Typing tool
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Typing tool
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Complete norovirus genomes
| PV784346 | GII.17 | |
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| GII.P17 |
ORF1: 1..5107
ORF2: 5088..6704
ORF3: 6704..7474
LOCUS PV784346 7540 bp RNA linear VRL 26-NOV-2025
DEFINITION Norovirus GII isolate Hu/GII.17/188/DE/2024 nonstructural
polyprotein (ORF1) gene, partial cds; and VP1 (ORF2) and VP2 (ORF3)
genes, complete cds.
ACCESSION PV784346
VERSION PV784346.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7540)
AUTHORS Tohma,K., Jacobsen,S., Altmann,B., Kendra,J.A., Landivar,M., De
La,O. Jr., Fernandez-Garcia,M.D., Gomes,K.A., Chudnovsky,S.,
Ford-Siltz,L.A., Pilewski,K.A., Gao,Y., Mazo,I., Niendorf,S. and
Parra,G.I.
TITLE GII.17 norovirus re-emerged in the 2020s as a result of dynamic and
adaptive evolutionary processes
JOURNAL Nat Commun (2025) In press
PUBMED 41285779
REMARK Publication Status: Available-Online prior to print
REFERENCE 2 (bases 1 to 7540)
AUTHORS Jacobsen,S., Altmann,B. and Niendorf,S.
TITLE Direct Submission
JOURNAL Submitted (12-JUN-2025) Infectious diseases, Robert Koch-Institute,
Seestr. 10, Berlin 13353, Germany
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) HIVE-hexagon aligner v.
2.1; High-performance Integrated Virtual
Environment (HIVE) HIVE-heptagon profiler
v. 2.1
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7540
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Hu/GII.17/188/DE/2024"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Germany"
/collection_date="14-Feb-2024"
/note="genotype: GII.17"
gene <1..5107
/gene="ORF1"
CDS <1..5107
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="XVJ37796.1"
/translation="KMASNDASVAVAGKNNNNDNVKSSSDSLFSNMTVTFKKALGARS
KQPPPGETKQTLRPPRPPTPELVKKIPPPPPNGEDEPKVTYKVGEGVSGLPDLTTVAQ
PDAQNTAYSVPPLSQREVGEAREPLPGSILEMWDGEIYHYGLYVERGHVLGVHKPPAA
ISLAKIELTPLSLYWRVVYTPQYLIAPETLKNLNGETFPYTAFDNNCYAFCCWVLDLN
DSWLSRRMVQRTTGFFRPYQDWNRKPLPTMDEPKIKKAANAVLCALSSLFTRPIKDVI
GKLKPLNIMNILATCDWTFAGIVESMILLAELFGVFWTPPDVSAIIAPLLGDYEMQGP
EDLAVELVPVVMGGIGLVLGFTKEKIGKMLSSAATTLRACKDLGSYGLEILKLVMKWF
FPKKEEANELAMVRAIEDAVLDLEAIENNHMTTLLKDKDALATYMRTLDLEEEKARKL
SSKSASPDIVGTVNALLARIAAARSLVHKAKEELSSRQRPVVVMISGKPGIGKTHLAR
ELAKKVASTLSGDQRIGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIQDALRLQELAD
TCPLTLNCDRIENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPDI
EKAKRDFPGQPDMWKDHYRSDFSHIKLQLAPQGGFDKSGNTPHGKGVVKSLTIGSLIA
RASGLLHERMDEFELQGPNLPTFNFDRNKVAAFRQLAAENKYGLMDTLRVGNQLKSVK
TLDELKQAIKNITIKKCQIVYNGCTYTMESDGRNKVVVEKVQNATVQTNNELAGALHH
LRSARIRYYVKCFQEAIYSILQIAGAAFVTTRIVRRMNISNLWSKPPVEEGDEPEDKG
GCPKPRDEDDLTIDSKDIKAEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREER
NGKYSIEEYLQDRDRYYEELAIAKATEEDFCEEEEIKIRQRIFRPTRKQRKEERATLG
LVTGSEIRKRNPDDFKPKGKLWADDNRSVDYNERIDFEAPPSVWSRIVNFGTGWGFWV
SPSLFITSTHVIPKGITEAFGVPINQIQIHKSGEFCRLRFPKPIRPDVSGMILEEGAP
EGTVVSILIKRTTGELMPLAVRMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTP
GDCGCPYIYKRGNDFVVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPI
LGPGNAPKLSTKTKFWRSSNAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFT
EPRGKPPKPSVLESAKKTIINVLEQTIDPPEKWSYAQACASLDKTTSSGYPHHVRKND
YWSGESFTGKLADQASKANLMYEEGKHMQPVYTAALKDELVKTDKIYGKIKKRLLWGS
DLSTMIRCARAFGGLMDELKANCITLPIRVGMNMNEDGPITFEKHSRYRYHYDADYSR
WDSTQQRAVLEAALEIMVRFSAEPQLAQIVAEDLLSPSVVDVGDFKITINEGLPSGVP
CTSQWNSIAHWLLTLCALSEVTGLGPDIIQANSMYSFYGDDEIVSTDIKLDPEKLTAK
LKEYGLKPTRPDKTEGPLVISEDLNGLTFLRRTVTRDPAGWFGKLDQNSILRQLYWTR
GPNHEDPSETMIPHAQRPVQLMALLGESSLHGPSFYSKVSKLVISELKEGGMDFYVPR
QESMFRWMRFSDLSTWEGDRNLAPSFVNEDGVE"
mat_peptide <1..997
/gene="ORF1"
/product="p48"
mat_peptide 998..2095
/gene="ORF1"
/product="NTPase"
mat_peptide 2096..2632
/gene="ORF1"
/product="p22"
mat_peptide 2633..3031
/gene="ORF1"
/product="VPg"
mat_peptide 3032..3574
/gene="ORF1"
/product="Pro"
mat_peptide 3575..5104
/gene="ORF1"
/product="RdRp"
gene 5088..6704
/gene="ORF2"
CDS 5088..6704
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="XVJ37797.1"
/translation="MKMASNDAAPSNDGAAGLVPEGNNETLPLEPVAGAAIAAPVTGQ
NNIIDPWIRTNFVQAPNGEFTVSPRNSPGEILLNLELGPDLNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKILFAAVPPNFPVEFLSPAQITMLPHIIVDVRTLEPIMIPLPD
VRNTFFHYNNQPNSRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPTPDFEFTYLVPP
SVESKTKPFSLPILTLSELTNSRFPVPIDSLFTAQNNVLQVQCQNGRCTLDGELQGTT
QLLPSGICAFRGRVTTETDNPDKWHMQLQNLNGTTYDPTDDVPAPLGTPDFKGVVFGM
ASQRNVGNDAPGSTRSHEAVISTYSPRFVPKLGSVNFKSNDDDFQLQPTRFTPVGIND
DGNQPFRQWELPDYSGVLTLNMNLAPPVAPNFPGEQLLFFRSSVPCSGGYNQGIIDCL
IPQEWIQHFYQESAPSQSEVALIRYVNPDTGRTLFEAKLHRSGYITVAHSGDYPLVVP
ANGYFRFDSWVNQFYSLAPMGTGNGRRRAQ"
gene 6704..7474
/gene="ORF3"
CDS 6704..7474
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="XVJ37798.1"
/translation="MAGAFIAGLAGDMLTSSVGSLVNAGANAINQKIDFENNKQLQSA
SFQHDKEMLQAQVNATKQLQSEMIALKQGVLAAGGFSPTDAARGAIGAPMTKVLDWSG
TRYWAPNSTKTTGYSGQFTSSPVHMPSPSVPQSKPAKPKSLGSSSSSSSVYSMSTQLT
SLTSGSSSNASSASTKLTNLSSGSSQNRTAEWVNQQRSLSPFMSGALNITPPSSRASS
SGTVSTVPKEVLDSWTSAFNTRRQPLFAHLRVRGESRV"
ORIGIN
1 gaagatggcg tctaacgacg cttccgttgc cgttgctggc aaaaacaaca acaacgacaa
61 tgtaaaatct tcaagtgaca gcttgttttc taacatgact gttactttta agaaagccct
121 cggggcgcgg tctaagcagc cgcccccggg agaaacaaaa caaacactaa gaccaccaag
181 gccgccgaca ccggaattgg tgaagaagat acccccacct ccccccaatg gcgaggatga
241 accaaaggta acgtataagg tgggagaagg tgtgtctggg ctgcccgact taacaaccgt
301 ggcacaacct gacgcacaga acacagccta tagtgtcccc ccacttagcc agagagaggt
361 cggcgaagct agagaaccgt tgcctggctc cattctggaa atgtgggatg gtgagatcta
421 ccactatggg ctgtatgttg agcgggggca tgtgctggga gtgcacaaac cacctgctgc
481 aataagcctt gccaaaattg agttaacacc gctgtctctc tactggagag tggtctacac
541 tccccagtac ttgatagctc cagagaccct caagaattta aatggagaga ctttcccata
601 cacggccttt gacaacaact gttatgcctt ctgttgttgg gttctagacc ttaacgactc
661 ctggcttagc agaagaatgg tccaaagaac aaccggattc ttcagaccgt atcaggactg
721 gaacagaaaa cccttaccaa ccatggatga accaaaaatc aagaaggccg cgaatgctgt
781 tctgtgtgct ctctcctcac tcttcactag gcccatcaaa gatgtcattg gaaagcttaa
841 accactaaac attatgaaca tactggcaac ttgtgattgg acttttgcgg gcatagtgga
901 atccatgatc cttcttgctg aactctttgg ggtgttctgg acgcccccag atgtgtctgc
961 aataattgct cccttactcg gtgactacga gatgcaaggc cccgaagacc tggccgtgga
1021 acttgtgccc gtggtaatgg gaggaatagg tttggtgtta ggattcacca aggaaaagat
1081 cggcaagatg ctttcatcag ctgcaaccac actcagggcc tgtaaggatc taggatctta
1141 tgggttggag atactcaaac tggtcatgaa gtggttcttc cccaagaagg aggaggccaa
1201 cgagttagcc atggtgaggg ccattgagga tgcagttctg gatttggagg caatagaaaa
1261 caaccacatg accactctcc ttaaggacaa agacgccctg gccacataca tgaggactct
1321 tgacttggaa gaagaaaaag caaggaaact atcttccaaa tcggcgtcac ctgacatcgt
1381 gggcacagta aacgcattat tggcaagaat agcagccgcc aggtcactgg tccacaaggc
1441 taaggaggag ctctcgagca gacagagacc tgttgttgta atgatatcag gtaagccagg
1501 tataggaaag acccatctgg ccagagagct agccaagaag gttgcgtcaa cactgtcagg
1561 cgaccaaagg attggactga tacccagaaa tggcgtcgac cattgggacg cctacaaagg
1621 agagcgggtg gttctgtggg atgactatgg catgagcaac cctatacagg acgcactgag
1681 gctccaagaa ttggctgaca cctgtcctct gaccctaaat tgtgacagaa ttgaaaacaa
1741 aggaaaagtg ttcgacagtg acgccataat cataacgacc aaccttgcaa acccagcacc
1801 attggattat gtcaactttg aggcttgctc cagacgcata gacttcttgg tgtatgcaga
1861 cgcacctgac atcgagaagg ctaagcgtga cttccctggc caaccagata tgtggaaaga
1921 ccattacaga tcagacttct cacacattaa acttcagctc gcaccacagg gaggctttga
1981 taagagtggc aacaccccac atggcaaagg tgtggttaag tctctgacga ttggttctct
2041 gatcgccagg gcttctggct tgctccatga gagaatggat gaattcgagc tccaaggccc
2101 caacttacca accttcaatt tcgaccgtaa caaagtcgcc gccttcagac aattggcagc
2161 tgaaaacaaa tacggtctta tggacacact gagggtcggc aaccaactga aaagtgtcaa
2221 aaccctggat gagctgaagc aggctataaa gaacatcacc atcaagaagt gccagatagt
2281 gtacaatgga tgcacctaca ccatggaatc tgatgggagg aacaaggttg tggttgaaaa
2341 ggttcaaaat gcaacagtcc aaaccaacaa tgaacttgca ggagcactcc accacctgag
2401 atctgcaaga ataaggtatt atgtcaaatg tttccaagaa gctatttact ctatactcca
2461 aattgctggt gcagccttcg tcaccacacg catcgtgagg cgcatgaaca tctcaaacct
2521 ctggtcgaag ccacccgtcg aagagggtga tgagcctgaa gacaaagggg ggtgccccaa
2581 gcccagggat gaagatgacc tcactattga ctccaaagac attaaagcag aaggtaagaa
2641 gggcaagaac aaatctggcc ggggcaagaa acacacagct ttctcatcca agggtctcag
2701 tgatgaagag tacgatgagt acaagagaat cagggaggag agaaatggca agtactcaat
2761 agaagaatac ctccaggata gggatagata ctatgaagag cttgccattg ctaaggccac
2821 tgaggaagac ttctgtgaag aggaggaaat caaaattcgc cagagaatct tccggcccac
2881 caggaagcag cggaaagagg aaagagccac gcttgggctc gtcacaggat cggaaatcag
2941 aaagaggaac ccagatgatt ttaagccaaa aggaaaattg tgggctgatg acaacaggag
3001 tgtggactac aatgagagga tagattttga ggctccccca agtgtttggt ctaggatagt
3061 caactttggt acaggatggg gattctgggt ctccccaagt ctctttataa cttcaacaca
3121 tgtcatacca aaaggaatca ctgaggcctt tggagttccc attaaccaaa ttcaaattca
3181 caaatctgga gagttttgcc gcttgcggtt tccaaaacca atcaggccag acgtgagtgg
3241 aatgatcttg gaagagggtg cccctgaagg cactgttgtt tccattctca tcaagaggac
3301 gacaggggaa ctgatgcctc tcgcagtcag aatgggaact catgccacaa tgaaaatcca
3361 aggtagaacg gtgggcggtc aaatgggcat gcttctcact ggctcaaacg ccaaaagcat
3421 ggacctaggc acaacaccag gtgactgtgg gtgcccatat atatacaaaa ggggcaatga
3481 cttcgtggtc attggggtgc acactgcagc agcccgtgga ggtaacacgg tcatatgtgc
3541 cacacagggg agtgaaggcg aagccaccct cgaaggaggt gacaacaagg gcacctattg
3601 tggagccccc atcttgggtc ctggcaacgc accaaaattg agcacaaaaa caaaattctg
3661 gagatcttct aacgcgccgc tcccgccagg cacctatgaa ccagcatacc ttggtggaaa
3721 agacccgcgt gtgaagggag gcccatctct acaacaggtt atgagagacc aactcaaacc
3781 ttttacagag cccagaggga agccaccaaa accaagtgtc ttagaatcag caaagaagac
3841 catcattaat gttctggaac aaaccattga cccccctgaa aagtggtcat atgcccaagc
3901 ttgtgcatcc ctcgacaaga caacctccag tggatacccg catcacgtcc ggaagaatga
3961 ctactggagt ggtgaatcct tcacggggaa acttgcagac caggcctcaa aagcaaatct
4021 catgtatgag gaaggtaagc acatgcaacc agtttacacc gcagcactca aagacgagct
4081 cgtgaaaact gacaaaattt atggcaagat caagaaaaga ctcctgtggg gctctgacct
4141 atccaccatg attcgatgcg ccagggcatt tggtggcctc atggacgagc tcaaagcaaa
4201 ttgtatcaca ctccctatca gagttggtat gaacatgaat gaagatggtc ccataacatt
4261 tgaaaagcac tccaggtaca ggtaccacta tgatgctgat tattcccgct gggattccac
4321 acaacagcgg gcagtgctgg aagcggcact tgaaatcatg gtgagatttt ctgctgagcc
4381 acagttggca caaatagtgg cagaggacct gctatcacca agtgtggttg atgtgggcga
4441 tttcaaaatt actattaatg aaggcctacc atctggcgtg ccttgcactt cacaatggaa
4501 ttctattgcc cactggttac tcaccctatg tgccctgtct gaagtgacag gactaggccc
4561 tgacatcata caagccaact ccatgtactc tttctatggt gatgatgaga ttgtgagcac
4621 agacataaaa ttagacccag agaaattgac tgcaaaactc aaagaatatg gtctcaaacc
4681 cacccggcct gacaagactg aggggccact ggtaattagt gaggacctga atgggttgac
4741 tttcctccgc cgaacagtca cccgcgatcc agcgggttgg tttggaaagt tggaccaaaa
4801 ctccatcctc agacagctgt actggacaag gggacccaac catgaagacc ccagtgagac
4861 tatgatacca cacgcacaga gacctgtgca gctcatggca ttgctaggag aatcctccct
4921 acatggaccc tcattttaca gcaaggttag caagctggtt atatctgaac ttaaagaggg
4981 aggaatggat ttttatgtgc ccagacaaga gtcaatgttc aggtggatga ggttctcaga
5041 tctaagcaca tgggagggcg atcgcaatct ggctcccagt tttgtgaatg aagatggcgt
5101 cgaatgacgc cgctccatct aatgatggtg ctgctggtct cgtaccagag ggcaataacg
5161 agacccttcc cctagaacca gttgcgggcg cagctatagc cgcacccgtc actggccaaa
5221 ataatataat tgacccctgg attagaacaa attttgtgca agcaccaaat ggagagttca
5281 cagtgtcacc cagaaactct cctggagaaa ttttactaaa cctagagttg ggccctgatc
5341 tgaaccctta tttggctcat ttgtcaagga tgtataatgg atatgctggt ggtgttgaag
5401 tccaggttct cctggcaggg aacgcgttca ctgccgggaa gatcctcttc gccgctgtcc
5461 cgccaaattt tccggtggaa ttcttaagcc cagcccagat tacaatgctc ccacatataa
5521 tagtagatgt taggactctt gaaccaatta tgatcccatt acctgatgtt aggaatacat
5581 tcttccacta taataatcag cccaacagcc gcatgagatt agtggctatg ctctacaccc
5641 cccttagatc taatggctca ggtgatgatg ttttcactgt ttcttgcagg gttttgacta
5701 ggcctactcc tgattttgag ttcacttatc tagtgccacc ctctgttgaa tctaagacta
5761 aacccttttc tttacccatt ctaacccttt ctgagctcac aaattcgagg ttcccggtcc
5821 ccatcgattc gcttttcacc gcccaaaata atgtgttgca ggtgcagtgt caaaatggca
5881 ggtgcacact tgacggtgag ctacaaggca caacccagtt gctcccatct ggcatctgtg
5941 cgttcagggg acgggtgaca acagaaactg acaatcctga caagtggcac atgcaactgc
6001 aaaaccttaa tggcacaaca tatgacccaa ctgatgatgt gccagcccca ctgggtacac
6061 ctgacttcaa gggcgtcgtg tttgggatgg caagccaaag aaatgtgggt aacgacgcgc
6121 ccggctcaac caggtcccat gaggcggtga tttcaaccta cagccccaga tttgttccta
6181 aattaggctc tgtcaatttc aaaagcaatg acgatgattt ccaattgcag ccaacaagat
6241 tcacaccagt gggcattaat gatgatggca accaaccatt cagacaatgg gaattaccag
6301 attattcagg ggtgcttacc ttgaatatga accttgcccc ccctgttgct ccaaatttcc
6361 ctggcgaaca attactattc ttcagatctt ctgtgccatg ttcaggaggt tacaaccaag
6421 gtattataga ttgccttatc ccccaagaat ggatccaaca cttctaccag gaatcagcac
6481 cttctcagtc agaagtggcc ctaatcaggt acgtcaaccc cgacacgggt cgtacactgt
6541 ttgaggcaaa attgcatagg tcaggctata tcactgtggc tcattctgga gactatcctc
6601 ttgttgttcc ggctaatgga tactttagat ttgactcttg ggtaaatcag ttttactcac
6661 tcgccccaat gggaactggg aatgggcgaa ggagggctca gtaatggctg gagctttcat
6721 tgcaggattg gcgggtgaca tgctcacgtc atccgtgggc tccctggtga acgcaggggc
6781 aaacgccatc aaccaaaaga tagactttga aaacaacaaa caactccagt ctgcttcctt
6841 tcaacatgat aaagagatgc tccaagcgca ggtgaacgca accaagcagc tgcaatctga
6901 gatgatagcc ctaaaacagg gggttttggc cgcaggcggc ttttccccca ctgatgcagc
6961 gaggggggcc atcggtgcac ccatgacaaa ggtgcttgac tggtctggca ctcgatactg
7021 ggctcccaat tccacaaaga caactggtta ttcggggcaa ttcacctctt cacctgtgca
7081 catgcccagc ccgagtgtcc cacaatcaaa acccgcaaag cccaagtctc taggttcttc
7141 ttcttcttct agtagtgttt acagtatgtc tacccaatta acttctctaa catctggctc
7201 ttctagtaat gcttcttctg cttctacaaa attgacaaat ttgagctccg gctcttctca
7261 aaacagaaca gcagagtggg tgaaccaaca gagaagtctc agccctttca tgagtggcgc
7321 actcaatatc acgccacctt caagtagggc ctccagttct gggacggtct caaccgtgcc
7381 caaggaagtt ttggactcct ggacatctgc attcaacaca cgcagacagc cgctcttcgc
7441 acacctcaga gtgagggggg agtcacgtgt ttagtgaaaa gaaataattg gctataatat
7501 gatttcttta aaatttaaat ttggctaatt tgtatctttt
//