Typing tool
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Typing tool
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Complete norovirus genomes
| MK733202 | GII.27 | |
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| GII.PNA9 |
ORF1: 1..4903
ORF2: 4884..6515
ORF3: 6515..7279
LOCUS MK733202 7314 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GII isolate Arg15465 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MK733202
VERSION MK733202.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7314)
AUTHORS Tohma,K., Lepore,C.J., Degiuseppe,J.I., Stupka,J.A., Saito,M.,
Mayta,H., Zimic,M., Ford-Siltz,L.A., Gilman,R.H. and Parra,G.I.
TITLE Recombinant Nontypeable Genotype II Human Noroviruses in the
Americas
JOURNAL Emerging Infect. Dis. 26 (1), 157-159 (2020)
PUBMED 31855537
REFERENCE 2 (bases 1 to 7314)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 7314)
AUTHORS Tohma,K., Lepore,C.J., Degiuseppe,J.I., Stupka,J.A., Saito,M.,
Mayta,H., Zimic,M., Ford-Siltz,L.A., Gilman,R.H. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (01-APR-2019) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2.3.1
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7314
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Arg15465"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Argentina"
/collection_date="04-Jul-2017"
/note="genotype: GII"
gene <1..4903
/gene="ORF1"
CDS <1..4903
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QBR98795.1"
/translation="KTTIPPIPPPPPNGEDIVVTYTKQDDKISGVPTVFTVENSPLHD
TAYSVPPLDQREKVDAKEPLTGSILEMWDGEIYHYGLYVERGLVLGVHKPPSALSMAR
IELTPLSLYWRVVYTPPYLVAPDTLRKLHGESFPYTAFDNNCYMFCCWVLDLNDSWLN
RKFVSRTTGFYRPYQDWNRKPLPTMDEGKLKKVANVLLCGLSSLFTRPIKDLISRLKP
LNILNIVSNCDWTFPGVVEALILLAELFGIFWTPPDISAFVASLLGDYEMQGPEDIAT
EIVPVVLGGIGMVLGFTKEKIGRLLSSAASSLRACREIGNYGIEVVKLIMKWFFPTKN
EVNEMEMVRAIEDAVLDFEAIENNHMTALLKDKNNLATFLRALDMEEEKARKLSTKSA
SPDIVGTINAILARIAAARSLVHRAKEEMSSRMRPVVIMISGRPGIGKTHLARDLAKR
MASTLSGDQRVGLVPRNGVDHWDAYKGERIVLWDDYGMSNPVADALRLQELADTCPLT
LNCDRIENKGKVFDSDTIIITTNLSNPAPLDYVNFEACSRRIDFLVYADSPSVDKAKK
DFPGQPDMWKDAFKPDFSHIKLQLAPQGGFDKNGNTPHGKGVMKTLTTHSLIARATGL
LHERLDEFDLQGTELPMYNFDQNKVAAFRRLAADNKYGLMETLKAGNKLKEVKTLEHF
KEAVKDIRIKPCRIIYSSTAYELESSGTGRVIVKKVGDQKVQANNELYSALNNLRRAR
IRYYIKCFQEMIYTLLQIAGAAFVTSRMTQRMNIGRLWAKPEKQVETSVEPPPPPIED
WTISPTDTVQEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERQGKYSIEEYL
QDRDRYYEELAIAQATEENFCEEEEIKIRQRIFRPTRKQRREERANLGLVTGSEIRKR
NPDDFKPRGKLWADDDRSVNYNEKIDFEAPPSLWSRIVNFGSGWGFWVSSNLFITSTH
VVPPNITEAFGVPISQIQVHRSGEFCKMRFPKAIRPDVSGMILEEGAPEGTVVTILIK
RTTGELMPLASRMGTHATMKIQGRMIGGQMGMLLTGSNAKNMDLGTIPGDCGCPYVYK
RGNEWVVIGVHTAAARGGNTVICATQGPEGEATLEGGDNHGTYCGAPILGPGNAPKLS
TKTKFWRSSNAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMREQLKPFTAPRGKPPRPA
ILEAAKETICNVLEQTIEPPQKWSYAQACASLDKTTSSGYPHHKKKNDNWNGESFTGV
LADQASKANLMFEQGKHMQPVYTAALKDELVKTSKIYDKIKKRLLWGSDLGTMIRCAR
SFGGLMDEMKANCVRLPIRVGMNMNEDGPIIFEKHSRYRYHYDADYSRWDSTQQRHVL
GLALEIMVRFSAEPELAQIVAEDLLSPSVVDVGDFKITINEGLPSGVPCTSQWNSIAH
WLLTLCAMSEVSGLSPDVVQSNSCFSFYGDDEIVSTDIKLDPQKLTDKLKEYGLIPTR
PDKTEGPLIIKESLEGLTFLRRNICRDPVGWYGQLDQSSIMRQLYWTKGPNHEDPNET
MIPHSQRPVQLMSLLGEASLHGPAFYKKVSKLVITELREGGMDFYVPRQEPMFRWMRF
SDLSTWEGDRNLAPEGVNEDGVE"
mat_peptide <1..808
/gene="ORF1"
/product="p48"
mat_peptide 809..1906
/gene="ORF1"
/product="NTPase"
mat_peptide 1907..2431
/gene="ORF1"
/product="p22"
mat_peptide 2432..2827
/gene="ORF1"
/product="VPg"
mat_peptide 2828..3370
/gene="ORF1"
/product="Pro"
mat_peptide 3371..4900
/gene="ORF1"
/product="RdRp"
gene 4884..6515
/gene="ORF2"
CDS 4884..6515
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QBR98793.1"
/translation="MKMASNDAAPSNDGAAGLVPEINNETMALEPVAGGAIAAPLTGQ
TNFIDPWIRNNYVQAPNGEFTVSPRNSPGEILLNLELGPELNPFLAHLSRMYNGFAGG
IEVQVIMAGNAFTAGKIIFAAVPPNFPTENLSPPQITMFPHVIIDVRTLEPVNIPLPD
VRNNFFHYSQNNEPRMRLLAMLYTPLRSNGSAEDVFTVSCRVLTKPSPDFEFNYLVPP
TVESRTKPFTIPILTIGEMTNSRFPVAIDFLHTSPTENIVVQPQNGRCTLDGELLGTT
QLVTSNICAFRGSISGHENTGDNHQWHFNITNPNGTPFDPTEDVPAPLGTPDFTGQLY
GVISQRNREGTPGENNQKANRSHEGVISTLAPRFTPKLGSVMIGTWTTNDIENQPSRF
APIGLNDDDNYNQWQLPNYSGALTLNMGLASSVFPTYPGEQLLFFRSYIPMKGGYGSP
FIDCLIPQEWVSHFYQESAPSQTDVALIRYVNPDTGRVLFEAKLHRQGYITVAKTGDS
PINVPANGYFRFDSWVNQFYSLAPMGTGNGRRRIQ"
gene 6515..7279
/gene="ORF3"
CDS 6515..7279
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QBR98794.1"
/translation="MAGAFIAGLAGDMLTNTVGSLVNAGANAINQKVDFENNKYLQNA
SFAHDKEMLQAQVEATKKLQAEMIAIKQGVLTAGGFSPSDAARGAINAPMTKVLDWNG
TRYWAPNATSTTSMSGGFTGQTVHRPTPNFKTNQAPKSIPSSGSSVRSNTTQLSSLSS
HSSGSSRSSGSTTVSSLPSSSRTRDWVNQQNLNLEPHMPGSLRTAFVTPPSSRASSSG
TVSTVPKGVLDSWTSAFNTRRQPLFAHLRRRGESNV"
ORIGIN
1 caaaaccacc atccccccaa tacctccccc accacctaat ggggaggaca ttgtcgtcac
61 gtacacaaaa caagacgaca aaatcagtgg agttcccacc gtcttcaccg ttgaaaactc
121 tcccttgcat gacaccgcat acagtgttcc acccttggac caaagggaaa aggttgatgc
181 aaaggagccc ctgacgggtt caatactcga aatgtgggat ggtgagattt accactatgg
241 gctttatgtg gaaaggggtc tggtcctcgg cgtgcacaag ccaccatctg ctctgagcat
301 ggcacgcatt gagttgaccc ccctttccct ctattggagg gtggtgtata ccccgcccta
361 ccttgttgcc ccagacaccc tcaggaaact ccatggggaa tccttcccct acacagcatt
421 tgacaacaac tgttacatgt tctgctgttg ggtcctggat cttaacgatt cgtggctcaa
481 caggaagttc gtgtcaagga ctacaggatt ctacagaccc taccaggact ggaacaggaa
541 gcccctgccc accatggatg aaggcaaact caagaaggta gccaatgtgc tactgtgtgg
601 tctatccagc ctcttcacca ggcccattaa agacctcata agtaggctga aaccactaaa
661 cattctcaac attgtatcta attgtgattg gacattcccc ggtgttgtag aggctcttat
721 cctgcttgca gaactctttg gtatcttctg gactccacca gacatatctg ctttcgtcgc
781 ttccctgttg ggagactacg aaatgcaggg tcctgaggac attgcaaccg agatcgtgcc
841 agtcgttctt ggtggcattg gtatggtcct tggtttcacc aaggagaaga ttggccgact
901 actcagctcg gctgcgtcat cactccgggc gtgtagggag attggcaact acgggataga
961 ggtggtcaaa ttaataatga aatggttctt ccccaccaaa aatgaagtga acgagatgga
1021 aatggtcagg gcgatagagg atgcagtgct tgactttgag gcaatagaaa acaatcacat
1081 gacagctcta ctcaaggaca agaataattt ggccaccttt cttagagccc tagacatgga
1141 ggaggagaag gcgcgaaaac tgtcaaccaa atccgcatct ccagacatag tcggcaccat
1201 aaatgccatt ctagccagga tagctgctgc taggtcccta gtccacagag ccaaggaaga
1261 aatgtcatcc aggatgcgtc ctgttgtcat catgatttcg ggccgacctg gaatagggaa
1321 gacacatcta gcccgggact tagccaagag gatggcgtcc acactctcgg gagaccagag
1381 agtgggcctt gtaccaagaa acggcgtcga ccactgggat gcctacaaag gtgagagaat
1441 cgtcctttgg gatgattatg gcatgagtaa ccccgtggcg gacgccctgc gcctccagga
1501 gcttgccgac acctgccctc tgacactcaa ctgtgatagg atagagaaca aggggaaggt
1561 gtttgacagt gacaccataa tcataaccac caacttgtca aaccccgccc cacttgacta
1621 tgtgaacttt gaggcctgtt cacgccgcat tgacttcctt gtttatgcgg actctccttc
1681 agttgacaag gcaaagaaag acttccccgg ccaaccagac atgtggaaag atgcattcaa
1741 acctgacttc tcgcacataa aattacaatt ggcaccgcag ggaggattcg acaagaacgg
1801 gaacacccca catggcaagg gagtgatgaa gaccctgacc acgcactccc tcatagccag
1861 ggccaccggc ttgctgcatg aaagattgga tgaattcgat ttacagggga cagagctacc
1921 aatgtacaac tttgaccaaa acaaagtggc cgcattcagg aggctagcgg ccgacaacaa
1981 gtacggccta atggaaacct taaaggcggg caacaagttg aaggaggtca agaccctaga
2041 acacttcaag gaggctgtca aggacatccg cataaaacca tgcaggataa tctacagttc
2101 caccgcttac gaattggagt caagcgggac tgggagagtc atcgtcaaga aagtgggtga
2161 ccagaaggtg caggccaata atgaactcta ctctgccctc aacaatctgc gcagagctag
2221 gatcaggtac tacatcaagt gtttccagga gatgatctac acactcctcc aaatcgctgg
2281 tgcggctttt gtaacatcaa gaatgacaca gaggatgaac attggcagac tgtgggccaa
2341 accggaaaag caagtggaaa cctctgtaga gccccccccc cctcctattg aagactggac
2401 cataagccca actgacacag tccaggaagg caagaagggc aaaaacaaga gcggtagagg
2461 caagaaacat accgccttct ctagtaaagg tctcagtgat gaagagtacg acgagtacaa
2521 aaggatcaga gaggagcgcc aggggaaata ctctatagag gagtatctcc aggacagaga
2581 ccggtactat gaagaattgg ccatagccca agcaacagaa gaaaatttct gtgaggagga
2641 agagatcaaa ataagacaaa ggattttcag gccaaccagg aaacaacgca gagaggagag
2701 ggccaatctg ggcctggtca cagggagtga aattaggaag aggaaccctg acgacttcaa
2761 gccaagagga aagctgtggg ccgatgatga ccgcagtgtc aactacaatg agaaaataga
2821 ctttgaggcc cctcccagtc tgtggtccag aatagtcaac tttggctcgg ggtggggttt
2881 ctgggtctcg tccaacctgt tcatcacatc aacgcatgtt gtgccaccaa acatcacgga
2941 agcttttggg gtcccaataa gccaaatcca agtccacagg agcggagagt tctgcaaaat
3001 gaggttcccc aaggccatca ggcctgatgt ttctgggatg attcttgaag aaggtgcgcc
3061 agaggggacg gttgtgacca tactgatcaa aaggacaacc ggtgagctca tgccattagc
3121 atcccgcatg ggcacccatg ccaccatgaa aatacaggga agaatgattg gtggccaaat
3181 gggaatgctc ctcacagggt ccaacgccaa aaacatggac cttggcacca ttccagggga
3241 ctgtggctgc ccctatgtct acaagagggg caatgagtgg gttgtgatcg gggtacacac
3301 cgctgcggcc agagggggca acacggtgat atgtgcaaca caagggcccg aaggtgaggc
3361 cacacttgaa ggaggagaca accatggaac ctactgtggt gcaccaatct tgggaccagg
3421 aaatgcacca aaactcagca ccaaaaccaa gttttggaga tcctccaatg ccccacttcc
3481 ccctggcacg tatgagcctg cctacctcgg tgggaaggat cctagagtca agggtggccc
3541 atcactacag caagtcatga gagaacaact caagccattc actgccccgc gcgggaagcc
3601 acctaggccg gcaatcttgg aagctgcaaa ggagaccatc tgcaacgtgc tcgagcaaac
3661 catcgaacca cctcaaaaat ggtcttacgc gcaagcctgc gcctccctgg acaagaccac
3721 gtcaagtggc tacccccatc ataagaaaaa gaatgacaac tggaatggtg aatcttttac
3781 tggtgttttg gccgatcagg catcaaaagc aaacctcatg tttgaacagg gaaaacacat
3841 gcaacccgtg tacacagctg cactcaagga tgagcttgta aagactagta agatatatga
3901 taagatcaag aagaggctct tgtggggctc tgacctgggc acgatgattc gctgcgcaag
3961 gtcgtttggg ggcctgatgg atgagatgaa agctaactgt gtgagattgc ctatcagagt
4021 tgggatgaac atgaatgagg atggacccat aatctttgag aaacattcaa gatacaggta
4081 ccattatgat gctgactact ccaggtggga ctcgacccag caaaggcacg tgttgggtct
4141 tgcacttgaa atcatggtta ggttttcagc cgaacctgaa ttggcacaaa tagtggctga
4201 ggaccttttg tcacccagtg tcgtggacgt tggtgacttc aaaattacaa taaacgaggg
4261 attgccctct ggtgttccat gcacatcaca atggaactca attgcccact ggctgttaac
4321 attgtgtgcc atgtcggagg tctcaggact ctcgccagat gtggtgcagt caaattcgtg
4381 cttctccttc tatggagacg acgagatagt cagcacagac ataaaattgg acccacaaaa
4441 actgacagac aagctgaaag aatatggact gatcccaacc cggcccgaca agacagaggg
4501 gccactcata atcaaagaga gcttagaagg cctgacattt ctaagaagaa acatatgcag
4561 ggacccggtt ggatggtatg gtcaacttga ccagtcatca atcatgaggc agttgtattg
4621 gacaaaagga cccaaccatg aagaccccaa cgaaacaatg atcccacact cccaaagacc
4681 agtgcagtta atgtctctcc ttggtgaagc ttccctacac ggccctgctt tttacaagaa
4741 agttagcaaa ttggtcataa ctgaattgag ggaagggggg atggatttct atgtgcccag
4801 acaagaacca atgttcagat ggatgagatt ctctgacttg agcacgtggg agggcgatcg
4861 caatcttgct cccgaaggtg tgaatgaaga tggcgtcgaa tgacgccgct ccatctaatg
4921 atggtgcagc cggtctcgta ccagagatca acaacgagac aatggctttg gaaccagtag
4981 ctggaggagc aatcgctgcc cctctaactg gacaaacaaa tttcattgat ccctggatta
5041 gaaataatta tgtgcaggca cctaatggtg aatttacagt ttctcccaga aattcccctg
5101 gtgaaatttt gctcaatttg gaattgggtc ccgagctcaa ccctttcttg gcccatttgt
5161 ctaggatgta taatggtttt gctggcggca ttgaggttca ggtcatcatg gcgggcaacg
5221 ccttcaccgc tggtaagatc atctttgcag cagtgcctcc caattttccc acagaaaatc
5281 ttagccctcc acaaatcacc atgtttcccc acgtcataat agatgtgaga accctcgagc
5341 ctgtcaacat tcccttgcct gatgttagaa acaatttctt ccattatagc caaaacaatg
5401 agccccgcat gagattgtta gcaatgttgt ataccccact cagatcaaat ggttctgcag
5461 aagatgtttt cactgtgtcg tgtagggtcc tcaccaaacc ctcaccagat tttgaattca
5521 actacttggt ccccccaact gtcgagtcta ggacaaagcc cttcaccata ccaatactca
5581 caattggaga gatgacaaat tcaagattcc ctgtggccat tgatttcctg cacaccagcc
5641 ccactgagaa catcgttgtt cagccgcaaa acggcaggtg cacgctggat ggtgaactgc
5701 tgggcaccac tcaattggtc acttctaaca tctgtgcctt cagagggtcc atctcaggac
5761 acgagaatac aggagataac caccaatggc attttaatat caccaacccc aatggcactc
5821 cgtttgaccc cacagaggat gtgcctgctc cacttggaac cccagacttc acaggccagc
5881 tctatggagt catttctcaa cggaacaggg aggggactcc tggtgaaaac aaccagaagg
5941 ccaacaggtc ccatgaggga gtgatctcaa cactcgcacc aagatttaca ccaaagctgg
6001 ggtcggtcat gattggcaca tggaccacca atgacattga aaaccaaccc tccagattcg
6061 ctccaattgg cttgaatgat gatgacaatt ataaccagtg gcaattgcca aactactccg
6121 gggcactcac tctcaacatg gggttggcct cgtctgtttt ccctacttac cctggtgaac
6181 agcttctttt cttccgctca tacatcccaa tgaagggggg atatggtagc ccattcatcg
6241 actgtcttat accccaagag tgggtctccc atttctatca agaatcagca ccctcacaga
6301 cagatgtggc tctgatcagg tatgtcaacc ccgacactgg acgcgtcctg ttcgaggcca
6361 aattgcacag acaaggatac atcaccgtcg ccaagaccgg tgacagcccc atcaatgtac
6421 ctgctaatgg ttatttcaga tttgattctt gggttaatca gttctactct ctcgccccca
6481 tgggaactgg gaatgggcgc agaaggattc aataatggca ggagctttta tagcaggatt
6541 ggctggtgac atgttaacaa acactgtagg gtctttagtt aatgcagggg ctaatgctat
6601 taatcagaaa gttgattttg agaataataa atatttgcaa aatgcatcat ttgcccatga
6661 taaggagatg ttacaagcac aagttgaggc cacaaagaaa ctgcaggccg aaatgattgc
6721 catcaaacaa ggggttttaa ccgcaggcgg cttttcccct tctgatgcgg cccgtggggc
6781 aattaacgcc cctatgacaa aagtcttaga ttggaatggg acaagatact gggcccccaa
6841 cgccacctct acaacctcta tgtcaggtgg cttcacgggt caaaccgtgc acaggcccac
6901 accaaatttc aaaacaaacc aggcacccaa atctataccc agtagtggat cctcagtaag
6961 gtcaaacacg acccaacttt ctagtctgag ttcacattcc tctgggtctt cccgatccag
7021 cgggtccaca actgtcagct ccctaccatc atccagtagg actagggact gggttaatca
7081 gcaaaatctc aatttggaac cacatatgcc tggatccctc agaacagctt ttgtcactcc
7141 accatctagc agggcctcca gttcaggcac agtctcaacc gtgcccaaag gtgttttgga
7201 ctcctggaca tctgcgttta acacacgcag acagccgctg tttgcacacc ttcggagaag
7261 gggggagtca aatgtttagt gaaaagatta gtttaaattt gatttaattt ggat
//