Typing tool
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Typing tool
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Complete norovirus genomes
| PV750892 | GII.17 | |
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| GII.P17 |
ORF1: 1..5098
ORF2: 5079..6695
ORF3: 6695..7474
LOCUS PV750892 7540 bp RNA linear VRL 26-NOV-2025
DEFINITION Norovirus GII isolate O1_Patient_18_ONCO nonstructural polyprotein
(ORF1) gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes,
complete cds.
ACCESSION PV750892
VERSION PV750892.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7540)
AUTHORS Tohma,K., Jacobsen,S., Altmann,B., Kendra,J.A., Landivar,M., De
La,O. Jr., Fernandez-Garcia,M.D., Gomes,K.A., Chudnovsky,S.,
Ford-Siltz,L.A., Pilewski,K.A., Gao,Y., Mazo,I., Niendorf,S. and
Parra,G.I.
TITLE GII.17 norovirus re-emerged in the 2020s as a result of dynamic and
adaptive evolutionary processes
JOURNAL Nat Commun (2025) In press
PUBMED 41285779
REMARK Publication Status: Available-Online prior to print
REFERENCE 2 (bases 1 to 7540)
AUTHORS Kutter,J.S. and Fernandez-Garcia,M.D.
TITLE Direct Submission
JOURNAL Submitted (06-JUN-2025) Enterovirus And Viral Gastroenteritis,
Instituto de Salud Carlos III, Ctra. Majadahonda-Pozuelo, Km 2,
Majadahonda, Madrid 28220, Spain
COMMENT ##Assembly-Data-START##
Assembly Method :: Metaspades v. v. v3.14.0
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7540
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="O1_Patient_18_ONCO"
/isolation_source="stool"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Spain: Getafe, Madrid"
/collection_date="17-Feb-2024"
/note="genotype: GII.17"
gene <1..5098
/gene="ORF1"
CDS <1..5098
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="XUS55912.1"
/translation="SNDASVAVAGKNNNNDNVKSSSDSLFSNMTVTFKKALGARSKQP
PPGETKQTLRPPRPPTPELVKKIPPPPPNGEDEPKVMYKVGEGVSGLPDLTTVAQPDA
QNTAYSVPPLSQREVGEAREPLPGSILEMWDGEIYHYGLYVERGHVLGVHKPPAAISL
AKIELTPLSLYWRVVYTPQYLIAPETLKNLNGETFPYTAFDNNCYAFCCWVLDLNDSW
LSRRMVQRTTGFFRPYQDWNRKPLPTMDEPKIKKAANAVLCALSSLFTRPIKDVIGKL
KPLNIMNILATCDWTFAGIVESMILLAELFGVFWTPPDVSAIIAPLLGDYEMQGPEDL
AVELVPVVMGGIGLVLGFTKEKIGKMLSSAATTLRACKDLGSYGLEILKLVMKWFFPK
KEEANELAMVRAIEDAVLDLEAIENNHMTTLLKDKDALATYMRTLDLEEEKARKLSSK
SASPDIVGTVNALLARIAAARSLVHKAKEELSSRQRPVVVMISGRPGIGKTHLARELA
KKVASTLSGDQRIGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIQDALRLQELADTCP
LTLNCDRIENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPDIEKA
KRDFPGQPDMWKDHYRPDFSHIKLQLAPQGGFDKSGNTPHGKGVVKSLTIGSLIARAS
GLLHERMDEFELQGPNLPTFNFDRNKVAAFRQLAAENKYGLMDTLRVGNQLKSVKTLD
ELKQAIKNITIKKCQIVYNGCTYTMESDGRNKVVVEKVQNATVQTNNELAGALHHLRS
ARIRYYVKCFQEAIYSILQIAGAAFVTTRIVRRMNISNLWSKPPVEEGDEPEDKGGCP
KPRDEDDLTIDSKDIKAEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERNGK
YSIEEYLQDRDRYYEELAIAKATEEDFCEEEEIKIRQRIFRPTRKQRKEERATLGLVT
GSEIRKRNPDDFKPKGKLWADDNRSVDYNERIDFEAPPSVWSRIVNFGTGWGFWVSPS
LFITSTHVIPKGITEAFGVPINQIQIHKSGEFCRLRFPKPIRPDVSGMILEEGAPEGT
VVSILIKRTTGELMPLAVRMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDC
GCPYIYKRGNDFVVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPILGP
GNAPKLSTKTKFWRSSNAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPR
GKPPKPSVLESAKKTIINVLEQTIDPPEKWSYAQACASLDKTTSSGYPYHVRKNDYWS
GESFTGKLADQASKANLMYEEGKHMQPVYTAALKDELVKTDKIYGKIKKRLLWGSDLS
TMIRCARAFGGLMDELKANCITLPIRVGMNMNEDGPIIFEKHSRYRYHYDADYSRWDS
TQQRAVLEAALEIIVRFSAEPQLAQIVAEDLLSPSVVDVGDFKITINEGLPSGVPCTS
QWNSIAHWLLTLCALSEVTGLGPDIIQANSMYSFYGDDEIVSTDIKLDPEKLTAKLKE
YGLKPTRPDKTEGPLVISEDLNGLTFLRRTVTRDPAGWFGKLDQNSILRQLYWTRGPN
HEDPSETMIPHAQRPVQLMALLGESSLHGPSFYSKVSKLVISELKEGGMDFYVPRQES
MFRWMRFSDLSTWEGDRNLAPSFVNEDGVE"
mat_peptide <1..988
/gene="ORF1"
/product="p48"
mat_peptide 989..2086
/gene="ORF1"
/product="NTPase"
mat_peptide 2087..2623
/gene="ORF1"
/product="p22"
mat_peptide 2624..3022
/gene="ORF1"
/product="VPg"
mat_peptide 3023..3565
/gene="ORF1"
/product="Pro"
mat_peptide 3566..5095
/gene="ORF1"
/product="RdRp"
gene 5079..6695
/gene="ORF2"
CDS 5079..6695
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="XUS55913.1"
/translation="MKMASNDAAPSNDGAAGLVPEGNNETLPLEPVAGAAIAAPVTGQ
NNIIDPWIRTNFVQAPNGEFTVSPRNSPGEILLNLELGPDLNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKILFAAVPPNFPVEFLSPAQITMLPHIIVDVRTLEPIMIPLPD
VRNTFFHYNNQPNSRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPTPDFEFTYLVPP
SVESKTKPFSLPILTLSELTNSRFPVPIDSLFTAQNNVLQVQCQNGRCTLDGELQGTT
QLLPSGICAFRGRVTAETDNPDKWHMQLQNLNGTTYDPTDDVPAPLGTPDFKGVVFGM
ASQRNVGNDAPGSTRSHEAVISTYSPRFVPKLGSVNFKSNDDDFQLQPTRFTPVGIND
DGNQPFRQWELPDYSGVLTLNMNLAPPVAPNFPGEQLLFFRSSVPCSGGYNQGIIDCL
IPQEWIQHFYQESAPSQSEVALIRYVNPDTGRTLFEAKLHRSGYITVAHSGDYPLVVP
ANGYFRFDSWVNQFYSLAPMGTGNGRRRAQ"
gene 6695..7474
/gene="ORF3"
CDS 6695..7474
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="XUS55914.1"
/translation="MAGAFIAGLAGDMLTSSVGSLVNAGANAINQKIDFENNKQLQSA
SFQHDKEMLQAQVNATKQLQSEMIALKQGVLAAGGFSPTDAARGAIGAPMTKVLDWSG
TRYWAPNSTKTTGYSGQFTSSPVHMPSPSVPQSKPAKPKSLGSSSSSSSVHSMSTQLT
SLTSGSSSNASSASTKLTNLSSGSSQNRTAEWVNQQRSLSPFMSGALNISHVTPPSSR
ASSSGTVSTVPKEVLDSWTSAFNTRRQPLFAHLRVRGESRV"
ORIGIN
1 gtctaacgac gcttccgttg ccgttgctgg caaaaacaac aacaacgaca atgtaaaatc
61 ttcaagtgac agcttgtttt ctaacatgac tgttactttt aagaaagccc tcggggcgcg
121 gtctaagcag ccgcccccgg gagaaacaaa acaaacacta agaccaccaa ggccgccgac
181 accggaattg gtgaagaaga tacccccacc cccccccaat ggcgaggatg aaccaaaggt
241 aatgtataag gtgggagaag gtgtgtctgg gctgcccgac ttaacaactg tggcacaacc
301 tgacgcacag aacacagcct atagtgtccc cccacttagc cagagagagg tcggcgaagc
361 tagagaaccg ttgcctggct ccattctgga aatgtgggat ggtgagatct accactatgg
421 gctgtatgtt gagcgggggc atgtgctggg agtgcacaaa ccacctgctg caataagcct
481 tgccaaaatt gagttaacac cgctgtctct ctactggaga gtggtctaca ctccccagta
541 cttgatagct ccagagaccc tcaagaattt aaatggagag actttcccat acacggcctt
601 tgacaacaac tgttatgcct tctgttgttg ggttctagac ctcaacgact cctggcttag
661 cagaagaatg gtccaaagaa caaccggatt cttcagaccg tatcaggact ggaacagaaa
721 acccttacca accatggatg aaccaaaaat caagaaggcc gcgaatgctg ttctgtgtgc
781 tctctcctca ctcttcacta ggcccatcaa agatgtcatt ggaaagctta aaccactaaa
841 cattatgaac atactggcaa cttgtgattg gacttttgcg ggcatagtgg aatccatgat
901 ccttcttgct gaactctttg gggtgttctg gacgccccca gatgtgtctg caataattgc
961 tcccttactc ggtgactacg agatgcaagg ccccgaagac ctggccgtgg aacttgtgcc
1021 cgtggtaatg ggaggaatag gtttggtgtt aggattcacc aaggaaaaga tcggcaagat
1081 gctttcatca gctgcaacca cactcagggc ctgtaaggat ctaggatctt atgggttgga
1141 gatactcaaa ctggtcatga agtggttctt ccccaagaag gaggaggcca acgagttagc
1201 catggtgagg gccattgagg atgcagttct ggatttggag gcaatagaaa acaaccacat
1261 gaccactctc cttaaggaca aagacgccct ggccacatac atgaggactc ttgacttgga
1321 agaagaaaaa gcaaggaaac tatcttccaa atcggcgtca cctgacatcg tgggcacagt
1381 aaacgcatta ttggcaagaa tagcagccgc caggtcactg gtccacaagg ctaaggagga
1441 gctctcgagc agacagagac ctgttgttgt aatgatatca ggtaggccag gtataggaaa
1501 gacccatctg gccagagagc tagccaagaa ggttgcgtca acactgtcag gcgaccaaag
1561 gattggactg atacccagaa atggcgtcga ccattgggac gcctacaaag gagagcgggt
1621 ggttctgtgg gatgactatg gcatgagcaa ccctatacag gacgcactga ggctccaaga
1681 attggctgac acctgtcctc tgaccctaaa ttgtgacaga attgaaaaca aaggaaaagt
1741 gttcgacagt gacgccataa tcataacgac caaccttgca aacccagcac cattggatta
1801 tgttaacttt gaggcttgtt ccagacgcat agacttcttg gtgtatgcag acgcacctga
1861 catcgagaag gctaagcgtg acttccctgg ccaaccagat atgtggaaag accattacag
1921 accagacttc tcacacatta aacttcagct cgcaccacag ggaggctttg ataagagtgg
1981 caacacccca catggcaaag gtgtggttaa gtctctgacg attggttctc tgatcgccag
2041 ggcttctggc ttgctccatg agagaatgga tgaattcgag ctccaaggcc ccaacttacc
2101 aaccttcaat ttcgaccgta acaaagtcgc cgccttcaga caattggcag ctgaaaacaa
2161 atacggtctt atggacacac tgagggtcgg caaccaactg aaaagtgtca aaaccctgga
2221 tgagctgaag caggctataa agaacatcac catcaagaag tgccagatag tgtacaatgg
2281 atgcacctac accatggaat ctgatgggag gaacaaggtt gtggttgaaa aggttcaaaa
2341 tgcaacagtc caaaccaaca atgaacttgc aggagcactc caccacctga gatctgcaag
2401 aataaggtat tatgtcaaat gtttccaaga agctatttac tctatactcc aaattgctgg
2461 tgcagccttc gtcaccacac gcatcgtgag gcgcatgaac atctcaaacc tctggtcgaa
2521 gccacccgtc gaagagggtg atgagcctga agacaaaggg gggtgcccca agcccaggga
2581 tgaagatgac ctcactattg actccaaaga cattaaagca gaaggtaaga agggcaagaa
2641 caaatctggc cggggcaaga aacacacagc tttctcatcc aagggcctca gtgatgaaga
2701 gtacgatgag tacaagagaa tcagggagga gagaaatggc aagtactcaa tagaagaata
2761 cctccaggat agggatagat actatgaaga gcttgccatt gctaaggcca ctgaggaaga
2821 cttctgtgaa gaggaagaaa tcaaaattcg ccagagaatc ttccggccca ccaggaagca
2881 gcgaaaagag gaaagagcca cgcttgggct cgtcacagga tcggaaatca gaaagaggaa
2941 cccagatgat tttaagccaa aaggaaaatt gtgggctgat gacaacagga gtgtggacta
3001 caatgagagg atagattttg aggctccccc aagtgtttgg tctaggatag tcaactttgg
3061 tacagggtgg ggattctggg tctccccaag tctctttata acttcaacac atgtcatacc
3121 aaaaggaatc actgaggcct ttggagttcc cattaaccaa attcaaattc acaaatctgg
3181 agagttttgc cgcttgcggt ttccaaaacc aatcaggcca gacgtgagtg gaatgatctt
3241 ggaagagggt gcccctgaag gcactgttgt ttccattctc atcaagagga cgacagggga
3301 actgatgcct ctcgcagtca gaatgggaac tcatgccaca atgaaaatcc aaggtagaac
3361 ggtgggcggt caaatgggca tgcttctcac tggctcaaac gccaaaagca tggacctagg
3421 cacaacacca ggtgactgtg ggtgcccata catatacaaa aggggcaatg acttcgtggt
3481 cattggggtg cacactgcag cagcccgtgg aggtaacacg gtcatatgtg ccacacaggg
3541 gagtgaaggc gaagccaccc tcgaaggagg tgacaacaag ggcacctatt gtggagcccc
3601 catcttgggt cctggcaacg caccaaaatt gagcacaaaa acaaaattct ggagatcttc
3661 taacgcgccg ctcccgccag gcacctatga accagcatac cttggtggaa aagacccgcg
3721 tgtgaaggga ggcccatctc tacaacaggt tatgagagac caactcaaac cttttacaga
3781 gcccagaggg aagccaccaa aaccaagcgt cctagaatca gcaaagaaga ccatcattaa
3841 tgttctggaa caaaccattg acccacctga aaagtggtca tatgcccaag cttgtgcatc
3901 cctcgacaag acaacctcca gtggataccc gtatcacgtc cggaagaatg actactggag
3961 tggtgaatcc ttcacgggga aacttgcaga ccaggcctca aaagcaaatc tcatgtatga
4021 ggaaggtaag cacatgcaac cagtttacac cgcagcactc aaagacgagc tcgtgaaaac
4081 tgacaaaatt tatggcaaga tcaagaaaag actcctgtgg ggctctgacc tatccaccat
4141 gattcgatgc gccagggcat ttggtggcct catggacgag ctcaaagcaa attgtatcac
4201 actccctatc agagttggta tgaacatgaa tgaagatggt cccataatat ttgaaaagca
4261 ctccaggtac aggtaccact atgatgctga ttattcccgc tgggattcca cacaacagcg
4321 ggcagtgctg gaagcggcac ttgaaatcat agtgagattt tctgctgagc cacagttggc
4381 acaaatagtg gcagaggacc tgctatcacc aagtgtggtt gatgtgggcg atttcaaaat
4441 tactattaat gaaggcctac catctggcgt gccttgcact tcacaatgga attctattgc
4501 ccactggtta ctcaccctat gtgccctgtc tgaagtgaca ggactaggcc ctgacatcat
4561 acaagccaac tccatgtact ctttctatgg tgatgatgag attgtgagca cagacataaa
4621 attagaccca gagaaattga ctgcaaaact caaagaatat ggtcttaaac ccacccggcc
4681 tgacaagact gaggggccac tggtaattag tgaggacctg aatgggttga ctttcctccg
4741 ccgaacagtc acccgcgatc cagcgggttg gtttggaaag ttggaccaaa actccatcct
4801 cagacagctg tactggacaa ggggacccaa ccatgaagac cccagtgaga ctatgatacc
4861 acacgcacag agacctgtgc agctcatggc attgctagga gaatcctccc tacatggacc
4921 ctcattttac agcaaggtta gcaagctggt tatatctgaa cttaaagagg gaggaatgga
4981 tttttatgtg cccagacaag agtcaatgtt caggtggatg aggttctcag atctaagcac
5041 atgggagggc gatcgcaatc tggctcccag ttttgtgaat gaagatggcg tcgaatgacg
5101 ccgctccatc taatgatggt gctgctggtc tcgtaccaga gggcaataac gagacccttc
5161 ccctagaacc agttgcgggc gcagccatag ccgcacccgt cactggccaa aataatataa
5221 ttgacccctg gattagaaca aattttgtgc aagcaccaaa tggagagttc acagtgtcac
5281 ccagaaactc tcctggagaa attttactaa acctagagtt gggccctgat ctgaaccctt
5341 atttggctca tttgtcaagg atgtataatg gatatgctgg tggagttgaa gtccaggttc
5401 tcctggcagg gaacgcgttc actgccggga agatcctctt cgccgctgtc ccgccaaatt
5461 ttccggtgga attcttaagc ccagcccaga ttacaatgct cccacatata atagtagatg
5521 ttaggactct tgaaccaatt atgatcccat tacctgatgt taggaataca ttcttccact
5581 ataataatca gcccaacagc cgcatgagat tagtggctat gctctacacc ccccttagat
5641 ctaatggctc aggtgatgat gttttcactg tttcttgcag ggttttgact aggcctactc
5701 ctgattttga gttcacttat ctagtgccac cctctgttga atctaagact aaaccctttt
5761 ctttacccat tctaaccctt tctgagctca caaattcgag gttcccggtc cccatcgatt
5821 cgcttttcac cgcccaaaat aatgtgttgc aggtgcagtg tcaaaatggc aggtgcacac
5881 ttgacggtga gctacaaggc acaacccagt tgctcccatc tggcatctgt gcgttcaggg
5941 gacgggtgac agcagaaact gacaatcctg acaagtggca catgcaactg caaaacctta
6001 atggcacaac atatgaccca actgatgatg tgccagcccc actgggtaca cctgacttca
6061 agggcgtcgt gtttgggatg gcaagccaaa gaaatgtggg taacgacgcg cccggctcaa
6121 ccaggtccca tgaggcggtg atttcaacct acagccccag atttgttcct aaattaggct
6181 ctgtcaattt caaaagcaat gacgatgatt tccaattgca gccaacaaga ttcacaccag
6241 tgggcattaa tgatgatggc aaccaaccat tcagacaatg ggaactacca gattattcag
6301 gggtgcttac cttgaatatg aaccttgccc cccctgttgc tccaaatttc cctggcgaac
6361 aattactatt cttcagatct tctgtgccat gttcaggagg ttacaaccaa ggtattatag
6421 attgccttat cccccaagaa tggatccaac atttctacca ggaatcagca ccttctcagt
6481 cagaagtggc cctaatcagg tacgtcaacc ccgatacggg tcgtacactg tttgaggcaa
6541 aattgcatag gtcaggctat atcactgtgg ctcattctgg agactatcct cttgttgttc
6601 cggctaatgg atactttaga tttgactctt gggtaaatca gttttactca ctcgccccaa
6661 tgggaactgg gaatgggcga aggagggctc agtaatggct ggagctttca ttgcaggatt
6721 ggcgggtgac atgctcacgt catccgtggg ctccctggtg aacgcagggg caaacgccat
6781 caaccaaaag atagactttg aaaacaacaa acaactccag tctgcttcct ttcaacatga
6841 taaagagatg ctccaagcgc aggtgaacgc aaccaagcag ctgcaatctg agatgatagc
6901 cctaaaacag ggggttttgg ccgcaggcgg cttttccccc actgatgcag cgaggggggc
6961 catcggtgca cccatgacaa aggtgcttga ctggtctggc actcgatact gggctcccaa
7021 ttccacaaag acaactggtt attcggggca attcacctct tcacctgtgc acatgcccag
7081 cccgagtgtc ccacaatcaa aacccgcaaa gcccaagtct ctaggttctt cttcttcttc
7141 tagtagtgtt cacagtatgt ctacccaatt aacttctcta acatctggct cttctagtaa
7201 tgcttcttct gcttctacaa aattgacaaa tttgagctcc ggctcttctc aaaacagaac
7261 agcagagtgg gtgaaccaac agagaagtct cagccctttc atgagtggcg cactcaatat
7321 ctcgcatgtc acgccacctt caagtagggc ctccagttct gggacggtct caaccgtgcc
7381 caaggaagtt ttggactcct ggacatctgc attcaacaca cgcagacagc cgctcttcgc
7441 acacctcaga gtgagggggg agtcacgtgt ttagtgaaaa gaaataattg gctataatat
7501 gatttcttta aaatttaaat ttggctaatt tgtatctttt
//