Typing tool
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Typing tool
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Complete norovirus genomes
| MK733201 | GII.12 | |
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| GII.P26 |
ORF1: 1..5060
ORF2: 5041..6648
ORF3: 6648..7427
LOCUS MK733201 7468 bp RNA linear VRL 13-APR-2022
DEFINITION Norovirus GII isolate Arg1382 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MK733201
VERSION MK733201.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7468)
AUTHORS Tohma,K., Lepore,C.J., Degiuseppe,J.I., Stupka,J.A., Saito,M.,
Mayta,H., Zimic,M., Ford-Siltz,L.A., Gilman,R.H. and Parra,G.I.
TITLE Recombinant Nontypeable Genotype II Human Noroviruses in the
Americas
JOURNAL Emerging Infect. Dis. 26 (1), 157-159 (2020)
PUBMED 31855537
REFERENCE 2 (bases 1 to 7468)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 7468)
AUTHORS Tohma,K., Lepore,C.J., Degiuseppe,J.I., Stupka,J.A., Saito,M.,
Mayta,H., Zimic,M., Ford-Siltz,L.A., Gilman,R.H. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (01-APR-2019) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2.3.1
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7468
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Arg1382"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Argentina"
/collection_date="03-Apr-1998"
/note="genotype: GII.12"
gene <1..5060
/gene="ORF1"
CDS <1..5060
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QBR98792.1"
/translation="TAGTTSTNSEIHNKDENPSSNIFANMTVGIKRALGARPKQSAPG
ATSSDKNGKTTIPSIPPPPPNGEDIVIKYTKQGDTISGVPIVSTADISPLHDTAYSVP
PLDQREKVDAKEPLTGSIIEMWDGEIYHYGLYVERGLVLGVHKPPAAVSVARIELTPL
SLYWRTVYTPPYLVAPDTLKKLHGETFPYTAFDNNCYSFCCWVLDLNDSWLNRKFVSR
TTGFYRPYQDWNRKPMPTMDEGKLKKVANVFLCGLSGLFTRPIKDLIGKLKPLNILNI
VTNCDWTFPGVVESIILLAELFGIFWTPPDISAFVASLLGDYEMQGPEDIATEIVPVI
LGGIGMVLGFTKEKIGRLLSSAASSLRACREIGNYGIEVVKLVMKWFFPTKNEVNEME
MVRTIEDAVLDFEAIENNHMTALLKDKNSLATFLRALDMEEEKARKLSTKSASPDIVG
TINSLLARIAAARSLVHRAKEEMSSRMRPVVIMISGRPGIGKTHLARDLAKKMAATLS
GDQRVGLVPRNGVDHWDAYKGERIVLWDDYGMSNPVADALRLQELADTCPLTLNCDRI
ENKGKVFDSDTLIITTNLANPAPLDYVNFEACSRRIDFLVYADSPSVDKAKRDFPGQP
DMWKDAFKPDFSHIKLQLAPQGGFDKNGNTPHGKGVMKTLTTHSLIARATGLLHERLD
EFDLQGPELPVYNFDQNKVAAFRKLAADNKYGFMDTLRAGNKLKEVKTLDQFKEAVKD
IRIKPCRIIYNSLAYDLDSNGSGKVNVKKVGDQRVQANNELNSALNRLRGARIRYYVK
CFQEMVYSLLQIAGAAFVTSRMAQRMNINKLWAKPGKQLETPAEPPTPPAEEWTITPM
DAVQEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERQGKYSIEEYLQDRDRY
YEELAIAKATEENFCEEEEVKIRQRIFRPTKKQRREERATLGLVTGSEIRKRNPDDFK
PKGKLWADDDRSVNYNERIDFEAPPSLWSRIVNFGSGWGFWVSSNLFITSTHVIPQNM
SEAFGVPINQIQIHRSGEFCKMRFPKAIRPDVAGMILEEGAPEGTVVTILIKRTTGEL
MPLASRMGTHATMKIQGRMIGGQMGMLLTGSNAKNMDLGTIPGDCGCPYVYKRGNDWV
VIGVHTAAARGGNTVICATQGPDGEATLEGGDNHGTYCGAPILGPGNAPKLSTKTKFW
RSSNTPLPPGTYEPAYLGGKDPRVKGGPSLQQVMREQLKPFTAPRGKPPRPAVLEAAK
ETICNVLEQTIEPPQKWSYAQACASLDKTTSSGHPHHKKKNDNWNGESFTGVLADQAS
KANLMFEQGKHMQPVYTGALKDELVKTSKIYENIKKRLLWGSDLGTMIRCARSFGGLM
DEMKANCVNLPVRVGMNMNEDGPIIFEKHSKYRYHYDADYSRWDSTQQRHVLGAALEI
MVRYSAEPELAQIVAEDLLSPSVMDVGDFKIIINEGLPSGVPCTSQWNSIAHWLLTLC
AMSEVSGLSPDVVQSNSCFSFYGDDEIVSTDIKLDPQKLTDKLREYGLIPTRPDKTEG
PLIIRESLEGLTFLRRDVCRDPVGWYGKLDQSSIMRQLYWTKGPNHEDPNETMIPHSQ
RPVQLMSLLGEAALHGPAFYKKVSKLVITELKEGGMDFYVPRQEPMFRWMRFSDLSTW
EGDRNLAPESVNEDGVE"
mat_peptide <1..965
/gene="ORF1"
/product="p48"
mat_peptide 966..2063
/gene="ORF1"
/product="NTPase"
mat_peptide 2064..2585
/gene="ORF1"
/product="p22"
mat_peptide 2586..2984
/gene="ORF1"
/product="VPg"
mat_peptide 2985..3527
/gene="ORF1"
/product="Pro"
mat_peptide 3528..5057
/gene="ORF1"
/product="RdRp"
gene 5041..6648
/gene="ORF2"
CDS 5041..6648
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QBR98790.1"
/translation="MKMASNDAAPSNDGAAGLVPEANNETMALEPVAGASIAAPLTGQ
NNVIDPWIRLNFVQAPNGEFTVSPRNSPGEILLNLELGPELNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKLVFAAVPPHFPLENISPGQITMFPHVIIDVRTLEPVLLPLPD
VRNSFFHYNQQNESRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPSPDFDFNYLVPP
TVESKTKPFTLPILTIGELTNSRFPVPIDELYTSPNENLVVQPQNGRCALDGELHGTT
QLLPTAVCSFRGRINQKVSGENHVWNMQVTNINGTPFDPTEDVPAPLGTPDFSGKLFG
VLSQRDHDNACRSHDAVIATDSTKFTPKLGAIQIGTWEVDDVHINQPTKFTPVGLFEN
EGFNQWTLPNYSGALTLNMGLAPPVAPTFPGEQLLFFRSHIPLKGGVADPVIDCLLPQ
EWIQHLYQESAPSQTDVALIRFTNPDTGRVLFEAKLHRNGFITVANTGSRPIVVPANG
YFRFDSWVNQFYSLAPMGTGNGRRRVQ"
gene 6648..7427
/gene="ORF3"
CDS 6648..7427
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QBR98791.1"
/translation="MAGAFIAGLAGDIVTNGIGSLVNAGANAINQRVDFENNKQLQQA
SFNHDKEMLQAQIQATKQLQADMIAIRQGVLTAGGFSPTDAARGAVNAPMTQVLDWNG
TRHWAPGATKTTTFSGGFTSASHTRTVDLTKKTSATPAPMPASRPSSTVSTVSTRSTL
VSGSSNPSSLARSSFSVSSQPTSSSSRTSEWVRTQNRTLEPYMRGALQTTYVTPPSSR
ASSNGTVSTVPKEVLDSWTSAFNTRRQPLFAHLRRRGESQA"
ORIGIN
1 cgaccgctgg cacaaccagc acaaacagtg aaattcacaa caaagatgag aatccctcat
61 caaacatatt tgccaacatg actgttggca taaaaagggc tctaggggcg agaccaaagc
121 agtccgctcc tggagccaca tcaagcgata agaatgggaa aaccaccatc ccctctatac
181 ctcccccacc cccaaatggt gaggacatag tgatcaaata caccaaacaa ggggacacga
241 tcagtggagt gcccatcgtc tccactgcag acatatctcc tctgcacgac actgcgtaca
301 gtgtccctcc cctggaccaa agggaaaagg tagacgcaaa ggagccccta actggctcaa
361 taattgaaat gtgggacggt gagatttacc attatgggct ctatgtggag agagggttgg
421 tcctcggtgt gcacaaacca ccagctgccg tgagcgttgc acgcatcgag ttgacccccc
481 tttctctgta ctggagaaca gtttacacac ccccttactt ggttgctcct gacactctta
541 agaagctcca tggtgaaacc tttccctaca cagcattcga caacaactgt tactcattct
601 gttgctgggt tttggacctg aacgattctt ggcttaacag aaagttcgtg tcaagaacca
661 caggcttcta cagaccctat caagattgga acagaaaacc aatgccaact atggacgagg
721 ggaaactcaa gaaagtggcc aatgtgttcc tgtgcggtct gtctgggctg ttcactaggc
781 ccattaaaga ccttataggt aagcttaaac cactaaacat cctcaacatt gtcaccaact
841 gcgactggac cttccctggc gttgtggaat caataatcct ccttgcagaa ctctttggca
901 tcttttggac accaccagac atatctgctt tcgttgcatc cttattaggt gactatgaaa
961 tgcaaggtcc tgaagatatc gcaaccgaga ttgttccagt catccttggc ggcattggta
1021 tggtcctcgg tttcaccaaa gagaaaattg gtcggctgct gagctccgcg gcatcatccc
1081 ttagagcatg cagggagatt ggcaactatg gaatagaagt ggtgaaactg gtgatgaaat
1141 ggttcttccc gaccaagaat gaagttaatg aaatggagat ggtcagaaca atagaggatg
1201 cagtgcttga ctttgaagca atagaaaaca accatatgac agctttgctc aaagacaaga
1261 atagtctggc caccttcctc agagcattag acatggaaga ggaaaaggca cgtaaactgt
1321 caaccaagtc cgcctcaccc gacatagtcg gtaccataaa ctcacttttg gcgagaatcg
1381 ccgctgccag atccctagtg cacagggcta aggaagagat gtcatctagg atgcgtcctg
1441 ttgttatcat gatatctgga cgacctggga tagggaagac tcacctggca cgcgatctgg
1501 ccaaaaagat ggcagccact ctatcgggtg accaaagagt gggccttgtc ccaagaaacg
1561 gtgtcgacca ctgggatgca tataagggag agaggatcgt cctctgggac gattatggca
1621 tgagcaaccc cgtggcagat gccctccggc tccaagaact cgccgacact tgccccttaa
1681 cactcaactg tgatagaata gaaaacaaag ggaaggtctt tgacagtgac accctgatca
1741 tcactaccaa tttggccaat ccagctcccc ttgactatgt gaattttgag gcttgctcac
1801 gtcgcataga cttccttgtc tacgcggact ccccctcagt tgacaaggca aagagagact
1861 ttccaggcca gccagacatg tggaaggacg cctttaagcc agacttctca catataaagt
1921 tacagttggc accacaagga ggatttgaca agaatggaaa cactccgcac gggaagggcg
1981 tcatgaagac actgaccaca cattccctca tagcccgtgc cactggccta ctccatgaga
2041 gactggatga atttgaccta caaggcccag agttgccagt gtacaatttt gaccaaaaca
2101 aggtggctgc gttccgaaaa ctcgcggccg acaacaagta tggctttatg gacaccttga
2161 gagcaggtaa caaattgaag gaagtcaaaa ccctagatca attcaaggaa gcagtgaagg
2221 acatacgcat aaaaccctgt aggataattt acaattccct ggcctatgat ttggattcaa
2281 atgggtcagg aaaagtcaat gtcaaaaagg taggggacca aagggtccag gccaacaatg
2341 aactcaactc cgcactcaat agactgcgcg gagccagaat cagatactat gtgaagtgct
2401 ttcaagaaat ggtctactca ctcctccaga ttgctggtgc ggcttttgtc acatcgagga
2461 tggcacagag gatgaatatc aacaagctgt gggcaaaacc aggaaaacaa ttggagaccc
2521 ccgcagaacc acccacccct ccagctgaag aatggactat aacaccaatg gatgcagtcc
2581 aggaaggtaa gaaaggcaaa aacaagagtg gcaggggcaa gaaacacact gctttctcta
2641 gtaaaggtct cagcgatgag gagtatgatg agtacaaaag aattagggag gagcgccaag
2701 ggaagtactc catagaagaa tacctccagg atagggaccg gtactatgaa gaattggcca
2761 tagccaaagc aacagaagaa aacttctgtg aagaggaaga agtcaaaata aggcagagga
2821 ttttccgccc aactaagaaa caacgtaggg aggagagggc caccttgggt cttgttactg
2881 gtagtgagat aagaaagagg aatcctgatg acttcaagcc aaaagggaag ttgtgggctg
2941 atgatgaccg cagtgttaat tataatgaaa gaatagattt cgaagctccc cccagtctct
3001 ggtccagaat agtcaacttt ggatcgggct ggggtttctg ggtttcctcc aatctgttta
3061 tcacttccac acatgtcatc ccacaaaaca tgtccgaagc ctttggtgtg ccaataaacc
3121 aaatacagat acacagaagt ggggagttct gtaagatgag gttcccaaaa gccatcaggc
3181 ccgacgtggc tggcatgatc cttgaggaag gtgcccctga aggaacagtc gtgaccatat
3241 tgatcaaaag aacaactggt gagctcatgc cattagcatc tcgcatgggc acccatgcta
3301 ctatgaaaat acaaggcaga atgattggag gtcagatggg aatgctcctc acaggatcca
3361 atgccaagaa catggatctc ggcaccatcc ctggtgactg tggttgtcct tacgtctaca
3421 agaggggcaa tgactgggtt gtcatcgggg tgcacactgc cgccgctagg ggcggtaaca
3481 cggtgatctg tgctacccag ggaccagatg gtgaggccac cctcgagggg ggtgacaacc
3541 atgggacata ctgtggtgcg cccatactag ggccagggaa tgctccaaaa ctcagcacca
3601 agaccaaatt ttggagatcc tccaacaccc cgcttccccc tggcacatat gaacctgcct
3661 atctcggtgg taaagaccca agggttaagg gcggcccatc actgcagcag gtcatgaggg
3721 aacagctcaa acccttcact gctccacgtg ggaaaccgcc gagaccagcg gttctggagg
3781 ccgcaaagga aaccatctgt aatgtgttag agcaaaccat tgaaccaccc cagaaatggt
3841 cctacgcgca agcctgcgca tccctggaca aaacaacctc aagtggtcat ccccaccaca
3901 agaagaaaaa tgacaactgg aatggtgaat ccttcactgg tgttctggcc gatcaggcat
3961 caaaggccaa cctcatgttc gagcagggga aacacatgca gcctgtgtat acaggagcgc
4021 tcaaagatga acttgtcaaa accagcaaaa tttacgagaa catcaagaag aggcttctgt
4081 ggggctcaga cctgggtacg atgatacgct gtgccagatc atttggtggt ctcatggatg
4141 aaatgaaggc aaactgcgta aacctaccag tcagagttgg catgaacatg aatgaggacg
4201 ggcccataat ctttgagaaa cattcaaaat acagatatca ttatgatgct gactactcta
4261 ggtgggattc aacacaacaa agacatgtct taggtgctgc acttgaaata atggtcaggt
4321 actcagccga gcccgaattg gcacaaattg tggctgagga ccttttgtcg cccagtgtca
4381 tggacgttgg cgacttcaaa atcatcataa acgagggttt gccctctggg gtcccatgca
4441 catcacaatg gaattcaatc gctcattggc tgctaacatt gtgtgccatg tcagaagtct
4501 cagggttgtc accagatgtg gtgcaatcaa actcatgctt ctccttttat ggggacgatg
4561 agatagttag cacagacatc aaactggatc cccaaaaatt aacagacaaa ctgagggaat
4621 acggcttgat cccaaccaga cctgataaga cagaaggccc cctcataatc agggaaagct
4681 tggagggtct aaccttcctg agaagggatg tgtgcagaga cccagttggg tggtatggca
4741 aacttgacca atcttcaatc atgagacaac tgtattggac caaaggaccc aatcatgaag
4801 accccaacga aacgatgatc ccacactccc agagacctgt gcaattgatg tccctacttg
4861 gtgaagcggc cctacacgga ccagctttct acaaaaaggt tagcaaattg gtcataactg
4921 aactcaaaga aggtggaatg gatttttatg tacccaggca agaacctatg tttagatgga
4981 tgagattctc tgatctgagc acgtgggagg gcgatcgcaa tctggctccc gaaagtgtga
5041 atgaagatgg cgtcgaatga cgccgctcca tctaatgatg gtgcagccgg tctcgtacca
5101 gaggctaaca atgagaccat ggcactcgag ccggtggctg gggcttcaat agctgcccca
5161 ctcaccggtc aaaataatgt tatagacccc tggattagat taaactttgt gcaggctccc
5221 aatggagagt tcacggtttc accccgcaat tctcctgggg aaatcctact aaatttggaa
5281 ttaggtcccg aactaaatcc atacctggca catctttcta gaatgtataa tggttatgca
5341 ggtggagttg aggtgcaagt actattggct gggaacgcgt tcacagctgg aaaattggtg
5401 ttcgctgcag tcccccctca ttttccatta gaaaatataa gccctggcca aataaccatg
5461 ttccctcatg taattattga tgttaggact ttagaaccag ttttgttgcc cctcccagac
5521 gttaggaata gcttctttca ctacaaccag caaaatgaat caaggatgag attagtagca
5581 atgctctata ctccccttag atctaatggc tctggtgatg atgtgttcac tgtctcctgt
5641 agggtgctta ctcgaccttc tcctgatttt gatttcaatt atttggtccc ccctactgtt
5701 gagtctaaaa ctaaaccctt cacactccct atcttgacta taggggagtt aaccaattcc
5761 aggttccctg tacctataga tgagctctac accagtccca atgagaattt ggtggtgcag
5821 ccacagaacg ggagatgcgc gctggatggg gagttgcatg gcacgactca gctccttccc
5881 acggcggttt gctcgttcag gggccggatt aaccaaaagg tgagtggaga aaaccatgtt
5941 tggaatatgc aggttaccaa catcaacggg accccttttg atccaacaga ggatgtcccg
6001 gcccctttag gcactccaga cttttccggc aagctctttg gtgtcttaag ccagagggac
6061 catgacaatg cctgcaggag tcatgatgca gtaattgcaa ctgactctac caaattcacc
6121 ccaaaattgg gcgctataca aattggcaca tgggaagtag atgatgtgca catcaaccaa
6181 cccactaaat tcaccccagt tggtttattt gaaaatgaag gctttaatca atggacgctc
6241 cccaactact ctggagcctt aacacttaat atgggactgg cccctcctgt ggcccctact
6301 ttccctggtg aacaacttct tttctttaga tcccacatcc ctcttaaagg aggtgtggca
6361 gacccagtca ttgactgcct tttgcctcaa gaatggatcc aacatcttta ccaagagtcg
6421 gccccttcac aaacagacgt ggcactaatt aggttcacaa atccagacac agggcgtgtc
6481 ctatttgaag caaaactgca tagaaatggt tttattacag tggccaatac tggtagtaga
6541 ccgattgtgg tgccagctaa tggctacttc aggtttgact cttgggttaa tcagttctac
6601 tctcttgccc ccatgggaac tgggaacggg cgcagaaggg tgcagtaatg gctggagctt
6661 ttatagcagg gcttgccggt gacatagtca ccaatggcat cggttcactc gtgaatgccg
6721 gggccaatgc aataaaccaa agagtagact ttgaaaacaa taagcaacta cagcaggctt
6781 ctttcaacca tgataaagag atgttgcaag ctcaaatcca ggccaccaaa cagctacagg
6841 ctgatatgat tgcaatcaga caaggggtgt tgaccgcagg cggcttctcc cccactgatg
6901 cagcaagagg ggcagttaat gcacccatga ctcaggtttt agactggaac gggaccaggc
6961 attgggcccc aggagccacg aaaaccacca ctttctccgg tgggttcacc agtgcttccc
7021 ataccaggac tgttgacctg accaagaaaa catcagccac accagcccct atgcctgctt
7081 ccagacctag ttctactgtc tctacagtct ctactcgctc aaccttggtt agcgggtctt
7141 ccaacccttc ttctctagct aggagttctt ttagtgtttc ttctcaacct acctcctcct
7201 cctcccggac cagtgagtgg gtacgcactc aaaacaggac actggagcct tacatgagag
7261 gggcgctgca aacaacctat gtaacgcctc cctctagtag agcttctagc aatggcacag
7321 tctcaaccgt gccaaaagag gttttggact cctggacatc tgcgtttaac acccgcagac
7381 aaccgctatt cgctcacctc cgccggaggg gggagtcaca agcttagtga aaagatgatt
7441 tttctttctt ccctttgaaa atttctgt
//