Typing tool
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Typing tool
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Complete norovirus genomes
| PV920372 | GII.17 | |
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| GII.P17 |
ORF1: 1..5099
ORF2: 5080..6696
ORF3: 6696..7475
LOCUS PV920372 7548 bp RNA linear VRL 30-SEP-2025
DEFINITION Norovirus GII isolate Hu/GII.17/WT-NORO-2571/2023/UK nonstructural
polyprotein (ORF1) gene, partial cds; and VP1 (ORF2) and VP2 (ORF3)
genes, complete cds.
ACCESSION PV920372
VERSION PV920372.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7548)
AUTHORS Tully,D.C., Roy,S., Tutill,H., Williams,R., Celma,C.,
Lindesmith,L.C., Baric,R.S. and Breuer,J.
TITLE Rapid evolution and global emergence of a novel, genetically
distinct GII.17 norovirus variant
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7548)
AUTHORS Tully,D.
TITLE Direct Submission
JOURNAL Submitted (11-JUL-2025) Infectious Diseases Epidemiology, London
School of Hygiene and Tropical Medicine, Keppel Street, London WC1E
7HT, United Kingdom
COMMENT ##Assembly-Data-START##
Assembly Method :: CLC Genomics Workbench v. 11.0.01
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7548
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Hu/GII.17/WT-NORO-2571/2023/UK"
/isolation_source="stool"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="United Kingdom"
/collection_date="Feb-2023"
/note="genotype: GII.17[P17]"
gene <1..5099
/gene="ORF1"
CDS <1..5099
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="XXN27315.1"
/translation="SNDASVAVAGKNNNNDKEKSSSDSLFSNMTVTFKKALGARSKQP
PPGETKQTQRPPRPPTPELVKKIPPPTPNGEDELKITYKVGEGVSGLPDLTTVAQPDA
QNTAYSVPPLSQREVGEAKEPLPGSILEMWDGEIYHYGLYVERGHVLGVHKPPAAISL
AKIELTPLSLYWRVVYTPQYLIAPETLKNLNGEVFPYTAFDNNCYAFCCWVLDLNDSW
LSRRMIQRTTGFFRPYQDWNRKPLPTMDEPKIKKAANAVLCALSSLFTRPIKDVIGKL
KPLNIMNILATCDWTFAGIVESMILLAELFGVFWTPPDVSAMIAPLLGDYEMQGPEDL
AVELVPVVMGGIGLVLGFTKEKIGKMLSSAATTLRACKDLGSYGLEILKLVMKWFFPK
KEEANELAMVRAIEDAVLDLEAIENNHMTTLLKDKDSLATYMKTLDLEEEKARKLSSK
SASPDIVGTVNALLARIAAARSLVHKAKEELSSRQRPVVVMISGKPGIGKTHLARELA
KKVASTLTGDQRIGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIQDALRLQELADTCP
LTLNCDRIENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPDIEKA
KRDFPGQPDMWKDHYRSDFSHIKLQLAPQGGFDKNGNTPHGKGVVKSLTIGSLIARAS
GLLHERMDEFELQGSDLPTFNFDRNKVAAFRQLAAENKYGLMDTLRVGNQLKSVKTLD
ELKQAIKNITIKKCQIVYNGCTYTMESDGRNKVVVEKVQNATVQTNNELTGALHHLRS
ARIRYYVKCFQEAIYSLLQIAGAAFVTTRIVRRMNISNLWSKPPVEEGDEPEDEGGCP
KPRDEDDLTVDSKDIKAEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERNGK
YSIEEYLQDRDRYYEELAIAKATEEDFCEEEEIKIRQRIFRPTRKQRREERATLGLVT
GSEIRKRNPDDFKPKGKLWADDNRSVDYNERIDFEAPPSVWSRIVNFGTGWGFWVSPS
LFITSTHVIPKGITEAFGVPINQIQIHKSGEFCRLRFPKPIRPDVSGMILEEGAPEGT
VVSILIKRTTGELMPLAVRMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDC
GCPYIYKRGNDFVVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPILGP
GNAPKLSTKTKFWRSSNASLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPR
GKPPKPSVLESAKKTIINVLEQTIDPPEKWSYAQACASLDKTTSSGYPHHVRKNDYWS
GESFTGKLADQASKANLMYEEGKHMQPVYTAALKDELVKTDKIYGKIKKRLLWGSDLS
TMIRCARAFGGLMDELKANCITLPVRVGMNMNEDGPIIFEKHSRYRYHYDADYSRWDS
TQQRAVLEAALEIMVRFSAEPQLAQIVAEDLLSPSVVDVGDFKIVINEGLPSGVPCTS
QWNSIAHWLLTLCALSEVTGLGPDIIQANSMYSFYGDDEIVSTDIKLDPEKLTAKLKE
YGLKPTRPDKTEGPLVISEDLNGLTFLRRTVTRDPVGWFGKLDQNSILRQLYWTRGPN
HEDPSETMIPHAQRPVQLMALLGESSLHGPSFYSKVSKLVISELKEGGMDFYVPRQES
MFRWMRFSDLSTWEGDRNLAPSFVNEDGVE"
mat_peptide <1..989
/gene="ORF1"
/product="p48"
mat_peptide 990..2087
/gene="ORF1"
/product="NTPase"
mat_peptide 2088..2624
/gene="ORF1"
/product="p22"
mat_peptide 2625..3023
/gene="ORF1"
/product="VPg"
mat_peptide 3024..3566
/gene="ORF1"
/product="Pro"
mat_peptide 3567..5096
/gene="ORF1"
/product="RdRp"
gene 5080..6696
/gene="ORF2"
CDS 5080..6696
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="XXN27316.1"
/translation="MKMASNDAAPSNDGAAGLVPEGNNETLPLEPVAGAAIAAPVTGQ
NNIIDPWIRTNFVQAPNGEFTVSPRNSPGEILLNLELGPDLNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKILFAAVPPNFPVEFLSPAQITMLPHIIVDVRTLEPIMIPLPD
VRNTFFHYNNQPNSRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPTPDFEFTYLVPP
SVESKTKPFSLPILTLSELTNSRFPVPIDSLFTAQNNVLQVQCQNGRCTLDGELQGTT
QLLPSGICAFRGRVTAETDNPDKWHIQLQNLNGTTYDPTDDVPAPLGTPDFKGVVFGM
ASQRNVGNDAPGSTRAHEAVISTYSPRFVPKLGSVNFKSNDDDFQLQPTRFTPVGIND
DNDHPFRQWELPDYSGVLTLNMNLAPPVAPNFPGEQLLFFRSSVPCSGGYNQGIIDCL
IPQEWIQHFYQESAPSQSDVALIRYVNPDTGRTLFEAKLHRSGYITVAHSGDYPLVVP
ANGYFRFDSWVNQFYSLAPMGTGNGRRRAQ"
gene 6696..7475
/gene="ORF3"
CDS 6696..7475
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="XXN27317.1"
/translation="MAGAFIAGLAGDMLTSSVGSLVNAGASAISQKIDFENNKQLQSA
SFQHDKEMLQAQVNATKQLQSEMIALKQGILAAGGFSPTDAARGAIGAPMTKVLDWSG
TRYWAPNSTKTTGYSGQFTSSPVHMPSPSAPQSKSAKSRSLGSSSSSSSVYSMSTQST
SLTSGSSSNASSASTKLTNLSSGSSQNRTAEWVNQQRSLSPFMSGALNISHVTPPSSR
ASSSGTVSTVPKEVLDSWTSAFNTRRQPLFARLRVRGESRV"
ORIGIN
1 cgtctaacga cgcttccgtc gccgttgctg gcaaaaacaa caacaacgac aaggaaaaat
61 cttcaagtga cagcttgttt tctaacatga ctgttacttt taagaaagcc ctcggggcgc
121 ggtctaaaca gccgcccccg ggagaaacaa aacaaacaca aagaccacca aggccaccga
181 caccggaatt ggtgaagaag atacccccac ccacccccaa tggcgaggat gaactaaaga
241 taacgtataa agtgggagaa ggtgtgtctg ggctgcccga cttgacaacc gtggcacaac
301 ctgacgcaca gaatacagcc tacagtgtcc ccccacttag ccagagagag gtcggcgaag
361 ctaaagaacc gttgcctggc tccattctgg aaatgtggga tggtgagatc taccactatg
421 ggctgtatgt tgagcggggg catgtactgg gagtgcacaa accacctgcc gctataagcc
481 ttgccaaaat tgaattaaca ccgctgtctc tctactggag agtggtttac actccccagt
541 atttgatagc tccagagacc cttaagaatt taaatggaga ggttttccca tacacggcct
601 ttgacaacaa ctgttatgcc ttctgttgtt gggttttaga cctcaacgac tcctggctta
661 gcagaagaat gatccaaaga acaactggat tcttcagacc gtatcaggac tggaacagaa
721 aacccttgcc aaccatggat gaaccaaaaa tcaagaaggc cgcgaatgct gttctgtgtg
781 ctctctcctc actcttcact aggcccatca aagatgtcat tggaaagctc aaaccactga
841 acatcatgaa tatactggca acttgtgatt ggacttttgc gggcatagtg gaatccatga
901 tccttcttgc tgagctcttt ggggtgttct ggacgccccc agatgtgtct gcaatgattg
961 ctcccttact cggtgactac gagatgcaag gccccgaaga cctggccgta gaacttgtgc
1021 ccgtggtaat gggaggaata ggtttggtgt taggattcac caaggaaaag atcggcaaga
1081 tgctttcatc agctgcgacc acactcaggg cctgtaagga tctaggatct tatgggttgg
1141 agatactcaa actggtcatg aagtggttct tccccaagaa ggaggaggcc aacgagttag
1201 ccatggtgag ggccattgag gatgcagttc tggatttgga ggcaatagaa aacaaccaca
1261 tgaccactct ccttaaggac aaagacagcc tggccacata catgaagact cttgacttgg
1321 aagaagaaaa agcaaggaaa ctgtcatcca aatcggcatc acctgacatc gtgggcacag
1381 taaatgcatt attggcaagg atagcagccg ccaggtcact ggtccacaag gctaaggagg
1441 agctctcgag cagacagagg cctgttgttg taatgatatc aggtaagcca ggtataggaa
1501 agacccattt ggccagagag ctagccaaga aggttgcgtc aacactgaca ggcgaccaaa
1561 ggattggact gatacctaga aatggcgtcg accattggga cgcatacaaa ggagagcggg
1621 tggttctgtg ggatgactat ggcatgagca accctataca ggacgcactg aggctccaag
1681 aattggctga cacctgtcct ctgaccctaa attgtgacag gattgaaaac aaaggaaaag
1741 tgttcgacag tgacgccata attataacaa ccaacctcgc aaacccagca ccactggatt
1801 acgtcaactt tgaggcttgt tctagacgca tagacttctt ggtgtatgca gacgcacctg
1861 acatcgagaa ggctaagcgt gacttccctg gccaaccaga tatgtggaaa gaccattaca
1921 gatcagactt ctcacacatc aaactccagc tggcaccaca gggaggcttt gataagaatg
1981 gcaacacccc acatggcaaa ggtgtggtta agtctctgac gattggttct ctgatcgcca
2041 gggcttctgg cttgctccat gagagaatgg atgaatttga gctccaaggc tctgacttac
2101 caaccttcaa tttcgaccgt aacaaagtcg ccgccttcag acaattggca gctgaaaaca
2161 aatatggtct tatggacaca ctgagggtcg gtaaccaact gaaaagtgtc aaaaccctgg
2221 atgagctgaa gcaggctata aagaacatca ccatcaagaa gtgccagata gtgtacaatg
2281 gatgcaccta caccatggaa tctgatggga ggaacaaggt tgtggttgaa aaggttcaaa
2341 atgcaacagt ccaaaccaac aatgaactta caggagcact ccaccaccta agatctgcaa
2401 ggataaggta ttatgttaaa tgtttccaag aagctattta ctctctactc caaattgctg
2461 gtgcagcctt cgtcaccaca cgcatcgtga ggcgcatgaa catctcaaac ctctggtcga
2521 agccacccgt cgaagagggt gatgagcctg aagacgaagg ggggtgcccc aagcccaggg
2581 atgaagatga cctcactgtc gactctaaag acattaaagc agaagggaag aagggcaaga
2641 acaaatctgg ccggggcaag aagcacacag ctttctcatc caagggcctc agtgatgaag
2701 agtacgatga gtacaagaga atcagggagg agaggaatgg caaatactca attgaagaat
2761 acctccagga cagagataga tactatgaag agcttgccat tgctaaggcc actgaggaag
2821 acttctgtga agaggaggaa atcaaaattc gccagagaat cttccggccc accaggaagc
2881 aacggagaga ggaaagagcc acgcttgggc ttgtcacagg atcggaaatc agaaagagga
2941 acccagatga ctttaagcca aaaggaaaat tgtgggctga tgacaacaga agtgtggact
3001 acaatgagag gatagatttt gaggctcccc cgagtgtttg gtctaggata gtaaactttg
3061 gtacaggatg gggattctgg gtctccccaa gtctctttat aacttcaaca catgtcatac
3121 caaaaggaat cactgaggcc tttggagttc ccattaacca aattcaaatt cacaaatctg
3181 gagagttttg ccgcttgcgg tttccaaaac caatcaggcc agacgtgagt ggaatgatct
3241 tggaagaggg tgcccctgaa ggcactgttg tgtccattct catcaagagg acaacagggg
3301 aactgatgcc tctcgcagtt aggatgggga cccacgccac aatgaaaatc caaggtagaa
3361 cggtgggtgg tcaaatgggc atgcttctca ctggctcaaa cgctaaaagc atggacctag
3421 gcacaacacc gggtgactgt gggtgcccat acatatacaa aaggggcaat gacttcgtgg
3481 tcattggggt gcacactgca gcagcccgtg gaggcaacac ggtcatatgt gccacacagg
3541 gaagtgaagg cgaagccacc ctcgaaggag gtgacaacaa gggcacctat tgtggagccc
3601 ccatcttggg acctggcaac gcaccaaaat taagcacaaa aacaaaattt tggagatctt
3661 ccaacgcgtc gcttcctcca ggtacctatg aaccagcata ccttggtgga aaagacccgc
3721 gtgtgaaggg aggcccatct ctacaacagg ttatgagaga ccaacttaaa ccttttacag
3781 agccaagagg gaagccacca aaaccaagtg tcctagaatc agcaaagaag accatcatta
3841 atgttctgga gcaaaccatt gacccccctg aaaagtggtc atatgcccaa gcttgtgcat
3901 ccctcgacaa gacaacctcc agtggatacc cgcatcacgt ccggaaaaat gactattgga
3961 gtggtgaatc cttcacgggg aaacttgcag accaggcctc aaaagcaaac cttatgtatg
4021 aggaaggcaa gcacatgcaa ccagtttaca ccgcagcact caaagacgag ctcgtgaaaa
4081 ctgacaaaat ttatggcaag atcaagaaaa gactcctgtg gggctctgac ctatctacca
4141 tgattcgatg cgccagggca tttggtggtc tcatggatga gctcaaagca aattgtatca
4201 cactccctgt cagagttggt atgaatatga atgaagatgg tcccataata tttgaaaagc
4261 actccaggta caggtaccac tatgatgctg attactcccg ctgggattcc acacaacagc
4321 gggcagtgct ggaagcggca cttgaaatca tggtgagatt ttctgctgag ccacagttgg
4381 cacaaatagt ggcagaggac ctgctatcac caagtgtggt tgatgtgggc gatttcaaaa
4441 ttgttatcaa tgaaggccta ccatctggcg tgccttgcac ttcacaatgg aattccattg
4501 cccactggtt actcaccctg tgtgccctgt ctgaagtaac aggactaggc cctgacatca
4561 tacaagccaa ctccatgtac tctttctatg gtgatgatga gattgtgagc acagacataa
4621 aattagatcc agagaaactg actgcaaaac tcaaagaata tggccttaaa cccacccggc
4681 ctgacaagac tgaggggcca ctggtaatta gtgaggacct gaatgggttg actttcctcc
4741 gccgaacagt cacccgcgat ccagtgggtt ggtttggaaa gttggaccaa aactccatcc
4801 tcaggcagct gtactggaca aggggaccca accatgaaga ccccagtgag actatgatac
4861 cacacgcaca gagacctgtg cagctcatgg cactgctagg agagtcctcc ctacatggac
4921 cctcatttta cagcaaggtt agcaagctgg tcatatctga acttaaagag ggaggaatgg
4981 atttttatgt gcccagacaa gagtcaatgt tcaggtggat gaggttctca gatctaagca
5041 catgggaggg cgatcgcaat ctggctccca gttttgtgaa tgaagatggc gtcgaatgac
5101 gccgctccat ctaatgatgg tgctgctggt ctcgtaccag agggcaataa cgagaccctt
5161 cccctagaac cagttgcggg cgcagctata gccgcacccg tcaccggcca aaacaatata
5221 attgacccct ggattagaac aaattttgtg caagcaccaa atggagagtt cacagtgtca
5281 cccagaaact ctcctggaga aattttacta aacctagagt tgggccctga tttgaaccct
5341 tatttggctc atttatcaag gatgtacaat gggtacgctg gtggagttga agtccaggtt
5401 ctcctggcag ggaacgcgtt cactgccggg aagatcctct tcgccgctgt cccgccaaat
5461 ttcccagtgg aattcttaag cccagcccag attacaatgc tcccacatat aatagtagat
5521 gttaggactc ttgaaccaat tatgatccca ttacctgatg ttaggaacac attcttccac
5581 tataacaacc agcccaacag ccgcatgaga ttagtggcta tgctctatac cccccttaga
5641 tctaatggct caggtgatga tgttttcact gtttcttgta gggttttgac tagacctact
5701 cctgattttg agttcactta tctagtgcca ccctctgttg aatctaagac taagcccttt
5761 tccttaccca ttttaaccct ttctgagctc acaaattcga ggttcccggt ccccattgat
5821 tcgcttttca ccgcccagaa taatgtgttg caggtgcagt gtcaaaatgg caggtgcaca
5881 cttgacggtg agctacaagg cacaacccag ttgctcccat ctggtatctg tgcgttcaga
5941 ggacgggtga cagcagaaac cgacaatcct gataagtggc acatacaact gcaaaacctc
6001 aatggcacaa cgtatgaccc aactgatgat gtgccagccc cactgggtac acctgacttc
6061 aagggcgtcg tgtttgggat ggcaagccaa agaaatgtgg gtaacgatgc gcccggctca
6121 accagggctc atgaggcggt aatttcaacc tacagcccca gatttgttcc caaattaggc
6181 tctgtcaatt ttaaaagtaa tgacgatgat ttccaattac agccaacaag attcacacca
6241 gtgggcatca atgatgataa cgaccacccg ttcagacaat gggaactgcc agactattca
6301 ggggtgctta ccttgaatat gaaccttgcc cccccggttg ctccaaattt ccctggtgaa
6361 caattattat tcttcagatc ttccgtgcca tgttcaggag gttacaacca aggtattata
6421 gattgtctta tcccccaaga atggatccag cacttctacc aggaatcagc accttctcag
6481 tcagacgtgg ccctgatcag gtacgtcaac cccgacacgg gtcgcacact atttgaggca
6541 aaactgcata gatctggcta tatcactgtg gctcactctg gagactatcc tcttgttgtt
6601 ccggctaatg gatactttag atttgactct tgggtaaatc agttctactc actcgcccca
6661 atgggaactg ggaatgggcg aaggagggct cagtaatggc tggagctttc attgcaggat
6721 tggcgggtga catgctcacg tcatccgtgg gctccctggt gaacgcaggg gcaagcgcca
6781 tcagccaaaa gatagacttt gaaaacaaca aacaactcca gtctgcttcc tttcaacatg
6841 ataaagagat gctccaagcg caggtaaatg caaccaagca gctgcaatct gagatgatag
6901 ccctaaaaca ggggattttg gccgcaggcg gcttttcccc cactgatgca gcgagggggg
6961 ccatcggtgc acccatgaca aaggtgcttg actggtctgg cactcgatat tgggctccca
7021 attccacaaa gacaactggt tattcggggc aattcacctc ttcacctgtg cacatgccca
7081 gcccgagtgc tccacaatca aaatccgcaa agtccagatc tctaggttct tcctcttctt
7141 ctagtagtgt ctatagtatg tctacccaat caacttctct aacatctggc tcttctagta
7201 atgcttcttc tgcttctaca aaattgacaa atttaagctc tggctcctct caaaacagga
7261 cagcagagtg ggtgaaccaa cagagaagtc tcagcccttt catgagtggc gcactcaata
7321 tctcacatgt cacgccacct tcaagtaggg cctccagttc tgggacggtc tcaaccgtgc
7381 ccaaggaagt tttggactcc tggacatctg cattcaacac acgcagacag ccgctcttcg
7441 cacgcctcag agtgaggggg gagtcacgtg tttagtgaaa agaaataatt ggctataata
7501 tgatttcttt aaaatttaaa tttggctaat ttgcatttct tttaaaaa
//