Typing tool
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Typing tool
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Complete norovirus genomes
| PV750896 | GII.17 | |
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| GII.P17 |
ORF1: 1..5101
ORF2: 5082..6698
ORF3: 6698..7477
LOCUS PV750896 7543 bp RNA linear VRL 26-NOV-2025
DEFINITION Norovirus GII isolate O1_Patient_21_GER nonstructural polyprotein
(ORF1) gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes,
complete cds.
ACCESSION PV750896
VERSION PV750896.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7543)
AUTHORS Tohma,K., Jacobsen,S., Altmann,B., Kendra,J.A., Landivar,M., De
La,O. Jr., Fernandez-Garcia,M.D., Gomes,K.A., Chudnovsky,S.,
Ford-Siltz,L.A., Pilewski,K.A., Gao,Y., Mazo,I., Niendorf,S. and
Parra,G.I.
TITLE GII.17 norovirus re-emerged in the 2020s as a result of dynamic and
adaptive evolutionary processes
JOURNAL Nat Commun (2025) In press
PUBMED 41285779
REMARK Publication Status: Available-Online prior to print
REFERENCE 2 (bases 1 to 7543)
AUTHORS Kutter,J.S. and Fernandez-Garcia,M.D.
TITLE Direct Submission
JOURNAL Submitted (06-JUN-2025) Enterovirus And Viral Gastroenteritis,
Instituto de Salud Carlos III, Ctra. Majadahonda-Pozuelo, Km 2,
Majadahonda, Madrid 28220, Spain
COMMENT ##Assembly-Data-START##
Assembly Method :: Metaspades v. v. v3.14.0
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7543
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="O1_Patient_21_GER"
/isolation_source="stool"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Spain: Getafe, Madrid"
/collection_date="19-Feb-2024"
/note="genotype: GII.17"
gene <1..5101
/gene="ORF1"
CDS <1..5101
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="XUS55924.1"
/translation="ASNDASVAVAGKNNNNDNVKSSSDSLFSNMTVTFKKALGARSKQ
PPPGETKQTLRPPRPPTPELVKKIPPPPPNGEDEPKVTYKVGEGVSGLPDLTTVAQPD
AQNTAYSVPPLSQREVGEAREPLPGSILEMWDGEIYHYGLYVERGHVLGVHKPPAAIS
LAKIELTPLSLYWRVVYTPQYLIAPETLKNLNGETFPYTAFDNNCYAFCCWVLDLNDS
WLSRRMVQRTTGFFRPYQDWNRKPLPTMDEPKIKKAANAVLCALSSLFTRPIKDVIGK
LKPLNIMNILATCDWTFAGIVESMILLAELFGVFWTPPDVSAIIAPLLGDYEMQGPED
LAVELVPVVMGGIGLVLGFTKEKIGKMLSSAATTLRACKDLGSYGLEILKLVMKWFFP
KKEEANELAMVRAIEDAVLDLEAIENNHMTTLLKDKDALATYMRTLDLEEEKARKLSS
KSASPDIVGTVNALLARIAAARSLVHKAKEELSSRQRPVVVMISGRPGIGKTHLAREL
AKKVASTLSGDQRIGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIQDALRLQELADTC
PLTLNCDRIENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPDIEK
AKRDFPGQPDMWKDHYRPDFSHIKLQLAPQGGFDKSGNTPHGKGVVKSLTIGSLIARA
SGLLHERMDEFELQGPNLPTFNFDRNKVAAFRQLAAENKYGLMDTLRVGNQLKSVKTL
DELKQAIKNITIKKCQIVYNGCTYTMESDGRNKVVVEKVQNATVQTNNELAGALHHLR
SARIRYYVKCFQEAIYSILQIAGAAFVTTRIVRRMNISNLWSKPPVEEGDEPEDKGGC
PKPRDEDDLTIDSKDIKAEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERNG
KYSIEEYLQDRDRYYEELAIAKATEEDFCEEEEIKIRQRIFRPTRKQRKEERATLGLV
TGSEIRKRNPDDFKPKGKLWADDNRSVDYNERIDFEAPPSVWSRIVNFGTGWGFWVSP
SLFITSTHVIPKGITEAFGVPINQIQIHKSGEFCRLRFPKPIRPDVSGMILEEGAPEG
TVVSILIKRTTGELMPLAVRMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGD
CGCPYIYKRGNDFVVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPILG
PGNAPKLSTKTKFWRSSNAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEP
RGKPPKPSVLESAKKTIINVLEQTIDPPEKWSYAQACASLDKTTSSGYPHHVRKNDYW
SGESFTGKLADQASKANLMYEEGKHMQPVYTAALKDELVKTDKIYGKIKKRLLWGSDL
STMIRCARAFGGLMDELKANCITLPIRVGMNMNEDGPIIFEKHSRYRYHYDADYSRWD
STQQRAVLEAALEIMVRFSAEPQLAQIVAEDLLSPSVVDVGDFKITINEGLPSGVPCT
SQWNSIAHWLLTLCALSEVTGLGPDIIQANSMYSFYGDDEIVSTDIKLDPEKLTAKLK
EYGLKPTRPDKTEGPLVISEDLNGLTFLRRTVTRDPAGWFGKLDQNSILRQLYWTRGP
NHEDPSETMIPHAQRPVQLMALLGESSLHGPSFYSKVSKLVISELKEGGMDFYVPRQE
SMFRWMRFSDLSTWEGDRNLAPSFVNEDGVE"
mat_peptide <1..991
/gene="ORF1"
/product="p48"
mat_peptide 992..2089
/gene="ORF1"
/product="NTPase"
mat_peptide 2090..2626
/gene="ORF1"
/product="p22"
mat_peptide 2627..3025
/gene="ORF1"
/product="VPg"
mat_peptide 3026..3568
/gene="ORF1"
/product="Pro"
mat_peptide 3569..5098
/gene="ORF1"
/product="RdRp"
gene 5082..6698
/gene="ORF2"
CDS 5082..6698
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="XUS55925.1"
/translation="MKMASNDAAPSNDGAAGLVPEGNNETLPLEPVAGAAIAAPVTGQ
NNIIDPWIRTNFVQAPNGEFTVSPRNSPGEILLNLELGPDLNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKILFAAVPPNFPVEFLSPAQITMLPHIIVDVRTLEPIMIPLPD
VRNTFFHYNNQPNSRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPTPDFEFTYLVPP
SVESKTKPFSLPILTLSELTNSRFPVPIDSLFTAQNNVLQVQCQNGRCTLDGELQGTT
QLLPSGICAFRGRVTAETDNPDKWHMQLQNLNGTTYDPTDDVPAPLGTPDFKGVVFGM
ASQRNVGNDAPGSTRSHEAVISTYSPRFVPKLGSVNFKSNDDDFQLQPTRFTPVGIND
DGNQPFRQWELPDYSGVLTLNMNLAPPVAPNFPGEQLLFFRSSVPCSGGYNQGIIDCL
IPQEWIQHFYQESAPSQSEVALIRYVNPDTGRTLFEAKLHRSGYITVAHSGDYPLVVP
ANGYFRFDSWVNQFYSLAPMGTGNGRRRAQ"
gene 6698..7477
/gene="ORF3"
CDS 6698..7477
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="XUS55926.1"
/translation="MAGAFIAGLAGDMLTSSVGSLVNAGANAINQKIDFENNKQLQSA
SFQHDKEMLQAQVNATKQLQSEMIALKQGVLAAGGFSPTDAARGAIGAPMTKVLDWSG
TRYWAPNSTKTTGYSGQFTSSPVHMPSPSVPQSKPAKPKSLGSSSSSSSVYSMSTQLT
SLTSGSSSNASSASTKLTNLSSGSSQNRTAEWVNQQRSLSPFMSGALNISHVTPPSSR
ASSSGTVSTVPKEVLDSWTSAFNTRRQPLFAHLRVRGESRV"
ORIGIN
1 ggcgtctaac gacgcttccg ttgccgttgc tggcaaaaac aacaacaacg acaatgtaaa
61 atcttcaagt gacagcttgt tttctaacat gactgttact tttaagaaag ccctcggggc
121 gcggtctaag cagccgcccc cgggagaaac aaaacaaaca ctaagaccac caaggccgcc
181 gacaccggaa ttggtgaaga agataccccc accccccccc aatggcgagg atgaaccaaa
241 ggtaacgtat aaggtgggag aaggtgtgtc tgggctgccc gacttaacaa ccgtggcaca
301 acctgacgca cagaacacag cctatagtgt ccccccactt agccagagag aggtcggcga
361 agctagagaa ccgttgcctg gctccattct ggaaatgtgg gatggtgaga tctaccacta
421 tgggctgtat gttgagcggg ggcatgtgct gggagtgcac aaaccacctg ctgcaataag
481 ccttgccaaa attgagttaa caccgctgtc tctctactgg agagtggtct acactcccca
541 gtacttgata gctccagaga ccctcaagaa tttaaatgga gagactttcc catacacggc
601 ctttgacaac aactgttatg ccttctgttg ttgggttcta gacctcaacg actcctggct
661 tagcagaaga atggtccaaa gaacaaccgg attcttcaga ccgtatcagg actggaacag
721 aaaaccctta ccaaccatgg atgaaccaaa aatcaagaag gccgcgaatg ctgttctgtg
781 tgctctctcc tcactcttca ctaggcccat caaagatgtc attggaaagc ttaaaccact
841 aaacattatg aacatactgg caacttgtga ttggactttt gcgggcatag tggaatccat
901 gatccttctt gctgaactct ttggggtgtt ctggacgccc ccagatgtgt ctgcaataat
961 tgctccctta ctcggtgact acgagatgca aggccccgaa gacctggccg tggaacttgt
1021 gcccgtggta atgggaggaa taggtttggt gttaggattc accaaggaaa agatcggcaa
1081 gatgctttca tcagctgcaa ccacactcag ggcctgtaag gatctaggat cttatgggtt
1141 ggagatactc aaactggtca tgaagtggtt cttccccaag aaggaggagg ccaacgagtt
1201 agccatggtg agggccattg aggatgcagt tctggatttg gaggcaatag aaaacaacca
1261 catgaccact ctccttaagg acaaagacgc cctggccaca tacatgagga ctcttgactt
1321 ggaagaagaa aaagcaagga aactatcttc caaatcggcg tcacctgaca tcgtgggcac
1381 agtaaacgca ttattggcaa gaatagcagc cgccaggtca ctggtccaca aggctaagga
1441 ggagctctcg agcagacaga gacctgttgt tgtaatgata tcaggtaggc caggtatagg
1501 aaagacccat ctggccagag agctagccaa gaaggttgcg tcaacactgt caggcgacca
1561 aaggattgga ctgataccca gaaatggcgt cgaccattgg gacgcctaca aaggagagcg
1621 ggtggttctg tgggatgact atggcatgag caaccctata caggacgcac tgaggctcca
1681 agaattggct gacacctgtc ctctgaccct aaattgtgac agaattgaaa acaaaggaaa
1741 agtgttcgac agtgacgcca taatcataac gaccaatctt gcaaacccag caccattgga
1801 ttatgtcaac tttgaggctt gttccagacg catagacttc ttggtgtatg cagacgcacc
1861 tgacatcgag aaggctaagc gtgacttccc tggccaacca gatatgtgga aagaccatta
1921 cagaccagac ttctcacaca ttaaacttca gctcgcacca cagggaggct ttgataagag
1981 tggcaacacc ccacatggca aaggtgtggt taagtctctg acgattggtt ctctgatcgc
2041 cagggcttct ggcttgctcc atgagagaat ggatgaattc gagctccaag gccccaactt
2101 accaaccttc aatttcgacc gtaacaaagt cgccgccttc agacaattgg cagctgaaaa
2161 caaatacggt cttatggaca cactgagggt cggcaaccaa ctgaaaagtg tcaaaaccct
2221 ggatgagctg aagcaggcta taaagaacat caccatcaag aagtgccaga tagtgtacaa
2281 tggatgcacc tacaccatgg aatctgatgg gaggaacaag gttgtggttg aaaaggttca
2341 aaatgcaaca gtccaaacca acaatgagct tgcaggagca ctccaccacc tgagatctgc
2401 aagaataagg tattatgtca aatgtttcca agaagctatt tactctatac tccaaattgc
2461 tggtgcagcc ttcgtcacca cacgcatcgt gaggcgcatg aacatctcaa acctctggtc
2521 gaagccaccc gtcgaagagg gtgatgagcc tgaagacaaa ggggggtgcc ccaagcccag
2581 ggatgaagat gacctcacta ttgactccaa agacattaaa gcagaaggta agaagggcaa
2641 gaacaaatct ggccggggca agaaacacac agctttctca tccaagggcc tcagtgatga
2701 agagtacgat gagtacaaga gaatcaggga ggagagaaat ggcaagtact caatagaaga
2761 atacctccag gatagggata gatactatga agagcttgcc attgctaagg ccactgagga
2821 agacttctgt gaagaggagg aaatcaaaat tcgccagaga atcttccggc ccaccaggaa
2881 gcagcggaaa gaggaaagag ccacgcttgg gctcgtcaca ggatcggaaa tcagaaagag
2941 gaacccagat gattttaagc caaaaggaaa attgtgggct gatgacaaca ggagtgtgga
3001 ctacaatgag aggatagatt ttgaggctcc cccaagtgtt tggtctagga tagtcaactt
3061 tggtacaggg tggggattct gggtctcccc aagtctcttt ataacttcaa cacatgtcat
3121 accaaaagga atcactgagg cctttggagt tcctattaac caaattcaaa ttcacaaatc
3181 tggagagttt tgccgcttgc ggtttccaaa accaatcagg ccagacgtga gtggaatgat
3241 cttggaagag ggtgcccctg aaggcactgt tgtttccatt ctcatcaaga ggacgacagg
3301 ggaactgatg cctctcgcag tcagaatggg aactcatgcc acaatgaaaa tccaaggtag
3361 aacggtgggc ggtcaaatgg gcatgcttct cactggctca aacgccaaaa gcatggacct
3421 aggcacaaca ccaggtgact gtgggtgccc atacatatac aaaaggggca atgacttcgt
3481 ggtcattggg gtgcacactg cagcagcccg tggaggtaac acggtcatat gtgccacaca
3541 ggggagtgaa ggcgaagcca ccctcgaagg aggtgacaac aagggcacct attgtggagc
3601 ccccatcttg ggtcctggca acgcaccaaa attgagcaca aaaacaaaat tctggagatc
3661 ttctaacgcg ccgctcccgc caggcaccta tgaaccagca taccttggtg gaaaagaccc
3721 gcgtgtgaag ggaggcccat ctctacaaca ggttatgaga gaccaactca aaccttttac
3781 agagcccaga gggaagccac caaaaccaag tgtcctagaa tcagcaaaga agaccatcat
3841 taatgttctg gaacaaacca ttgacccccc tgaaaagtgg tcatatgccc aagcttgtgc
3901 atccctcgac aagacaacct ccagtggata cccgcatcac gtccggaaga atgactactg
3961 gagtggtgaa tccttcacgg ggaaacttgc agaccaggcc tcaaaagcaa atctcatgta
4021 tgaggaaggt aagcacatgc aaccagttta caccgcagca ctcaaagacg agctcgtgaa
4081 aactgacaaa atttatggca agatcaagaa aagactcctg tggggctctg acctatccac
4141 catgattcga tgcgccaggg catttggtgg cctcatggac gagctcaaag caaattgtat
4201 cacactccct atcagagttg gtatgaacat gaatgaagat ggtcccataa tatttgaaaa
4261 gcactccagg tacaggtacc actatgatgc tgattattcc cgctgggatt ccacacaaca
4321 gcgggcagtg ctggaagcgg cacttgaaat catggtgaga ttttctgctg agccacagtt
4381 ggcacaaata gtggcagagg acctgctatc accaagtgtg gttgatgtgg gcgatttcaa
4441 aattactatt aatgaaggcc taccatctgg cgtgccttgc acttcacaat ggaattctat
4501 tgcccactgg ttactcaccc tatgtgccct gtctgaagtg acaggactag gccctgacat
4561 catacaagcc aactccatgt actctttcta tggtgatgat gagattgtga gcacagacat
4621 aaaattagac ccagagaaat tgactgcaaa actcaaagaa tatggtctta aacccacccg
4681 gcctgacaag actgaggggc cactggtaat tagtgaggac ctgaatgggt tgactttcct
4741 ccgccgaaca gtcacccgcg atccagcggg ttggtttgga aagttggacc aaaactccat
4801 cctcagacag ctgtactgga caaggggacc caaccatgaa gaccccagtg agactatgat
4861 accacacgca cagagacctg tgcagctcat ggcattgcta ggagaatcct ccctacatgg
4921 accctcattt tacagcaagg ttagcaagct ggttatatct gaacttaaag agggaggaat
4981 ggatttttat gtgcccagac aagagtcaat gttcaggtgg atgaggttct cagatctaag
5041 cacatgggag ggcgatcgca atctggctcc cagttttgtg aatgaagatg gcgtcgaatg
5101 acgccgctcc atctaatgat ggtgctgctg gtctcgtacc agagggcaat aacgagaccc
5161 ttcccctaga accagttgcg ggcgcagcca tagccgcacc cgtcactggc caaaataata
5221 taattgaccc ctggattaga acaaattttg tgcaagcacc aaatggagag ttcacagtgt
5281 cacccagaaa ctctcctgga gaaattttac taaacctaga gttgggccct gatctgaacc
5341 cttatttggc tcatttgtca aggatgtata atggatatgc tggtggagtt gaagtccagg
5401 ttctcctggc agggaacgcg ttcactgccg ggaagatcct cttcgccgct gtcccgccaa
5461 attttccggt ggaattctta agcccagccc agattacaat gctcccacat ataatagtag
5521 atgttaggac tcttgaacca attatgatcc cattacctga tgttaggaat acattcttcc
5581 actataataa tcagcccaac agccgcatga gattagtggc tatgctctac acccccctta
5641 gatctaatgg ctcaggtgat gatgttttca ctgtttcttg cagggttttg actaggccta
5701 ctcctgattt tgagttcact tatctagtgc caccctctgt tgaatctaag actaaaccct
5761 tttctttacc cattctaacc ctttctgagc tcacaaattc gaggttcccg gtccccatcg
5821 attcgctttt caccgcccaa aataatgtgt tgcaggtgca gtgtcaaaat ggcaggtgca
5881 cacttgacgg tgagctacaa ggcacaaccc agttgctccc atctggcatc tgtgcgttca
5941 ggggacgggt gacagcagaa actgacaatc ctgacaagtg gcacatgcaa ctgcaaaacc
6001 ttaatggcac aacatatgac ccaactgatg atgtgccagc cccactgggt acacctgact
6061 tcaagggcgt cgtgtttggg atggcaagcc aaagaaatgt gggtaacgac gcgcccggct
6121 caaccaggtc ccatgaggcg gtgatttcaa cctacagccc cagatttgtt cctaaattag
6181 gctctgtcaa tttcaaaagc aatgacgatg atttccaatt gcagccaaca agattcacac
6241 cagtgggcat taatgatgat ggcaaccaac cattcagaca atgggaacta ccagattatt
6301 caggggtgct taccttgaat atgaaccttg ccccccctgt tgctccaaat ttccctggcg
6361 aacaattact attcttcaga tcttctgtgc catgttcagg aggttacaac caaggtatta
6421 tagattgcct tatcccccaa gaatggatcc aacatttcta ccaggaatca gcaccttctc
6481 agtcagaagt ggccctaatc aggtacgtca accccgacac gggtcgtaca ctgtttgagg
6541 caaaattgca taggtcaggc tatatcactg tggctcattc tggagactat cctcttgttg
6601 ttccggctaa tggatatttt agatttgact cttgggtaaa tcagttttac tcactcgccc
6661 caatgggaac tgggaatggg cgaaggaggg ctcagtaatg gctggagctt tcattgcagg
6721 attggcgggt gacatgctca cgtcatccgt gggctccctg gtgaacgcag gggcaaacgc
6781 catcaaccaa aagatagact ttgaaaacaa caaacaactc cagtctgctt cctttcaaca
6841 tgataaagag atgctccaag cgcaggtgaa cgcaaccaag cagctgcaat ctgagatgat
6901 agccctaaaa cagggggttt tggccgcagg cggcttttcc cccactgatg cagcgagggg
6961 ggccatcggt gcacccatga caaaggtgct tgactggtct ggcactcgat actgggctcc
7021 caattccaca aagacaactg gttattcggg gcaattcacc tcttcacctg tgcacatgcc
7081 cagcccgagt gtcccacaat caaaacccgc aaagcccaag tctctaggtt cttcttcttc
7141 ttctagtagt gtttacagta tgtctaccca attaacttct ctaacatctg gctcttctag
7201 taatgcttct tctgcttcta caaaattgac aaatttgagc tccggctctt ctcaaaacag
7261 aacagcagag tgggtgaacc aacagagaag tctcagccct ttcatgagtg gcgcactcaa
7321 tatctcgcat gtcacgccac cttcaagtag ggcctccagt tctgggacgg tctcaaccgt
7381 gcccaaggaa gttttggact cctggacatc tgcattcaac acacgcagac agccgctctt
7441 cgcacacctc agagtgaggg gggagtcacg tgtttagtga aaagaaataa ttggctataa
7501 tatgatttct ttaaaattta aatttggcta atttgtatct ttt
//