt ttgagaataa taaatatttg caaaatgcat catttgccca tgataaggag
6661 atgttacaag cacaagttga ggccacaaag aaactgcagg ccgaaatgat tgccatcaaa
6721 caaggggttt tgaccgcagg cggcttttcc ccttctgatg cggcccgtgg ggcaattaac
6781 gcccctatga caaaagtctt agattggaat gggacaagat actgggcccc caacgccacc
6841 tctacaacct ctatgtcagg tggcttcacg ggtcaaaccg tgcacaggcc cacaccaaat
6901 ttcaaaacaa accaggcacc caaatctata cccagtagtg gatcctcagt aaggtcaaac
6961 acgacccaac tttctagtct gagttcacat tcctctgggt cttcccgatc cagcgggtcc
7021 acaactgtca gctccctacc atcatccagt aggactaggg actgggttaa tcagcaaaat
7081 ctcaatttgg aaccacatat gcctggatcc ctcagaacag cttttgtcac tccaccatct
7141 agcagggcct ccagttcagg cacagtctca accgtgccca aaggtgtttt ggactcctgg
7201 acatctgcgt ttaacacacg cagacagccg ctgtttgcac accttcggag aaggggggag
7261 tcaaatgttt agtgaaaaga ttagtttaaa tttgatttaa tt
//