Typing tool
|
|
|
|
|
|
Typing tool
|
Complete norovirus genomes
| PV784289 | GII.17 | |
|
|---|---|---|---|
| GII.P17 |
ORF1: 1..5108
ORF2: 5089..6705
ORF3: 6705..7484
LOCUS PV784289 7540 bp RNA linear VRL 26-NOV-2025
DEFINITION Norovirus GII isolate Hu/GII.17/131/DE/2023 nonstructural
polyprotein (ORF1) gene, partial cds; and VP1 (ORF2) and VP2 (ORF3)
genes, complete cds.
ACCESSION PV784289
VERSION PV784289.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7540)
AUTHORS Tohma,K., Jacobsen,S., Altmann,B., Kendra,J.A., Landivar,M., De
La,O. Jr., Fernandez-Garcia,M.D., Gomes,K.A., Chudnovsky,S.,
Ford-Siltz,L.A., Pilewski,K.A., Gao,Y., Mazo,I., Niendorf,S. and
Parra,G.I.
TITLE GII.17 norovirus re-emerged in the 2020s as a result of dynamic and
adaptive evolutionary processes
JOURNAL Nat Commun (2025) In press
PUBMED 41285779
REMARK Publication Status: Available-Online prior to print
REFERENCE 2 (bases 1 to 7540)
AUTHORS Jacobsen,S., Altmann,B. and Niendorf,S.
TITLE Direct Submission
JOURNAL Submitted (12-JUN-2025) Infectious diseases, Robert Koch-Institute,
Seestr. 10, Berlin 13353, Germany
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) HIVE-hexagon aligner v.
2.1; High-performance Integrated Virtual
Environment (HIVE) HIVE-heptagon profiler
v. 2.1
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7540
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Hu/GII.17/131/DE/2023"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Germany"
/collection_date="04-Jan-2023"
/note="genotype: GII.17"
gene <1..5108
/gene="ORF1"
CDS <1..5108
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="XVJ37695.1"
/translation="KMASNDASVAVAGKNNNNDKEKSSSDSLFSNMTVTFKKALGARS
KQPPPGETKQTQRPPRPPTPELVKKIPPPPPNGEDEPKIAYKVGEGVSGLPDLTTVAQ
PDAQNTAYSVPPLSQREVGEAKEPLPGSILEMWDGEIYHYGLYVERGHVLGVHKPPAA
ISLAKIELTPLSLYWRVVYTPQYLIAPETLKNLNGEAFPYTAFDNNCYAFCCWVLDLN
DSWLSRRMIQRTTGFFRPYQDWNRKPLPTMDEPKIKKAANAVLCALSSLFTRPIKDVI
GKLKPLNIMNILATCDWTFAGIVESMILLAELFGVFWTPPDVSAMIAPLLGDYEMQGP
EDLAVELVPVVMGGIGLVLGFTKEKIGKMLSSAATTLRACKDLGSYGLEILKLVMKWF
FPKKEEANELAMVRAIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKL
SSKSASPDIVGTVNALLARIAAARSLVHKAKEELSSRQRPVVVMLSGRPGIGKTHLAR
ELAKKVASTLSGDQRIGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIQDALRLQELAD
TCPLTLNCDRIENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPDI
EKAKRDFPGQPDMWKDHYRSDFSHIKLQLAPQGGFDKNGNTPHGKGVVKSLTIGSLIA
RASGLLHERMDEFELQGSDLPTFNFDRNKVAAFRQLAAENKYGLMDTLRVGNQLKSVK
TLDELKQAIKNITIKKCQIVYNGCTYTMESDGRNKVVVEKVQNATVQTNNELAGALHH
LRSARIRYYVKCFQEAIYSLLQIAGAAFVTTRIVRRMNISNLWSKPPVEEGDEPEDKG
GCPKPRDEDDLTIDSKDIKAEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREER
NGKYSIEEYLQDRDRYYEELAIAKATEEDFCEEEEIKIRQRIFRPTRKQRREERATLG
LVTGSEIRKRNPDDFKPKGKLWADDNRSVDYNERIDFEAPPSVWSRIVNFGTGWGFWV
SPSLFITSTHVIPKGITEAFGVSINQIQIHKSGEFCRLRFPKPIRPDVSGMILEEGAP
EGTVVSILIKRTTGELMPLAVRMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTP
GDCGCPYIYKRGNDFVVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPI
LGPGNAPKLSTKTKFWRSSNAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFT
EPRGKPPKPSVLESAKKTIINVLEQTIDPPEKWSYAQACASLDKTTSSGYPHHVRKND
YWSGESFTGKLADQASKANLMYEEGKHMQPVYTAALKDELVKTDKIYGKIKKRLLWGS
DLSTMIRCARAFGGLMDELKANCITLPVRVGMNMNEDGPIIFEKHSRYRYHYDADYSR
WDSTQQRAVLEAALEIMVRFSAEPQLAQIVAEDLLSPSVVDVGDFKIVINEGLPSGVP
CTSQWNSIAHWLLTLCALSEVTGLGPDVIQANSMYSFYGDDEIVSTDIKLDPEKLTAK
LKEYGLKPTRPDKTEGPLVISEDLNGLTFLRRTVTRDPAGWFGKLDHNSILRQLYWTR
GPNHEDPSETMIPHAQRPVQLMALLGESSLHGPSFYSKVSKLVISELKEGGMDFYVPR
QESMFRWMRFSDLSTWEGDRNLAPSFVNEDGVE"
mat_peptide <1..998
/gene="ORF1"
/product="p48"
mat_peptide 999..2096
/gene="ORF1"
/product="NTPase"
mat_peptide 2097..2633
/gene="ORF1"
/product="p22"
mat_peptide 2634..3032
/gene="ORF1"
/product="VPg"
mat_peptide 3033..3575
/gene="ORF1"
/product="Pro"
mat_peptide 3576..5105
/gene="ORF1"
/product="RdRp"
gene 5089..6705
/gene="ORF2"
CDS 5089..6705
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="XVJ37696.1"
/translation="MKMASNDAAPSNDGAAGLVPEGNNETLPLEPVAGAAIAAPVTGQ
NNIIDPWIRTNFVQAPNGEFTVSPRNSPGEILLNLELGPDLNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKILFAAVPPNFPVEFLSPAQITMLPHIIVDVRTLEPIMIPLPD
VRNTFFHYNNQPNSRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPTPDFEFTYLVPP
SVESKTKPFSLPILTLSELTNSRFPVPIDSLFTAQNNVLQVQCQNGRCTLDGELQGTT
QLLPSGICAFRGRVTAETDNPDKWHMQLQNLNGTTYDPTDDVPAPLGTPDFKGVVFGM
ASQRNVGNDAPGSTRAHEAVISTYSPRFVPKLGSVNFKSNDDDFQLQPTRFTPVGIND
DGDHPFRQWELPDYSGVLTLNMNLAPPVAPNFPGEQLLLFRSSVPCSGGYNQGIIDCL
IPQEWIQHFYQESAPSQSDVALIRYVNPDTGRTLFEAKLHRSGYITVAHSGDYPLVVP
ANGYFRFDSWVNQFYSLAPMGTGNGRRRAQ"
gene 6705..7484
/gene="ORF3"
CDS 6705..7484
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="XVJ37697.1"
/translation="MAGAFIAGLAGDMLTSSVGSLVNAGANAINQKIDFENNKQLQSA
SFQHDKEMLQAQVNATKQLQSEMIALKQGVLAAGGFSPTDAARGAIGAPMTKVLDWSG
TRYWAPNSTKTTGYSGQFTSSPVHMPSPSAPQSKPAKPRSLGSSSSSSSVYSMSTQST
SLTSGSSSNASSASTKLTNLSSGSSQNRTAEWVNQQRNLSPFMSGALNISHVTPPSSR
ASSSGTVSTVPKEVLDSWTSAFNTRRQPLFAHLRVRGESRV"
ORIGIN
1 tgaagatggc gtctaacgac gcttccgtcg ccgttgctgg caaaaacaac aacaacgaca
61 aggaaaaatc ttcaagtgac agcttgtttt ctaacatgac tgttactttt aagaaagccc
121 tcggggcgcg gtctaaacag ccgcccccgg gagaaacaaa acaaacacaa agaccaccaa
181 ggccaccgac accggaattg gtgaagaaga tacccccacc cccccccaat ggcgaggatg
241 aaccaaagat agcgtataag gtgggagaag gtgtgtctgg gctgcccgac ttgacaaccg
301 tggcacaacc tgacgcacag aacacagcct acagtgtccc cccacttagc cagagagagg
361 tcggcgaagc taaagaaccg ttgcctggct ccattctgga aatgtgggat ggtgagatct
421 accactatgg gctgtatgtt gagcgggggc atgtgctggg agtgcacaaa ccacctgccg
481 caataagcct tgccaaaatt gaattaacac cgctgtctct ctactggaga gtggtttaca
541 ctccccaata tttgatagct ccagagaccc ttaagaattt aaatggagag gctttcccat
601 acacggcctt tgacaacaac tgttatgcct tctgttgttg ggttttagac ctcaacgact
661 cctggcttag cagaagaatg atccaaagaa caactggatt ctttagaccg tatcaggact
721 ggaacagaaa acccttgcca accatggatg aaccaaaaat caagaaggcc gcgaatgctg
781 ttttgtgtgc tctctcctca ctcttcacta ggcccatcaa agatgtcatt ggaaagctca
841 aaccactgaa cattatgaac atactggcaa cttgtgattg gacctttgcg ggcatagtgg
901 aatccatgat ccttcttgct gagctctttg gggtgttctg gacgccccca gatgtgtctg
961 caatgattgc tcccttactc ggtgactacg agatgcaagg ccccgaagac ctggccgtgg
1021 aacttgtgcc cgtggtaatg ggaggaatag gtttggtgtt aggattcacc aaggaaaaga
1081 tcggcaagat gctttcatca gctgcgacca cactcagggc ctgtaaggat ctaggatctt
1141 atgggttgga gatactcaaa ctggtcatga agtggttctt ccccaagaag gaggaggcca
1201 acgagttagc catggtgagg gccattgagg atgcagttct ggatttggag gcaatagaaa
1261 acaaccacat gaccactctc cttaaggaca aagacagcct ggccacatac atgaggactc
1321 ttgacttgga agaagaaaaa gcaaggaaac tgtcatccaa atcggcgtca cctgacatcg
1381 tgggcacagt aaacgcatta ttggcaagga tagcagccgc caggtcactg gtccacaagg
1441 ctaaggagga gctctcgagc agacagaggc ctgttgttgt aatgttatca ggtaggccag
1501 gtataggaaa gacccatctg gccagagagc tagccaagaa ggttgcgtca acactgtcag
1561 gcgaccaaag gattggactg atacctagaa atggcgtcga ccattgggac gcctacaaag
1621 gagagcgggt ggttctgtgg gatgactatg gcatgagcaa ccccatacag gacgcactga
1681 ggctccaaga attggctgac acctgtcctc tgaccctaaa ttgtgacagg attgaaaaca
1741 aaggaaaagt gttcgacagt gacgccataa ttataacaac caacctcgca aacccagcac
1801 cactggatta tgtcaacttt gaggcttgtt ctagacgcat agacttcctg gtgtatgcag
1861 acgcacctga catcgagaag gctaagcgtg acttccctgg ccaaccagat atgtggaaag
1921 accattacag atcagacttc tcacacatta aacttcagct ggcaccacag ggaggctttg
1981 ataagaatgg caacacccca catggcaaag gtgtggttaa gtctctgacg attggttctc
2041 tgatcgccag ggcttctggc ttgctccatg agagaatgga tgaatttgag ctccaaggct
2101 ctgacttacc aaccttcaat ttcgaccgta acaaagtcgc cgccttcaga caattggcag
2161 ctgaaaacaa atatggtctt atggacacac ttagggtcgg caaccaattg aaaagtgtca
2221 aaaccctgga tgagctgaag caggctataa agaacatcac catcaagaag tgccagatag
2281 tgtacaatgg atgcacctac accatggaat ctgatgggag gaacaaggtt gtggttgaaa
2341 aggttcaaaa tgcaacagtc caaaccaaca atgaacttgc aggagcactc caccacctgc
2401 gatctgcaag gataaggtat tatgttaaat gtttccaaga agctatttac tctctactcc
2461 aaattgctgg tgcagccttc gtcaccacac gcatcgtgag gcgcatgaac atctcaaacc
2521 tctggtcgaa gccacccgtc gaagagggtg atgagcctga agacaaaggg gggtgcccca
2581 agcccaggga tgaagatgac ctcactattg actctaaaga cattaaagca gaagggaaga
2641 agggcaagaa caaatctggc cggggcaaga aacacactgc tttctcatcc aagggcctca
2701 gtgatgaaga gtacgatgag tacaagagaa tcagggagga gaggaatggc aaatactcaa
2761 ttgaagaata cctccaggac agggatagat actatgaaga gcttgccatt gctaaggcca
2821 ctgaggaaga cttctgtgaa gaggaggaaa tcaaaattcg ccagaggatc ttccggccca
2881 ccaggaagca acggagagag gaaagagcca cgcttgggct cgttacagga tcggaaatca
2941 gaaagaggaa cccagatgac ttcaagccaa aaggaaaatt gtgggctgat gacaacagaa
3001 gtgtggacta caatgagagg atagattttg aggctccccc gagtgtttgg tctaggatag
3061 tcaactttgg tacaggatgg ggattctggg tctccccaag tctctttata acttcaacac
3121 atgtcatacc aaaaggaatc actgaggcct ttggagtttc cattaaccaa attcaaattc
3181 acaaatctgg agagttttgc cgcttgcggt ttccaaaacc aatcaggcca gacgtgagtg
3241 gaatgatctt ggaagagggt gcccctgaag gcactgttgt gtccattctc atcaagagga
3301 caacagggga actgatgcct ctcgcagtta gaatgggaac tcatgccaca atgaaaatcc
3361 aaggtagaac ggtgggtggt caaatgggca tgcttctcac tggctcaaac gctaaaagca
3421 tggacctagg cacaacacca ggtgactgtg ggtgcccata catatacaaa aggggcaatg
3481 acttcgtggt cattggggtg cacactgcag cagcccgtgg aggcaacacg gtcatatgtg
3541 ccacacaagg aagtgaaggc gaagccaccc tcgaaggagg tgacaacaag ggcacctatt
3601 gtggagcccc catcttggga cctggcaacg caccaaaatt aagcacaaaa acaaaattct
3661 ggagatcttc taacgcgccg cttcctccag gtacctatga accagcatac cttggtggaa
3721 aagacccgcg tgtgaaggga ggcccatctc tacaacaggt tatgagagac caacttaaac
3781 cttttacaga gcccagaggg aagccaccaa aaccaagtgt cctagaatca gcaaagaaga
3841 ccatcattaa tgttctggag caaaccattg acccccctga aaagtggtca tatgcccaag
3901 cttgtgcatc cctcgacaag acaacctcca gtggataccc gcatcacgtc cggaagaatg
3961 actattggag tggtgaatcc ttcacgggga aacttgcaga ccaggcctca aaagcaaacc
4021 ttatgtatga ggaaggcaag cacatgcaac cagtttacac cgcagcactc aaagacgagc
4081 tcgtgaaaac tgacaaaatt tatggcaaga tcaagaaaag actcctgtgg ggctctgacc
4141 tatccaccat gattcgatgc gctagggcat ttggtggcct catggatgag ctcaaagcaa
4201 attgtatcac actccctgtc agagttggta tgaacatgaa tgaagatggt cccataatat
4261 ttgaaaagca ctccaggtac aggtaccact atgatgctga ttactcccgc tgggattcca
4321 cacaacagcg ggcagtgctg gaagcggcac ttgaaatcat ggtgagattt tctgctgagc
4381 cacagttggc acaaatagtg gcagaggacc tgctatcacc aagtgtggtt gatgtgggcg
4441 atttcaaaat tgttatcaat gaaggcctac catctggcgt gccttgcact tcacaatgga
4501 attctattgc ccactggtta ctcaccctgt gtgccctgtc tgaagtaaca ggactaggcc
4561 ctgacgtcat acaagccaac tccatgtact ctttctatgg tgatgatgag attgtgagca
4621 cagacataaa attagaccca gagaaattga ctgcaaaact caaagaatat ggtcttaaac
4681 ccacccggcc tgacaagact gaggggccac tggtaattag tgaggacctg aatgggttga
4741 ctttcctccg ccgaacagtt acccgcgatc cagctggttg gtttggaaag ttggaccaca
4801 actccatcct caggcagctg tactggacaa ggggacccaa ccatgaagac cccagtgaga
4861 ctatgatacc acacgcacag agacctgtgc agctcatggc actgctagga gagtcctccc
4921 tacatggacc ctcattttac agcaaggtta gcaagctggt catatctgaa cttaaagagg
4981 gaggaatgga tttttatgtg cccagacaag agtcaatgtt caggtggatg aggttctcag
5041 atctaagcac atgggagggc gatcgcaatc tggctcccag ttttgtgaat gaagatggcg
5101 tcgaatgacg ccgctccatc taatgatggt gctgctggtc tcgtaccaga gggcaataac
5161 gagacccttc ccctagaacc agttgcgggc gcagctatag ccgcacccgt cactggccaa
5221 aacaatataa ttgacccctg gattagaact aattttgtgc aagcaccaaa tggagagttc
5281 acagtgtcac ccagaaactc tcctggagaa attttactaa acctagagtt gggccctgat
5341 ttgaaccctt atttggctca tttgtcaagg atgtacaatg ggtacgctgg tggagttgaa
5401 gtccaggttc tcctggcagg gaacgcgttc actgccggga agatcctctt cgccgctgtc
5461 ccgccaaatt tcccagtgga attcttaagc ccagcccaga ttacaatgct cccacatata
5521 atagtagatg ttaggactct tgaaccaatt atgatcccat tacctgatgt taggaataca
5581 ttcttccact ataataacca gcccaacagc cgcatgagat tagtggctat gctctatacc
5641 ccccttagat ctaatggctc aggtgatgat gttttcactg tttcttgcag ggttttgact
5701 agacctactc ctgattttga gttcacttat ctagtgccac cctctgttga atctaaaact
5761 aagccctttt ccttacccat tttaaccctt tctgagctca caaattcgag gttcccggtc
5821 cccattgatt cgcttttcac cgcccagaat aatgtgttgc aggtgcagtg tcaaaatggc
5881 aggtgcacac ttgacggtga gctacaaggc acaacccagt tgctcccatc tggcatctgt
5941 gcgttcagag gacgggtgac agcagaaact gacaatcctg ataagtggca catgcaactg
6001 caaaacctca atggcacaac gtatgaccca actgatgatg tgccagcccc actgggtaca
6061 cctgacttca agggcgtcgt gtttgggatg gcaagccaaa gaaatgtggg taacgatgcg
6121 cccggctcaa ccagggctca tgaggcggtg atttcaacct acagccccag atttgtcccc
6181 aaattaggct ctgtcaattt taaaagtaat gatgatgatt tccaattgca gccaacaaga
6241 ttcacaccag tgggcattaa tgatgatggc gaccacccgt tcagacaatg ggaactgcca
6301 gactattcag gggtgcttac cttgaatatg aaccttgccc ccccggtcgc tccaaatttc
6361 cctggtgaac aattattact cttcagatct tccgtgccat gttcaggagg ttacaaccaa
6421 ggtattatag attgtcttat cccccaagaa tggatccaac acttctacca ggaatcagca
6481 ccttctcagt cagacgtggc cctgatcagg tacgtcaacc ccgacacggg tcgcacactg
6541 tttgaggcaa aattgcacag atctggttat atcactgtgg ctcactctgg agactatcct
6601 cttgttgtcc cggctaatgg atattttaga tttgattctt gggtaaacca gttttactca
6661 ctcgccccaa tgggaactgg gaatgggcga aggagggctc agtaatggct ggagctttca
6721 ttgcaggatt ggcgggtgac atgctcacgt catccgtggg ctccctggtg aacgcagggg
6781 caaacgccat caaccaaaag atagactttg aaaacaacaa acaactccag tctgcttcct
6841 ttcaacatga taaagagatg ctccaagcgc aggtaaatgc aaccaagcag ctgcaatctg
6901 aaatgatagc cctaaaacag ggggttttgg ccgcaggcgg cttttccccc actgatgcag
6961 cgaggggggc catcggtgca cccatgacaa aggtgcttga ctggtctggc actcgatatt
7021 gggctcccaa ttccacaaag acaactggtt attcggggca attcacctct tcacctgtgc
7081 acatgcccag ccccagtgct ccacaatcaa aacccgcaaa gcccagatct ctaggttctt
7141 cttcttcttc tagtagtgtt tatagtatgt ctacccaatc aacttctcta acatctggct
7201 cttctagtaa tgcctcttct gcttctacaa aattgacaaa tttaagctct ggctcctctc
7261 aaaacaggac agcagagtgg gtgaaccaac agagaaatct cagccctttc atgagtggcg
7321 cactcaatat ctcacatgtc acgccacctt caagtagggc ctccagttct gggacggtct
7381 caaccgtgcc caaggaagtt ttggactcct ggacatctgc attcaacaca cgcagacagc
7441 cgctcttcgc acacctcaga gtgagggggg agtcacgtgt ttagtgaaaa gaaataattg
7501 gctataatat gatttcttta aaatttaaat ttggctaatt
//