Typing tool
|
|
|
|
|
|
Typing tool
|
Complete norovirus genomes
| PV920371 | GII.17 | |
|
|---|---|---|---|
| GII.P17 |
ORF1: 1..5098
ORF2: 5079..6701
ORF3: 6701..7480
LOCUS PV920371 7546 bp RNA linear VRL 30-SEP-2025
DEFINITION Norovirus GII isolate Hu/GII.17/WT-NORO-2670/2023/UK nonstructural
polyprotein (ORF1) gene, partial cds; and VP1 (ORF2) and VP2 (ORF3)
genes, complete cds.
ACCESSION PV920371
VERSION PV920371.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7546)
AUTHORS Tully,D.C., Roy,S., Tutill,H., Williams,R., Celma,C.,
Lindesmith,L.C., Baric,R.S. and Breuer,J.
TITLE Rapid evolution and global emergence of a novel, genetically
distinct GII.17 norovirus variant
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7546)
AUTHORS Tully,D.
TITLE Direct Submission
JOURNAL Submitted (11-JUL-2025) Infectious Diseases Epidemiology, London
School of Hygiene and Tropical Medicine, Keppel Street, London WC1E
7HT, United Kingdom
COMMENT ##Assembly-Data-START##
Assembly Method :: CLC Genomics Workbench v. 11.0.01
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7546
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Hu/GII.17/WT-NORO-2670/2023/UK"
/isolation_source="stool"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="United Kingdom"
/collection_date="Feb-2023"
/note="genotype: GII.17[P17]"
gene <1..5098
/gene="ORF1"
CDS <1..5098
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="XXN27312.1"
/translation="SNDASAAVAGKNNNNDKEKSSSDSLFANMSVTFKKALGARSKQP
PPGETKQIQKPPRPPTPELVKKIPPPPPNGEDEPGIVYKVGEGVSGLPDLTTVAQPDA
QNTAYSVPPLSQREVGEAKEPLPGSILEMWDGEIYHYGLYVERGHVLGVHKPPAAISL
AKIEITPLSLYWRVVYTPQYLIDPGTLKNLSGETFPYTAFDNNCYAFCCWVLDLNDSW
LSRRMIQRTTGFFKPYQDWNRKPLPTMDEPKIKKAANAVLCALSSLFTRPIKDIIGKL
RPLNILNILATCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYEMQGPEDL
AVELVPVVMGGIGLVLGFTKEKIGKMLSSAATTLRACKDLGSYGLEILKLVMKWFFPK
KEEANELAMVRAIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTK
SASPDIVGTINALLARIAAARSLVHKAKEELSSRQRPVVVMISGRPGIGKTHLARELA
KKVASTLSGDQRIGLVPRNGVDHWDAYKGERVVLWDDYGMSNPIQDALRLQELADTCP
LTLNCDRIENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPDIEKA
KRDFPGQPDMWKDHFRPDFSHIKLQLAPQGGFDKNGNTPHGKGVVKSLTIGSLIARAS
GLLHERMDEFELQGSDLPTFNFDRNKVAAFRQLAAENKYGLMDTLRVGNQLKSVKTLD
ELKQAIKNISIKKCQIVYNGCTYTMESDGRGKVVVEKVQNATVQTNNELVGALHHLRS
ARIRYYVKCFQEAIYSLLQIAGAAFVTSRIVRRMNISNLWSKPPIEEGDEPEDRGGCP
KPRDEDDLTIDSRDIKVEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERNGK
YSIEEYLQDRDRYYEELAIAKATEEDFCEEEEIKIRQRIFRPTRKQRKEERATLGLVT
GTEIRKRNPDDFKPKGKLWADDNRSVDYNERIDFEAPPSVWSRIVNFGTGWGFWVSPS
LFITSTHVIPKGITEAFGVPINQIQIHKSGEFCRLRFPKPIRPDVSGMILEEGAPEGT
VVSILIKRTTGELMPLAVRMGTHATMKIQGRTVGGQMGMLLTGSNAKGMDLGTTPGDC
GCPYIYKRGNDLVVIGVHTAAARGGNTVICATQGSEGEATLEGDDNKGTYCGAPILGP
GNAPKLSTKTKFWRSSNAPLPPGTYEPAYLGGRDPRVKGGPSLQQVMRDQLKPFTEPR
GKPPNPNVLESAKKTIINVLEQTIDPPQKWSYAQACASLDKTTSSGYPHHVRKNDYWS
GESFTGKLADQASKANLMYEEGKHMQPVYTAALKDELVKTDKIYGKIKKRLLWGSDLS
TMIRCARAFGGLMDELKANCITLPIRVGMNMNEDGPIIFEKHSRYRYHYDADYSRWDS
TQQRAVLEAALEIMVRFSAEPQLAQIVAEDLLSPSVVDVGDFKIAINEGLPSGVPCTS
QWNSIAHWLLTLCALSEVTGLGPDIIQANSMYSFYGDDEIVSTDIKLDPEKLTAKLKE
YGLKPTRPDKTEGPLVISEDLNGLTFLRRTVTRDPAGWFGKLDQNSILRQLYWTRGPN
HEDPSETMIPHAQRPVQLMALLGESSLHGPSFYSKVSKLVISELKEGGMDFYVPRQES
MFRWMRFSDLSTWEGDRNLAPSFVNEDGVE"
mat_peptide <1..988
/gene="ORF1"
/product="p48"
mat_peptide 989..2086
/gene="ORF1"
/product="NTPase"
mat_peptide 2087..2623
/gene="ORF1"
/product="p22"
mat_peptide 2624..3022
/gene="ORF1"
/product="VPg"
mat_peptide 3023..3565
/gene="ORF1"
/product="Pro"
mat_peptide 3566..5095
/gene="ORF1"
/product="RdRp"
gene 5079..6701
/gene="ORF2"
CDS 5079..6701
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="XXN27313.1"
/translation="MKMASNDAAPSNDGAAGLVPEGNNETLPLEPVAGAAIAAPVTGQ
NNIIDPWIRTNFVQAPNGEFTVSPRNSPGEILLNLELGPDLNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKILFAAVPPNFPVEFLSPAQITMLPHLIVDVRTLEPIMIPLPD
VRNTFFHYNNQPNSRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPTPDFEFTYLVPP
SVESKTKPFSLPILTLSELTNSRFPVPIDSLFTAQNNVLQVQCQNGRCTLDGELQGTT
QLLPTGICAFRGRVTAQINQRDRWHMQLQNLNGTTYDPTDDVPAPLGTPDFRGVVFGM
VSQRNVGSDAPGSTRAQQAWVSTYSPQFVPKLGSVNLRISDNDDFQFQPTKFTPVGIN
DDDDDHPFRQWELPNYSGELTLNMNLAPPVAPNFPGEQLLFFRSFVPCSGGYNQGIID
CLIPQEWIQHFYQESAPSQSDVALIRYVNPDTGRTLFEAKLHRSGYITVAHSGDYPLV
VPANGHFRFDSWVNQFYSLAPMGTGNGRRRAQ"
gene 6701..7480
/gene="ORF3"
CDS 6701..7480
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="XXN27314.1"
/translation="MAGAFIAGLAGDLLTSSVGSLVNAGANAINQKVDFENNKQLQSA
SFQHDKEMLQAQVRATKQLQSEMIALKQGVLAAGGFSPTDAARGSIGAPMTKVLDWSG
TRYWAPNSTKTTGYSGQFTSSPVHMSSPNAPQSKPAKPRSPVPSSSSSSVYSMYTQST
HLTSGSSSSASSASTKLTNLSSGSSQNRTAEWVNQQRSLSPFMSGALNISHVTPPSSR
ASSSGTVSTMPKEVLDSWTSAFNTHRQPLFAHLRVRGESRV"
ORIGIN
1 gtctaacgac gcttccgctg ccgttgctgg caaaaacaac aacaacgaca aggaaaaatc
61 ttcaagtgac agcttgtttg ctaatatgtc tgtcactttt aagaaagccc tcggggcgcg
121 gtctaaacaa ccgcccccgg gagaaacaaa acaaatacaa aaaccaccaa ggccaccgac
181 accggaattg gtgaagaaaa tacctccacc cccacccaat ggcgaggatg aaccagggat
241 agtgtacaag gtgggagagg gtgtgtctgg gctgcccgac ctaacaactg tggcacaacc
301 tgacgcacag aacacagctt acagtgttcc cccacttagc cagagagaag tcggcgaagc
361 taaagaaccg ctgcctggct ccattctgga aatgtgggat ggtgagatct accactatgg
421 gctgtatgtt gagcgggggc atgtgctcgg agtacacaaa ccacctgctg caataagcct
481 tgccaaaatt gaaataacac cgctgtctct ctactggaga gtggtctaca ctccccagta
541 tttgatagat ccaggaactc ttaagaactt gagtggggag actttcccat acacggcctt
601 tgacaataac tgctatgcct tctgttgctg ggtcctagac ctcaacgact cctggcttag
661 caggagaatg atccaaagaa caactggatt tttcaaacct tatcaggatt ggaatagaaa
721 acccttacca accatggatg aaccgaaaat caagaaagcc gcgaatgctg tcctatgcgc
781 tctctcctca ctcttcacta gacccattaa ggacatcatt gggaagctta gaccactgaa
841 cattcttaat atactggcaa cctgcgattg gacttttgca ggcatagtgg aatccttgat
901 ccttcttgct gaactctttg gggtgttctg gacaccccca gatgtgtctg cgatgattgc
961 tcccttactc ggcgactacg agatgcaagg ccccgaggac ctggctgtgg aacttgtacc
1021 cgtggtgatg gggggaatag gtttggtgtt aggattcacc aaagaaaaga tcggcaagat
1081 gctttcatca gctgcgacca cacttagggc ctgcaaggat ttaggatctt atggattgga
1141 gatactcaaa ttggtcatga agtggttctt ccccaaaaag gaggaggcta acgaactagc
1201 catggtgagg gccattgagg atgcagtcct ggatttggag gcaatagaaa acaatcacat
1261 gaccaccctt ctcaaggata aagacagcct ggccacatac atgaggactc ttgacttgga
1321 agaagagaaa gcaaggaaac tgtcgaccaa atcggcgtca cctgacatcg tgggtacaat
1381 aaacgcactg ctggctagga tagcagccgc cagatcactg gtccacaagg ctaaggagga
1441 gctctcgagc agacagagac ctgttgttgt aatgatatca ggtagaccag gtataggaaa
1501 gacccatctg gccagagagc tagccaagaa agtcgcgtca acactgtcag gcgaccaaag
1561 aatcggactg gtacctagga atggtgtcga ccattgggac gcctacaagg gagaaagggt
1621 ggtcctgtgg gatgattatg gtatgagcaa ccctatacag gacgcactga ggctccaaga
1681 attggctgac acctgtcctc tgacactaaa ttgtgatagg attgaaaaca aaggaaaagt
1741 gttcgacagt gacgccataa ttataacaac caaccttgca aacccagcac cactagacta
1801 tgtcaacttt gaggcctgct ctagacgcat agacttcttg gtgtatgcag acgcacctga
1861 cattgagaag gctaagcgtg acttccctgg ccaaccagat atgtggaaag accatttcag
1921 accagatttc tcacacatta aacttcagct ggcaccacag ggaggttttg acaaaaatgg
1981 caacacccca catggcaaag gtgtggtaaa gtccctaacg attggttccc tgatcgccag
2041 ggcctccggc ttgctccacg agagaatgga tgagttcgag ctccaaggct ctgacctacc
2101 aaccttcaat tttgaccgca ataaagtcgc tgccttcaga caattggcag ctgaaaacaa
2161 atatggtctt atggacacat tgagggtcgg caaccaactg aaaagtgtta agaccctgga
2221 tgagctgaag caggccataa agaacatcag tatcaagaag tgtcaaatag tgtataatgg
2281 atgcacctat actatggaat ctgatgggag gggcaaggtt gtggttgaaa aggtacaaaa
2341 cgcaacagtt caaaccaaca atgaactcgt aggggcactc caccacctga gatctgcaag
2401 gataagatac tatgttaaat gtttccaaga agccatttac tctctactcc aaattgctgg
2461 cgcagccttt gtcacctcac gcatcgtgag gcgcatgaat atatcaaacc tctggtcgaa
2521 gccacccatt gaggagggtg atgagcctga ggacagagga gggtgcccca agcccaggga
2581 tgaagatgac ctcactattg actctagaga cattaaagtg gaagggaaga agggcaagaa
2641 caagtctggc cggggcaaga aacacacagc cttctcttcc aagggcctca gtgatgaaga
2701 gtacgacgag tacaagagaa tcagagagga gaggaatggc aagtactcaa tagaggaata
2761 cctccaagac agggacaggt actatgaaga gcttgccatt gctaaggcca ctgaggaaga
2821 cttctgtgaa gaggaggaga tcaaaatccg ccagagaatc ttccgaccca ccaggaagca
2881 acggaaagag gaaagggcca cgctcgggct tgtcacagga acggaaatca gaaagaggaa
2941 tccagatgat tttaaaccaa aaggaaaatt gtgggctgat gacaacagga gcgtggatta
3001 caatgagagg atagattttg aggctccccc gagtgtttgg tctaggatag tcaactttgg
3061 cacaggctgg ggattctggg tctctccaag tctctttata acttcaacac acgtcatacc
3121 aaaaggaatc actgaggcct ttggagtgcc cataaaccaa atccaaatcc acaaatctgg
3181 agaattttgc cgcttgcggt ttccaaagcc aattagacca gacgtgagtg ggatgatctt
3241 ggaagagggc gcccctgaag gcactgttgt gtctattctc atcaaaagga caacagggga
3301 gctgatgcct cttgcagtca gaatggggac tcatgccaca atgaaaatcc aaggtagaac
3361 ggtgggtggt cagatgggta tgcttctcac tggctcaaat gctaaaggca tggatctagg
3421 cacaacgcca ggtgactgcg gatgtccata catatacaaa aggggcaatg accttgtggt
3481 cattggggtg cacactgcag cagctcgtgg aggcaacacg gtcatatgtg ccacacaggg
3541 aagtgagggt gaagccactc ttgaaggaga tgacaacaag ggcacctatt gtggagcccc
3601 cattttggga cctggcaatg caccaaaatt gagcacaaag acaaaattct ggagatcctc
3661 taacgcaccg cttcccccag gtacttatga accagcatac cttggtggga gggacccgcg
3721 cgtgaaggga ggcccatctc tgcaacaagt tatgagagat caactcaaac cttttacaga
3781 gcccagaggg aagccaccaa acccaaatgt cttagagtca gcaaagaaga ctatcatcaa
3841 tgttctggaa cagaccattg accctcctca aaagtggtca tatgcccaag cttgtgcatc
3901 cctcgacaag acaacctcca gtggataccc gcaccacgtt cggaagaatg actactggag
3961 tggtgaatcc ttcacaggaa aacttgcaga tcaggcttca aaagcaaatc tcatgtatga
4021 ggaaggcaag cacatgcaac cagtttacac cgcagcactc aaagacgagc tcgtgaaaac
4081 tgacaaaatt tatggcaaaa tcaagaaaag actcctatgg ggctctgacc tctccacaat
4141 gattcgatgc gccagagcat ttggtggtct catggatgaa ctcaaagcaa attgtatcac
4201 actccctatc agagttggta tgaatatgaa tgaagatggt cccataatat ttgagaaaca
4261 ctccaggtac aggtaccact atgatgctga ttactcccgc tgggactcca cacaacagcg
4321 ggcagtgctg gaagcggcac ttgaaatcat ggtgagattt tctgctgagc cacagctggc
4381 acaaatagtg gcagaggacc tgctgtcacc aagtgtggtt gatgtgggcg atttcaaaat
4441 cgctatcaat gaaggcctac catctggcgt gccttgcacc tcacaatgga attctattgc
4501 ccactggtta cttaccttgt gtgccctttc tgaagtgacg ggattaggtc ctgacatcat
4561 tcaagctaac tccatgtact ctttctatgg tgatgatgag attgtgagca cagacataaa
4621 attggaccca gagaaattaa ccgcaaagct caaagaatat ggccttaaac ccactcggcc
4681 cgacaaaact gaggggccgt tggtgattag tgaggacctg aatgggttaa ctttccttcg
4741 ccggacagtc acccgtgatc cagcaggttg gtttggaaag ttggaccaaa actccatcct
4801 caggcagttg tactggacaa gaggacccaa ccatgaagac cccagtgaga ccatgatacc
4861 acacgcacaa agacctgtgc agctcatggc actactagga gagtcctctc tacatggacc
4921 ctcattttac agcaaggtta gcaagttagt catatctgaa cttaaagagg gaggaatgga
4981 tttttatgtg cccagacaag aatcaatgtt cagatggatg aggttctcag atctaagcac
5041 atgggagggc gatcgcaatc tggctcccag ttttgtgaat gaagatggcg tcgaatgacg
5101 ccgctccatc taatgatggt gctgctggtc tcgtaccaga gggcaacaac gagacccttc
5161 ccctagaacc agttgcgggc gcagctatag ccgcacccgt cactggccaa aacaatataa
5221 ttgacccctg gattagaaca aattttgtgc aagcaccaaa tggagagttc acagtgtcac
5281 ccagaaactc tcctggagaa attttattaa atttagagtt gggccctgat ttgaaccctt
5341 atttggctca tttgtcaagg atgtacaatg ggtatgctgg tggagtggaa gttcaggttc
5401 tcctggcagg gaacgcgttc actgccggaa agatcctctt cgccgccgtc ccgccaaatt
5461 ttccagtgga attcttaagc ccagcccaga tcacaatgct cccacactta atagtagatg
5521 ttaggactct tgaaccaatc atgatcccac tccctgatgt taggaataca ttcttccatt
5581 ataataatca gcctaacagc cgcatgagat tagtggctat gctctatacc ccactcagat
5641 ctaatggttc aggtgatgac gtctttactg tctcttgtag ggttttgact aggcctactc
5701 ctgattttga gttcacttat ttagtgccac cttctgttga atctaaaacc aagccttttt
5761 ccctacctat tttaaccctt tctgagctca caaattcgag gtttccagtc cccatcgatt
5821 cgctttttac cgcccagaat aatgtgttgc aggtgcagtg tcaaaatggc aggtgtacac
5881 ttgatggtga gctacaaggc acaacccagt tgctcccaac cggcatctgt gcattcagag
5941 gacgggtgac agcacaaatc aaccaacgtg acaggtggca catgcaactg caaaacctca
6001 atggtacaac atatgaccca actgatgatg tgccagcccc gctgggtaca cctgacttca
6061 ggggcgtcgt gtttggaatg gtaagccaaa gaaatgtggg tagtgatgcg cctggctcaa
6121 ccagagccca acaggcgtgg gtttcaacct atagccccca atttgtcccc aaattaggtt
6181 ctgtcaatct tagaattagt gataatgatg acttccaatt ccagccaaca aaattcacac
6241 cagtgggcat caatgatgat gatgatgatc acccgttcag acagtgggag ctaccaaatt
6301 attcagggga gcttaccttg aacatgaatc ttgccccccc agttgctcca aattttcctg
6361 gtgaacaatt gttattcttc agatctttcg tgccatgctc aggaggttac aaccaaggta
6421 ttatagattg tcttatcccc caagaatgga tccaacattt ctatcaggaa tcagcaccct
6481 cccagtcaga tgtggcccta atcaggtatg tcaaccccga tacgggacgt acactgtttg
6541 aagcaaaatt gcacagatct ggttacatta ctgtggctca ctctggagat tatcctcttg
6601 ttgttccggc taatggacac tttagatttg attcttgggt aaatcagttt tactcactcg
6661 ccccaatggg aactgggaat gggcgaagga gggctcagta atggctgggg ctttcattgc
6721 aggattggca ggcgatttgc tcacgtcatc tgtgggctcc cttgtgaacg caggggcaaa
6781 cgccatcaac caaaaggtag actttgaaaa caataaacaa cttcagtctg cttcctttca
6841 gcatgataaa gagatgctcc aagcgcaggt gagggcaacc aagcagctgc aatctgaaat
6901 gatagcccta aaacaggggg ttttggccgc aggcggcttt tcccccactg atgcagcaag
6961 gggatccatt ggtgcaccca tgacaaaggt gcttgactgg tctggcactc gatactgggc
7021 acccaattcc acaaagacaa ctggctattc gggacaattc acctcttcac ctgtgcatat
7081 gtctagccca aatgctccac aatcaaaacc tgcaaagcct aggtctccag ttccttcatc
7141 ctcttctagt agtgtttata gtatgtatac tcaatctact catttgacat ctggctcttc
7201 tagtagtgct tcttctgcct ccacaaagtt gacaaattta agctctggct cctctcaaaa
7261 cagaacagca gaatgggtga atcaacagag aagtcttagc cctttcatga gtggcgcact
7321 taacatctca catgttacgc caccctcaag tagggcttcc agttctggga cggtctcaac
7381 catgccaaag gaagttttgg actcctggac gtctgcgttt aacacacaca gacagccgct
7441 cttcgcacac ctcagggtga ggggggagtc acgtgtttag tgaaaagaaa taattggcta
7501 taatgtgatt tctttctgaa tttggctaat ttgcatcttt taaaaa
//