Typing tool
|
|
|
|
|
|
Typing tool
|
Complete norovirus genomes
| PV920376 | GII.17 | |
|
|---|---|---|---|
| GII.PNA5 |
ORF1: 1..5125
ORF2: 5106..6728
ORF3: 6728..7507
LOCUS PV920376 7573 bp RNA linear VRL 30-SEP-2025
DEFINITION Norovirus GII isolate Hu/GII.17/WT-NORO-2472/2016/UK nonstructural
polyprotein (ORF1) gene, partial cds; and VP1 (ORF2) and VP2 (ORF3)
genes, complete cds.
ACCESSION PV920376
VERSION PV920376.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7573)
AUTHORS Tully,D.C., Roy,S., Tutill,H., Williams,R., Celma,C.,
Lindesmith,L.C., Baric,R.S. and Breuer,J.
TITLE Rapid evolution and global emergence of a novel, genetically
distinct GII.17 norovirus variant
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7573)
AUTHORS Tully,D.
TITLE Direct Submission
JOURNAL Submitted (11-JUL-2025) Infectious Diseases Epidemiology, London
School of Hygiene and Tropical Medicine, Keppel Street, London WC1E
7HT, United Kingdom
COMMENT ##Assembly-Data-START##
Assembly Method :: CLC Genomics Workbench v. 11.0.01
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7573
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Hu/GII.17/WT-NORO-2472/2016/UK"
/isolation_source="stool"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="United Kingdom"
/collection_date="Apr-2016"
/note="genotype: GII.17[PNA5]"
gene <1..5125
/gene="ORF1"
CDS <1..5125
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="XXN27327.1"
/translation="SNDAATATAGKTSTNSEIHNQDVNSTSSLFANMTVGLKRALGAR
PKQPTPRVPSPNREGKPETTPRAPPPNKGGKTNIPPIPPPPPNGEDIIIKYTKQDDVV
VGVPTVATADVPPTHNTAYSVPPLDQREKVEAKEPLTGSIIEMWDGEIYHYGLYVEKG
LVLGVHKPPAAVSFARIELTPLSLYWRTVYTPPYLVAPETLRKLHGESFPYNAFDNNC
YTFCCWVLDLNDSWLNRKFVSRTTGFYRPYQEWNRKPLPTMDEGKLKKVANVFLCGLS
GLFTRPIKDLIGKLRPLNILNIITNCDWTFPGVVEALILLAELFGVFWTPPDISTFIA
SLLGDYEMQGPEDIAVEIVPVVLGGIGMVLGFTKERIGRLLSSAASSLRACREIGNYG
IEVVKLVMKWFFPTKDETNEMDMVRAIEDAVLDFEAIQNNHMTALLKDKNSLATFLRE
LDMEEEKARKLSTKSASPDIIGTINALLARIAAARSLVHKAKEEMSSRMRPVVIMISG
RPGIGKTHLARDLAKKMAATLSGDQRVGLVPRNGVDHWDAYKGERIVLWDDYGMSNPV
TDALRLQELADTCPLTLNCDRIENKGKVFDSDTIIITTNLANPAPLDYVNFEACSRRI
DFLVYADSPSVDKAKRDFPGQPDMWKDAFKPDFSHIKLQLAPQGGFDKNGNTPHGKGV
MKTLTTHSLIARATGLLHERLDEFDLQGPELPVYNFDQNRVAAFRKLAADNKYGLMET
IKVGNKLKGVKTLEQLKDALKDISIKPCRIVYNSMAYDLDSNGSGRVNVKKVVDHKIQ
TNNELNSALNNLRGARVRYYVKCVQEMVYSLLQIAGAAFVTSRMVRRLNVSGIWARPE
KRVEAIEEPPTPPTEDWTIAPANAVQEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEFK
RIREERQGKYSIEEYLQDRDRYYEELAIAKATEENFCEEEEIKIRQRIFRPTRKQRRE
ERATLGLVTGSEIRKRNPDDFKPKGKLWADDDRSVNYNEKIDFEAPPSLWSRIVNFGS
GWGFWVSSNLLITSTHVIPPNMTEAFGVPISQIQIHRSGEFCKMRFPKAIRPDVSGMI
LEEGAPEGTVVTILIKRTTGELMPLAARMGTHATMKIQGKMLGGQMGMLLTGSNAKNM
DLGTIPGDCGCPYVYKRGNDWVVIGVHTAAARGGNTVICATQGPDGEATLEGGDNHGT
YCGAPILGPGSAPKLSTKTKFWRSSNAPLPPGTYEPAYLGGKDPRIKGGPSLQQVMRD
QLKPFTAPRGKPPRPAIIEAAKETICNVLEQTIEPPQKWSYAQACASLDKTTSSGHPH
HMRKNDNWNGESFTGVLADQASKANLMFEQGKHMQPVYTAALKDELVKTSKIYEKIKK
RLLWGSDLGTMVRCARAFGGLMDEMKANCVNLPIRVGMNMNEDGPIIFEKHSKYKYHY
DADYSRWDSTQQRHILGAALEIMVRFSAEPELAQVVSEDLLAPSVVDVGDFKIVIGEG
LPSGVPCTSQWNSISHWLITLCAISEVSGLSPDVVQTNSCFSFYGDDEIVSTDIKLDP
MELTNKLKEYGLIPTRPDKTEGPLIVKESLEGLTFLRRDVCRDPAGWYGKLDQSSIMR
QLFWTKGPNHEDPNETMIPHSQRPIQLMSLLGEAALHGPAFYKKVSKLVITELKEGGM
DFYVPRQEPMFRWMRFSDLSTWEGDRNLAPEGVNEDGVE"
mat_peptide <1..1030
/gene="ORF1"
/product="p48"
mat_peptide 1031..2128
/gene="ORF1"
/product="NTPase"
mat_peptide 2129..2650
/gene="ORF1"
/product="p22"
mat_peptide 2651..3049
/gene="ORF1"
/product="VPg"
mat_peptide 3050..3592
/gene="ORF1"
/product="Pro"
mat_peptide 3593..5122
/gene="ORF1"
/product="RdRp"
gene 5106..6728
/gene="ORF2"
CDS 5106..6728
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="XXN27328.1"
/translation="MKMASNDAAPSNDGAAGLVPEGNNETLPLEPVAGAAIAAPVTGQ
NNIIDPWIRTNFVQAPNGEFTVSPRNSPGEILLNLELGPDLNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKILFAAVPPNFPVEFLSPAQITMLPHLIVDVRTLEPIMIPLPD
VRNTFFHYSNQPNSRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPTPDFDFTYLVPP
SVESKTKPFSLPILTLSELTNSRFPVPIDSLFTAQNNVLQVQCQNGRCTLDGELQGTT
QLLPSGICAFRGRVTAQINQRDRWHMQLQNLNGTTYDPTDDVPAPLGTPDFKGVVFGM
VSQRNVGNDAPGSTRAQQAWVSTYSPQFVPKLGSVNLRISDNDDFQFQPTKFTPVGVN
DDDDGHPFRQWELPNYSGELTLNMNLAPPVAPNFPGEQLLFFRSFVPCSGGYNQGIID
CLIPQEWIQHFYQESAPSQSDVALIRYVNPDTGRTLFEAKLHRSGYITVAHSGDYPLV
VPANGHFRFDSWVNQFYSLAPMGTGNGRRRAQ"
gene 6728..7507
/gene="ORF3"
CDS 6728..7507
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="XXN27329.1"
/translation="MAGAFIAGLAGDMLTSSVGSLANAGANAINQKIDFENNKQLQSA
SFQHDKEMLQAQVKATKQLQSEMIALKQGVLAAGGFSPTDAARGAIGAPMTKVLDWSG
TRYWAPNSTKTTGYSGQFTSSPVHMSSPNAPQSKPAKPRSLAPSSSSSSVYSMYTQST
HLTSGSSSNASSASTKLTNLSSGSSQNRTAEWVNQQRSLSPFMSGALNISHVTPPSSR
ASSSGTVSTVPKEVLDSWTSAFNTHRQPLFAHLRVRGESRV"
ORIGIN
1 gtctaacgac gctgccactg cgaccgctgg caaaaccagc acaaacagtg aaattcacaa
61 ccaagatgta aactctacat ctagtctctt cgccaacatg actgttggct tgaagagggc
121 cctgggggcg aggccaaaac agcccacccc tagggtcccc tcccccaaca gggaggggaa
181 acccgaaacc acccccagag ctcctccacc aaacaaggga gggaagacca acatcccccc
241 aatacctccc ccaccaccca acggtgagga cataatcatc aaatacacta aacaagatga
301 tgtggttgta ggggtgccca ccgttgctac agcggatgtc ccccccacac acaataccgc
361 ctacagtgtc ccccccttgg atcagaggga gaaggttgag gcaaaggaac cactaacagg
421 ctcaataatt gagatgtggg atggtgagat ctaccactat gggctctatg ttgagaaggg
481 cttggtcctc ggcgtgcaca aacccccagc tgctgtgagc ttcgcacgca tagagctcac
541 tcccctttct ctatactgga gaacagtcta tacaccaccc tacttggttg ctccagaaac
601 tctcagaaag ctccacgggg agtcattccc atacaatgca tttgacaaca attgctacac
661 cttctgctgt tgggtcttgg acctgaatga ttcttggctc aacagaaaat ttgtatcaag
721 gaccacgggt ttctacaggc cctaccaaga gtggaacaga aagcctctac caaccatgga
781 tgagggaaaa cttaagaaag tggctaatgt gtttctgtgc ggtctttctg ggcttttcac
841 tagaccaatc aaggacctca tagggaagct gaggccacta aacatactca acatcatcac
901 caactgtgat tggaccttcc ccggagttgt agaagctctc atattgcttg cagaactctt
961 cggagttttc tggacaccac cagacatttc cacctttata gcatcactcc tgggcgatta
1021 tgagatgcag ggccctgaag acattgcggt tgaaattgtg ccagtggtct tgggtggcat
1081 aggtatggtg cttggattca ccaaggagag gattggccgg ttgctgagct ccgctgcatc
1141 ctcactcagg gcatgcaggg agatcggcaa ttatgggata gaagtggtga agctagtgat
1201 gaaatggttt ttccccacca aagatgagac aaatgaaatg gacatggtga gggcaataga
1261 ggatgctgtg ctcgactttg aagccataca gaacaaccac atgacagcat tgctcaaaga
1321 caaaaacagc ctggctacct tcctcaggga gttggacatg gaagaggaga aggcgcgcaa
1381 gttatcaaca aagtctgcgt ccccagacat cattggcacc ataaacgccc ttctagccag
1441 gattgccgct gctagatccc tagtccacaa ggccaaagag gaaatgtcat ctaggatgcg
1501 tcctgttgtc atcatgatct ctggccggcc cggaatagga aagacgcatc tggcccgtga
1561 cttggccaag aagatggcgg caaccctctc aggtgatcag agggtgggtc ttgtaccgag
1621 gaatggtgtt gatcattggg atgcttataa aggagagaga attgtgcttt gggatgatta
1681 tggaatgagc aaccctgtga ccgacgcgct gcggctccaa gaacttgccg atacatgtcc
1741 cttaacgctc aactgtgata gaatagaaaa caaggggaaa gtatttgaca gtgataccat
1801 aattattacc actaatttgg ccaatcctgc ccctctagat tatgttaatt ttgaagcctg
1861 ctctcgccgg atcgacttcc ttgtctatgc agactctcct tcggtggaca aggcaaagag
1921 agacttcccc ggccaaccag acatgtggaa ggacgccttt aaaccagatt tctcacacat
1981 aaaacttcag ctggcaccac aagggggatt cgataagaac gggaataccc cacatgggaa
2041 gggtgtcatg aaaacactga ccacacattc ccttatcgcc cgtgctacgg gtctactgca
2101 tgagagatta gatgagttcg acttgcaggg acccgagctg cccgtgtaca actttgatca
2161 aaacagagtc gctgctttca gaaaacttgc ggctgacaat aagtacgggc tcatggagac
2221 cataaaagtg ggcaacaagc tgaaaggtgt caagactcta gaacaactca aggacgcctt
2281 aaaagacata agtatcaagc cttgcagaat agtctacaat tcgatggctt atgaccttga
2341 ctcgaacggg tcagggagag tcaatgtcaa gaaggttgta gaccataaga tccagactaa
2401 caatgagctc aattccgcgc tcaacaacct gcgtggcgct agggtgagat actatgtcaa
2461 atgtgtccaa gagatggtgt actctcttct ccagatcgct ggcgcagcct tcgtcacttc
2521 aaggatggta cggaggctaa acgtcagtgg catttgggcc aggccagaga agcgggtgga
2581 ggccattgaa gaacccccaa cccccccaac tgaagattgg actatagccc cagcaaatgc
2641 agtccaggag ggcaaaaagg gtaagaacaa aagtggcaga ggtaagaaac atactgcctt
2701 ctccagcaaa gggctaagtg atgaggaata cgatgagttt aaaaggatca gggaagaaag
2761 gcaaggaaaa tactccatag aagaatacct ccaggacagg gacaggtact atgaggaatt
2821 ggccatagcc aaagcaacag aagaaaactt ctgtgaggag gaagaaataa aaataagaca
2881 gagaatcttc cgcccaacca gaaaacagcg tagggaggaa agggcaaccc tagggctggt
2941 cacaggtagt gaaattagga agagaaaccc agatgacttc aaaccaaaag gaaaattgtg
3001 ggctgatgat gaccgcagtg taaattacaa tgagaaaata gattttgaag cccctcctag
3061 cctttggtcc cgaatagtga acttcggatc aggttggggt ttctgggtgt cttctaacct
3121 gctaatcaca tcaacacatg tcatcccccc gaacatgact gaggcttttg gcgtaccaat
3181 aagtcaaata caaatacaca gaagtggaga attctgcaaa atgaggttcc ccaaggctat
3241 aagacctgat gtctcaggca tgatccttga ggaaggggct cctgaaggaa cagtggtgac
3301 catactgatc aagagaacca ctggtgaact catgccactg gccgcccgaa tgggcaccca
3361 cgccaccatg aaaatacaag gaaaaatgct tggaggccaa atgggtatgc tcctcactgg
3421 ttccaatgcc aaaaatatgg atctcggtac catccctgga gactgtggct gtccttatgt
3481 gtacaagagg ggcaatgatt gggtggtcat aggagtgcac accgcagctg ccagaggtgg
3541 caacaccgtg atctgtgcca cccagggacc agacggtgag gccacactcg agggagggga
3601 caaccatggt acctattgtg gtgcaccaat acttggacca ggaagtgcac caaaactcag
3661 caccaagacc aaattctgga ggtcatccaa cgccccactc ccacctggca cttacgagcc
3721 cgcttacctg ggaggaaagg acccaagaat caaaggaggc ccgtcattac agcaagttat
3781 gagggatcaa ctcaaacctt tcaccgctcc ccgagggaaa ccaccacgac cagcgatcat
3841 agaggctgct aaagaaacta tttgcaatgt acttgagcag accattgaac caccccaaaa
3901 atggtcctac gctcaagcct gcgcctcgtt ggataagaca acatcgagtg gtcaccccca
3961 tcacatgagg aagaacgaca attggaatgg agaatccttc actggtgtgc tggctgacca
4021 ggcctccaaa gcaaacctta tgtttgaaca aggaaaacac atgcagcctg tgtacactgc
4081 tgccctcaaa gatgagttgg tcaagaccag taagatatat gaaaagatca agaaaaggct
4141 tctatggggt tcagacctgg gcacgatggt ccgttgcgct agggcttttg gcggcctcat
4201 ggatgaaatg aaagcaaatt gtgtgaactt accaattagg gttggcatga acatgaatga
4261 agatgggccc atcatttttg agaaacattc aaagtataag taccactatg acgctgacta
4321 ctctaggtgg gattcgaccc agcagaggca catcctagga gctgcccttg aaattatggt
4381 taggttttca gctgagcccg aattggcaca agtagtgtct gaggacctct tggcccccag
4441 cgtggtggac gttggtgatt tcaaaattgt cataggtgag ggcttgccct ctggggtacc
4501 atgcacatca caatggaact caatttccca ctggctgata acactgtgcg ccatatcaga
4561 agtttctggg ctatcgccag atgtggtgca aacaaattcc tgtttctctt tttatgggga
4621 tgatgagata gtcagcaccg acatcaaact ggatcccatg gagctgacta ataagttaaa
4681 agagtatggg ctgatcccaa cgaggccaga taaaacagag ggacccctca tagtcaaaga
4741 gagcctggag ggcttgacct tcctcaggag ggatgtgtgt cgggacccag ctggttggta
4801 tggaaaactt gatcaatcat caattatgag gcagttattc tggactaagg gacccaacca
4861 tgaagatccc aatgagacaa tgatcccaca ctcccaaagg cccatacaac taatgtcatt
4921 gttgggagag gcagcattgc atgggccagc tttttataag aaagtcagca aactggttat
4981 cactgaactc aaagagggtg ggatggattt ctatgtgcca agacaggaac ctatgttcag
5041 gtggatgaga ttctctgatc tcagcacttg ggagggcgat cgcaatcttg ctcccgaagg
5101 tgtgaatgaa gatggcgtcg aatgacgccg ctccatctaa tgatggtgct gctggtctcg
5161 taccagaggg caacaacgag acccttcccc tagaaccagt tgcgggcgca gctatagccg
5221 cacccgtcac tggccaaaat aacataattg acccctggat tagaacaaat tttgtgcaag
5281 caccaaatgg agagttcaca gtgtcaccca gaaactctcc tggagaaatt ttattaaact
5341 tagagttggg ccctgatttg aacccttatt tggctcattt gtcaaggatg tacaatgggt
5401 atgctggtgg agtggaagtt caggttctcc tggcagggaa cgcgttcact gccggaaaga
5461 tcctcttcgc cgccgtcccg ccaaatttcc cagtggaatt cttaagccca gcccagatca
5521 caatgctccc acatttaata gtagatgtta ggactcttga accaattatg atcccactcc
5581 ctgatgttag gaatacattc ttccattata gtaaccagcc taacagccgc atgagattag
5641 tggctatgct ctatacccca ctcagatcta atggctcagg tgatgatgtc tttactgtct
5701 cttgcagggt tttgactagg cctactcctg attttgattt cacttattta gtgccacctt
5761 ctgttgaatc taaaactaag cctttttcct tacctatttt aaccctttct gagctcacaa
5821 attcgaggtt cccagtcccc atcgattcgc ttttcaccgc ccagaataat gtgttgcagg
5881 tgcagtgtca aaatggcagg tgtacacttg atggtgagtt acaaggcaca acccagttgc
5941 tcccatctgg catttgtgca ttcagaggac gggtgacagc gcaaattaac caacgtgaca
6001 ggtggcacat gcaactgcaa aacctcaatg gtacaacata tgacccaact gatgatgtgc
6061 cagccccgct gggtacacct gacttcaagg gcgtcgtgtt tgggatggta agccaaagaa
6121 atgtgggtaa tgatgcgcct ggctcaacca gagcccaaca ggcgtgggtt tcaacctata
6181 gccctcaatt tgtccccaaa ttaggttctg tcaatcttag aattagtgat aatgatgatt
6241 tccaattcca gccgacaaaa ttcacaccag tgggcgtcaa tgatgacgat gatggccacc
6301 cgttcagaca atgggaatta ccaaactatt caggggagct taccttgaat atgaatcttg
6361 cccccccagt tgctccaaat tttcctggtg aacaattgtt attcttcaga tctttcgtgc
6421 catgctcagg aggttacaac caaggtatta tagattgcct tattccccaa gaatggatcc
6481 aacacttcta tcaggaatca gcaccctccc agtcagacgt ggccctaatc aggtatgtca
6541 accctgatac gggacgtaca ctgtttgaag caaaattgca cagatctggt tacattactg
6601 tggctcactc tggagactat cctcttgttg ttccggctaa tggacacttt agatttgatt
6661 cttgggtaaa tcagttttac tcactcgccc caatgggaac tgggaatggg cgaaggaggg
6721 ctcagtaatg gctggggctt tcattgcagg attggcaggc gacatgctca cgtcatctgt
6781 gggctccctt gcgaacgcag gggcaaacgc catcaaccaa aagatagact ttgaaaacaa
6841 caaacaactc cagtctgctt cctttcagca tgataaagag atgctccaag cgcaggtgaa
6901 ggcaaccaag cagctgcagt ctgaaatgat agccctaaaa cagggggttt tggccgcagg
6961 cggcttttcc cccactgatg cagcaagggg agccattggt gcacccatga caaaggtgct
7021 tgactggtct ggcactcgat actgggcgcc caactccaca aagacaactg gttattcggg
7081 acaattcacc tcttcacccg tgcacatgtc tagcccaaat gctccacaat caaaacctgc
7141 aaagcctagg tctctagctc cttcctcttc ttctagcagt gtctatagta tgtatactca
7201 atctactcat ttaacatctg gctcttctag taatgcttct tctgcctcta caaaattgac
7261 aaatttaagc tctggctcct ctcaaaacag aacagcagag tgggtaaatc aacagagaag
7321 tcttagccct ttcatgagtg gcgcacttaa catctcacat gtcacgccac cctcaagtag
7381 ggcttccagt tctgggacgg tctcgaccgt acccaaggaa gttttggact cctggacgtc
7441 tgcgtttaat acacacagac agccgctctt cgcacacctc agagtgaggg gggagtcacg
7501 tgtttagtga aaagaaataa ttggctataa tgtgatttct ttctaaattt ggctaatttg
7561 tgtcttttaa aaa
//