Typing tool
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Typing tool
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Complete norovirus genomes
| PQ336942 | GII.17 | |
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| GII.P17 |
ORF1: 1..5092
ORF2: 5073..6689
ORF3: 6689..7468
LOCUS PQ336942 7468 bp RNA linear VRL 17-OCT-2024
DEFINITION Norovirus GII isolate Hu/NL/2024/GII.17[P17]Rotterdam/100266
nonstructural polyprotein (ORF1) gene, partial cds; and VP1 (ORF2)
and VP2 (ORF3) genes, complete cds.
ACCESSION PQ336942
VERSION PQ336942.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7468)
AUTHORS Chhabra,P., Wong,S., Niendorf,S., Lederer,I., Vennema,H., Faber,M.,
Nisavanh,A., Jacobsen,S., Williams,R., Colgan,A., Yandle,Z.,
Garvey,P., Al-Hello,H., Ambert-Balay,K., Barclay,L., de Graaf,M.,
Celma,C., Breuer,J., Vinje,J. and Douglas,A.
TITLE Increased circulation of GII.17 noroviruses, six European countries
and the United States, 2023 to 2024
JOURNAL Euro Surveill 29 (39) (2024)
REMARK DOI: 10.2807/1560-7917.ES.2024.29.39.2400625
REFERENCE 2 (bases 1 to 7468)
AUTHORS de Graaf,M.
TITLE Direct Submission
JOURNAL Submitted (17-SEP-2024) Viroscience, Erasmus MC, Wytemaweg 80,
Rotterdam 1055SV, Netherlands
COMMENT ##Assembly-Data-START##
Sequencing Technology :: Sanger dideoxy sequencing
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7468
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Hu/NL/2024/GII.17[P17]Rotterdam/100266"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Netherlands"
/collection_date="23-Apr-2024"
/note="genotype: GII.17"
gene <1..5092
/gene="ORF1"
CDS <1..5092
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="XGX96926.1"
/translation="DASAAVAGKNNNNDNVKSSSDSLFSNMTVTFKKALGARSKQPPP
GETKQTLRPPRPPTPELVKKIPPPPPNGEDEPKVTYKVGEGVSGLPDLTTVAQPDAQN
TAYSVPPLSQREVGEAREPLPGSILEMWDGEIYHYGLYVERGHVLGVHKPPAAISLAK
IELTPLSLYWRVVYTPQYLIAPETLKNLNGETFPYTAFDNNCYAFCCWVLDLNDSWLS
RRMVQRTTGFFRPYQDWNRKPLPTMDEPKIKKAANAVLCALSSLFTRPIKDVIGKLKP
LNIMNILATCDWTFAGIVESMILLAELFGVFWTPPDVSAIIAPLLGDYEMQGPEDLAV
ELVPVVMGGIGLVLGFTKEKIGKMLSSAATTLRACKDLGSYGLEILKLVMKWFFPKKK
EANELAMVRAIEDAVLDLEAIENNHMTTLLKDKDALATYMRTLDLEEEKARKLSSKSA
SPDIVGTVNALLARIAAARSLVHKAKEELSSRQRPVVVMISGRPGIGKTHLARELAKK
VASTLSGDQRIGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIQDALRLQELADTCPLT
LNCDRIENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPDIEKAKR
DFPGQPDMWKDHYRPDFSHIKLQLAPQGGFDKSGNTPHGKGVVKSLTIGSLIARASGL
LHERMDEFELQGPNLPTFNFDRNKVAAFRQLAAENKYGLMDTLRVGNQLKSVKTLDEL
KQAIKNITIKKCQIVYNGCTYTMESDGRNKVVVEKVQNATVQTNNELAGALHHLRSAR
IRYYVKCFQEAIYSILQIAGAAFVTTRIVRRMNISNLWSKPPVEEGDEPEDKGGCPKP
RDEDDLTIDSKDIKAEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYS
IEEYLQDRDRYYEELAIAKATEEDFCEEEEIKIRQRIFRPTRKQRKEERATLGLVTGS
EIRKRNPDDFKPKGKLWADDNRSVDYNERIDFEAPPSVWSRIVNFGTGWGFWVSPSLF
ITSTHVIPKGITEAFGVPINQIQIHKSGEFCRLRFPKPIRPDVSGMILEEGAPEGTVV
SILIKRTTGELMPLAVRMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGC
PYIYKRGNDFVVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPILGPGN
APKLSTKTKFWRSSNAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGK
PPKPSVLESAKKTIINVLEQTIDPPEKWSYAQACASLDKTTSSGYPHHVRKNDYWSGE
SFTGKLADQASKANLMYEEGKHMQPVYTAALKDELVKTDKIYGKIKKRLLWGSDLSTM
IRCARAFGGLMDELKANCITLPIRVGMNMNEDGPIIFEKHSRYRYHYDADYSRWDSTQ
QRAVLEAALEIMVRFSAEPQLAQIVAEDLLSPSVVDVGDFKITINEGLPSGVPCTSQW
NSIAHWLLTLCALSEVTGLGPDIIQANSMYSFYGDDEIVSTDIKLDPEKLTAKLKEYG
LKPTRPDKTEGPLVISEDLNGLTFLRRTVTRDPAGWFGKLDQNSILRQLYWTRGPNHE
DPSETMIPHAQRPVQLMALLGESSLHGPSFYSKVSKLVISELKEGGMDFYVPRQESMF
RWMRFSDLSTWEGDRNLAPSFVNEDGVE"
mat_peptide <1..982
/gene="ORF1"
/product="p48"
mat_peptide 983..2080
/gene="ORF1"
/product="NTPase"
mat_peptide 2081..2617
/gene="ORF1"
/product="p22"
mat_peptide 2618..3016
/gene="ORF1"
/product="VPg"
mat_peptide 3017..3559
/gene="ORF1"
/product="Pro"
mat_peptide 3560..5089
/gene="ORF1"
/product="RdRp"
gene 5073..6689
/gene="ORF2"
CDS 5073..6689
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="XGX96927.1"
/translation="MKMASNDAAPSNDGAAGLVPEGNNETLPLEPVAGAAIAAPVTGQ
NNIIDPWIRTNFVQAPNGEFTVSPRNSPGEILLNLELGPDLNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKILFAAVPPNFPVEFLSPAQITMLPHIIVDVRTLEPIMIPLPD
VRNTFFHYNNQPNSRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPTPDFEFTYLVPP
SVESKTKPFSLPILTLSELTNSRFPVPIDSLFTAQNNVLQVQCQNGRCTLDGELQGTT
QLLPSGICAFRGRVTAETDNPDKWHMQLQNLNGTTYDPTDDVPAPLGTPDFKGVVFGM
ASQRNVGNDAPGSTRSHEAVISTYSPRFVPKLGSVNFKSNDDDFQLQPTRFTPVGIND
DGNQPFRQWELPDYSGVLTLNMNLAPPVAPNFPGEQLLFFRSSVPCSGGYNQGIIDCL
IPQEWIQHFYQESAPSQSEVALIRYVNPDTGRTLFEAKLHRSGYITVAHSGDYPLVVP
ANGYFRFDSWVNQFYSLAPMGTGNGRRRAQ"
gene 6689..7468
/gene="ORF3"
CDS 6689..7468
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="XGX96928.1"
/translation="MAGAFIAGLAGDMLTSSVGSLVNAGANAINQKIDFENNKQLQSA
SFQHDKEMLQAQVNATKQLQSEMIALKQGVLAAGGFSPTDAARGAIGAPMTKVLDWSG
TRYWAPNSTKTTGYSGQFTSSPVHMPSPSVPQSKPAKPKSLGSSSSSSSVYSMSTQLT
SLTSGSSSNASSASTKLTNLSSGSSQNRTAEWVNQQRSLSPFMSGALNISHVTPPSSR
ASSSGTVSTVPKEVLDSWTSAFNTRRQPLFAHLRVRGESRV"
ORIGIN
1 cgacgcttcc gctgccgttg ctggcaaaaa caacaacaac gacaatgtaa aatcttcaag
61 tgacagcttg ttttctaaca tgactgttac ttttaagaaa gccctcgggg cgcggtctaa
121 gcagccgccc ccgggagaaa caaaacaaac actaagacca ccaaggccgc cgacaccgga
181 attggtgaag aagatacccc cgcctccccc caatggcgag gatgaaccaa aggtaacgta
241 taaggtggga gaaggtgtgt ctgggctgcc cgacttaaca accgtggcac aacctgacgc
301 acagaacaca gcctatagtg tccccccact tagccagaga gaggtcggcg aagctagaga
361 accgttgcct ggctccattc tggaaatgtg ggatggtgag atctaccact atgggctgta
421 tgttgagcgg gggcatgtgc tgggagtgca caaaccacct gctgcaataa gccttgccaa
481 aattgagtta acaccgctgt ctctctactg gagagtggtc tacactcccc agtacttgat
541 agctccagag accctcaaga atttaaatgg agagactttc ccatacacgg cctttgacaa
601 caactgttat gccttctgtt gttgggttct agacctcaac gactcctggc ttagcagaag
661 aatggtccaa agaacaaccg gattcttcag accgtatcag gactggaaca gaaaaccctt
721 accaaccatg gatgaaccaa aaatcaagaa ggccgcgaat gctgttctgt gtgctctctc
781 ctcactcttc actaggccca tcaaagatgt cattggaaag cttaaaccac taaacattat
841 gaacatactg gcaacttgtg attggacttt tgcgggcata gtggaatcca tgatccttct
901 tgctgaactc tttggggtgt tctggacgcc cccagatgtg tctgcaataa ttgctccctt
961 actcggtgac tacgagatgc aaggccccga agacctggcc gtggaacttg tgcccgtggt
1021 aatgggagga ataggtttgg tgttaggatt caccaaggaa aagatcggca agatgctttc
1081 atcagctgca accacactca gggcctgtaa ggatctagga tcttatgggt tggagatact
1141 caaactggtc atgaagtggt tcttccccaa gaagaaggag gccaacgagt tagccatggt
1201 gagggccatt gaggatgcag ttctggattt ggaggcaata gaaaacaacc acatgaccac
1261 tctccttaag gacaaagacg ccctggccac atacatgagg actcttgact tggaagaaga
1321 aaaagcaagg aaactatctt ccaaatcggc gtcacctgac atcgtgggca cagtaaacgc
1381 attattggca agaatagcag ccgccaggtc actggtccac aaggctaagg aggagctctc
1441 gagcagacag agacctgttg ttgtaatgat atcaggtagg ccaggtatag gaaagaccca
1501 tctggccaga gagctagcca agaaggttgc gtcaacactg tcaggcgacc aaaggattgg
1561 actgataccc agaaatggcg tcgaccattg ggacgcctac aaaggagagc gggtggttct
1621 gtgggatgac tatggcatga gcaaccctat acaggacgca ctgaggctcc aagaattggc
1681 tgacacctgt cctctgaccc taaattgtga tagaattgaa aacaaaggaa aagtgttcga
1741 cagtgacgcc ataatcataa cgaccaacct tgcaaaccca gcaccattgg attatgtcaa
1801 ctttgaggct tgttccagac gcatagactt cttggtgtat gcagacgcac ctgacatcga
1861 gaaggctaag cgtgacttcc ctggccaacc agatatgtgg aaagaccatt acagaccaga
1921 cttctcacac attaaacttc agctcgcacc acagggaggc tttgataaga gtggcaacac
1981 cccacatggc aaaggtgtgg ttaagtctct gacgattggt tctctgatcg ccagggcttc
2041 tggcttgctc catgagagaa tggatgaatt cgagctccaa ggccccaact taccaacctt
2101 caatttcgac cgtaacaaag tcgccgcctt cagacaattg gcagctgaaa acaaatacgg
2161 tcttatggac acactgaggg tcggcaacca actgaaaagt gtcaaaaccc tggatgagct
2221 gaagcaggct ataaagaaca tcaccatcaa gaagtgccag atagtgtaca atggatgcac
2281 ctacaccatg gaatctgatg ggaggaacaa ggttgtggtt gaaaaggttc aaaatgcaac
2341 agtccaaacc aacaatgaac ttgcaggagc actccaccac ctgagatctg caagaataag
2401 gtattatgtc aaatgtttcc aagaagctat ttactctata ctccaaattg ctggtgcagc
2461 cttcgtcacc acacgcatcg tgaggcgcat gaacatctca aacctctggt cgaagccacc
2521 cgtcgaagag ggtgatgagc ctgaagacaa aggggggtgc cccaagccca gggatgaaga
2581 tgacctcact attgactcca aagacattaa agcagaaggt aagaagggca agaacaaatc
2641 tggccggggc aagaaacaca cagctttctc atccaagggc ctcagtgatg aagagtacga
2701 tgagtacaag agaatcaggg aggagagaaa tggcaagtac tcaatagaag aatacctcca
2761 ggatagggat agatactatg aagagcttgc cattgctaag gccactgagg aagacttctg
2821 tgaagaggag gaaatcaaaa ttcgccagag aatcttccgg cccaccagga agcagcggaa
2881 agaggaaaga gccacgcttg ggctcgtcac aggatcggaa atcagaaaga ggaacccaga
2941 tgattttaag ccaaaaggaa aattgtgggc tgatgacaac aggagtgtgg actacaatga
3001 gaggatagat tttgaggctc ccccaagtgt ttggtctaga atagtcaact ttggtacagg
3061 atggggattc tgggtctccc caagtctctt tataacttca acacatgtca taccaaaagg
3121 aatcactgag gcctttggag ttcccattaa ccaaattcaa attcacaaat ctggagagtt
3181 ttgccgcttg cggtttccaa aaccaatcag gccagacgtg agtggaatga tcttggaaga
3241 gggtgcccct gaaggcactg ttgtttccat tctcatcaag aggacgacag gggaactgat
3301 gcctctcgca gtcagaatgg gaactcatgc cacaatgaaa atccaaggta gaacggtggg
3361 cggtcaaatg ggcatgcttc tcactggctc aaacgccaaa agcatggacc taggcacaac
3421 accaggtgac tgtgggtgcc catacatata caaaaggggc aatgacttcg tggtcattgg
3481 ggtgcacact gcagcagccc gtggaggtaa cacggtcata tgtgccacac aggggagtga
3541 aggcgaagcc accctcgaag gaggtgacaa caagggcacc tattgtggag cccccatctt
3601 gggtcctggc aacgcaccaa aattgagcac aaaaacaaaa ttctggagat cttctaacgc
3661 gccgctcccg ccaggcacct atgaaccagc ataccttggt ggaaaagacc cgcgtgtgaa
3721 gggaggccca tctctacaac aggttatgag agaccaactc aaacctttta cagagcccag
3781 agggaagcca ccaaaaccaa gtgtcttaga atcagcaaag aagaccatca ttaatgttct
3841 ggaacaaacc attgaccccc ctgaaaagtg gtcatatgcc caagcttgtg catccctcga
3901 caagacaacc tccagtggat acccgcatca cgtccggaag aatgactact ggagtggtga
3961 atccttcacg gggaaacttg cagaccaggc ctcaaaagca aatctcatgt atgaggaagg
4021 taagcacatg caaccagttt acaccgcagc actcaaagac gagctcgtga aaactgacaa
4081 aatttatggc aagatcaaga aaagactcct gtggggctct gacctatcca ccatgattcg
4141 atgcgccagg gcatttggtg gcctcatgga cgagctcaaa gcaaattgta tcacactccc
4201 tatcagagtt ggtatgaaca tgaatgaaga tggtcccata atatttgaaa agcactccag
4261 gtacaggtac cactatgatg ctgattattc ccgctgggat tccacacaac agcgggcagt
4321 gctggaagcg gcacttgaaa tcatggtgag attttctgct gagccacagt tggcacaaat
4381 agtggcagag gacctgctat caccaagtgt ggttgatgtg ggcgatttca aaattactat
4441 taatgaaggc ctaccatctg gcgtgccttg cacttcacaa tggaattcta ttgcccactg
4501 gttactcacc ctatgtgccc tgtctgaagt gacaggacta ggccctgaca tcatacaagc
4561 caactccatg tactctttct atggtgatga tgagattgtg agcacagaca taaaattaga
4621 cccagagaaa ttgactgcaa aactcaaaga atatggtctt aaacccaccc ggcctgacaa
4681 gactgagggg ccactggtaa ttagtgagga cctgaatggg ttgactttcc tccgccgaac
4741 agtcacccgc gatccagcgg gttggtttgg aaagttggac caaaactcca tcctcagaca
4801 gctgtactgg acaaggggac ccaaccatga agaccccagt gagactatga taccacacgc
4861 acagagacct gtgcagctca tggcattgct aggagaatcc tccctacatg gaccctcatt
4921 ttacagcaag gttagcaagc tggttatatc tgaacttaaa gagggaggaa tggattttta
4981 tgtgcccaga caagagtcaa tgttcaggtg gatgaggttc tcagatctaa gcacatggga
5041 gggcgatcgc aatctggctc ccagttttgt gaatgaagat ggcgtcgaat gacgccgctc
5101 catctaatga tggtgctgct ggtctcgtac cagagggcaa taacgagacc cttcccctag
5161 aaccagttgc gggcgcagct atagccgcac ccgtcactgg ccaaaataat ataattgacc
5221 cctggattag aacaaatttt gtgcaagcac caaatggaga gttcacagtg tcacccagaa
5281 actctcctgg agaaatttta ctaaacctag agttgggccc tgatctgaac ccttatttgg
5341 ctcatttgtc aaggatgtat aatggatatg ctggtggagt tgaagtccag gttctcctgg
5401 cagggaacgc gttcactgcc gggaagatcc tcttcgccgc tgtcccgcca aattttccgg
5461 tggaattctt aagcccagcc cagattacaa tgctcccaca tataatagta gatgttagga
5521 ctcttgaacc aattatgatc ccattacctg atgttaggaa tacattcttc cactataata
5581 atcagcccaa cagccgcatg agattagtgg ctatgctcta cacccccctt agatctaatg
5641 gctcaggtga tgatgttttc actgtttctt gcagggtttt gactaggcct actcctgatt
5701 ttgagttcac ttatctagtg ccaccctctg ttgaatctaa gactaaaccc ttttctttac
5761 ccattctaac cctttctgag ctcacaaatt cgaggttccc ggtccccatc gattcgcttt
5821 tcaccgccca aaataatgtg ttgcaggtgc agtgtcaaaa tggcaggtgc acacttgacg
5881 gtgagctaca aggcacaacc cagttgctcc catctggcat ctgtgcgttc aggggacggg
5941 tgacagcaga aactgacaat cctgacaagt ggcacatgca actgcaaaac cttaatggca
6001 caacatatga cccaactgat gatgtgccag ccccactggg tacacctgac ttcaagggcg
6061 tcgtgtttgg gatggcaagc caaagaaatg tgggtaacga cgcgcccggc tcaaccaggt
6121 cccatgaggc ggtgatttca acctacagcc ccagatttgt tcctaaatta ggctctgtca
6181 atttcaaaag caatgacgat gatttccaat tgcagccaac aagattcaca ccagtgggca
6241 ttaatgatga tggcaaccaa ccattcagac aatgggaatt accagattat tcaggggtgc
6301 ttaccttgaa tatgaacctt gccccccctg ttgctccaaa tttccctggc gaacaattac
6361 tattcttcag atcttctgtg ccatgttcag gaggttacaa ccaaggtatt atagattgcc
6421 ttatccccca agaatggatc caacacttct accaggaatc agcaccttct cagtcagaag
6481 tggccctaat caggtacgtc aaccccgaca cgggtcgtac actgtttgag gcaaaattgc
6541 ataggtcagg ctatatcact gtggctcatt ctggagacta tcctcttgtt gttccggcta
6601 atggatactt tagatttgac tcttgggtaa atcagtttta ctcactcgcc ccaatgggaa
6661 ctgggaatgg gcgaaggagg gctcagtaat ggctggagct ttcattgcag gattggcggg
6721 tgacatgctc acgtcatccg tgggctccct ggtgaacgca ggggcaaacg ccatcaacca
6781 aaagatagac tttgaaaaca acaaacaact ccagtctgct tcctttcaac atgataaaga
6841 gatgctccaa gcgcaggtga acgcaaccaa gcagctgcaa tctgagatga tagccctaaa
6901 acagggggtt ttggccgcag gcggcttttc ccccactgat gcagcgaggg gggccatcgg
6961 tgcacccatg acaaaggtgc ttgactggtc tggcactcga tactgggctc ccaattccac
7021 aaagacaact ggttattcgg ggcaattcac ctcttcacct gtgcacatgc ccagcccgag
7081 tgtcccacaa tcaaaacccg caaagcccaa gtctctaggt tcttcttctt cttctagtag
7141 tgtttacagt atgtctaccc aattaacttc tctaacatct ggctcttcta gtaatgcttc
7201 ttctgcttct acaaaattga caaatttgag ctccggctct tctcaaaaca gaacagcaga
7261 gtgggtgaac caacagagaa gtctcagccc tttcatgagt ggcgcactca atatctcgca
7321 tgtcacgcca ccttcaagta gggcctccag ttctgggacg gtctcaaccg tgcccaagga
7381 agttttggac tcctggacat ctgcattcaa cacacgcaga cagccgctct tcgcacacct
7441 cagagtgagg ggggagtcac gtgtttag
//