Typing tool
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Typing tool
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Complete norovirus genomes
| PV784275 | GII.17 | |
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| GII.P17 |
ORF1: 5..5113
ORF2: 5094..6710
ORF3: 6710..7489
LOCUS PV784275 7555 bp RNA linear VRL 26-NOV-2025
DEFINITION Norovirus GII isolate Hu/GII.17/117/DE/2022, complete genome.
ACCESSION PV784275
VERSION PV784275.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7555)
AUTHORS Tohma,K., Jacobsen,S., Altmann,B., Kendra,J.A., Landivar,M., De
La,O. Jr., Fernandez-Garcia,M.D., Gomes,K.A., Chudnovsky,S.,
Ford-Siltz,L.A., Pilewski,K.A., Gao,Y., Mazo,I., Niendorf,S. and
Parra,G.I.
TITLE GII.17 norovirus re-emerged in the 2020s as a result of dynamic and
adaptive evolutionary processes
JOURNAL Nat Commun (2025) In press
PUBMED 41285779
REMARK Publication Status: Available-Online prior to print
REFERENCE 2 (bases 1 to 7555)
AUTHORS Jacobsen,S., Altmann,B. and Niendorf,S.
TITLE Direct Submission
JOURNAL Submitted (12-JUN-2025) Infectious diseases, Robert Koch-Institute,
Seestr. 10, Berlin 13353, Germany
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) HIVE-hexagon aligner v.
2.1; High-performance Integrated Virtual
Environment (HIVE) HIVE-heptagon profiler
v. 2.1
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7555
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Hu/GII.17/117/DE/2022"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Germany"
/collection_date="2022"
/note="genotype: GII.17"
gene 5..5113
/gene="ORF1"
CDS 5..5113
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="XVJ37659.1"
/translation="MKMASNDASVAVAGKNNNNDKEKSSSDSLFSNMTVTFKKALGAR
SKQPPPGETKQTQRPPRPPTPELVKKIPPPPPNGEDEPKIAYKVGEGVSGLPDLTTVA
QPDAQNTAYSVPPLSQREVGEAKEPLPGSILEMWDGEIYHYGLYVERGHVLGVHKPPA
AISLAKIELTPLSLYWRVVYTPQYLIAPETLKNLNGEAFPYTAFDNNCYAFCCWVLDL
NDSWLSRRMIQRTTGFFRPYQDWNRKPLPTMDEPKIKKAANAVLCALSSLFTRPIKDV
IGKLKPLNIMNILATCDWTFAGIVESMILLAELFGVFWTPPDVSAMIAPLLGDYEMQG
PEDLAVELVPVVMGGIGLVLGFTKEKIGKMLSSAATTLRACKDLGSYGLEILKLVMKW
FFPKKEEANELAMVRAIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARK
LSSKSASPDIVGTVNALLARIAAARSLVHKAKEELSSRQRPVVVMISGRPGIGKTHLA
RELAKKVASTLSGDQRIGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIQDALRLQELA
DTCPLTLNCDRIENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPD
IEKAKRDFPGQPDMWKDHYRSDFSHIKLQLAPQGGFDKNGNTPHGKGVVKSLTIGSLI
ARASGLLHERMDEFELQGSGLPTFNFDRNKVAAFRQLAAENKYGLMDTLRVGNQLKSV
KTLDELKQAIKNITIKKCQIVYNGCTYTMESDGRNKVVVEKVQNATVQTNNELAGALH
HLRSARIRYYVKCLQEAIYSLLQIAGAAFVTTRIVRRMNISNLWSKPPVEEGDEPEDK
GGCPKPRDEDDLTIDSKDIKAEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREE
RNGKYSIEEYLQDRDRYYEELAIAKATEEDFCEEEEIKIRQRIFRPTRKQRREERATL
GLVTGSEIRKRNPDDFKPKGRLWADDNRSVDYNERIDFEAPPSVWSRIVNFGTGWGFW
VSPSLFITSTHVIPKGITEAFGVPINQIQIHKSGEFCRLRFPKPIRPDVSGMILEEGA
PEGTVVSILIKRTTGELMPLAVRMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTT
PGDCGCPYIYKRGNDFVVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAP
ILGPGNAPKLSTKTKFWRSSNAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPF
TEPRGKPPKPSVLESAKKTIINVLEQTIDPPEKWSYAQACASLDKTTSSGYPHHVRKN
DYWSGESFTGKLADQASKANLMFEEGKHMQPVYTAALKDELVKTDKIYGKIKKRLLWG
SDLSTMIRCARAFGGLMDELKANCITLPVRVGMNMNEDGPIIFEKHSRYRYHYDADYS
RWDSTQQRAVLEAALEIMVRFSAEPQLAQIVAEDLLSPSVVDVGDFKIVINEGLPSGV
PCTSQWNSIAHWLLTLCALSEVTGLGPDIIQANSMYSFYGDDEIVSTDIKLDPEKLTA
KLKEYGLKPTRPDKTEGPLVISEDLNGLTFLRRTVTRDPAGWFGKLDQNSILRQLYWT
RGPNHEDPSETMIPHAQRPVQLMALLGESSLHGPSFYSKVSKLVISELKEGGMDFYVP
RQESMFRWMRFSDLSTWEGDRNLAPSFVNEDGVE"
mat_peptide 5..1003
/gene="ORF1"
/product="p48"
mat_peptide 1004..2101
/gene="ORF1"
/product="NTPase"
mat_peptide 2102..2638
/gene="ORF1"
/product="p22"
mat_peptide 2639..3037
/gene="ORF1"
/product="VPg"
mat_peptide 3038..3580
/gene="ORF1"
/product="Pro"
mat_peptide 3581..5110
/gene="ORF1"
/product="RdRp"
gene 5094..6710
/gene="ORF2"
CDS 5094..6710
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="XVJ37660.1"
/translation="MKMASNDAAPSNDGAAGLVPEGNNETLPLEPVAGAAIAAPVTGQ
NNIIDPWIRTNFVQAPNGEFTVSPRNSPGEILLNLELGPDLNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKILFAAVPPNFPVEFLSPAQITMLPHIIVDVRTLEPIMIPLPD
VRNTFFHYNNQSNSRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPTPDFEFTYLVPP
SVESKTKPFSLPILTLSELTNSRFPVPIDSLFTAQNNVLQVQCQNGRCTLDGELQGTT
QLLPSGICAFRGRVTAETDNSDKWHMQLQNLNGTTYDPTDDVPAPLGTPDFKGVVFGM
ASQRNVGNDAPGSTRAHEAVISTYSPRFVPKLGSVNFKSYDDDFQLQPTRFTPVGIND
DDDHPFRQWELPDYSGVLTLNMNLAPPVAPNFPGEQLLLFRSSVPCSGGYNQGIIDCL
IPQEWIQHFYQESAPSQSEVALIRYVNPDTGRTLFEAKLHRSGYITVAHSGDYPLVVP
ANGYFRFDSWVNQFYSLAPMGTGNGRRRAQ"
gene 6710..7489
/gene="ORF3"
CDS 6710..7489
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="XVJ37661.1"
/translation="MAGAFIAGLAGDMLTSSVGSLVNAGANAISQKIDFENNKQLQSA
SFQHDKEMLQAQVNATKQLQSEMIALKQGVLAAGGFSPTDAARGAIGAPMTKVLDWSG
TRYWAPNSTKTTGYSGQFTSSPVHMPSPSAPQLKPAKPRSLGSSSSSSSVYSMSTQST
SLTSGSSSNASSASTKLTNLSSGSSQNRTAEWVNQQRSLSPFMSGALNISHVTPPSSR
ASSSGTVSTVPKEVLDSWTSAFNTRRQPLFAHLRVRGESRV"
ORIGIN
1 gtgaatgaag atggcgtcta acgacgcttc cgtcgccgtt gctggcaaaa acaacaacaa
61 cgacaaggaa aaatcttcaa gtgacagctt gttttctaac atgactgtta cttttaagaa
121 agccctcggg gcgcggtcta aacagccgcc cccgggagaa acaaaacaaa cacaaagacc
181 accaaggcca ccgacaccgg aattggtgaa gaagataccc ccaccccccc ccaatggcga
241 ggatgaacca aagatagcgt ataaggtggg agaaggtgtg tctgggctgc ccgacttgac
301 aaccgtggca caacctgacg cacagaacac agcctacagt gtccccccac ttagccagag
361 agaggtcggc gaagctaaag aaccgttgcc tggctccatt ctggaaatgt gggatggtga
421 gatctaccac tatgggctgt atgttgagcg ggggcatgta ctgggagtgc acaaaccacc
481 tgccgcaata agccttgcca aaattgaatt gacaccgctg tctctctact ggagagtggt
541 ttacactccc caatacttga tagcaccaga gacccttaag aatttaaatg gagaggcttt
601 cccatacacg gcctttgaca acaactgtta tgccttctgt tgttgggttt tagacctcaa
661 cgactcctgg cttagcagaa gaatgatcca aagaacaact ggattcttca gaccgtatca
721 ggactggaac agaaaaccct tgccaaccat ggatgaacca aaaatcaaga aggccgcgaa
781 tgctgttctg tgtgctctct cctcactctt cactaggccc atcaaagatg tcattggaaa
841 gctcaaacca ctgaacatta tgaacatact ggcaacttgt gattggactt ttgcgggcat
901 agtggaatcc atgatccttc ttgctgagct ctttggggtg ttctggacgc ccccagatgt
961 gtctgcaatg attgctccct tactcggtga ctacgagatg caaggccccg aagacctggc
1021 cgtggaactt gtgcccgtgg taatgggagg aataggtttg gtgttaggat tcaccaagga
1081 aaagatcggc aagatgcttt catcagctgc gaccacactc agggcctgta aggatctagg
1141 atcttatggg ttggagatac tcaaactggt catgaagtgg ttcttcccca agaaggagga
1201 ggccaacgag ttagccatgg tgagggccat tgaggatgca gttctggatt tggaggcaat
1261 agaaaacaac cacatgacca ccctccttaa ggacaaagac agcctggcca catacatgag
1321 gactcttgac ttggaagaag aaaaagcaag gaaactgtca tccaaatcgg cgtcacctga
1381 catcgtgggc acagtaaacg cattattggc aaggatagca gccgccaggt cactggtcca
1441 caaggctaag gaggagctct cgagcagaca gaggcctgtt gttgtaatga tatcaggtag
1501 gccaggtata ggaaagaccc atctggccag agagctagcc aagaaggttg cgtcaacact
1561 gtcaggcgac caaaggattg gactgatacc tagaaatggc gtcgaccatt gggacgccta
1621 caaaggagag cgggtggttc tgtgggatga ctatggcatg agcaacccta tacaggacgc
1681 actgaggctc caagaattgg ctgacacctg tcctctgacc ctaaattgtg acaggattga
1741 aaacaaagga aaagtgttcg acagtgacgc cataattata acaaccaacc tcgcaaaccc
1801 agcaccactg gattatgtca actttgaggc ttgttctaga cgcatagact tcttggtgta
1861 tgcagacgca cctgacatcg agaaggctaa gcgtgacttc cctggccaac cagatatgtg
1921 gaaagaccat tacagatcag acttctcaca cattaaactt cagctggcac cacagggagg
1981 ctttgataag aatggcaaca ccccacatgg caaaggtgtg gttaagtctc tgacgattgg
2041 ttctctgatc gccagggctt ctggcttgct ccatgagaga atggatgaat ttgagctcca
2101 aggctctggc ttaccaacct tcaatttcga ccgtaacaaa gtcgccgcct tcagacaatt
2161 ggcagctgaa aacaaatatg gtcttatgga cacactgagg gtcggcaacc aactaaaaag
2221 tgtcaaaacc ctggatgagc tgaagcaggc tataaagaat atcaccatca agaagtgcca
2281 gatagtgtac aatggatgca cctacaccat ggaatctgat gggaggaaca aggttgtggt
2341 tgaaaaggtt caaaatgcaa cagtccaaac caacaatgaa cttgcaggag cactccacca
2401 cctgagatct gcaaggataa ggtattatgt taaatgtctc caagaagcta tttactctct
2461 actccaaatt gctggtgcag ccttcgtcac cacacgcatc gtgaggcgca tgaacatctc
2521 aaacctctgg tcgaagccac ccgtcgaaga gggtgatgag cctgaagaca aaggggggtg
2581 ccccaagccc agggatgaag atgacctcac tattgactct aaagacatta aagcagaagg
2641 gaagaagggc aagaacaaat ctggccgggg caagaaacat acagctttct catccaaggg
2701 cctcagtgat gaagagtacg atgagtacaa gagaatcagg gaggagagga atggcaaata
2761 ctcaattgaa gaatacctcc aggacaggga taggtactat gaagagcttg ccattgctaa
2821 ggccactgag gaagacttct gtgaagagga ggaaatcaaa attcgccaga gaatcttccg
2881 gcccaccagg aagcaacgga gagaggaaag agccacgctt gggcttgtca caggatctga
2941 aatcagaaag aggaacccag atgactttaa gccaaaagga agattgtggg ctgatgacaa
3001 cagaagtgtg gactacaatg agaggataga ttttgaggct cccccgagtg tttggtctag
3061 gatagtcaac tttggtacag gatggggatt ctgggtctcc ccaagtctct ttataacttc
3121 aacacatgtc ataccaaaag gaatcactga ggcctttgga gttcccatta accaaattca
3181 aattcacaaa tctggagagt tttgccgctt gcggtttcca aaaccaatca ggccagacgt
3241 gagtggaatg atcttggaag agggtgcccc tgaaggcact gttgtgtcca ttctcatcaa
3301 gaggacaaca ggggaactga tgcctctcgc agttagaatg ggaactcatg ccacaatgaa
3361 aatccaaggt agaacggtgg gtggtcaaat gggcatgctt ctcactggct caaacgctaa
3421 aagcatggac ctaggcacaa caccaggtga ctgtgggtgc ccatacatat acaaaagggg
3481 caatgacttc gtggtcattg gggtgcacac tgcagcagcc cgtggaggca acacggtcat
3541 atgtgccaca cagggaagtg aaggcgaagc caccctcgaa gggggtgaca acaagggcac
3601 atattgtgga gcccccatct tgggacctgg caacgcacca aaactgagca caaaaacaaa
3661 attctggaga tcttctaacg cgccgcttcc tccaggtacc tatgaaccag cataccttgg
3721 tggaaaagac ccgcgtgtga agggaggccc atctctacaa caggttatga gagatcaact
3781 taaacctttt acagagccca gagggaagcc accaaaacca agtgtcctag aatcagcaaa
3841 gaagaccatc attaatgttc tggagcaaac cattgacccc cctgaaaagt ggtcatatgc
3901 ccaagcttgt gcatccctcg acaagacaac ctccagtgga tacccgcatc acgtccggaa
3961 gaatgattat tggagtggtg aatccttcac ggggaaactt gcagaccagg cctcaaaagc
4021 aaaccttatg tttgaggaag gcaagcacat gcaaccagtt tacaccgcag cactcaaaga
4081 cgagctcgtg aaaactgaca aaatttatgg caagatcaag aaaagactcc tgtggggctc
4141 tgacctatcc accatgattc gatgcgccag ggcatttggt ggcctcatgg atgagctcaa
4201 agcaaattgt atcacactcc ctgtcagagt tggtatgaac atgaatgaag atggtcccat
4261 aatatttgaa aagcactcca ggtacaggta ccactatgat gctgattact cccgctggga
4321 ttccacacaa cagcgggcag tgctggaagc ggcacttgaa atcatggtga gattttctgc
4381 tgagccacag ttggcacaaa tagtggcaga ggacctgcta tcaccaagtg tggttgatgt
4441 gggcgatttc aaaattgtta tcaatgaagg cctaccatct ggcgtgcctt gcacttcaca
4501 atggaattct attgcccact ggttactcac cctgtgtgcc ctgtctgaag taacaggact
4561 aggccctgac atcatacaag ccaactccat gtactctttc tatggtgatg atgagattgt
4621 gagcacagac ataaaattag acccagagaa attgactgca aaactcaaag aatatggtct
4681 taaacccacc cggcctgaca agactgaggg accactggta attagtgagg acctgaatgg
4741 gttgactttc ctccgccgaa cagtcacccg cgatccagca ggttggtttg gaaagttgga
4801 ccaaaactcc atcctcaggc agctgtactg gacaagggga cccaaccatg aagaccccag
4861 tgagactatg ataccacacg cacagagacc tgtgcagctc atggcactgc taggagagtc
4921 ctccctacat ggaccatcat tttacagcaa ggttagcaag ctggtcatat ctgaacttaa
4981 agagggagga atggattttt atgtgcccag acaagaatca atgttcaggt ggatgaggtt
5041 ctcagatcta agcacatggg agggcgatcg caatctggct cccagttttg tgaatgaaga
5101 tggcgtcgaa tgacgccgct ccatctaatg atggtgctgc tggtctcgta ccagagggca
5161 ataacgagac ccttccctta gaaccagttg cgggcgcagc tatagccgca cccgtcactg
5221 gccaaaacaa tataattgac ccctggatta gaacaaattt tgtgcaagca ccaaatggag
5281 agttcacagt gtcacccaga aactctcctg gagaaatttt actaaaccta gagttgggcc
5341 ctgatttgaa cccttatttg gctcatttgt caaggatgta caatgggtac gctggtggag
5401 ttgaagtcca ggttctcctg gcagggaacg cgttcactgc cgggaagatc ctcttcgccg
5461 ctgtcccgcc aaatttccca gtggaattct taagcccagc ccagattaca atgctcccac
5521 atataatagt agatgttagg actcttgaac caattatgat cccattacct gatgttagga
5581 acacattctt ccactataac aaccagtcca acagccgcat gagattagtg gctatgctct
5641 atacccccct tagatctaat ggttcaggtg atgatgtttt cactgtttct tgcagggttt
5701 tgactaggcc tactcctgat tttgagttca cttatctagt gccaccctct gttgaatcta
5761 agactaagcc cttttcctta cccattttaa ccctttctga gctcacaaat tcgaggttcc
5821 cggtccccat tgattcgctt ttcaccgccc agaataatgt gttgcaggtg cagtgtcaaa
5881 atggcaggtg cacacttgac ggtgagctac aaggcacaac ccagttgctc ccatctggca
5941 tctgtgcgtt cagaggacgg gtgacagcag aaactgacaa ttctgataag tggcacatgc
6001 aactgcaaaa cctcaatggc acaacgtatg acccaactga tgatgtgcca gccccactgg
6061 gtacacctga cttcaagggc gtcgtgtttg ggatggcaag ccaaagaaat gtgggtaacg
6121 atgcgcccgg ctcaaccagg gctcatgagg cggtgatttc aacctacagc cccagatttg
6181 ttcccaaatt aggctctgtc aattttaaaa gttatgatga tgatttccaa ttgcagccaa
6241 caagattcac accagtgggc attaatgatg atgacgacca cccgttcaga caatgggaac
6301 tgccagacta ttcaggggtg cttaccttga atatgaacct tgcccccccg gttgctccaa
6361 atttccctgg tgaacaatta ttactcttca gatcttccgt gccatgttca ggaggttaca
6421 accaaggcat tatagattgt cttatccccc aagaatggat ccaacacttc taccaggaat
6481 cagcaccttc tcagtcagaa gtggccctga tcaggtacgt caaccccgac acgggtcgca
6541 cactgtttga ggcaaaatta cacagatctg gttatatcac tgtggctcac tctggagact
6601 atcctcttgt tgttccggct aatggatact ttagatttga ctcttgggta aatcagtttt
6661 actcactcgc cccaatggga actgggaatg ggcgaaggag ggctcagtaa tggctggagc
6721 tttcattgca ggattggcgg gtgacatgct cacgtcatcc gtgggctccc tggtgaacgc
6781 aggggcaaac gccatcagcc aaaagataga ctttgaaaac aacaaacaac tccagtctgc
6841 ttcctttcaa catgataaag agatgctcca agcgcaggta aatgcgacca agcagctgca
6901 atctgagatg atagccctaa aacagggggt tttggccgca ggcggctttt cccccactga
6961 tgcagcgagg ggggccatcg gtgcacctat gacaaaggtg cttgactggt ctggcactcg
7021 atattgggct cccaattcca caaagacaac tggttattcg gggcaattca cctcttcacc
7081 tgtgcacatg cccagcccga gtgctccaca attaaaaccc gcaaagccca gatctctagg
7141 ttcttcttct tcttctagta gtgtttatag tatgtctacc caatcaactt ctctaacatc
7201 tggctcttct agtaatgctt cttctgcttc tacaaaattg acaaatttaa gctctggctc
7261 ctctcaaaac aggacagcag agtgggtgaa ccaacagaga agtctcagcc ctttcatgag
7321 tggcgcactc aatatctcac atgtcacgcc accttcaagt agggcctcca gttctgggac
7381 ggtctcaacc gtgcccaagg aagttttgga ctcctggaca tctgcattca acacacgcag
7441 acagccgctc ttcgcacacc tcagagtgag gggggagtca cgtgtttagt gaaaagaagt
7501 aattggctat aatatgattt ctttaaaatt taaatttggc taatttgtat ctttt
//