Typing tool
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Typing tool
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Complete norovirus genomes
| PZ038581 | GII.17 | |
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| GII.PNA6 |
ORF1: 1..5109
ORF2: 5090..6703
ORF3: 6703..7473
LOCUS PZ038581 7497 bp RNA linear VRL 14-JUL-2026
DEFINITION Norovirus GII isolate Hu/US/2024/GII.17/Hartford0068 nonstructural
polyprotein (ORF1), VP1 (ORF2), and VP2 (ORF3) genes, complete cds.
ACCESSION PZ038581
VERSION PZ038581.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7497)
AUTHORS Barclay,L., Wikswo,M.E., Wall,H., Kambhampati,A.K.,
Montmayeur,A.M., Mallory,M.L., Lindesmith,L.C., Mirza,S.A.,
Baric,R.S., Vinje,J. and Chhabra,P.
TITLE Epidemiology and molecular evolution of norovirus GII.17 in the
United States, 2021-2025
JOURNAL J Infect Dis (2026) In press
PUBMED 42418796
REMARK Publication Status: Available-Online prior to print
REFERENCE 2 (bases 1 to 7497)
AUTHORS Popowich,M., Barclay,L., Montmayeur,A.M., Vinje,J. and Chhabra,P.
TITLE Direct Submission
JOURNAL Submitted (23-FEB-2026) Viral Gastroenteritis Branch, Division of
Viral Diseases, Centers for Disease Control and Prevention, 1600
Clifton Road NE, Atlanta/GA, GA 30329, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: CN 2.0 Pipeline v. 1
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7497
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Hu/US/2024/GII.17/Hartford0068"
/isolation_source="stool"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="USA"
/collection_date="25-May-2024"
/note="genotype: GII.17"
gene 1..5109
/gene="ORF1"
CDS 1..5109
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="YDD39348.1"
/translation="MKMASNDASAAVAGKNNNNDNAKSSSDSLFSNMSVSFKKALGAR
PKQPPPGETKQQTKPPRPPTPELVKNIPPPPPNGEDEPIVTFKRGEGVSGLPDLTTVR
RPDVQNTAYSVPPLSLREVGEAKEPLPGAILEMWDGEIYHYGLYVERGHVLGVHKPPA
AVSIARIELTPLSLYWRVVYTPQYLISPDTLKNLDGESFPYTAFDNNCYAFCCWVLDL
NDSWLSRRMIQRTTKFFRPYQEWNRKPLPTMDEPKIKKVANALLCALSSLFTRPIKDI
IGKLRPLNILNILATCDWTFAGIVESMILLAELFGVFWTPPDVSAMIAPLLGDYEMQG
PEDLAVELVPVVMGGIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKW
FFPKKEEADELAMVRAIEDAVLDLEAIENNHMTALLKDRDSLATYMKTLDLEEAKARK
LSTKSSSPDIVGTINALLARIAAARSLVHKAKEELSGRQRPVVVMISGRPGIGKTHLA
RELAKKIATSLAGDQRVGLVPRNGVDHWDAYKGERVVLWDDYGMSNPISDALRLQELA
DTCTLTLNCDRIENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPD
VEKAKRDFPGQPDMWKEHYRPDFSHIKLQLAPQGGFDKNGNTPHGKGVMKSLTVGSLI
ARATGLLHERMDEFEFQGPELTTFNFDRNKIVAFRQLAAENKYGMMDTLRVGNQLKNV
KTMSELKQAIKNITIKKCQIVYGGCTYTMESDGHGKVTVDKVQSAVVQTNNELSGALH
HLRSARIRYYVKCFQEAVYSILQIAGAAFVTSRIVRRMNISNLWSKPPVEESDESEND
GGCPKPRDEDEITIDSRDIKAEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREE
RNGKYSIEEYLQDRDRYYEELAIARATDEDFCEEEEVKIRQRIFRPTRKQRKEERATL
GLVTGSEIRKRNPDDFKPKGKLWADDNRSVDYNERIDFEAPPSIWSRIVSFGSGWGFW
VSPSLFITSTHVIPKGITEAFGVPISQIQIHKSGEFCRLRFPKPIRTDVSGMILEEGA
PEGTVATILVKRPTGELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTT
PGDCGCPYIYKRGNDFVVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAP
ILGPGNAPKLSTKTKFWRSSNAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPF
TEPRGKQPNPSVLEAAKQTIINVLEQTIDPPQRWTYAQACASLDKTTSSGHPHHVRKN
DYWSGESFTGKLADQASRANLMYEEGKHMTPVYTAALKDELVKTDKIYGKIKKRLLWG
SDLSTMIRCARAFGGLMDELKAHCITLPVRVGMNMNEDGPIIFEKHSRYRYHYDADYS
RWDSTQQRAVLAAALEIMVRFSAEPNLAQIVAEDLLAPSVVDVGDFKITINEGLPSGV
PCTSQWNSISHWLLTLCALSEVTGLGPDIIQANSMYSFYGDDEIVSTDIKLDPEKLTA
KLKEYGLKPTRPDKTEGPLVISEDLNGLTFLRRTVTRDPAGWFGKLDQSSILRQIYWT
RGPNHEDPSETMIPHAQRPVQLMALLGESSLHGPSFYSKISKLVISELKEGGMDFYVP
RQEPMFRWMRFSDLSTWEGDRNLAPSLVNEDGVE"
mat_peptide 1..999
/gene="ORF1"
/product="p48"
mat_peptide 1000..2097
/gene="ORF1"
/product="NTPase"
mat_peptide 2098..2634
/gene="ORF1"
/product="p22"
mat_peptide 2635..3033
/gene="ORF1"
/product="VPg"
mat_peptide 3034..3576
/gene="ORF1"
/product="Pro"
mat_peptide 3577..5106
/gene="ORF1"
/product="RdRp"
gene 5090..6703
/gene="ORF2"
CDS 5090..6703
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="YDD39349.1"
/translation="MKMASNDAAPSNDGATGLVPEINHETLPLEPVAGAAIAAPVTGQ
NNIIDPWIRTNFVQAPNGEFTVSPRNSPGEILLNLELGPDLNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKILFAAVPPNFPVEFLSPAQITMLPHLIVDVRTLEPIMIPLPD
VRNTFFHYSNQPAQRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPTPDFEFTYLVPP
SVESKTKPFSLPILTISELTNSRFPAPIDSLFTAQNNNLNVQCQNGRCTLDGELQGTT
QLLPSGICAFRGKITADVHGQHNDRWHMQLTNLNGTPFDPTEDVPAPLGSPDFTGLLY
GVASQRNPDNSTRAHEVVISTTSTQFVPKLGSINFGSESTDFQTNQPTKFTPVGIKME
DGHDFDQWTLPKYSGHLTLNMNLAPPIAPNFPGEQLLFFRSNVPCAGGINAGIIDCLI
PQEWIQHFYQESAPSQSDVALIRYVNPDTGRTLFEAKLHRSGYITVAHSGDYPLVVPA
NGYFRFDSWVNQFYSLAPMGTGNGRRRLQ"
gene 6703..7473
/gene="ORF3"
CDS 6703..7473
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="YDD39350.1"
/translation="MAGAFIAGLAGDMLTNAVGSLANAGANAITQKIDFENNKQLQSA
SFQHDKDMLQAQVAATKQLQADMIAIKQGILTAGGFSPTDAARGAVGAPITKVLDWSG
TRYWAPNSTKTTSYSGQFTSTPVHMSVKQPTPVRKTQPPPSSSGSVYSLSTQSTSLPA
SSSSSSVSSASTQSTKLSSVSSMDRTANWVNQQRSLSPYMSGALNISHVTPPSSRASS
SGTVSTVPKEVLDSWTSAFNTRRQPLFAHLRVRGESRV"
ORIGIN
1 atgaagatgg cgtctaacga cgcttccgct gccgttgctg gcaaaaacaa caacaacgac
61 aacgcaaaat cttcaagtga cagcttgttt tctaacatgt ctgtctcttt taagaaagcc
121 ctcggggcgc ggcctaaaca gccgcccccg ggagaaacaa aacagcaaac taaaccacca
181 agaccaccga caccggaact ggtgaaaaat ataccaccac ccccgcctaa cggtgaggat
241 gaaccaatag tgaccttcaa acgtggggag ggcgtgtctg ggttgcctga cctaacaact
301 gtcaggcggc cagacgtgca aaacacagct tacagtgttc ctccactcag cctgagggag
361 gttggtgaag ctaaagagcc tctgcctggt gccattttgg aaatgtggga tggtgaaatc
421 taccactatg ggttgtatgt ggagcgtggt cacgtgcttg gggtgcacaa gccacctgct
481 gcagtgagta tcgctaggat tgagttgaca cctttatcat tatattggag ggtggtttac
541 accccccagt atttgatatc cccagacact ctgaagaacc tggatggtga atcatttcct
601 tacactgcat ttgacaacaa ctgctacgcc ttctgctgtt gggtcctcga cctcaatgac
661 tcatggctta gcagaagaat gatccagcga accactaagt tctttaggcc ttatcaagag
721 tggaacagaa agcccctgcc gaccatggat gagcccaaga tcaagaaggt tgcaaatgcc
781 ctgttatgtg cactctcttc gctcttcacc aggccaatca aagatattat tggaaaactc
841 agaccattga acattctcaa catacttgct acctgtgatt ggaccttcgc aggcattgtg
901 gaatccatga tccttctagc tgaacttttc ggggtgttct ggacgccccc agatgtgtct
961 gctatgattg cccccttact cggtgattac gagatgcaag gccccgaaga cctggccgtc
1021 gagctcgtac ccgtggtgat ggggggaata ggcttggtgc tcggattcac caaggaaaag
1081 atcggcaaga tgctatcatc agctgcttct acactcagag cctgcaaaga tttaggtgcc
1141 tatggactgg agatactcaa actagtcatg aaatggtttt tcccaaagaa agaggaggcc
1201 gacgagctag ctatggtgag ggctatagaa gacgctgtgt tagatctgga ggcaatagaa
1261 aacaaccaca tgacagccct cctcaaagac agggacagct tggcaacata tatgaagacc
1321 cttgacctag aagaggcaaa agcaagaaaa ctctccacca aatcttcttc tcctgatatt
1381 gtgggtacaa taaatgcact attggcaagg attgcagcag ccagatcact ggtgcacaaa
1441 gcaaaggagg aattgtcagg aagacagagg cctgtagtgg tgatgatatc tggaagaccg
1501 ggcataggaa agacccacct cgcccgggag ctggccaaga agattgccac gtcactagca
1561 ggtgaccaga gagtagggtt agtgcccaga aatggtgtgg accactggga cgcctacaag
1621 ggggagagag tggtgttgtg ggacgattat ggcatgagca atccaatatc agatgcactg
1681 agactccagg agctggccga cacctgcaca ctgaccctga actgtgacag gatcgaaaac
1741 aaaggaaagg tgtttgacag cgatgccata attataacaa ctaaccttgc aaaccccgcg
1801 ccgctggact acgtcaactt cgaagcctgt tccaggcgaa tagacttcct tgtgtatgca
1861 gatgcaccag acgtagaaaa ggccaaacgc gactttcctg ggcagccaga catgtggaaa
1921 gaacactaca gaccagactt ctcacacatc aaactccaac ttgcaccaca agggggcttt
1981 gacaagaatg gcaacactcc gcatggtaaa ggtgtcatga aatccttaac agtgggttca
2041 ctgattgcca gggccaccgg actactccac gaaagaatgg atgagttcga attccagggt
2101 cccgaattga caactttcaa tttcgaccgc aacaagatcg ttgccttcag acaattggca
2161 gctgagaaca agtacggtat gatggacacc ctaagagttg gcaaccaact gaagaatgtc
2221 aagaccatga gtgagcttaa gcaggccatc aagaatatta ccatcaagaa gtgtcagata
2281 gtgtatggtg gatgcaccta cacgatggag tctgatggac atggcaaggt gacagttgat
2341 aaggttcaaa gtgcagtggt tcaaaccaac aatgagcttt caggagctct acaccacctt
2401 aggtctgcaa gaataaggta ctatgtcaaa tgtttccaag aggcagtcta ctccatacta
2461 caaattgctg gtgcagcatt cgtcacctca cgcatcgtga ggcgcatgaa catctcaaac
2521 ctctggtcaa agccacctgt tgaagagagt gatgaatctg agaatgatgg agggtgcccc
2581 aaacctagag acgaggatga gatcacaatc gactctaggg acataaaggc agaaggaaag
2641 aaaggcaaga acaagactgg ccgtggtaag aaacatacgg ctttctctag caagggactc
2701 agtgatgaag agtatgatga gtacaagaga atcagagaag aaaggaatgg caaatactca
2761 atagaggagt atcttcaaga cagggacagg tactatgaag agcttgccat tgccagggcc
2821 actgatgagg acttttgtga ggaggaggaa gtgaaaatcc gccaaaggat cttccggccc
2881 accaggaaac aacggaaaga agaaagggcc acgctgggac tcgtcacagg gtcagaaatc
2941 aggaaaagaa acccagatga tttcaaacca aaaggaaaat tgtgggccga tgacaatagg
3001 agtgtggact acaatgaaag gatagacttt gaagcacccc cgagcatttg gtctaggata
3061 gtcagctttg gttcaggatg ggggttctgg gtttccccaa gtctcttcat aacatcaaca
3121 catgtgatac cgaaaggtat cacggaggcc tttggagtac caatcagcca gatccagatc
3181 cataaatcag gggagttttg ccgtctgcgg tttccaaaac caatcaggac agatgtaagt
3241 ggaatgatct tggaggaggg agctcccgag ggaacagttg caaccatcct tgtcaaacgg
3301 ccaactggag agctgatgcc cctcgcagcc aggatgggaa ctcatgccac aatgaaaatc
3361 caaggaagga cggttggcgg ccaaatgggc atgctcctga caggctcaaa cgctaagagc
3421 atggacctcg gaacaacacc aggtgactgt gggtgtcctt acatatacaa gagaggcaac
3481 gactttgtgg ttatcggtgt gcacacggca gcagcacgcg gaggcaacac agtcatttgt
3541 gccacacaag gaagtgaagg tgaggccact cttgagggag gtgacaacaa aggaacttac
3601 tgtggggctc ctattttagg acctggcaat gcaccaaaat tgagcacgaa aacaaaattc
3661 tggagatctt ccaacgcacc actcccacca ggtacctatg aaccagccta ccttggtggg
3721 aaggatcccc gtgtaaaggg aggcccatct ctgcaacagg ttatgagaga tcaactaaaa
3781 cccttcacag agcccagggg aaagcaacca aacccaagcg tccttgaagc agccaaacaa
3841 accataatca atgttcttga acaaaccatt gatcctcccc agagatggac ttacgctcag
3901 gcttgtgcat ctcttgacaa aacaacttcc agcgggcatc cccatcacgt ccgcaagaat
3961 gactactgga gtggtgagtc ttttacagga aaattggcag atcaagcttc aagggcaaac
4021 ctcatgtacg aggagggtaa acacatgaca ccagtgtaca ctgcagcact caaagatgag
4081 ctagtgaaga ctgacaagat ctatggaaag atcaagaaaa gactcttgtg gggttcggac
4141 ctttcaacca tgatacggtg tgccagggca tttggtggct tgatggatga actcaaagca
4201 cactgtataa ccctccctgt aagagttggc atgaacatga atgaggacgg gcccataata
4261 tttgagaaac actccaggta caggtaccac tatgatgctg actactctcg ttgggactcc
4321 acacaacaaa gagcagtgct ggcagcagca cttgaaatca tggtgaggtt ctcagcagaa
4381 ccaaatttag cacaaatagt ggctgaggac ttgctggcac caagtgtggt tgacgtgggt
4441 gacttcaaaa tcacaataaa tgagggttta ccctctggtg tgccttgcac gtcacaatgg
4501 aattccatct cccactggct actcacgttg tgtgccctgt cagaagtcac tggtttaggt
4561 cctgacatca tacaagcaaa ttccatgtac tctttctatg gtgatgatga aattgtgagc
4621 actgacatca aacttgaccc agagaaattg actgcaaaac ttaaagaata tggtctcaaa
4681 cccacccgtc ccgacaagac tgaggggcca ttggtgatta gtgaagatct gaacggactg
4741 acattcctcc ggcgaacggt gacccgagat ccagcaggct ggtttgggaa gttagaccaa
4801 agctccatac tcagacaaat ttattggacc agaggaccaa atcatgaaga tcccagtgag
4861 acaatgatac cacatgcaca aaggcctgtt cagctcatgg cattgctggg ggagtcctcc
4921 ttgcatggac catcattcta tagcaaaatc agcaaattgg ttatatctga acttaaagag
4981 ggggggatgg atttttatgt gcccagacaa gaacccatgt tcagatggat gagattctca
5041 gatttgagca catgggaggg cgatcgcaat ctggctccca gtcttgtgaa tgaagatggc
5101 gtcgaatgac gccgctccat ctaatgatgg tgctacgggc ctcgtcccag agatcaacca
5161 cgagaccctt cccctggaac cagtggcagg cgcagcaatt gccgcacctg ttactggaca
5221 aaataacata attgatccct ggataagaac aaattttgta caagcaccca acggagagtt
5281 cacagtttca cccagaaact ctcccggaga aattcttcta aatttggagt taggtcctga
5341 tttgaaccct tatttggcac acctgtctag aatgtacaat gggtatgctg gtggtgtgga
5401 agtccaagtt ctcctggcgg ggaatgcgtt caccgcagga aagatcctct tcgctgccgt
5461 gccaccaaac ttccccgttg aattcttgag ccccgcccaa attaccatgt tgccacattt
5521 gattgttgat gttagaaccc ttgaacctat catgatacca ctccctgatg ttaggaacac
5581 cttctttcat tacagtaatc aacctgccca gcgcatgcgc ctagtggcca tgttatatac
5641 tcctttgaga tctaatggtt ctggtgatga tgttttcact gtctcttgca gggttcttac
5701 tagacccacc ccagattttg agttcacata cttagtccct ccttcagtag agtctaaaac
5761 taaacccttt tccctgccta tcctgactat ctctgagctt actaactcta gattccctgc
5821 acctatagat tcactgttca cagcccaaaa caacaatctc aatgtccagt gccaaaatgg
5881 taggtgcacg ctagatggtg agttgcaagg gactacccag ctgctgccat cgggcatatg
5941 tgctttcaga ggcaaaataa cagcagatgt gcacggccag cacaatgata gatggcacat
6001 gcaattgaca aatctcaacg ggaccccatt tgatccaaca gaggatgtgc cagcccccct
6061 gggctcccca gacttcacag gccttctcta cggggtagcc agtcagagga accctgacaa
6121 ctccactcgg gcacatgagg tcgtgatctc cacgaccagc acacagttcg tgcccaaact
6181 ggggtcaatc aactttggta gtgagagcac tgatttccag acaaatcaac caaccaagtt
6241 cacaccagtt ggaatcaaaa tggaagatgg gcatgacttt gaccagtgga ccttgcccaa
6301 gtattcaggc catttaactc tcaacatgaa tctagccccg cctattgccc caaatttccc
6361 tggtgaacag ttgctattct tcagatcaaa tgtcccttgt gctggcggta tcaacgctgg
6421 tattattgat tgcctgatac ctcaagagtg gatacaacac ttctaccaag aatctgcacc
6481 gtctcaatct gatgtagccc taatcaggta tgtcaaccct gacacagggc gcacactctt
6541 cgaggcaaaa cttcacagat ctggctacat tactgttgct cattcaggtg attatcctct
6601 tgttgtcccc gctaatggat acttcagatt tgactcttgg gtaaaccagt tttactcact
6661 tgcccccatg ggaacaggga acgggcgcag acggttgcag taatggctgg agcttttata
6721 gcaggtcttg caggtgacat gctcaccaat gcagtcggct cactggcaaa cgccggggcc
6781 aatgctataa cccagaagat agattttgag aacaataaac agctccaatc tgcctccttc
6841 caacatgaca aagacatgct ccaagcgcaa gtggctgcaa ccaagcagct acaggctgac
6901 atgatcgcca tcaagcaggg gatactgacc gctggcggct tttcccccac tgatgcggcg
6961 agaggagcag tgggtgcacc cattaccaag gtcctagatt ggtctggcac ccgctactgg
7021 gcaccaaatt ccacaaaaac aaccagttac tcagggcaat tcacatcaac gcctgtgcat
7081 atgtctgtca aacagcccac tcccgtcaga aagacccagc cccctccttc ttcttctggc
7141 agtgtctata gcctttctac acagagcact tctttgcctg catcttcttc tagttcttct
7201 gtttcttctg cttcaacaca atcaacaaaa ttaagttcag tttcctctat ggatagaaca
7261 gcaaattggg tgaatcagca gagaagcctt agcccctaca tgagtggtgc tcttaacatc
7321 tctcatgtaa cacctccatc aagcagggct tcaagttcgg gaacagtctc aactgtaccc
7381 aaagaagttt tggactcctg gacgtctgca ttcaacacac gcagacagcc gctcttcgca
7441 cacctcagag tgagggggga gtcacgagtt tagtgaaaag aatcaattgg tttaaaa
//