Typing tool
|
|
|
|
|
|
Typing tool
|
Complete norovirus genomes
| PV784284 | GII.17 | |
|
|---|---|---|---|
| GII.P17 |
ORF1: 1..5108
ORF2: 5089..6705
ORF3: 6705..7484
LOCUS PV784284 7519 bp RNA linear VRL 26-NOV-2025
DEFINITION Norovirus GII isolate Hu/GII.17/126/DE/2022 nonstructural
polyprotein (ORF1) gene, partial cds; and VP1 (ORF2) and VP2 (ORF3)
genes, complete cds.
ACCESSION PV784284
VERSION PV784284.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7519)
AUTHORS Tohma,K., Jacobsen,S., Altmann,B., Kendra,J.A., Landivar,M., De
La,O. Jr., Fernandez-Garcia,M.D., Gomes,K.A., Chudnovsky,S.,
Ford-Siltz,L.A., Pilewski,K.A., Gao,Y., Mazo,I., Niendorf,S. and
Parra,G.I.
TITLE GII.17 norovirus re-emerged in the 2020s as a result of dynamic and
adaptive evolutionary processes
JOURNAL Nat Commun (2025) In press
PUBMED 41285779
REMARK Publication Status: Available-Online prior to print
REFERENCE 2 (bases 1 to 7519)
AUTHORS Jacobsen,S., Altmann,B. and Niendorf,S.
TITLE Direct Submission
JOURNAL Submitted (12-JUN-2025) Infectious diseases, Robert Koch-Institute,
Seestr. 10, Berlin 13353, Germany
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) HIVE-hexagon aligner v.
2.1; High-performance Integrated Virtual
Environment (HIVE) HIVE-heptagon profiler
v. 2.1
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7519
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Hu/GII.17/126/DE/2022"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Germany"
/collection_date="01-Nov-2022"
/note="genotype: GII.17"
gene <1..5108
/gene="ORF1"
CDS <1..5108
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="XVJ37680.1"
/translation="KMASNDASVAVAGKNNNNDKEKSSSDSLFSNMTVTFKKALGARS
KQPPPGETKQTQRPPRPPTPELVKKIPPPPPNGEDEPKIAYKVGEGVSGLPDLTTVAQ
PDAQNTAYSVPPLSQREVGEAKEPLPGSILEMWDGEIYHYGLYVERGHVLGVHKPPAA
ISLAKIELTPLSLYWRVVYTPQYLIAPETLKNLNGEAFPYTAFDNNCYAFCCWVLDLN
DSWLSRRMIQRTTGFFRPYQDWNRKPLPTMDEPKIKKAANAVLCALSSLFTRPIKDVI
GKLKPLNIMNILATCDWTFAGIVESMILLAELFGVFWTPPDVSAMIAPLLGDYEMQGP
EDLAVELVPVVMGGIGLVLGFTKEKIGKMLSSAATTLRACKDLGSYGLEILKLVMKWF
FPKKEEANELAMVRAIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKL
SSKSASPDIVGTVNALLARIAAARSLVHKAKEELSSRQRPVVVMISGKPGIGKTHLAR
ELAKKVASTLSGDQRIGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIQDALRLQELAD
TCPLTLNCDRIENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPDI
EKAKRDFPGQPDMWKDHYRSDFSHIKLQLAPQGGFDKNGNTPHGKGVVKSLTIGSLIA
RASGLLHERMDEFELQGSDLPTFNFDRNKVAAFRQLAAENKYGLMDTLRVGNQLKSVK
TLDELKQAIKNITIKKCQIVYNGCTYTMESDGRNKVVVEKVQNATVQTNNELTGALHH
LRSARIRYYVKCFQEAIYSLLQIAGAAFVTTRIVRRMNISNLWSKPPVEEGDEPEDKG
GCPKPRDEDDLTIDSKDIKAEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREER
NGKYSIEEYLQDRDRYYEELAIAKATEEDFCEEEEIKIRQRIFRPTRKQRREERATLG
LVTGSEIRKRNPDDFKPKGKLWADDNRSVDYNERIDFEAPPSVWSRIVNFGTGWGFWV
SPSLFITSTHVIPKGITEAFGVPINQIQIHKSGEFCRLRFPKPIRPDVSGMILEEGAP
EGTVVSILIKRTTGELMPLAVRMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTP
GDCGCPYIYKRGNDFVVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPI
LGPGNAPKLSTKTKFWRSSNAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFT
EPRGKPPKPSVLESAKKTIINVLEQTIDPPEKWSYAQACASLDKTTSSGYPHHVRKND
YWSGESFTGKLADQASKANLMYEEGKHMQPVYTAALKDELVKTDKIYGKIKKRLLWGS
DLSTMIRCARAFGGLMDELKANCITLPVRVGMNMNEDGPIIFEKHSRYRYHYDADYSR
WDSTQQRAVLEAALEIMVRFSAEPQLAQIVAEDLLSPSVVDVGDFKIVINEGLPSGVP
CTSQWNSIAHWLLTLCALSEVTGLGPDIIQANSMYSFYGDDEIVSTDIKLDPEKLTAK
LKEYGLKPTRPDKTEGPLVISEDLNGLTFLRRTVTRDPAGWFGKLDQNSILRQLYWTR
GPNHEDPSETMIPHAQRPVQLMALLGESSLHGPSFYSKVSKLVISELKEGGMDFYVPR
QESMFRWMRFSDLSTWEGDRNLAPSFVNEDGVE"
mat_peptide <1..998
/gene="ORF1"
/product="p48"
mat_peptide 999..2096
/gene="ORF1"
/product="NTPase"
mat_peptide 2097..2633
/gene="ORF1"
/product="p22"
mat_peptide 2634..3032
/gene="ORF1"
/product="VPg"
mat_peptide 3033..3575
/gene="ORF1"
/product="Pro"
mat_peptide 3576..5105
/gene="ORF1"
/product="RdRp"
gene 5089..6705
/gene="ORF2"
CDS 5089..6705
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="XVJ37681.1"
/translation="MKMASNDAAPSNDGAAGLVPEGNNETLPLEPVAGAAIAAPVTGQ
NNIIDPWIRTNFVQAPNGEFTVSPRNSPGEILLNLELGPDLNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKILFAAVPPNFPVEFLSPAQITMLPHIIVDVRTLEPIMIPLPD
VRNTFFHYNNQPNSRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPTPDFEFTYLVPP
SVESKTKPFSLPILTLSELTNSRFPVPIDSLFTAQNNVLQVQCQNGRCTLDGELQGTT
QLLPSGICAFRGRVTAETDNPDKWHMQLQNLNGTTYDPTDDVPAPLGTPDFKGIVFGM
ASQRNVGNDAPGSTRAHEVVISTYSPRFVPKLGSVNFKSNDDDFQLQPTRFTPVGIND
DGDHPFRQWELPDYSGVLTLNMNLAPPVAPNFPGEQLLFFRSSVPCSGGYNQGIIDCL
IPQEWIQHFYQESAPSQSDVALIRYVNPDTGRTLFEAKLHRSGYITVAHSGDYPLVVP
ANGYFRFDSWVNQFYSLAPMGTGNGRRRAQ"
gene 6705..7484
/gene="ORF3"
CDS 6705..7484
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="XVJ37682.1"
/translation="MAGAFIAGLAGDMLTSSVGSLVNAGANAINQKIDFENNKQLQSA
SFQHDKEMLQAQVNATKQLQSEMIALKQGVLAAGGFSPTDAARGAVGAPMTKVLDWSG
TRYWAPNSTKTTGYSGQFTSSPVHMPSPSAPQPKPAKSRSLGSSSSPSSVYSMSTQST
SLTSGSSSNASSASTKLTNLSSGSSQNRTAEWVNQQRSLSPFMSGALNISHVTPPSSR
ASSSGTVSTVPKEVLDSWTSAFNTRRQPLFAHLRVRGESRV"
ORIGIN
1 tgaagatggc gtctaacgac gcttccgtcg ccgttgctgg caaaaacaac aacaacgaca
61 aggaaaaatc ttcaagtgac agcttgtttt ctaacatgac tgttactttt aagaaagccc
121 tcggggcgcg gtctaaacag ccgcccccgg gagaaacaaa acaaacacaa agaccaccaa
181 ggccaccgac accggaattg gtgaagaaga tacccccacc cccccccaat ggcgaggatg
241 aaccaaaaat agcgtataag gtgggagaag gtgtgtctgg gctgcccgac ttgacaaccg
301 tggcacaacc tgacgcacag aacacagcct acagtgtccc cccacttagc cagagagagg
361 tcggcgaagc taaagaaccg ttgcctggct ccattctgga aatgtgggat ggtgagatat
421 accactatgg gctgtatgtt gagcgggggc atgtactggg agtacacaaa ccacctgccg
481 caataagcct tgccaaaatt gaattaacac cgctgtctct ctactggaga gtggtttaca
541 ctccccaata tttgatagct ccagagaccc ttaagaattt aaatggagag gctttcccat
601 acacggcctt tgacaacaac tgttatgcct tctgttgttg ggttttggac ctcaacgact
661 cttggcttag cagaagaatg atccaaagaa caactggatt cttcagaccg tatcaggact
721 ggaacagaaa acccttgcca accatggatg aaccaaaaat caagaaagcc gcgaatgctg
781 ttctgtgtgc tctctcctca ctcttcacta ggcccatcaa agatgtcatt ggaaagctca
841 aaccactgaa cattatgaac atactggcaa cttgtgattg gacttttgcg ggcatagtgg
901 aatccatgat ccttcttgct gagctctttg gggtgttctg gacgccccca gatgtgtctg
961 caatgattgc tcccttactc ggtgactacg agatgcaagg ccccgaagac ctagccgtgg
1021 aacttgtgcc cgtggtaatg ggaggaatag gtttggtgtt aggattcacc aaggaaaaga
1081 tcggcaagat gctttcatca gctgcgacca cactcagggc ctgtaaggat ctaggatctt
1141 atgggttgga gatactcaaa ctggtcatga agtggttctt ccccaagaag gaggaggcca
1201 acgagttagc catggtgagg gccattgagg atgcagttct ggatttggag gcaatagaaa
1261 acaaccacat gaccactctc cttaaggaca aagacagcct ggccacatac atgaggactc
1321 ttgacttgga agaagaaaaa gcaaggaaac tgtcatccaa atcggcgtca cctgacattg
1381 tgggcacagt aaacgcatta ttggcaagga tagcagccgc caggtcactg gtccacaagg
1441 ctaaggagga gctctcgagc agacaaaggc ctgttgttgt aatgatatca ggtaagccag
1501 gtataggaaa gactcatctg gccagagagc tagccaagaa ggttgcgtca acactgtcag
1561 gcgaccaaag aattggactg atacctagaa atggcgtcga ccattgggac gcctacaaag
1621 gagagcgggt ggttctgtgg gatgactatg gcatgagcaa ccctatacag gacgcactga
1681 ggcttcaaga attggctgac acctgtcctc tgaccctaaa ctgtgacagg attgaaaaca
1741 aaggaaaagt gttcgacagt gacgccataa ttataacaac caacctcgca aacccagcac
1801 cactggatta tgtcaacttt gaggcttgtt ctagacgcat agacttcttg gtgtatgcag
1861 acgcacctga catcgagaag gctaagcgtg acttccctgg ccaaccagat atgtggaaag
1921 accattacag atcagacttc tcacacatta aacttcagct tgcaccacag ggaggctttg
1981 ataagaatgg caacacccca catggcaaag gtgtggttaa gtctctgacg attggttctc
2041 tgatcgccag ggcttctggc ttgctccatg agagaatgga tgaatttgag ctccaaggct
2101 ctgacttacc aaccttcaat ttcgaccgta acaaagtcgc cgccttcaga caattggcag
2161 ctgaaaacaa atatggtctt atggacacac tgagggtcgg caaccaactg aaaagtgtca
2221 aaaccctgga tgagctgaag caggctataa agaacatcac catcaagaag tgccagatag
2281 tgtacaatgg atgcacctac accatggaat ctgatgggag gaacaaggtt gtagttgaaa
2341 aggttcaaaa tgcaacagtc caaaccaaca atgaacttac aggagcactc caccacctga
2401 gatctgcaag gataaggtat tatgttaaat gtttccaaga agctatttac tctctactcc
2461 aaattgctgg tgcagccttc gtcaccacac gcatcgtgag gcgcatgaac atctcaaacc
2521 tctggtcgaa gccacccgtc gaagagggtg atgagcctga agacaaaggg gggtgcccca
2581 agcccaggga tgaagatgac ctcactattg actctaaaga cattaaagca gaagggaaga
2641 agggcaagaa caaatctggc cggggcaaga aacacacagc tttctcatcc aagggcctca
2701 gtgatgaaga gtacgatgag tacaagagaa tcagggagga aaggaatggc aaatactcaa
2761 ttgaagaata cctccaggac agggatagat actatgaaga gcttgccatt gctaaggcca
2821 ctgaggaaga cttctgtgaa gaggaggaaa tcaaaattcg ccagagaatc ttccggccca
2881 ccaggaaaca acggagagag gaaagagcca cgcttgggct tgtcacagga tcggaaatca
2941 gaaagaggaa cccagatgac tttaagccaa aaggaaaatt gtgggctgat gacaacagaa
3001 gtgtggacta caatgagagg atagattttg aggctccccc gagtgtttgg tctaggatag
3061 tcaactttgg cacaggatgg ggattctggg tctccccaag tctctttata acttcaacac
3121 atgtcatacc aaaaggaatc actgaggcct ttggagttcc catcaaccaa attcaaattc
3181 acaaatctgg agagttctgc cgcttgcggt ttccaaaacc aatcaggcca gacgtgagtg
3241 gaatgatctt ggaagaaggt gcccctgaag gtactgttgt gtccattctc atcaagagga
3301 caacagggga actgatgcct ctcgcagtta gaatgggaac tcatgccaca atgaaaatcc
3361 aaggtagaac ggtgggtggt caaatgggca tgcttctcac tggctcaaac gctaaaagca
3421 tggacctagg cacaacacca ggtgactgtg ggtgcccata catatacaaa aggggcaatg
3481 acttcgtggt cattggggtg cacactgcag cagcccgtgg aggcaacacg gtcatatgtg
3541 ccacacaggg aagtgaaggc gaagccaccc tcgagggagg tgacaacaag ggcacctatt
3601 gtggagcccc catcttggga cctggcaacg caccaaaatt aagcacaaaa acaaaattct
3661 ggagatcttc caacgcgccg ctccctccag gtacctatga accagcatac cttggtggaa
3721 aagacccgcg tgtgaagggg ggcccatctc tacaacaggt tatgagagac caacttaaac
3781 cttttacaga gccaagaggg aagccaccaa aaccaagtgt cctagaatca gcaaagaaga
3841 ccatcattaa tgttctggaa caaaccattg acccccctga aaagtggtca tatgcccaag
3901 cttgtgcatc cctcgacaag acaacctcca gtggataccc gcatcacgtc cgaaagaatg
3961 actattggag tggtgaatcc ttcacgggga aacttgcaga ccaggcctca aaagcaaacc
4021 ttatgtatga ggaaggcaag cacatgcaac cagtttacac cgcagcactc aaagacgagc
4081 tcgtgaagac tgacaaaatt tatggcaaga tcaagaaaag actcctgtgg ggatctgacc
4141 tatccaccat gattcgatgc gccagggcat ttggtggtct catggatgag ctcaaagcta
4201 attgtatcac actccctgtc agagttggta tgaacatgaa tgaagatggt cccataatat
4261 ttgagaagca ctccaggtac aggtaccact atgatgctga ttactcccgc tgggattcca
4321 cacaacagcg ggcagttctg gaagcggcac ttgaaatcat ggtgagattt tctgctgagc
4381 cacagttggc acaaatagtg gcagaggacc tgctatcacc aagtgtggtt gatgtgggcg
4441 atttcaaaat tgttatcaat gaaggcctac catctggcgt gccttgcact tcacaatgga
4501 attctattgc ccactggtta ctcaccctgt gtgccctgtc tgaagtgaca ggactaggcc
4561 ctgacatcat acaagctaac tccatgtact ctttctatgg tgatgatgag attgtaagca
4621 cagacataaa attagaccca gagaaattga ctgcaaaact taaagaatat ggccttaaac
4681 ccacccggcc tgacaagact gaggggccac tggtaattag tgaggacctg aatgggctga
4741 ctttccttcg ccgaacagtc acccgcgatc cagcgggttg gtttggaaag ttggaccaaa
4801 actccatcct caggcagctg tactggacaa ggggacccaa ccatgaagac cccagtgaga
4861 ctatgatacc acatgcacag agacctgtgc agctcatggc actgctagga gagtcctccc
4921 tacatggacc ctcattttac agcaaggtta gcaagctggt catatctgaa cttaaagagg
4981 gaggaatgga tttttatgtg cccagacaag agtcaatgtt caggtggatg aggttctcag
5041 atctaagcac atgggagggc gatcgcaatc tggctcccag ttttgtgaat gaagatggcg
5101 tcgaatgacg ccgctccatc taatgatggt gctgctggtc tcgtaccaga gggcaataac
5161 gagacccttc ccctagaacc agttgcgggc gcagctatag ccgcacccgt cactggccaa
5221 aataatataa ttgacccctg gattagaaca aattttgtgc aagcaccaaa tggagagttc
5281 acagtgtcac ccagaaactc tcctggagaa attttactaa acctagagtt gggccctgat
5341 ttgaaccctt atttggctca tttgtcaagg atgtacaatg ggtacgctgg tggagttgaa
5401 gtccaggttc tcctggcagg gaacgcgttc actgccggga agatcctctt cgccgctgtc
5461 ccgccaaatt tcccagtgga attcttaagc ccagcccaga ttacaatgct cccacacata
5521 atagtagatg ttaggactct tgaaccaatt atgatcccat tacctgatgt taggaataca
5581 ttcttccatt ataataacca gcccaacagc cgcatgagat tagtggctat gctctatacc
5641 ccccttagat ctaatggctc aggtgatgat gttttcactg tttcttgcag agttttgact
5701 agacctactc ctgattttga gttcacttat ctagtgccac cctctgttga atctaagact
5761 aagccctttt ccttacccat tttaaccctt tctgagctca caaattcgag gttcccggtc
5821 cccattgatt cgcttttcac cgcccagaat aatgtgttgc aggtgcagtg tcaaaatggc
5881 aggtgcacac ttgacggtga gctacaaggc acaacccagt tgctcccatc tggcatctgt
5941 gcgttcagag gacgggtgac agcagaaact gacaatcctg ataagtggca catgcaactg
6001 caaaacctca atggcacaac gtatgaccca actgatgatg tgccagcccc actgggtaca
6061 cctgacttca agggcatcgt gtttgggatg gcaagccaaa gaaatgtggg taacgatgcg
6121 cccggctcaa ccagggccca tgaggtggtg atttcaacct acagccccag atttgtcccc
6181 aaattaggct ctgttaattt taaaagtaat gatgatgatt tccaattgca gccaacaaga
6241 ttcacaccag tgggcatcaa tgatgacggc gaccacccgt tcagacaatg ggaactgcca
6301 gactattcag gggtgcttac cttgaatatg aaccttgccc ccccggttgc tccaaatttc
6361 cctggtgaac aattattatt cttcagatct tccgtgccat gttcaggagg ttacaaccaa
6421 ggtattatag attgtcttat cccccaagaa tggatccaac acttctacca ggaatcagca
6481 ccttctcagt cagacgtggc cctgatcagg tacgtcaatc ccgacacggg tcgcacactg
6541 tttgaggcaa aattgcacag atctggctat atcactgtgg ctcactctgg agactatcct
6601 cttgttgttc cggctaatgg atactttaga tttgactctt gggtaaacca gttttactca
6661 ctcgccccaa tgggaactgg gaatgggcga aggagggctc agtaatggct ggagctttca
6721 ttgcaggatt ggcgggtgac atgctcacgt catccgtggg ctccctggtg aacgcagggg
6781 caaacgccat caaccaaaag atagactttg aaaacaacaa acaactccag tctgcttcct
6841 ttcaacatga taaagagatg ctccaagcgc aggtaaatgc aaccaagcag ctgcaatctg
6901 agatgatagc cctaaaacag ggggttttgg ccgcaggcgg cttttccccc actgatgcag
6961 cgaggggggc cgtcggtgca cccatgacaa aggtgcttga ctggtctggc actcgatatt
7021 gggctcccaa ttccacaaag acaactggtt attcggggca atttacctct tcacctgtgc
7081 acatgcccag cccgagtgct ccacaaccaa agcccgcaaa gtccagatct ctaggttctt
7141 cttcttctcc tagtagtgtt tatagtatgt ctacccaatc aacttctcta acatctggct
7201 cttctagtaa tgcttcttct gcttctacaa aattgacaaa tttaagctct ggctcctctc
7261 aaaacaggac agcagagtgg gtgaaccaac aaagaagtct cagccctttc atgagtggcg
7321 cactcaacat ctcacatgtc acgccacctt caagtagggc ctccagttct gggacggtct
7381 caaccgtgcc caaggaagtt ttggactcct ggacatctgc atttaacaca cgcagacagc
7441 cgctcttcgc acacctcaga gtgagggggg agtcacgtgt ttagtgaaaa gaaataattg
7501 gctataatat tatttcttt
//